Acute inhibition of the betaine transporter by ATP and adenosine in renal MDCK cells

American Journal of Physiology - Renal Physiology

Volumn 295, Issue 1, 2008, Pages

  Kempson, Stephen A ^a,b   Edwards, Jason M ^a   Osborn, Alyssa ^a   Sturek, Michael ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Medical Sciences   (United States)

Author keywords

Endocytosis; G proteins; Intracellular Ca2+; Madin Darby canine kidney cells; Phospholipase C

Indexed keywords

4 AMINOBUTYRIC ACID CARRIER; ADENOSINE; ADENOSINE RECEPTOR; ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; BETAINE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; PHOSPHOLIPASE C; PROTEIN BGT1; PURINERGIC P2 RECEPTOR; TAURINE; UNCLASSIFIED DRUG; BETAINE PLASMA MEMBRANE TRANSPORT PROTEINS; CALCIUM; CARRIER PROTEIN; SURAMIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE; CONTROLLED STUDY; ENDOCYTOSIS; HYDROLYSIS; IMMUNOHISTOCHEMISTRY; KIDNEY MEDULLA; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CYTOLOGY; DOG; DRUG ANTAGONISM; KIDNEY; METABOLISM; OSMOLARITY;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CARRIER PROTEINS; CELLS, CULTURED; DOGS; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; KIDNEY; OSMOLAR CONCENTRATION; RECEPTORS, PURINERGIC P2; SURAMIN;

EID: 49949100249     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00108.2008     Document Type: Article

References (64)

