Endothelial dysfunction in hypopituitary adults with growth hormone deficiency

Clinical Endocrinology

Volumn 50, Issue 4, 1999, Pages 457-464

  Evans, L M ^a,b   Davies, J S ^a   Goodfellow, J ^b   Rees, J A E ^a   Scanlon, M F ^a  

^a LLANDOUGH HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GLUCOSE; GLYCERYL TRINITRATE; GLYCOSYLATED HEMOGLOBIN; GROWTH HORMONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SOMATOMEDIN C; TRIACYLGLYCEROL;

ADULT; ARTERY DIAMETER; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; ATHEROSCLEROSIS; BRACHIAL ARTERY; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM INJURY; FEMALE; GROWTH HORMONE DEFICIENCY; HUMAN; HYPOPITUITARISM; MALE; PRIORITY JOURNAL; SUBLINGUAL DRUG ADMINISTRATION;

ADULT; BLOOD GLUCOSE; BRACHIAL ARTERY; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; CHOLESTEROL, LDL; ENDOTHELIUM, VASCULAR; FEMALE; GROWTH HORMONE; HUMANS; HYPOPITUITARISM; INSULIN; MALE; MIDDLE AGED; NITROGLYCERIN; RISK FACTORS; VASODILATION;

EID: 0032953347     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1999.00671.x     Document Type: Article

References (48)

