Deoxycholic acid impairs glycosylation and fucosylation processes in esophageal epithelial cells

Glycobiology

Volumn 22, Issue 5, 2012, Pages 638-648

  Byrne, Anne Marie ^a   Sharma, Ruchika ^a   Duggan, Gina ^a   Kelleher, Dermot ^a   Long, Aideen ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Barrett's esophagus; bile acid; E cadherin; esophageal cancer; glycosylation

Indexed keywords

ALPHA METHYL MANNOSIDE; BILE ACID; CELL SURFACE PROTEIN; CONCANAVALIN A; DEOXYCHOLIC ACID; FUCOSE; GLYCAN; LITHOCHOLIC ACID; N ACETYLGLUCOSAMINE; PEANUT AGGLUTININ; TUNICAMYCIN; UVOMORULIN; WHEAT GERM AGGLUTININ;

ARTICLE; BARRETT ESOPHAGUS; CANCER GROWTH; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPITHELIUM CELL; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGUS MUCOSA; FUCOSYLATION; GENE EXPRESSION PROFILING; GLYCOSYLATION; GOLGI COMPLEX; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; ULEX EUROPAEUS;

BARRETT ESOPHAGUS; CADHERINS; DEOXYCHOLIC ACID; EPITHELIAL CELLS; ESOPHAGUS; FUCOSE; GLYCOSYLATION; GOLGI APPARATUS; HUMANS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

ARACHIS HYPOGAEA; TRITICUM AESTIVUM; ULEX EUROPAEUS;

EID: 84859088074     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwr190     Document Type: Article

References (45)

