Erratum: Deletion of Microsomal Cytochrome b5 Profoundly Affects Hepatic and Extrahepatic Drug Metabolism (Molecular Pharmacology (2010) 78 (269-278) DOI: 10.1124/mol.110.064246);Deletion of microsomal cytochrome b5 profoundly affects hepatic and extrahepatic drug metabolism

Molecular Pharmacology

Volumn 78, Issue 2, 2010, Pages 269-278

  McLaughlin, Lesley A ^a   Ronseaux, Sebastien ^a   Finn, Robert D ^a   Henderson, Colin J ^a   Wolf, C Roland ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME B5; CYTOCHROME P450; CYTOCHROME P450 17; DRUG METABOLIZING ENZYME; HYDROLASE; ISOPROTEIN; LYASE; MESSENGER RNA; METHEMOGLOBIN; MICROSOME ENZYME; TESTOSTERONE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME SUBSTRATE; FEMALE; GENE DELETION; HORMONE METABOLISM; IN VITRO STUDY; IN VIVO STUDY; KIDNEY PARENCHYMA; KNOCKOUT MOUSE; LIPID METABOLISM; LIVER; LIVER METABOLISM; LUNG PARENCHYMA; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REDUCTION; SMALL INTESTINE; STEROID METABOLISM; TESTIS; TESTOSTERONE METABOLISM; TISSUE LEVEL; TISSUE METABOLISM;

EID: 77954890052     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.114.85er01     Document Type: Erratum

References (44)

