Downregulation of E-Cadherin enhances proliferation of head and neck cancer through transcriptional regulation of EGFR

Molecular Cancer

Volumn 10, Issue , 2011, Pages

  Wang, Dongsheng ^a   Su, Ling ^a   Huang, Donghai ^a   Zhang, Hongzheng ^a   Shin, Dong M ^a   Chen, Zhuo G ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERLOTINIB; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; SULFORHODAMINE B; UVOMORULIN; CADHERIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; QUINAZOLINE DERIVATIVE;

ARTICLE; CELL LINE; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GENETIC TRANSFECTION; HEAD AND NECK CANCER; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; HEAD AND NECK TUMOR; HUMAN; METABOLISM; RNA INTERFERENCE; RNA STABILITY; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TUMOR CELL CULTURE;

CADHERINS; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HEAD AND NECK NEOPLASMS; HUMANS; PROTEIN STABILITY; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA INTERFERENCE; RNA STABILITY; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 80053175737     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-10-116     Document Type: Article

References (29)

1. Jemal A, Murray T, Wardet E, Tiwari RC, Ghafoor A, Feuer EJ, Thun MJ. Cancer statistics. CA Cancer J Clin 2005, 55(1):10-30. 10.3322/canjclin.55.1.10, 15661684.
2. Parkin D, Pisani P, Ferlay J. Global cancer statistics. Cancer J Clin 1999, 49(1):33-64.
3. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. Cancer Statistics. CA Cancer J Clin 2009, 59(4):225-249. 10.3322/caac.20006, 19474385.
4. Neal D, Sharples L, Smith K, Fennelly J, Hall RR, Harris AL. The epidermal growth factor receptor and the prognosis of bladder cancer. Cancer 1990, 65(7):1619-1625. 10.1002/1097-0142(19900401)65:7<1619::AID-CNCR2820650728>3.0.CO;2-Q, 2311071.
5. Ennis B, Lippman ME, Dickson RB. The EGF receptor system as a target for antitumor therapy. Cancer Invest 1991, 9(5):553-562. 10.3109/07357909109018953, 1933488.
6. Yamanaka Y, Friess H, Kobrin MS, Buchler M, Beger HG, Korc M. Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Res 1993, 13(3):565-569.
7. Grandis JR, Tweardy DJ. Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Research 1993, 53(13):3579-3584.
8. Cohen G, Mustafi R, Chumsangsri A, Little N, Nathanson J, Cerda S, Jagadeeswaran S, Dougherty U, Joseph L, Hart J, Yerian L, Tretiakova M, Yuan W, Obara P, Khare S, Sinicrope FA, Fichera A, Boss GR, Carroll R, Bissonnette M. Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci. Cancer Research 2006, 66(11):5656-5664. 10.1158/0008-5472.CAN-05-0308, 16740703.
9. Grandis J, Melhem MF, Goodinget WE, Day R, Holst VA. Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst 1998, 90(14):824-832.
10. Maurizi M, Almadori G, Ferrandina G, Distefano M, Romanini ME, Cadoni G, Benedetti-Panici P, Paludetti G, Scambia G, Mancuso S. Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma. Br J Cancer 1996, 74(8):1253-1259. 10.1038/bjc.1996.525, 2075924, 8883413.
11. Chen Z, Zhang X, Li M, Wang Z, Wieand HS, Grandis JR, Shin DM. Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck. Clin Cancer Res 2004, 10(17):5930-5940. 10.1158/1078-0432.CCR-03-0677, 15355926.
12. Kalyankrishna S, Grandis JR. Epidermal growth factor receptor biology in head and neck cancer. J Clin Onco 2006, 24(17):2666-2672.
13. Ang K, Berkey BA, Tu X, Zhang HZ, Katz R, Hammond EH, Fu KK, Milas L. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Research 2002, 62(24):7350-7356.
