Up-regulation of the betaine/GABA transporter BGT1 by JAK2

Biochemical and Biophysical Research Communications

Volumn 420, Issue 1, 2012, Pages 172-177

  Hosseinzadeh, Zohreh ^a   Shojaiefard, Manzar ^a,b   Bhavsar, Shefalee K ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b FASA UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cell volume; Erythropoietin; GABA transport; Osmolyte

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID CARRIER; BETAINE; BREFELDIN A; DACTINOMYCIN; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; WATER;

ARTICLE; CELL MEMBRANE; ELECTRODE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MODIFICATION; ENZYME STABILITY; NONHUMAN; OOCYTE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; XENOPUS;

ANIMALS; BETAINE; CARRIER PROTEINS; GAMMA-AMINOBUTYRIC ACID; HUMANS; JANUS KINASE 2; MUTATION; OOCYTES; PROTEIN KINASE INHIBITORS; RNA, COMPLEMENTARY; TYRPHOSTINS; UP-REGULATION; XENOPUS;

EID: 84859108614     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.02.137     Document Type: Article

References (57)

1. Noon-Song E.N., Ahmed C.M., Dabelic R., Canton J., Johnson H.M. Controlling nuclear JAKs and STATs for specific gene activation by IFNgamma. Biochem. Biophys. Res. Commun. 2011, 410:648-653.
2. Spivak J.L. Narrative review: thrombocytosis, polycythemia vera, and JAK2 mutations: the phenotypic mimicry of chronic myeloproliferation. Ann. Intern. Med. 2010, 152:300-306.
3. Lopez A.F., Hercus T.R., Ekert P., Littler D.R., Guthridge M., Thomas D., Ramshaw H.S., Stomski F., Perugini M., D'Andrea R., Grimbaldeston M., Parker M.W. Molecular basis of cytokine receptor activation. IUBMB Life 2010, 62:509-518.
4. Morris D.L., Rui L. Recent advances in understanding leptin signaling and leptin resistance. Am. J. Physiol. Endocrinol. Metab. 2009, 297:E1247-E1259.
5. Yang N., Jiang J., Deng L., Waters M.J., Wang X., Frank S.J. Growth hormone receptor targeting to lipid rafts requires extracellular subdomain 2. Biochem. Biophys. Res. Commun. 2010, 391:414-418.
6. Brooks A.J., Waters M.J. The growth hormone receptor: mechanism of activation and clinical implications. Nat. Rev. Endocrinol. 2010, 6:515-525.
7. Santos F.P., Verstovsek S. JAK2 inhibitors: what's the true therapeutic potential?. Blood Rev. 2011, 25:53-63.
8. Pardanani A., Vannucchi A.M., Passamonti F., Cervantes F., Barbui T., Tefferi A. JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations. Leukemia 2011, 25:218-225.
9. Baskin R., Majumder A., Sayeski P.P. The recent medicinal chemistry development of Jak2 tyrosine kinase small molecule inhibitors. Curr. Med. Chem. 2010, 17:4551-4558.
10. Ho K., Valdez F., Garcia R., Tirado C.A. JAK2 translocations in hematological malignancies: review of the literature. J. Assoc. Genet. Technol. 2010, 36:107-109.
11. Oh S.T., Gotlib J. JAK2 V617F and beyond: role of genetics and aberrant signaling in the pathogenesis of myeloproliferative neoplasms. Expert. Rev. Hematol. 2010, 3:323-337.
12. Tefferi A. Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1. Leukemia 2010, 24:1128-1138.
13. Shen X.L., Wei W., Xu H.L., Zhang M.X., Qin X.Q., Shi W.Z., Jiang Z.P., Chen Y.J., Chen F.P. JAK2V617F/STAT5 signaling pathway promotes cell proliferation through activation of pituitary tumor transforming gene 1 expression. Biochem. Biophys. Res. Commun. 2010, 398:707-712.
14. Venkitachalam S., Chueh F.Y., Yu C.L. Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene. Biochem. Biophys. Res. Commun. 2012, 417:1058-1062.
15. Yao X., Balamurugan P., Arvey A., Leslie C., Zhang L. Heme controls the regulation of protein tyrosine kinases Jak2 and Src. Biochem. Biophys. Res. Commun. 2010, 403:30-35.
16. Mahfouz R.A., Hoteit R., Salem Z., Bazarbachi A., Mugharbel A., Farhat F., Ziyadeh A., Ibrahim A., Taher A. JAK2 V617F gene mutation in the laboratory work-up of myeloproliferative disorders: experience of a major referral center in Lebanon. Genet. Test. Mol. Biomarkers 2011, 15:263-265.
17. Kurdi M., Booz G.W. JAK redux: a second look at the regulation and role of JAKs in the heart. Am. J. Physiol. Heart Circ. Physiol. 2009, 297:H1545-H1556.