1. Aldulaimi D, Jankowski J. 1999. Barrett's esophagus: An overview of the molecular biology. Dis Esophagus. 12:177-180
2. Atherfold PA, Jankowski JA. 2006. Molecular biology of Barrett's cancer. Best Pract Res Clin Gastroenterol. 20:813-827
3. Badr CE, Hewett JW, Breakefield XO, Tannous BA. 2007. A highly sensitive assay for monitoring the secretory pathway and ER stress. PLoS One. 2: e571.
4. Bailey T, Biddlestone L, Shepherd N, Barr H, Warner P, Jankowski J. 1998. Altered cadherin and catenin complexes in the Barrett's esophagus-dysplasia- adenocarcinoma sequence: Correlation with disease progression and dedifferentiation. Am J Pathol. 152:135-144
5. Byrne AM, Foran E, Sharma R, Davies A, Mahon C, O'Sullivan J, O'Donoghue D, Kelleher D, Long A. 2010. Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells. Carcinogenesis. 31:737-744
6. Carpenter PM, Al-Kuran RA, Theuer CP. 2002. Paranuaclear E-cadherin in gastric adenocarcinoma. Am J Clin Pathol. 118:887-894
7. Crocker PR, Redelinghuys P. 2008. Siglecs as positive and negative regulators of the immune system. Biochem Soc Trans. 36:1467-1471
8. Curto M, Cole BK, Lallemand D, Liu CH, McClatchey AI. 2007. Contact-dependent inhibition of EGFR signaling by Nf2/Merlin. J Cell Biol. 177:893-903
9. Dennis JW, Lau KS, Demetriou M, Nabi IR. 2009. Adaptive regulation at the cell surface by N-glycosylation. Traffic. 10:1569-1578
10. Dinter A, Berger EG. 1998. Golgi-disturbing agents. Histochem Cell Biol. 109:571-590
11. Fan G, Goldsmith PK, Collins R, Dunn CK, Krapcho KJ, Rogers KV, Spiegel AM. 1997. N-linked glycosylation of the human Ca2+ receptor is essential for its expression at the cell surface. Endocrinology. 138:1916-1922
12. Fein M, Peters JH, Chandrasoma P, Ireland AP, Oberg S, Ritter MP, Bremner CG, Hagen JA, DeMeester TR. 1998. Duodenoesophageal reflux induces esophageal adenocarcinoma without exogenous carcinogen. J Gastrointest Surg. 2:260-268
13. Fukase K, Ohtsuka H, et al. 2008. Bile acids repress E-cadherin through the induction of Snail and increase cancer invasiveness in human hepatobiliary carcinoma. Cancer Sci. 99:1785-1792
14. Gong L, Debruyne PR, Witek M, Nielsen K, Snook A, Lin JE, Bombonati A, Palazzo J, Schulz S, Waldman SA. 2009. Bile acids initiate lineage-addicted gastroesophageal tumorigenesis by suppressing the EGF receptor-AKT axis. Clin Transl Sci. 2:286-293
15. Gu J, Isaji T, Sato Y, Kariya Y, Fukuda T. 2009. Importance of N-glycosylation on α5β1 integrin for its biological functions. Biol Pharm Bull. 32:780-785
16. Hang HC, Bertozzi CR. 2005. The chemistry and biology of mucin-type O-linked glycosylation. Bioorg Med Chem. 13:5021-5034
17. Jankowski JA, Wright NA, Meltzer SJ, Triadafilopoulos G, Geboes K, Casson AG, Kerr D, Young LS. 1999. Molecular evolution of the metaplasia-dysplasia- adenocarcinoma sequence in the esophagus. Am J Pathol. 154:965-973
18. Jovov B, Que J, Tobey NA, Djukic Z, Hogan BL, Orlando RC.. 2011 Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. Am J Gastroenterol. 106:1039-1047
19. Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T. 2008. DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer. Gastroenterology. 135:142-151.e143
20. Kellokumpu S, Sormunen R, Kellokumpu I. 2002. Abnormal glycosylation and altered Golgi structure in colorectal cancer: Dependence on intra-Golgi pH. FEBS Lett. 516:217-224
21. Lee TK, Koh AS, Cui Z, Peierce RH, Ballatori N. 2003. N-glycosylation controls functional activity of Oatp1, an organic anion transporter. Am J Physiol Gastrointest Liver Physiol. 285:G371-G381.
22. Liu T, Zhang X, So C-K., Wang S, Wang P, Yan L, Myers R, Chen Z, Patterson AP, Yang CS, Chen X. 2007. Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells. Carcinogenesis. 28, 488-496
23. Liwosz A, Lei T, Kukuruzinska MA. 2006. N-Glycosylation affects the molecular organization and stability of E-cadherin junctions. J Biol Chem. 281:23138-23149
24. Lo HW, Hsu SC, Xia W, Cao X, Shih JY, Wei Y, Abbruzzese JL, Hortobagyi GN, Hung MC. 2007. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelialmesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res. 67:9066-9076
25. Looby E, Long A, Kelleher D, Volkov Y. 2005. Bile acid deoxycholate induces differential subcellular localisation of the PKC isoenzymes β1, and δ in colonic epithelial cells in a sodium butyrate insensitive manner. Int J Cancer. 114:887-895
