Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans?

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 64, Issue 11, 2009, Pages 1126-1133

  Panici, Jacob A ^a   Wang, Feiya ^a   Bonkowski, Michael S ^b   Spong, Adam ^a   Bartke, Andrzej ^a   Pawlikowska, Ludmila ^c,d   Kwok, Pui Yan ^c   Masternak, Michal M ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; GHRKO; Insulin

Indexed keywords

ANIMALIA; MUS;

GROWTH HORMONE; GROWTH HORMONE RECEPTOR; INSULIN; MESSENGER RNA; PPARGC1A PROTEIN, MOUSE; SOMATOMEDIN C; TRANSACTIVATOR PROTEIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BLOOD; C3H MOUSE; C57BL MOUSE; GENETICS; GENOTYPE; LIVER; LONGEVITY; MALE; METABOLISM; MOUSE; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; GENOTYPE; GROWTH HORMONE; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LIVER; LONGEVITY; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, SOMATOTROPIN; RNA, MESSENGER; TRANS-ACTIVATORS;

EID: 70350435108     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glp111     Document Type: Article

References (23)

1. Weindruch R, Walford R. The Retardation of Aging and Disease by Dietary Restriction. Springfield, IL: Thomas; 1988.
2. Zhou Y, Xu BC, Maheshwari HG, et al. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc Natl Acad Sci U S A. 1997; 94: 13215-13220.
3. Liu JL, Coschigano KT, Robertson K, et al. Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. Am J Physiol Endocrinol Metab. 2004; 287: E405-E413.
4. Berryman DE, List EO, Coschigano KT, Behar K, Kim JK, Kopchick JJ. Comparing adiposity profiles in three mouse models with altered GH signaling. Growth Horm IGF Res. 2004; 14: 309-318.
5. Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology. 2000; 141: 2608-2613.
6. Coschigano KT, Holland AN, Riders ME, List EO, Flyvbjerg A, Kopchick JJ. Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology. 2003; 144: 3799-3810.
7. White MF. The IRS-1 signaling system. Curr Opin Genet Dev. 1994; 4: 47-54.
8. White MF, Kahn CR. The insulin signaling system. J Biol Chem. 1994; 269: 1-4.
9. Backer JM, Myers MG, Jr, Sun XJ, et al. Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3′-kinase. Formation of binary and ternary signaling complexes in intact cells. J Biol Chem. 1993; 268: 8204-8212.
10. Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, et al. Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci. 2 005; 6 0: 1 394- 1 398.
11. Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, et al. Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice. Exp Gerontol. 2005; 40: 679-684.
12. DeFronzo RA. Glucose intolerance and aging. Diabetes Care. 1981; 4: 493-501.
13. Spence JW. Some observations on sugar tolerance, with special reference to variations found at different ages. Q J Med. 1920; 14: 314-326.
14. Bonkowski MS, Rocha JS, Masternak MM, Al Regaiey KA, Bartke A. Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci U S A. 2006; 103: 7901-7905.
15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985; 28: 412-419.
16. Petkov PM, Cassell MA, Sargent EE, et al. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics. 2004; 83: 902-911.
17. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987; 162: 156-159.
18. Masternak MM, Przybylski GK, Smoczkiewicz P, Plotek W, Kowalczyk DW, Nowak JS. Novel competitive PCR methods for quantitation of T-cell receptor delta (TCRD) gene rearrangements. J Appl Genet. 2002; 43: 235-244.
19. Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, et al. Caloric restriction results in decreased expression of peroxisome proliferatoractivated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci. 2005; 60: 1238-1245.
20. Masternak MM, Al-Regaiey KA, Bonkowski MS, Panici JA, Bartke A. Effect of every other day feeding diet on gene expression in normal and in long-lived Ames dwarf mice. Exp Gerontol. 2005; 40: 491-497.
21. Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, et al. Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart. Exp Gerontol. 2006; 41: 417-429.
22. Masternak MM, Bartke A. PPARs in calorie restricted and genetically long-lived mice. PPAR Res. 2007; 2007: 28436.
23. de Magalhaes JP, Cabral JA, Magalhaes D. The infl uence of genes on the aging process of mice: a statistical assessment of the genetics of aging. Genetics. 2005; 169: 265-274.