Probing the ATP hydrolysis cycle of the abc multidrug transporter LmrA by pulsed EPR spectroscopy

Journal of the American Chemical Society

Volumn 134, Issue 13, 2012, Pages 5857-5862

  Hellmich, Ute A ^a   Lyubenova, Sevdalina ^a   Kaltenborn, Eva ^a   Doshi, Rupak ^b   Van Veen, Hendrik W ^b   Prisner, Thomas F ^a   Glaubitz, Clemens ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; APO-STATE; ATP BINDING; ATP BINDING CASSETTE TRANSPORTERS; ATP HYDROLYSIS; CATALYTIC CYCLES; CONFORMATIONAL CHANGE; CONFORMATIONAL SPACE; DOUBLE RESONANCE; DRUG BINDING; MULTIDRUG TRANSPORTERS; NUCLEOTIDE BINDING; NUCLEOTIDE-BINDING DOMAIN; PULSED EPR; SITE-DIRECTED SPIN LABELING; TRANSMEMBRANE HELICES;

HYDROLYSIS;

CONFORMATIONS;

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; PROTEIN LMRA; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; ELECTRON SPIN RESONANCE; HYDROLYSIS; INTERACTIONS WITH NUCLEIC ACID; NONHUMAN; PROTEIN CONFORMATION; PROTEIN DOMAIN; PULSED ELECTRON ELECTRON DOUBLE RESONANCE; SPIN LABELING;

ADENOSINE TRIPHOSPHATE; APOPROTEINS; BACTERIAL PROTEINS; BIOCATALYSIS; ELECTRON SPIN RESONANCE SPECTROSCOPY; HYDROLYSIS; LACTOCOCCUS LACTIS; MODELS, MOLECULAR; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; PROTEIN STRUCTURE, SECONDARY;

EID: 84859301159     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja211007t     Document Type: Article

References (42)