1. - cotransport in ATP-treated C11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms. J Biol Chem 281: 31317-31325, 2006.
2. Bagnasco S, Balaban R, Fales HM, Yang YM, Burg M. Predominant osmotically active organic solutes in rat and rabbit renal medullas. J Biol Chem 261: 5872-5877, 1986.
3. 2+]i in distal tubule cells. I. Evidence for a P2Y2 purinoceptor. Am J Physiol Renal Physiol 279: F92-F101, 2000.
4. Bitoun M, Tappaz M. Gene expression of taurine transporter and taurine biosynthetic enzymes in brain of rats with acute or chronic hyperosmotic plasma. A comparative study. Brain Res Mol Brain Res 77: 10-18, 2000.
5. Boudreault F, Grygorczyk R. Cell swelling-induced ATP release and gadolinium-sensitive channels. Am J Physiol Cell Physiol 282: C219-C226, 2002.
6. Bricker JL, Chu S, Kempson SA. Disruption of F-actin stimulates hypertonic activation of the BGT1 transporter in MDCK cells. Am J Physiol Renal Physiol 284: F930-F937, 2003.
7. +/myo-inositol transporters, aldose reductase and sorbitol dehydrogenase in macula densa cells of the kidney. Pflügers Arch 436: 807-809, 1998.
8. Chen Y, Shukla A, Namiki S, Insel PA, Junger WG. A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors. J Leukoc Biol 76: 245-253, 2004.
9. Cowley AW Jr, Mori T, Mattson D, Zou AP. Role of renal NO production in the regulation of medullary blood flow. Am J Physiol Regul Integr Comp Physiol 284: R1355-R1369, 2003.
10. Dellow WJ, Chambers ST, Lever M, Lunt H, Robson RA. Elevated glycine betaine excretion in diabetes mellitus patients is associated with proximal tubular dysfunction and hyperglycemia. Diabetes Res Clin Practice 43: 91-99, 1999.
11. + exchanger NHE3 in Xenopus laevis renal epithelial cells (A6/C1). J Physiol 515: 829-842, 1999.
12. Di Sole F, Cerull R, Babich V, Quinones H, Gisler SM, Biber J, Murer H, Burckhardt G, Helmle-Kolb C, Moe OW. Acute regulation of Na/H exchanger NHE3 by adenosine A1 receptors is mediated by calcineurin homologous protein. J Biol Chem 279: 2962-2974, 2004.
13. Ecelbarger CA, Maeda Y, Gibson CC, Knepper MA. Extracellular ATP increases intracellular calcium in rat terminal collecting duct via a nucleotide receptor. Am J Physiol Renal Fluid Electrolyte Physiol 267: F998-F1006, 1994.
14. Furlong TJ, Moriyama T, Spring KR. Activation of osmolyte efflux from cultured renal papillary epithelial cells. J Membrane Biol 123: 269-277, 1991.
15. - cotransport in Madin-Darby canine kidney cells: lack of involvement of known purinoceptor-coupled signaling pathways. J Membrane Biol 167: 193-204, 1999.
16. Gerwins P, Fredholm BB. ATP and its metabolite adenosine act synergistically to mobilize intracellular calcium via the formation of IP3 in a smooth muscle cell line. J Biol Chem 267: 16081-16087, 1992.
17. i oscillations reflect nucleotide release from renal epithelia. Pflügers Arch 455: 1105-1117, 2008.
18. Gordjani N, Nitschke R, Greger R, Leipziger J. Capacitative Ca2+ entry (CCE) induced by luminal and basolateral ATP in polarised MDCK-C7 cells is restricted to the basolateral membrane. Cell Calcium 22: 121-128, 1997.
19. Guan Z, Osmond DA, Inscho EW. Purinoceptors in the Kidney. Exp Biol Med 232: 715-726, 2007.
20. Gullans SR, Blumenfeld JD, Balschi JA, Kaleta M, Brenner RM, Heilig CW, Hebert SC. Accumulation of major organic osmolytes in rat renal inner medulla in dehydration. Am J Physiol Renal Fluid Electrolyte Physiol 255: F626-F634, 1988.
21. i-dependent activation of phospholipase C in isolated perfused afferent arterioles of mice. J Am Soc Nephrol 14: 2457-2465, 2003.
22. Hill BJ, Katwa LC, Wamhoff BR, Sturek M. Enhanced endothelin (A) receptor-mediated calcium mobilization and contraction in organ cultured porcine coronary arteries. J Pharmacol Exp Ther 295: 484-491, 2000.
23. Hohenegger M, Matyash M, Poussu K, Herrmann-Frank A, Sarkozi S, Lehmann-Horn F, Freissmuth M. Activation of the skeletal muscle ryanodine receptor by suramin and sramin analogs. Mol Pharmacol 50: 1443-1453, 1996.
24. 2+-sensing receptor couples to Gα 12/13 to activate phospholipase D in Madin-Darby canine kidney cells. Am J Physiol Cell Physiol 286: C22-C30, 2004.
25. Hughes AK, Stricklett PK, Kishore BK, Kohan DE. Adenosine Triphosphate Inhibits Endothelin-1 Production by Rat Inner Medullary Collecting Duct Cells. Exp Biol Med 231: 1006-1009, 2006.
26. Kempson SA. Differential activation of system A and betaine/GABA transport in MDCK cell membranes by hypertonic stress. Biochim Biophys Acta 1372: 117-123, 1998.
27. Kempson SA, Beck JA, Lammers PE, Gens JS, Montrose MH. Membrane insertion of betaine/GABA transporter during hypertonic stress correlates with nuclear accumulation of TonEBP. Biochim Biophys Acta 1712: 71-80, 2005.
28. Kempson SA, Edwards JM, Sturek M. Inhibition of the renal betaine transporter by calcium ions. Am J Physiol Renal Physiol 291: F305-F313, 2006.
29. Kempson SA, Helmle C, Abraham MI, Murer H. Parathyroid hormone action on phosphate transport is inhibited by high osmolality. Am J Physiol Renal Fluid Electrolyte Physiol 258: F1336-F1344, 1990.
30. Kempson SA, Parikh V, Xi L, Chu S, Montrose M. Subcellular distribution of the renal betaine transporter during hypertonic stress. Am J Physiol Cell Physiol 285: C1091-C1100, 2003.
31. Leipziger J. Control of epithelial transport via luminal P2 receptors. Am J Physiol Renal Physiol 284: F419-F432, 2003.
32. - secretion, and renal cyst growth: A study using CFTR inhibitors. Kidney Int 66: 1926-1938, 2004.