1. Akhtar MK, Kelly SL, and Kaderbhai MA (2005) Cytochrome b(5) modulation of 17{alpha} hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis. J Endocrinol 187:267-274.
2. Anzenbacher P and Hudecek J (2001) Differences in flexibility of active sites of cytochromes P450 probed by resonance Raman and UV-Vis absorption spectroscopy. J Inorg Biochem 87:209-213.
3. Auchus RJ, Lee TC, and Miller WL (1998) Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer. J Biol Chem 273:3158-3165.
4. Borthiry GR, Antholine WE, Kalyanaraman B, Myers JM, and Myers CR (2007) Reduction of hexavalent chromium by human cytochrome b5: generation of hydroxyl radical and superoxide. Free Radic Biol Med 42:738-755; discussion 735-737.
5. Bridges A, Gruenke L, Chang YT, Vakser IA, Loew G, and Waskell L (1998) Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase. J Biol Chem 273:17036-17049. (Pubitemid 28311737)
6. Croft JE, Harrelson WG, Parandoosh Z, and Philpot RM (1986) Unique properties of NADPH- and NADH-dependent metabolism of p-nitroanisole catalyzed by cytochrome P-450 isozyme 2 in pulmonary and hepatic microsomal preparations from rabbits. Chem Biol Interact 57:143-160. (Pubitemid 16168267)
7. Finn RD, Henderson CJ, Scott CL, and Wolf CR (2009) Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. Biochem J 417:43-54.
8. 5 null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis. Transgenic Res, in press.
9. Finn RD, McLaughlin LA, Ronseaux S, Rosewell I, Houston JB, Henderson CJ, and Wolf CR (2008) Defining the in vivo role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5. J Biol Chem 283:31385-31393.
10. Forrester LM, Henderson CJ, Glancey MJ, Back DJ, Park BK, Ball SE, Kitteringham NR, McLaren AW, Miles JS, and Skett P (1992) Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics. Biochem J 281:359-368.
11. Gruenke LD, Konopka K, Cadieu M, and Waskell L (1995) The stoichiometry of the cytochrome P-450-catalyzed metabolism of methoxyflurane and benzphetamine in the presence and absence of cytochrome b5. J Biol Chem 270:24707-24718.
12. Gu J, Weng Y, Zhang QY, Cui H, Behr M, Wu L, Yang W, Zhang L, and Ding X (2003) Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J Biol Chem 278:25895-25901.
13. Guryev OL, Gilep AA, Usanov SA, and Estabrook RW (2001) Interaction of apocytochrome b5 with cytochromes P4503A4 and P45017A: relevance of heme transfer reactions. Biochemistry 40:5018-5031.
14. Henderson CJ, Otto DM, Carrie D, Magnuson MA, McLaren AW, Rosewell I, and Wolf CR (2003) Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J Biol Chem 278:13480-13486.
15. Hildebrandt A and Estabrook RW (1971) Evidence for the participation of cytochrome b 5 in hepatic microsomal mixed-function oxidation reactions. Arch Biochem Biophys 143:66-79.
16. Hlavica P and Lewis DF (2001) Allosteric phenomena in cytochrome P450-catalyzed monooxygenations. Eur J Biochem 268:4817-4832.
17. Jeffcoat R, Brawn PR, Safford R, and James AT (1977) Properties of rat liver microsomal stearoyl-coenzyme A desaturase. Biochem J 161:431-437. (Pubitemid 8025747)
18. Kurian JR, Longlais BJ, and Trepanier LA (2007) Discovery and characterization of a cytochrome b5 variant in humans with impaired hydroxylamine reduction capacity. Pharmacogenet Genomics 17:597-603.
19. Lallemand Y, Luria V, Haffner-Krausz R, and Lonai P (1998) Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre sitespecific recombinase. Transgenic Res 7:105-112.
20. Lamb DC, Kaderbhai NN, Venkateswarlu K, Kelly DE, Kelly SL, and Kaderbhai MA (2001) Human sterol 14alpha-demethylase activity is enhanced by the membrane-bound state of cytochrome b(5). Arch Biochem Biophys 395:78-84.
21. Lee TC, Qian CG, and Snyder F (1991) Biosynthesis of choline plasmalogens in neonatal rat myocytes. Arch Biochem Biophys 286:498-503.
22. Meehan RR, Forrester LM, Stevenson K, Hastie ND, Buchmann A, Kunz HW, and Wolf CR (1988) Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy. Biochem J 254:789-797.
23. Naffin-Olivos JL and Auchus RJ (2006) Human cytochrome b5 requires residues E48 and E49 to stimulate the 17,20-lyase activity of cytochrome P450c17. Biochemistry 45:755-762.
24. Omura T and Sato R (1964) The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 239:2370-2378.
25. Paine MJ, McLaughlin LA, Flanagan JU, Kemp CA, Sutcliffe MJ, Roberts GC, and Wolf CR (2003) Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6. J Biol Chem 278:4021-4027.
26. Paltuaf F, Prough RA, Masters BS, and Johnston JM (1974) Evidence for the participation of cytochrome b5 in plasmalogen biosynthesis. J Biol Chem 249:2661-2662.
27. Patten CJ and Koch P (1995) Baculovirus expression of human P450 2E1 and cytochrome b5: spectral and catalytic properties and effect of b5 on the stoichiometry of P450 2E1-catalyzed reactions. Arch Biochem Biophys 317:504-513.
28. Porter TD (2002) The roles of cytochrome b5 in cytochrome P450 reactions. J Biochem Mol Toxicol 16:311-316.
29. Pritchard MP, Glancey MJ, Blake JA, Gilham DE, Burchell B, Wolf CR, and Fried-berg T (1998) Functional co-expression of CYP2D6 and human NADPH-cytochrome P450 reductase in Escherichia coli. Pharmacogenetics 8:33-42.
30. Schenkman JB and Jansson I (2003) The many roles of cytochrome b5. Pharmacol Ther 97:139-152.
31. Shimada T, Mernaugh RL, and Guengerich FP (2005) Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes. Arch Biochem Biophys 435:207-216.
32. Strobel HW and Dignam JD (1978) Purification and properties of NADPHcytochrome P-450 reductase. Methods Enzymol 52:89-96.
33. Umbreit J (2007) Methemoglobin-it's not just blue: a concise review. Am J Hematol 82:134-144.
34. van Herwaarden AE, van Waterschoot RA, and Schinkel AH (2009) How important is intestinal cytochrome P450 3A metabolism? Trends Pharmacol Sci 30:223-227.
35. Waskell L, Canova-Davis E, Philpot R, Parandoush Z, and Chiang JY (1986) Identification of the enzymes catalyzing metabolism of methoxyflurane. Drug Metab Dispos 14:643-648. (Pubitemid 17202400)
36. Woelk H and Jahrreiss R (1978) Enzymic studies on glial and neuronal cells during myelination. Adv Exp Med Biol 100:43-53.
37. Yamaori S, Yamazaki H, Suzuki A, Yamada A, Tani H, Kamidate T, Fujita K, and Kamataki T (2003) Effects of cytochrome b(5) on drug oxidation activities of human cytochrome P450 (CYP) 3As: similarity of CYP3A5 with CYP3A4 but not CYP3A7. Biochem Pharmacol 66:2333-2340.
38. Yamazaki H, Johnson WW, Ueng YF, Shimada T, and Guengerich FP (1996) Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/ NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5. J Biol Chem 271:27438-27444.
39. Yamazaki H, Nakamura M, Komatsu T, Ohyama K, Hatanaka N, Asahi S, Shimada N, Guengerich FP, Shimada T, Nakajima M, et al. (2002) Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. Protein Expr Purif 24:329-337.
40. Yamazaki H and Shimada T (2006) Cytochrome P450 reconstitution systems. Methods Mol Biol 320:61-71.
41. Zhang FP, Pakarainen T, Poutanen M, Toppari J, and Huhtaniemi I (2003) The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis. Proc Natl Acad Sci USA 100:13692-13697.
42. Zhang H, Hamdane D, Im SC, and Waskell L (2008) Cytochrome b5 inhibits electron transfer from NADPH-cytochrome P450 reductase to ferric cytochrome P450 2B4. J Biol Chem 283:5217-5225.
43. Zhang H, Im SC, and Waskell L (2007) Cytochrome b5 increases the rate of product formation by cytochrome P450 2B4 and competes with cytochrome P450 reductase for a binding site on cytochrome P450 2B4. J Biol Chem 282:29766-29776.
44. Zhang H, Myshkin E, and Waskell L (2005) Role of cytochrome b5 in catalysis by cytochrome P450 2B4. Biochem Biophys Res Commun 338:499-506.