1. Allain, C.C., Poon, L.S., Chan, C.S.G., Richmond, W, & Fu, P.C. (1974) Enzymatic determination of total serum cholesterol. Clinical Chemistry, 20, 470-475.
2. Al-Shoumer, K.A.S., Ali, K., Anyaoku, V., Niththyananthan, R. & Johnston, D.G. (1996) Overnight metabolic fuel deficiency in patients treated conventionally for hypopituitarism. Clinical Endocrinology, 45, 171-178.
3. Al-Shoumer, K.A.S., Cox, K.H., Hughes, C.L., Richmond, W. & Johnston, D.G. (1997) Fasting and post-prandial lipid abnormalities in hypopituitary women receiving conventional hormone replacement therapy. Journal of Clinical Endocrinology ami Metabolism, 82, 2653-2659.
4. Austin, M.A., Breslow, J.L., Hennekens, C.H., Buring, J.E., Willett, W.C. & Krauss, R.M. (1988) Low density lipoprotein subclass patterns and the risk of myocardial infarction. Journal of the American Medical Association, 260, 1917-1921.
5. Bang, P., Eriksson, U., Sara, V., Wivall, I.L. & Hall, K. (1991) Comparison of acid ethanol extraction and acid gel filtration prior to IGF-I and IGF-II radioimmunoassays: improvement of determinations in acid ethanol extracts by the use of truncated IGF-I as radioligand. Acta Endocrinologica, 124, 620-629.
6. Bates, A.S., Hoff, W.V., Jones, P.J. & Clayton, R.N. (1996) The effects of hypopituitarism on life expectancy. Journal of Clinical Endocrinology and Metabolism, 81, 1169-1172.
7. Bellamy, M., Ramsey, M., Goodfellow, J., Brownlee, M., Gorman, S.T., McDowell, I.F. & Lewis, M.J. (1996) Hyperhomocysteinaemia and endothelial dysfunction with low Vitamin B12/folate status. Circulation, 94 (Suppl. 8), 1-462.
8. Bengtsson, B.A., Eden, S., Lonn, L., Kvist, H., Stockland, A., Lindstedt, G., Boseaus, I., Tolli, J., Sjostrom, L. & Tsaksson, O. (1993) Treatment of adults with GHD with recombinant human GH. Journal of Clinical Endocrinology and Metabolism, 76: 309-317.
9. Berliner, J., Navab, M., Fogelman, A., Dermmer, L.L., Edwards, P.A. & Watson, A.D. (1995) Atherosclerosis: basic mechanisms. Circulation, 91, 2488-2496.
10. Binnerts, A., Duerenberg, P., Swart, G.R., Wilson, J.H.P. & Lamberts, S.W.J. (1992a) Body composition in growth hormone deficient adults. American Journal of Clinical Nutrition, 55, 918-923.
11. Binnerts, A., Swart, G.R., Wilson, J.H., Hogerbragge, N., Huibert, A.P., Pols, J.C, & Lamberts, S.J.W. (1992b) The effect of GH administration in GHD adults on hone, protein, carbohydrate and lipid homeostasis, as well as body composition. Clinical Endocrinology, 37, 79-87.
12. Boger, R.H., Skamira, C., Bode-Buger, S.M., Brabant, G., von zur Muhlen, A. & Frolich, J.C. (1996) Nitric oxide may mediate the haemodynamic effects of recombinant human GH in patients with acquired GHD. Journal of Clinical Investigation, 98, 2706-2713.
13. Bones, C., Bellamy, M., Brownlee, M., Goodfellow, J., Ramsey, M.W., Gorman, S.T. & Lewis, M.J. (1997) Endothelial function in healthy young adults is rapidly improved by physical training. European Heart Journal, 18, 265.
14. Celermajer, D., Sorenson, K., Gooch, V., Spiegelhalter, D. & Deanfield, J. (1992) Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet, 340, 1111-1115.
15. Celermajer, D., Sorcnsen, K., Georgakopoulos, D., Robinson, J., Bull, C. & Deanfield, J.E. (1993) Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation, 88, 2148-2155.
16. Clarkson, P., Adams, M., Powe, A., Donald, A.E., McRedie, R., Robinson, J., Mearthy, S.N., Keech, A., Celermajer, D.S. & Deanfield, J.E. (1996a) Oral l-arginine improves endothelium-dependent dilation in hypercholesterolaemic young adults. Journal of Clinical Investigation, 97, 1989-1994.
17. Clarkson, P., Celermajer, D., Donald, A., Sampson, M., Soransen, K.E., Adams, M., Yue, D.K., Betteridge, D.J. & Deanfield, J.E. (1996b) Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels. Journal of the American College of Cardiology, 28, 573-579.
18. Cuneo, R.C., Salomon, F., Wiles, C.M., Hesp, R. & Sonksen, P.H. (1991) Growth hormone treatment in growth hormone deficient adults. Effects on muscle mass and strength. Effects on exercise performante. Journal of Applied Physiology, 70, 688-694 & 695-700.
19. Despres, J.P. (1994) Dyslipidaemia and obesity, Balliere's Clinical Endocrinology and Metabolism, 8, 629-653.
20. Friedewald, W.T., Levy, R.L. & Fredrickson, D.S. (1972) Estimation of the concentration of LDL cholesterol without use of the preparative ultracentrifuge. Clinical Chemistry, 18, 499-502.
21. Goodfellow, J., Ramsey, M.W., Luddington, L.A., Jones, C.J., Coates, P.A., Dunstan, F., Lewis, M.J., Owens, D.R. & Henderson, A.H. (1996) Endothelium and inelastic arteries: an early marker of vascular dysfunction in non-insulin dependent diabetes mellitus. British Medical Journal, 312, 744-745.