33. Massari S, Vanoni C, Longhi R, Rosa P, Pietrini G. Protein kinase C-mediated phosphorylation of the BGT1 epithelial g-aminobutyric acid transporter regulates its association with LIN7 PDZ proteins: a post-translational mechanism regulating transporter surface density. J Biol Chem 280: 7388-7397, 2005.
34. McCoy DE, Taylor AL, Kudlow BA, Karlson K, Slattery MJ, Schwiebert LM, Schwiebert EM, Stanton BA. Nucleotides regulate NaCl transport in mIMCD-K2 cells via P2X and P2Y purinergic receptors. Am J Physiol Renal Physiol 277: F552-F559, 1999.
35. Migita K, Lu L, Zhao Y, Honda K, Iwamoto T, Kita S, Katsuragi T. Adenosine induces ATP release via an inositol 1,4,5-trisphosphate signaling pathway in MDCK cells. Biochem Biophys Res Commun 328: 1211-1215, 2005.
36. Migita K, Zhao Y, Katsuragi T. Mitochondria play an important role in adenosine-induced ATP release from Madin-Darby canine kidney cells. Biochem Pharmacol 73: 1676-1682, 2007.
37. Miyai A, Yamauchi A, Moriyama T, Kaneko T, Takenaka M, Sugiura T, Kitamura H, Ando A, Tohyama M, Shimada S, Imai E, Kamada T. Expression of betaine transporter mRNA: its unique localization and rapid regulation in rat kidney. Kidney Int 50: 819-827, 1996.
38. 2+-release mechanism in A7r5 cells. Mol Pharmacol 68: 241-250, 2005.
39. Nakanishi T, Burg MB. Osmoregulatory fluxes of myo-inositol and betaine in renal cells. Am J Physiol Cell Physiol 257: C964-C970, 1989.
40. 2+] regulation in MDCK cells. Kidney Int 60: 1800-1808, 2001.
41. Piggott LA, Hassell KA, Berkova Z, Morris AP, Silberbach M, Rich TC. Natriuretic Peptides and Nitric Oxide Stimulate cGMP Synthesis in Different Cellular Compartments. J Gen Physiol 128: 3-14, 2006.
42. Rauchman MI, Nigam SK, Delpire E, Gullans SR. An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse. Am J Physiol Renal Fluid Electrolyte Physiol 265: F416-F424, 1993.
43. Richardson JC, Scalera V, Simmons NL. Identification of two strains of MDCK cells which resemble separate nephron tubule segments. Biochim Biophys Acta 673: 26-36, 1981.
44. Rivard CJ, Brown LM, Almeida NE, Maunsbach AB, Pihakaski-Maunsbach K, Andres-Hernando A, Capasso JM, Berl T. Expression of the calcium-binding protein S100A4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive response. J Biol Chem 282: 6644-6652, 2007.
45. Schwiebert EM, Kishore BK. Extracellular nucleotide signaling along the renal epithelium. Am J Physiol Renal Physiol 280: F945-F963, 2001.
46. Sheikh-Hamad D, Garcia-Perez A, Ferraris JD, Peters EM, Burg MB. Induction of gene expression by heat shock versus osmotic stress. Am J Physiol Renal Fluid Electrolyte Physiol 267: F28-F34, 1994.
47. Shen J, Halenda SP, Sturek M, Wilden PA. Novel mitogenic effect of adenosine on coronary artery smooth muscle cells: role for the A1 adenosine receptor. Circ Res 96: 982-990, 2005.
48. Silva G, Beierwaltes WH, Garvin JL. Extracellular ATP Stimulates NO Production in Rat Thick Ascending Limb. Hypertension 47: 563-567, 2006.
49. Sizeland PC, Chambers ST, Lever M, Bason LM, Robson RA. Short-term response of nonurea organic osmolytes in human kidney to a water load and water deprivation. Am J Physiol Renal Fluid Electrolyte Physiol 268: F227-F233, 1995.
50. 2+ exchanger in metabolically inhibited MDCK cells. Am J Physiol Renal Physiol 286: F784-F794, 2004.
51. Strange K, Jackson PS. Swelling-activated organic osmolyte efflux: a new role for anion channels. Kidney Int 48: 994-1003, 1995.
52. Tanner GA, Maxwell MR, McAteer JA. Fluid transport in a cultured cell model of kidney epithelial cyst enlargement. J Am Soc Nephrol 2: 1208-1218, 1992.
53. Tawfik HE, Teng B, Morrison RR, Schnermann J, Mustafa SJ. Role of A1 adenosine receptor in the regulation of coronary flow. Am J Physiol Heart Circ Physiol 291: H467-H472, 2006.
54. Turner CM, King BF, Srai KS, Unwin RJ. Antagonism of endogenous putative P2Y receptors reduces the growth of MDCK-derived cysts cultured in vitro. Am J Physiol Renal Physiol 292: F15-F25, 2007.
55. Uchida S, Nakanishi T, Kwon HM, Preston AS, Handler JS. Taurine behaves as an osmolyte in Madin-Darby canine kidney cells. Protection by polarized, regulated transport of taurine. J Clin Invest 88: 656-662, 1991.
56. Vallon V. P2 receptors in the regulation of renal transport mechanisms. Am J Physiol Renal Physiol 294: F10-F27, 2008.
57. van der Wijk T, Tomassen SFB, Houtsmuller AB, de Jonge HR, Tilly BC. Increased Vesicle Recycling in Response to Osmotic Cell Swelling: cause and consequence of hypertonicity-provoked ATP release. J Biol Chem 278: 40020-40025, 2003.
58. Wang Y, Roman R, Lidofsky SD, Fitz JG. Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation. Proc Natl Acad Sci USA 93: 12020-12025, 1996.
59. 2+ entry into Mardin-Darby canine kidney-focus (MDCK-F) cells. Pflügers Arch 426: 95-100, 1994.
60. Wolff SD, Stanton TS, James SL, Balaban RS. Acute regulation of the predominant organic solutes of the rabbit renal inner medulla. Am J Physiol Renal Fluid Electrolyte Physiol 257: F676-F681, 1989.
61. Woo SK, Lee SD, Kwon HM. TonEBP transcriptional activator in the cellular response to increased osmolality. Pflügers Arch 444: 579-585, 2002.
62. Wunz TM, Wright SH. Betaine transport in rabbit renal brush-border membrane vesicles. Am J Physiol Renal Fluid Electrolyte Physiol 264: F948-F955, 1993.
63. Xia SL, Wang L, Cash MN, Teng X, Schwalbe RA, Wingo CS. Extracellular ATP-induced calcium signaling in mIMCD-3 cells requires both P2X and P2Y purinoceptors. Am J Physiol Renal Physiol 287: F204-F214, 2004.
64. Yamauchi A, Kwon HM, Uchida S, Preston AS, Handler J. Myo-inositol and betaine transporters regulated by tonicity are basolateral in MDCK cells. Am J Physiol Renal Fluid Electrolyte Physiol 261: F197-F202, 1991.