Bile acid toxicity structure-activity relationships: Correlations between cell viability and lipophilicity in a panel of new and known bile acids using an oesophageal cell line (HET-1A)

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 18, 2010, Pages 6886-6895

  Sharma, Ruchika ^a,b   Majer, Ferenc ^a   Peta, Vijaya Kumar ^a   Wang, Jun ^a   Keaveney, Ray ^a   Kelleher, Dermot ^b   Long, Aideen ^b   Gilmer, John F ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b ST JAMES S HOSPITAL   (Ireland)

Author keywords

Azido steroid; Bile acids; Cell viability; Cytotoxicity; Lipophilicity; Physicochemical characteristics

Indexed keywords

AMIDE; AZIDE; BILE ACID; CHENODEOXYCHOLIC ACID; CHOLIC ACID; DEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID;

ARTICLE; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; CYTOTOXICITY; DISPERSION; DRUG STRUCTURE; ESOPHAGUS; HUMAN; HUMAN TISSUE; HYDROPHOBICITY; LIPOPHILICITY; LIVER CELL CARCINOMA; PHYSICAL CHEMISTRY; SQUAMOUS EPITHELIUM; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY;

BILE ACIDS AND SALTS; CELL LINE; CELL SURVIVAL; CHROMATOGRAPHY, REVERSE-PHASE; CHROMATOGRAPHY, THIN LAYER; ESOPHAGUS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956342528     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.07.030     Document Type: Article

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