14. Astsaturov I, Cohen RB, Harari P. Targeting epidermal growth factor receptor signaling in the treatment of head and neck cancer. Expert Rev Anticancer Ther 2006, 6(9):1179-1184. 10.1586/14737140.6.9.1179, 17020453.
15. Guarino M, Rubino B, Ballabio G. The role of epithelial-mesenchymal transition in cancer pathology. Pathology 2007, 39(3):305-318. 10.1080/00313020701329914, 17558857.
16. Hsu SC, Xia W, Cao X, Shih JY, Wei Y, Abbruzzese JL, Hortobagyi GN, Hung MC. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Research 2007, 67(19):9066-9076. 10.1158/0008-5472.CAN-07-0575, 2570961, 17909010.
17. Lugo-Martínez VH, Petit CS, Fouquet S, Le Beyec J, Chambaz J, Pinçon-Raymond M, Cardot P, Thenet S. Epidermal growth factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherin-mediated junctions. Am J Physiol Gastrointest Liver Physiol 2009, 296(2):235-244.
18. Muller S, Tighiouart M, Saba N, Zhang H, Shin DM, Chen Z(G). Distinctive E-cadherin and epidermal growth factor receptor expression in metastatic and non-metastatic head and neck squamous cell carcinoma: Predictive and prognostic correlation. Cancer 2008, 113(1):97-107. 10.1002/cncr.23557, 18473353.
19. Huang D, Su L, Peng XH, Zhang H, Khuri FR, Shin DM, Chen ZG. Quantum dot-based quantification revealed differences in subcellular localization of EGFR and E-cadherin between EGFR-TKI sensitive and insensitive cancer cells. Nanotechnology 2009, 20(22). Epub.
20. Sacks P, Parnes S, Gallick G, Mansouri Z, Lichtner R, Lichtner R, Satya-Prakash KL, Pathak S, Parsons DF. Establishment and Characterization of Two New Squamous Cell Carcinoma Cell Lines Derived from Tumors of the Head and Neck. Cancer 1988, 48(10):2858-2866.
21. Beckhardt RN, Kiyokawa N, Xi L, Liu TJ, Hung MC, el-Naggar AK, Zhang HZ, Clayman GL. HER-2/neu oncogene characterization in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 1995, 121(11):1265-70.
22. Heo DS, Snyderman C, Gollin SM, Pan S, Walker E, Deka R, Barnes EL, Johnson JT, Herberman RB, Whiteside TL. Biology, cytogenetics, and sensitivity to immunological effector cells of new head and neck squamous cell carcinoma lines. Cancer Res 1989, 49(18):5167-5175.
23. Cowden Dahl KDSJ, Ning Y, Gutierrez E, Fishman DA, Adley BP, Stack MS, Hudson LG. Matrix metalloproteinase 9 is a mediator of epidermal growth factor-dependent e-cadherin loss in ovarian carcinoma cells. Cancer Research 2008, 68(12):4606-4613. 10.1158/0008-5472.CAN-07-5046, 18559505.
24. Roberts P, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007, 26(22):3291-3310. 10.1038/sj.onc.1210422, 17496923.
25. Qian X, Karpova T, Sheppard AM, McNally J, Lowy DR. E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases. EMBO J 2004, 23(8):1739-1748. 10.1038/sj.emboj.7600136, 394229, 15057284.
26. Perrais M, Chen X, Perez-Moreno M, Gumbiner BM. E-cadherin homophilic ligation inhibits cell growth and epidermal growth factor receptor signaling independently of other cell interactions. Mol Biol Cell 2007, 18(6):2013-2025. 10.1091/mbc.E06-04-0348, 1877107, 17392517.
27. Zhou B, Deng J, Xia W, Xu J, Li YM, Gunduz M, Hung MC. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 2004, 6(10):931-940. 10.1038/ncb1173, 15448698.
28. Saito T, Oda Y, Kawaguchi K, Sugimachi K, Yamamoto H, Tateishi N, Tanaka K, Matsuda S, Iwamoto Y, Ladanyi M, Tsuneyoshi M. E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma. Oncogene 2004, 23(53):8629-8638. 10.1038/sj.onc.1207960, 15467754.
29. Hipp S, Walch A, Schuster T, Losko S, Laux H, Bolton T, Höfler H, Becker KF. Activation of epidermal growth factor receptor results in Snail protein but not mRNA over-expression in endometrial cancer. J Cell Mol Med 2008, 13(9b):3858-3867.