메뉴 건너뛰기




Volumn 17, Issue 7-8, 2012, Pages 336-342

Stem cell technology for drug discovery and development

Author keywords

[No Author keywords available]

Indexed keywords

CELL DIFFERENTIATION; CELL TYPE; DRUG INDUSTRY; DRUG RESEARCH; REVIEW; STEM CELL;

EID: 84859219916     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2011.11.001     Document Type: Review
Times cited : (20)

References (50)
  • 1
    • 78149487692 scopus 로고    scopus 로고
    • Pluripotency and cellular reprogramming: Facts, hypotheses, unresolved issues
    • J.H. Hanna Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues Cell 143 2010 508 525
    • (2010) Cell , vol.143 , pp. 508-525
    • Hanna, J.H.1
  • 2
    • 58449093675 scopus 로고    scopus 로고
    • Attributes of adult stem cells
    • M.R. Alison, and S. Islam Attributes of adult stem cells J. Pathol. 217 2009 144 1460
    • (2009) J. Pathol. , vol.217 , pp. 144-1460
    • Alison, M.R.1    Islam, S.2
  • 3
    • 33646119401 scopus 로고    scopus 로고
    • Hematopoietic stem-cell transplantation
    • E.A. Copelan Hematopoietic stem-cell transplantation N. Engl. J. Med. 354 2006 1813 1826
    • (2006) N. Engl. J. Med. , vol.354 , pp. 1813-1826
    • Copelan, E.A.1
  • 4
    • 77952962850 scopus 로고    scopus 로고
    • Purified hematopoietic stem cell transplantation: The next generation of blood and immune replacement
    • A. Czechowicz, and I.L. Weissman Purified hematopoietic stem cell transplantation: the next generation of blood and immune replacement Immunol. Allergy Clin. North Am. 30 2010 159 171
    • (2010) Immunol. Allergy Clin. North Am. , vol.30 , pp. 159-171
    • Czechowicz, A.1    Weissman, I.L.2
  • 5
    • 33846423521 scopus 로고    scopus 로고
    • Oligodendrocyte progenitor cells derived from human embryonic stem cells express neurotrophic factors
    • DOI 10.1089/scd.2006.15.943
    • Y.W. Zhang Oligodendrocyte progenitor cells derived from human embryonic stem cells express neurotrophic factors Stem Cells Dev. 15 2006 943 952 (Pubitemid 46147864)
    • (2006) Stem Cells and Development , vol.15 , Issue.6 , pp. 943-952
    • Zhang, Y.W.1    Denham, J.2    Thies, R.S.3
  • 6
    • 68649120817 scopus 로고    scopus 로고
    • The neural stem cell line CTX0E03 promotes behavioral recovery and endogenous neurogenesis after experimental stroke in a dose-dependent fashion
    • P. Stroemer The neural stem cell line CTX0E03 promotes behavioral recovery and endogenous neurogenesis after experimental stroke in a dose-dependent fashion Neurorehabil. Neural Repair 23 2009 895 909
    • (2009) Neurorehabil. Neural Repair , vol.23 , pp. 895-909
    • Stroemer, P.1
  • 7
    • 33747195353 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
    • DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
    • K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 26 2006 663 676 (Pubitemid 44233629)
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 8
    • 0035189927 scopus 로고    scopus 로고
    • Embryo-derived stem cells: Of mice and men
    • DOI 10.1146/annurev.cellbio.17.1.435
    • A.G. Smith Embryo-derived stem cells: of mice and men Annu. Rev. Cell Dev. Biol. 17 2001 435 462 (Pubitemid 33096183)
    • (2001) Annual Review of Cell and Developmental Biology , vol.17 , pp. 435-462
    • Smith, A.G.1
  • 9
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • J.A. Thomson Embryonic stem cell lines derived from human blastocysts Science 282 1998 1145 1147 (Pubitemid 28516247)
    • (1998) Science , vol.282 , Issue.5391 , pp. 1145-1147
    • Thomson, J.A.1
  • 11
    • 57649181379 scopus 로고    scopus 로고
    • Capture of authentic embryonic stem cells from rat blastocysts
    • M. Buehr Capture of authentic embryonic stem cells from rat blastocysts Cell 135 2008 1287 1298
    • (2008) Cell , vol.135 , pp. 1287-1298
    • Buehr, M.1
  • 12
    • 79952264847 scopus 로고    scopus 로고
    • Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
    • R. Lister Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells Nature 471 2011 68 73
    • (2011) Nature , vol.471 , pp. 68-73