1. Davidson, A. L.; Maloney, P. C. Trends Microbiol. 2007, 15, 448-55
2. Jones, P. M.; OMara, M. L.; George, A. M. Trends Biochem. Sci. 2009, 34, 520-31
3. Oldham, M. L.; Davidson, A. L.; Chen, J. Curr. Opin. Struct. Biol. 2008, 18, 726-33
4. Dawson, R. J.; Hollenstein, K.; Locher, K. P. Mol. Microbiol. 2007, 65, 250-7
5. Linton, K. J.; Higgins, C. F. Pflugers Arch 2007, 453, 555-67
6. van Veen, H. W.; Venema, K.; Bolhuis, H.; Oussenko, I.; Kok, J.; Poolman, B.; Driessen, A. J.; Konings, W. N. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 10668-72
7. van Veen, H. W.; Margolles, A.; Muller, M.; Higgins, C. F.; Konings, W. N. EMBO J. 2000, 19, 2503-14
8. Milov, A. D.; Salikhov, K. M.; Shirov, M. D. Fiz. Tverd. Tela 1981, 23, 975-982
9. Martin, R. E.; Pannier, M.; Diederich, F.; Gramlich, V.; Hubrich, M.; Spiess, H. W. Angew. Chem., Int. Ed. 1998, 37, 2834-2837
10. Jeschke, G.; Polyhach, Y. Phys. Chem. Chem. Phys. 2007, 9, 1895-1910
11. Schiemann, O.; Prisner, T. F. Q. Rev. Biophys. 2007, 40, 1-53
12. Altenbach, C.; Kusnetzow, A. K.; Ernst, O. P.; Hofmann, K. P.; Hubbell, W. L. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 7439-7444
13. Dockter, C.; Volkov, A.; Bauer, C.; Polyhach, Y.; Joly-Lopez, Z.; Jeschke, G.; Paulsen, H. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 18485-18490
14. Mchaourab, H. S.; Steed, P. R.; Kazmier, K. Structure 2011, 19, 1549-61
15. Borbat, P. P.; Surendhran, K.; Bortolus, M.; Zou, P.; Freed, J. H.; McHaourab, H. S. PLoS Biol. 2007, 5, e271
16. Zou, P.; Bortolus, M.; McHaourab, H. S. J. Mol. Biol. 2009, 393, 586-97
17. Grote, M.; Polyhach, Y.; Jeschke, G.; Steinhoff, H. J.; Schneider, E.; Bordignon, E. J. Biol. Chem. 2009, 284, 17521-6
18. Do Cao, M. A.; Crouzy, S.; Kim, M.; Becchi, M.; Cafiso, D. S.; Di Pietro, A.; Jault, J. M. Protein Sci. 2009, 18, 1507-20
19. Dong, J.; Yang, G.; McHaourab, H. S. Science 2005, 308, 1023-8
20. Goetz, B. A.; Perozo, E.; Locher, K. P. FEBS Lett. 2009, 583, 266-70
21. Orelle, C.; Alvarez, F. J.; Oldham, M. L.; Orelle, A.; Wiley, T. E.; Chen, J.; Davidson, A. L. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 20293-8
22. Aller, S. G.; Yu, J.; Ward, A.; Weng, Y.; Chittaboina, S.; Zhuo, R.; Harrell, P. M.; Trinh, Y. T.; Zhang, Q.; Urbatsch, I. L.; Chang, G. Science 2009, 323, 1718-22
23. Pleban, K.; Kopp, S.; Csaszar, E.; Peer, M.; Hrebicek, T.; Rizzi, A.; Ecker, G. F.; Chiba, P. Mol. Pharmacol. 2005, 67, 365-74
24. Smriti; Zou, P.; McHaourab, H. S. J. Biol. Chem. 2009, 284, 13904-13
25. Hellmich, U. A.; Haase, W.; Velamakanni, S.; van Veen, H. W.; Glaubitz, C. FEBS Lett. 2008, 582, 3557-62
26. Pannier, M.; Veit, S.; Godt, A.; Jeschke, G.; Spiess, H. W. J. Magn. Reson. 2000, 142, 331-340
27. Venter, H.; Velamakanni, S.; Balakrishnan, L.; van Veen, H. W. Biochem. Pharmacol. 2008, 75, 866-874
28. Ward, A.; Reyes, C. L.; Yu, J.; Roth, C. B.; Chang, G. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 19005-10
29. Siarheyeva, A.; Lopez, J. J.; Lehner, I.; Hellmich, U. A.; van Veen, H. W.; Glaubitz, C. Biochemistry 2007, 46, 3075-83
30. Kern, D.; Zuiderweg, E. R. P. Curr. Opin. Struct. Biol. 2003, 13, 748-757
31. Dawson, R. J.; Locher, K. P. Nature 2006, 443, 180-5
32. Dawson, R. J.; Locher, K. P. FEBS Lett. 2007, 581, 935-8
33. Reuter, G.; Janvilisri, T.; Venter, H.; Shahi, S.; Balakrishnan, L.; van Veen, H. W. J. Biol. Chem. 2003, 278, 35193-35198
34. Velamakanni, S.; Yao, Y.; Gutmann, D. A. P.; van Veen, H. W. Biochemistry 2008, 47, 9300-9308
35. Zou, P.; McHaourab, H. S. J. Mol. Biol. 2009, 393, 574-85
36. Lee, J. Y.; Urbatsch, I. L.; Senior, A. E.; Wilkens, S. J. Biol. Chem. 2008, 283, 5769-79
37. Hellmich, U. A.; Glaubitz, C. Biol. Chem. 2009, 390, 815-34
38. Buchaklian, A. H.; Klug, C. S. Biochemistry 2005, 44, 5503-9
39. Hrycyna, C. A.; Ramachandra, M.; Germann, U. A.; Cheng, P. W.; Pastan, I.; Gottesman, M. M. Biochemistry 1999, 38, 13887-99
40. Orelle, C.; Dalmas, O.; Gros, P.; Di Pietro, A.; Jault, J. M. J. Biol. Chem. 2003, 278, 47002-8
41. Hoffman, A. D.; Urbatsch, I. L.; Vogel, P. D. Protein J. 2010, 29, 373-379
42. Smith, P. C.; Karpowich, N.; Millen, L.; Moody, J. E.; Rosen, J.; Thomas, P. J.; Hunt, J. F. Mol. Cell 2002, 10, 139-149