18. + exchange through Janus kinase 2 and calmodulin. J. Biol. Chem. 2003, 278:16908-16915.
19. Gatsios P., Terstegen L., Schliess F., Haussinger D., Kerr I.M., Heinrich P.C., Graeve L. Activation of the Janus kinase/signal transducer and activator of transcription pathway by osmotic shock. J. Biol. Chem. 1998, 273:22962-22968.
20. Handler J.S., Kwon H.M. Regulation of renal cell organic osmolyte transport by tonicity. Am. J. Physiol. 1993, 265:C1449-C1455.
21. Kempson S.A., Montrose M.H. Osmotic regulation of renal betaine transport: transcription and beyond. Pflugers Arch. 2004, 449:227-234.
22. Christie D.L. Functional insights into the creatine transporter. Subcell. Biochem. 2007, 46:99-118.
23. Takenaka M., Bagnasco S.M., Preston A.S., Uchida S., Yamauchi A., Kwon H.M., Handler J.S. The canine betaine gamma-amino-n-butyric acid transporter gene: diverse mRNA isoforms are regulated by hypertonicity and are expressed in a tissue-specific manner. Proc. Natl. Acad. Sci. USA 1995, 92:1072-1076.
24. Uchida S., Kwon H.M., Yamauchi A., Preston A.S., Marumo F., Handler J.S. Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(-)-dependent taurine transporter that is regulated by hypertonicity. Proc. Natl. Acad. Sci. USA 1992, 89:8230-8234.
25. Peters-Regehr T., Bode J.G., Kubitz R., Haussinger D. Organic osmolyte transport in quiescent and activated rat hepatic stellate cells (Ito cells). Hepatology 1999, 29:173-180.
26. Weik C., Warskulat U., Bode J., Peters-Regehr T., Haussinger D. Compatible organic osmolytes in rat liver sinusoidal endothelial cells. Hepatology 1998, 27:569-575.
27. Zhou Y., Holmseth S., Hua R., Lehre A.C., Olofsson A.M., Poblete-Naredo I., Kempson S.A., Danbolt N.C. The betaine-GABA transporter (BGT1, slc6a12) is predominantly expressed in the liver and at lower levels in the kidneys and at the brain surface. Am. J. Physiol. Renal Physiol. 2012, 302:F316-F328.
28. Zaidi S., Gallos G., Yim P.D., Xu D., Sonett J.R., Panettieri R.A., Gerthoffer W., Emala C.W. Functional expression of gamma-amino butyric acid transporter 2 in human and guinea pig airway epithelium and smooth muscle. Am. J. Respir. Cell Mol. Biol. 2011, 45:332-339.
29. Madsen K.K., White H.S., Schousboe A. Neuronal and non-neuronal GABA transporters as targets for antiepileptic drugs. Pharmacol. Ther. 2010, 125:394-401.
30. Kempson S.A. Differential activation of system A and betaine/GABA transport in MDCK cell membranes by hypertonic stress. Biochim. Biophys. Acta 1998, 1372:117-123.
31. Miyakawa H., Rim J.S., Handler J.S., Kwon H.M. Identification of the second tonicity-responsive enhancer for the betaine transporter (BGT1) gene. Biochim. Biophys. Acta 1999, 1446:359-364.
32. Nadkarni V., Gabbay K.H., Bohren K.M., Sheikh-Hamad D. Osmotic response element enhancer activity. Regulation through p38 kinase and mitogen-activated extracellular signal-regulated kinase kinase. J. Biol. Chem. 1999, 274:20185-20190.
33. Kempson S.A., Edwards J.M., Osborn A., Sturek M. Acute inhibition of the betaine transporter by ATP and adenosine in renal MDCK cells. Am. J. Physiol. Renal Physiol. 2008, 295:F108-F117.
34. Kempson S.A., Edwards J.M., Sturek M. Inhibition of the renal betaine transporter by calcium ions. Am. J. Physiol. Renal Physiol. 2006, 291:F305-F313.
35. Massari S., Vanoni C., Longhi R., Rosa P., Pietrini G. Protein kinase C-mediated phosphorylation of the BGT1 epithelial gamma-aminobutyric acid transporter regulates its association with LIN7 PDZ proteins: a post-translational mechanism regulating transporter surface density. J. Biol. Chem. 2005, 280:7388-7397.
36. Moeckel G.W., Zhang L., Fogo A.B., Hao C.M., Pozzi A., Breyer M.D. COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress. J. Biol. Chem. 2003, 278:19352-19357.
37. Neuhofer W., Steinert D., Fraek M.L., Beck F.X. Prostaglandin E2 stimulates expression of osmoprotective genes in MDCK cells and promotes survival under hypertonic conditions. J. Physiol. 2007, 583:287-297.