    • Lister, R.1
  • 13
    • 79952126043 scopus 로고    scopus 로고
    • Copy number variation and selection during reprogramming to pluripotency
    • S.M. Hussein Copy number variation and selection during reprogramming to pluripotency Nature 471 2011 58 62
    • (2011) Nature , vol.471 , pp. 58-62
    • Hussein, S.M.1
  • 14
    • 79952258224 scopus 로고    scopus 로고
    • Somatic coding mutations in human induced pluripotent stem cells
    • A. Gore Somatic coding mutations in human induced pluripotent stem cells Nature 471 2011 63 67
    • (2011) Nature , vol.471 , pp. 63-67
    • Gore, A.1
  • 15
    • 33751119584 scopus 로고    scopus 로고
    • Neural stem cells in mammalian development
    • DOI 10.1016/j.ceb.2006.09.008, PII S0955067406001530
    • F.T. Merkle, and A. Alvarez-Buylla Neural stem cells in mammalian development Curr. Opin. Cell Biol. 18 2006 704 709 (Pubitemid 44767726)
    • (2006) Current Opinion in Cell Biology , vol.18 , Issue.6 , pp. 704-709
    • Merkle, F.T.1    Alvarez-Buylla, A.2
  • 16
    • 24944484633 scopus 로고    scopus 로고
    • Niche-independent symmetrical self-renewal of a mammalian tissue stem cell
    • L. Conti Niche-independent symmetrical self-renewal of a mammalian tissue stem cell PLoS Biol. 3 2005 E283
    • (2005) PLoS Biol. , vol.3 , pp. 283
    • Conti, L.1
  • 17
    • 79957777958 scopus 로고    scopus 로고
    • Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors
    • W. Li Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors Proc. Natl Acad. Sci. U. S. A. 108 2011 8299 8304
    • (2011) Proc. Natl Acad. Sci. U. S. A. , vol.108 , pp. 8299-8304
    • Li, W.1
  • 18
    • 0342449328 scopus 로고    scopus 로고
    • Ten years of gene targeting: Targeted mouse mutants, from vector design to phenotype analysis
    • DOI 10.1016/S0925-4773(99)00021-0, PII S0925477399000210
    • U. Muller Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysis Mech. Dev. 82 1999 3 21 (Pubitemid 29243049)
    • (1999) Mechanisms of Development , vol.82 , Issue.1-2 , pp. 3-21
    • Muller, U.1
  • 19
    • 27944509526 scopus 로고    scopus 로고
    • ES cell technology: An introduction to genetic manipulation, differentiation and therapeutic cloning
    • DOI 10.1016/j.addr.2005.07.018, PII S0169409X05001596
    • L. Hook ES cell technology: an introduction to genetic manipulation, differentiation and therapeutic cloning Adv. Drug Deliv. Rev. 57 2005 1904 1917 (Pubitemid 41682362)
    • (2005) Advanced Drug Delivery Reviews , vol.57 , Issue.SPEC. ISS. , pp. 1904-1917
    • Hook, L.1    O'Brien, C.2    Allsopp, T.3
  • 20
    • 0037336820 scopus 로고    scopus 로고
    • Homologous recombination in human embryonic stem cells
    • DOI 10.1038/nbt788
    • T.P. Zwaka, and J.A. Thomson Homologous recombination in human embryonic stem cells Nat. Biotechnol. 21 2003 319 321 (Pubitemid 36314818)
    • (2003) Nature Biotechnology , vol.21 , Issue.3 , pp. 319-321
    • Zwaka, T.P.1    Thomson, J.A.2
  • 21
    • 79952153009 scopus 로고    scopus 로고
    • Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analysing developing endoderm
    • P. Wang Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analysing developing endoderm Cell Stem Cell 8 2011 335 346
    • (2011) Cell Stem Cell , vol.8 , pp. 335-346
    • Wang, P.1
  • 22
    • 45749145124 scopus 로고    scopus 로고
    • Zinc-finger nucleases: The next generation emerges
    • DOI 10.1038/mt.2008.114, PII MT2008114
    • T. Cathomen, and J.K. Joung Zinc-finger nucleases: the next generation emerges Mol. Ther. 16 2008 1200 1207 (Pubitemid 351866050)
    • (2008) Molecular Therapy , vol.16 , Issue.7 , pp. 1200-1207
    • Cathomen, T.1    Keith Joung, J.2
  • 23
    • 79957953948 scopus 로고    scopus 로고
    • Stem cell biology and drug discovery
    • L.L. Rubin, and K.M. Haston Stem cell biology and drug discovery BMC Biol. 9 2011 42
    • (2011) BMC Biol. , vol.9 , pp. 42
    • Rubin, L.L.1    Haston, K.M.2
  • 24
    • 79955023053 scopus 로고    scopus 로고
    • Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery
    • E. Kiris Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery Stem Cell Res. 6 2011 195 205
    • (2011) Stem Cell Res. , vol.6 , pp. 195-205
    • Kiris, E.1
  • 25
    • 79960560680 scopus 로고    scopus 로고
    • A screen for regulators of survival of motor neuron protein levels
    • N.R. Makhortova A screen for regulators of survival of motor neuron protein levels Nat. Chem. Biol. 7 2011 544 552
    • (2011) Nat. Chem. Biol. , vol.7 , pp. 544-552
    • Makhortova, N.R.1
  • 26
    • 77952756933 scopus 로고    scopus 로고
    • High-throughput screening in embryonic stem cell-derived neurons identifies potentiators of alpha-amino-3-hydroxyl-5-methyl-4- isoxazolepropionate-type glutamate receptors
    • J. McNeish High-throughput screening in embryonic stem cell-derived neurons identifies potentiators of alpha-amino-3-hydroxyl-5-methyl-4- isoxazolepropionate-type glutamate receptors J. Biol. Chem. 285 2010 17209 17217
    • (2010) J. Biol. Chem. , vol.285 , pp. 17209-17217
    • McNeish, J.1
  • 27
    • 79952446402 scopus 로고    scopus 로고
    • Modelling the long QT syndrome with induced pluripotent stem cells
    • I. Itzhaki Modelling the long QT syndrome with induced pluripotent stem cells Nature 471 2011 225 229
    • (2011) Nature , vol.471 , pp. 225-229
    • Itzhaki, I.1
  • 28
    • 62549153611 scopus 로고    scopus 로고
    • Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist
    • C.L. Erickson-Miller Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist Stem Cells 27 2009 424 430
    • (2009) Stem Cells , vol.27 , pp. 424-430
    • Erickson-Miller, C.L.1
  • 30
    • 78649392879 scopus 로고    scopus 로고
    • High-throughput screening of a small molecule library for promoters and inhibitors of mesenchymal stem cell osteogenic differentiation
    • D.M. Brey High-throughput screening of a small molecule library for promoters and inhibitors of mesenchymal stem cell osteogenic differentiation Biotechnol. Bioeng. 108 2011 163 174
    • (2011) Biotechnol. Bioeng. , vol.108 , pp. 163-174
    • Brey, D.M.1
  • 32
    • 79955428006 scopus 로고    scopus 로고
    • Concise review: Human pluripotent stem cell-based models for cardiac and hepatic toxicity assessment
    • P. Sartipy, and P. Bjorquist Concise review: human pluripotent stem cell-based models for cardiac and hepatic toxicity assessment Stem Cells 29 2011 744 748
    • (2011) Stem Cells , vol.29 , pp. 744-748
    • Sartipy, P.1    Bjorquist, P.2
  • 33
    • 77955933649 scopus 로고    scopus 로고
    • Human pluripotent stem cells in drug discovery and predictive toxicology
    • D. Laustriat Human pluripotent stem cells in drug discovery and predictive toxicology Biochem. Soc. Trans. 38 2010 1051 1057
    • (2010) Biochem. Soc. Trans. , vol.38 , pp. 1051-1057
    • Laustriat, D.1
  • 34
    • 77951480489 scopus 로고    scopus 로고
    • Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development
    • T. Touboul Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development Hepatology 51 2010 1754 1765
    • (2010) Hepatology , vol.51 , pp. 1754-1765
    • Touboul, T.1
  • 35
    • 49249091550 scopus 로고    scopus 로고
    • Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo
    • D.C. Hay Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo Stem Cells 26 2008 894 902
    • (2008) Stem Cells , vol.26 , pp. 894-902
    • Hay, D.C.1
  • 36
    • 61949300076 scopus 로고    scopus 로고
    • Functional cardiomyocytes derived from human induced pluripotent stem cells
    • J. Zhang Functional cardiomyocytes derived from human induced pluripotent stem cells Circ. Res. 104 2009 E30 E41
    • (2009) Circ. Res. , vol.104
    • Zhang, J.1
  • 37
    • 79551597211 scopus 로고    scopus 로고
    • Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines
    • S.J. Kattman Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines Cell Stem Cell 8 2011 228 240
    • (2011) Cell Stem Cell , vol.8 , pp. 228-240
    • Kattman, S.J.1
  • 40
    • 67649195858 scopus 로고    scopus 로고
    • Control of stem cell fate by physical interactions with the extracellular matrix