26. Maley F, Trimble RB, Tarentino AL, Plummer TH, Jr.. 1989. Characterization of glycoproteins and their associated oligosaccharides through the use of endoglycosidases. Anal Biochem. 180:195-204
27. Matsumoto K, Yokote H, Arao T, Maegawa M, Tanaka K, Fujita Y, Shimizu C, Hanafusa T, Fujiwara Y, Nishio K. 2008. N-Glycan fucosylation of epidermal growth factor receptor modulates receptor activity and sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor. Cancer Sci. 99:1611-1617
28. Mechref Y, Hussein A, Bekesova S, Pungpapong V, Zhang M, Dobrolecki LE, Hickey RJ, Hammoud ZT, Novotny MV. 2009. Quantitative serum glycomics of esophageal adenocarcinoma and other esophageal disease onsets. J Proteome Res. 8:2656-2666
29. Moriwaki K, Noda K, Furukawa Y, Ohshima K, Uchiyama A, Nakagawa T, Taniguchi N, Daigo Y, Nakamura Y, Hayashi N, Miyoshi E. 2009. Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling. Gastroenterology. 137:188-198, 198.e181-182
30. Nehra D, Howell P, Williams CP, Pye JK, Beynon J. 1999. Toxic bile acids in gastro-oesophageal reflux disease: Influence of gastric acidity. Gut. 44:598-602
31. Neumann H, Wex T, Monkemuller K, Vieth M, Fry LC, Malfertheiner P. 2008. Lectin UEA-I-binding proteins are specifically increased in the squamous epithelium of patients with Barrett's esophagus. Digestion. 78:201-207
32. Osumi D, Takahashi M, Miyoshi E, Yokoe S, Lee SH, Noda K, Nakamori S, Gu J, Ikeda Y, Kuroki Y. 2009. Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells. Cancer Sci. 100:888-895
33. Paulson JC. 1989. Glycoproteins: What are the sugar chains for? Trends in Biochem Sci. 14:272-276
34. Raimondi F, Santoro P, Barone MV, Pappacoda S, Barretta ML, Nanayakkara M, Apicella C, Capasso L, Paludetto R. 2008. Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation. Am J Physiol Gastrointest Liver Physiol, 294:G906-G913
35. Rivinoja A, Hassinen A, Kokkonen N, Kauppila A, Kellokumpu S. 2009. Elevated Golgi pH impairs terminal N-glycosylation by inducing mislocalization of Golgi glycosyltransferases. J Cell Physiol. 220:144-154
36. Shah SA, Volkov Y, Arfin Q, Abdel-Latif MM, Kelleher D. 2006. Ursodeoxycholic acid inhibits interleukin 1 beta [corrected] and deoxycholic acid-induced activation of NF-?B and AP-1 in human colon cancer cells. Int J Cancer. 118:532-539
37. Sharma R, Majer F, Peta VK, Wang J, Keaveney R, Kelleher D, Long A, Gilmer JF. 2010. Bile acid toxicity structure-activity relationships: Correlations between cell viability and lipophilicity in a panel of new and known bile acids using an oesophageal cell line (HET-1A). Bioorg Med Chem. 18:6886-6895
38. Shimamoto C, Weinstein WM, Boland CR. 1987. Glycoconjugate expression in normal, metaplastic, and neoplastic human upper gastrointestinal mucosa. J Clin Invest. 80:1670-1678
39. Takahashi M, Kuroki Y, Ohtsubo K, Taniguchi N. 2009. Core fucose and bisecting GlcNAc, the direct modifiers of the N-glycan core: Their functions and target proteins. Carbohydr Res. 344:1387-1390
40. Varki A., C.R., Esko JD, Freeze HH, Hart GW, Marth JD. 1999. Essentials of Glycobiology, Cold Spring Harbour Laboratory Press, Cold Spring Harbor, NY.
41. Wang D, Su L, Huang D, Zhang H, Shin DM, Chen ZG. 2011. Downregulation of E-Cadherin enhances proliferation of head and neck cancer through transcriptional regulation of EGFR. Mol Cancer. 10:116.
42. Xu YX, Liu L, Caffaro CE, Hirschberg CB. 2010. Inhibition of Golgi apparatus glycosylation causes endoplasmic reticulum stress and decreased protein synthesis. J Biol Chem. 285:24600-24608
43. Yang JM, Byrd JC, Siddiki BB, Chung YS, Okuno M, Sowa M, Kim YS, Matta KL, Brockhausen I. 1994. Alterations of O-glycan biosynthesis in human colon cancer tissues. Glycobiology. 4: 873-884
44. Yanyang Z, Yuya S, Tomoya I, Tomohiko F, Akio M, Eiji M, Jianguo G, Naoyuki T. 2008. Branched N-glycans regulate the biological functions of integrins and cadherins. FEBS Journal. 275:1939-1948
45. Zhou F, Su J, Fu L, Yang Y, Zhang L, Wang L, Zhao H, Zhang D, Li Z, Zha X. 2008. Unglycosylation at Asn-633 made extracellular domain of E-cadherin folded incorrectly and arrested in endoplasmic reticulum, then sequentially degraded by ERAD. Glycoconj J. 25: 727-740.