38. Basham J.C., Chabrerie A., Kempson S.A. Hypertonic activation of the renal betaine/GABA transporter is microtubule dependent. Kidney Int. 2001, 59:2182-2191.
39. Bricker J.L., Chu S., Kempson S.A. Disruption of F-actin stimulates hypertonic activation of the BGT1 transporter in MDCK cells. Am. J. Physiol. Renal Physiol. 2003, 284:F930-F937.
40. Alfieri R.R., Cavazzoni A., Petronini P.G., Bonelli M.A., Caccamo A.E., Borghetti A.F., Wheeler K.P. Compatible osmolytes modulate the response of porcine endothelial cells to hypertonicity and protect them from apoptosis. J. Physiol. 2002, 540:499-508.
41. Matskevitch I., Wagner C.A., Stegen C., Broer S., Noll B., Risler T., Kwon H.M., Handler J.S., Waldegger S., Busch A.E., Lang F. Functional characterization of the Betaine/gamma-aminobutyric acid transporter BGT-1 expressed in Xenopus oocytes. J. Biol. Chem. 1999, 274:16709-16716.
42. Feng J., Witthuhn B.A., Matsuda T., Kohlhuber F., Kerr I.M., Ihle J.N. Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol. Cell Biol. 1997, 17:2497-2501.
43. Mohamed M.R., Alesutan I., Foller M., Sopjani M., Bress A., Baur M., Salama R.H., Bakr M.S., Mohamed M.A., Blin N., Lang F., Pfister M. Functional analysis of a novel I71N mutation in the GJB2 gene among Southern Egyptians causing autosomal recessive hearing loss. Cell Physiol. Biochem. 2010, 26:959-966.
44. Eckey K., Strutz-Seebohm N., Katz G., Fuhrmann G., Henrion U., Pott L., Linke W.A., Arad M., Lang F., Seebohm G. Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT0. Cell Physiol. Biochem. 2010, 26:503-512.
45. Bohmer C., Sopjani M., Klaus F., Lindner R., Laufer J., Jeyaraj S., Lang F., Palmada M. The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19. Cell Physiol. Biochem. 2010, 25:723-732.
46. Rexhepaj R., Dermaku-Sopjani M., Gehring E.M., Sopjani M., Kempe D.S., Foller M., Lang F. Stimulation of electrogenic glucose transport by glycogen synthase kinase 3. Cell Physiol. Biochem. 2010, 26:641-646.
47. Dermaku-Sopjani M., Sopjani M., Saxena A., Shojaiefard M., Bogatikov E., Alesutan I., Eichenmuller M., Lang F. Downregulation of NaPi-IIa and NaPi-IIb Na-coupled phosphate transporters by coexpression of Klotho. Cell Physiol. Biochem. 2011, 28:251-258.
48. Hosseinzadeh Z., Bhavsar S.K., Sopjani M., Alesutan I., Saxena A., Dermaku-Sopjani M., Lang F. Regulation of the glutamate transporters by JAK2. Cell Physiol. Biochem. 2011, 28:693-702.
49. Gong T.W., Meyer D.J., Liao J., Hodge C.L., Campbell G.S., Wang X., Billestrup N., Carter-Su C., Schwartz J. Regulation of glucose transport and c-fos and egr-1 expression in cells with mutated or endogenous growth hormone receptors. Endocrinology 1998, 139:1863-1871.
50. Yokota I., Hayashi H., Matsuda J., Saijo T., Naito E., Ito M., Ebina Y., Kuroda Y. Effect of growth hormone on the translocation of GLUT4 and its relation to insulin-like and anti-insulin action. Biochim. Biophys. Acta 1998, 1404:451-456.
51. Hosseinzadeh Z., Bhavsar S.K., Shojaiefard M., Saxena A., Merches K., Sopjani M., Alesustan I., Lang F. Stimulation of the glucose carrier SGLT1 by JAK2. Biochem. Biophys. Res. Commun. 2011, 408:208-213.
52. Bhavsar S.K., Hosseinzadeh Z., Merches K., Gu S., Broer S., Lang F. Stimulation of the amino acid transporter SLC6A19 by JAK2. Biochem. Biophys. Res. Commun. 2011, 414:456-461.
53. Handler J.S., Kwon H.M. Regulation of the myo-inositol and betaine cotransporters by tonicity. Kidney Int. 1996, 49:1682-1683.
54. Hoffmann E.K., Pedersen S.F. Sensors and signal transduction pathways in vertebrate cell volume regulation. Contrib. Nephrol. 2006, 152:54-104.
55. Pasantes-Morales H., Cruz-Rangel S. Brain volume regulation: osmolytes and aquaporin perspectives. Neuroscience 2010, 168:871-884.
56. Coaxum S.D., Garnovskaya M.N., Gooz M., Baldys A., Raymond J.R. Epidermal growth factor activates Na(+/)H(+) exchanger in podocytes through a mechanism that involves Janus kinase and calmodulin. Biochim. Biophys. Acta 2009, 1793:1174-1181.
57. Lang F., Busch G.L., Ritter M., Volkl H., Waldegger S., Gulbins E., Haussinger D. Functional significance of cell volume regulatory mechanisms. Physiol. Rev. 1998, 78:247-306.