    • F. Guilak Control of stem cell fate by physical interactions with the extracellular matrix Cell Stem Cell 5 2009 17 26
    • (2009) Cell Stem Cell , vol.5 , pp. 17-26
    • Guilak, F.1
  • 41
    • 40549131272 scopus 로고    scopus 로고
    • Extracellular matrix dynamics in development and regenerative medicine
    • DOI 10.1242/jcs.006064
    • W.P. Daley Extracellular matrix dynamics in development and regenerative medicine J. Cell Sci. 121 2008 255 264 (Pubitemid 351356696)
    • (2008) Journal of Cell Science , vol.121 , Issue.3 , pp. 255-264
    • Daley, W.P.1    Peters, S.B.2    Larsen, M.3
  • 43
    • 77955843624 scopus 로고    scopus 로고
    • Novel regulators of stem cell fates identified by a multivariate phenotype screen of small compounds on human embryonic stem cell colonies
    • I. Barbaric Novel regulators of stem cell fates identified by a multivariate phenotype screen of small compounds on human embryonic stem cell colonies Stem Cell Res. 5 2010 104 119
    • (2010) Stem Cell Res. , vol.5 , pp. 104-119
    • Barbaric, I.1
  • 44
    • 62649138086 scopus 로고    scopus 로고
    • A small molecule that directs differentiation of human ESCs into the pancreatic lineage
    • S. Chen A small molecule that directs differentiation of human ESCs into the pancreatic lineage Nat. Chem. Biol. 5 2009 258 265
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 258-265
    • Chen, S.1
  • 45
    • 44349152907 scopus 로고    scopus 로고
    • High-Throughput Screening Assay for the Identification of Compounds Regulating Self-Renewal and Differentiation in Human Embryonic Stem Cells
    • DOI 10.1016/j.stem.2008.05.010, PII S1934590908002245
    • S.C. Desbordes High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells Cell Stem Cell 2 2008 602 612 (Pubitemid 351729221)
    • (2008) Cell Stem Cell , vol.2 , Issue.6 , pp. 602-612
    • Desbordes, S.C.1    Placantonakis, D.G.2    Ciro, A.3    Socci, N.D.4    Lee, G.5    Djaballah, H.6    Studer, L.7
  • 46
    • 77954071829 scopus 로고    scopus 로고
    • High-throughput methods to define complex stem cell niches
    • S. Kobel, and M. Lutolf High-throughput methods to define complex stem cell niches Biotechniques 48 2010 Ix xxii
    • (2010) Biotechniques , vol.48
    • Kobel, S.1    Lutolf, M.2
  • 47
    • 18744376054 scopus 로고    scopus 로고
    • An extracellular matrix microarray for probing cellular differentiation
    • DOI 10.1038/nmeth736
    • C.J. Flaim An extracellular matrix microarray for probing cellular differentiation Nat. Methods 2 2005 119 125 (Pubitemid 41131033)
    • (2005) Nature Methods , vol.2 , Issue.2 , pp. 119-125
    • Flaim, C.J.1    Chien, S.2    Bhatia, S.N.3
  • 48
    • 39449127641 scopus 로고    scopus 로고
    • Combinatorial signaling microenvironments for studying stem cell fate
    • DOI 10.1089/scd.2007.0085
    • C.J. Flaim Combinatorial signaling microenvironments for studying stem cell fate Stem Cells Dev. 17 2008 29 39 (Pubitemid 351271611)
    • (2008) Stem Cells and Development , vol.17 , Issue.1 , pp. 29-39
    • Flaim, C.J.1    Teng, D.2    Chien, S.3    Bhatia, S.N.4
  • 49
    • 77951583526 scopus 로고    scopus 로고
    • Three-dimensional cell culture microarray for high-throughput studies of stem cell fate
    • T.G. Fernandes Three-dimensional cell culture microarray for high-throughput studies of stem cell fate Biotechnol. Bioeng. 106 2010 106 118
    • (2010) Biotechnol. Bioeng. , vol.106 , pp. 106-118
    • Fernandes, T.G.1
  • 50
    • 84859222973 scopus 로고    scopus 로고
    • Use of combinatorial screening to discover protocols that effectively direct the differentiation of stem cells
    • D.O.C.Y. Shi, Springer Science + Business Media
    • Y. Choo Use of combinatorial screening to discover protocols that effectively direct the differentiation of stem cells D.O.C.Y. Shi, Stem Cell Research and Therapeutics 2008 Springer Science + Business Media 227 250
    • (2008) Stem Cell Research and Therapeutics , pp. 227-250
    • Choo, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.