22. Goodfellow, J., Ramsey, M., Bellamy, M., Gorman, S., Brownlee, M. & Lewis, M. (1998) Effect of dietary omega-3 fatty acids (fish oils) supplements on endothelial dysfunction in hypercholesterolaemic subjects. European Heart Journal, in press.
23. Healy, B. (1990) Endothelial cell dysfunction: an emerging endocrinopathy linked to coronary disease. Journal of the American College of Cardiology. 16, 357-358.
24. Henderson, A. (1991) Endothelium in control. British Heart Journal, 65, 116-125.
25. Hoeks, A., Brands, P., Smeets, F. & Reneman, R. (1990) Assessment of the distensibility of superficial arteries. Ultrasound in Medicine and Biology, 16, 121-128.
26. Hull, S., Kaiser, L., Jaffe, M, & Sparks, H. (1986) Endothelium-dependenl flow-induced dilation of canine femoral and saphenous arteries. Blood Vessels, 23, 183-198.
27. Joannides, R., Haefeli, W., Linder, L., Richard, V., El-Hamman, B., Thulliez, C. & Luscher, T.F. (1995) Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation, 91, 1314-1319.
28. Johansson, J.O., Fowelin, J., Landin, K., Lager, I. & Bengtsson, B.A. (1995) Growth hormone deficient adults are insulin resistant. Metabolism, 44, 434-437.
29. John, W.G., Gray, M.R., Bates, D.L. & Beacham, J.L. (1993) Enzyme immunoassay - a new technique for estimating haemoglobin Alc. Clinical Chemistry, 39, 663-666.
30. O'Neal, D., Few, F.L., Sikaris, K., Ward, G., Alford, F. & Best, J.D. (1996) Low density lipoprotein particle size in hypopituitary adults receiving conventional hormone replacement therapy. Journal of Clinical Endocrinology and Metabolism, 81, 2448-2454.
31. Paronini, P., Angelin, B., Lobie, P.E., Norstedt, G. & Rudling, M. (1995) Growth hormone specifically stimulates the expression of LDL. receptors in human hepatoma cells. Endocrinology, 136, 3767-3773.
32. Ramsey, M., Goodfellow, J., Jones, C., Luddington, L., Lewis, M. & Henderson, A. (1995) Endothelial control of arterial distensibility is impaired in chronic heart failure. Circulation, 92, 3212-3219.
33. Rosen, T. & Bengtsson, B.A. (1990) Premature mortality due to cardiovascular disease in hypopituitarism. Lancet, 336, 285-288.
34. Rosen, T., Bosaeus, I., Tolli, J., Lindstedt, G. & Bengtsson, B.A. (1993) Increased body fat mass and decreased extra-cellular fluid volume in adults with growth hormone deficiency. Clinical Endocrinology, 38, 63-71.
35. Rosen, T., Johannsson, G., Hallgren, P., Caidahl, K., Bosaeus, I. & Bengtsson, B.A. (1994) Beneficial effects of 12 months replacement with recombinant human GH to GHD adults. Endocrinology and Metabolism, 1, 55-66.
36. Ross, R. (1986) The pathogenesis of atherosclerosis - an update. New England Journal of Medicine, 8, 488-500.
37. Ross, R. (1993) The pathogenesisof atherosclerosis: a perspective for the 1990s. Nature, 362, 801-809.
38. Rubanyi, G., Romero, J. & Vanhoutte, P. (1986) Flow-induced release of endothelium-derived relaxing factor. American Journal of Physiology, 250, H1145-H1149.
39. Russell-Jones, D.L., Watts, G.F., Weissberger, A., Naoumava, R., Myers, J., Thompson, G.R. & Sonksen, P.H. (1994) The effect of GH replacement on serum lipids, lipoproteins, apolipoproteins and cholesterol precursors in adulty GHD patients. Clinical Endocrinology, 41, 345-350.
40. Salomon, F., Cuneo, R.C., Hesp, R. & Sonksen, P.H. (1989) Effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. New England Journal of Medicine, 321, 1797-1803.
41. Steinherg, D., Parthasarathy, S., Carew, T.E., Khoo, J.C. & Witztum, J.L. (1989) Beyond cholesterol: modifications of LDL that increase its atherogenicity. New England Journal of Medicine, 320, 915-924.
42. Stray, H.C. (1989) Evolution and progression of atherosclerotic lesions in coronary arteries in children and young adults. Arteriosclerosis, 99 (Suppl. I), 119-132.
43. Streicher, R., Katzka, J., Muller, G., Wiedland, D., Siegmeister, G., Munk, M. & Krone, W. (1996) SERBP-mediates activation of LDL receptor promoter region by insulin and IGF-I. Journal of Biology and Chemistry. 271, 7128-7133.
44. Tsukahara, H., Gordienko, D.V., Tonshof, B., Gelato, M.C. & Goligorsky, M.S. (1994) Direct demonstration of insulin like growth factor-I induced nitric oxide production by endothelial cells. Kidney International, 45, 598-604.
45. Voors, A.A., Oosterga, M., Buehema, H., May, J.F., Grandjean, J.G., Van-buten, A. & Van-gilst, W.H. (1997) Dyslipidaemia and endothelium dependent function in internal mammary arteries used For coronary bypass surgery. Cardiovascular Research, 34, 568-567.
46. Wahlefeld, A.W. & Triglycerides. (1974) Determination after enzymatic hydrolysis. In Methods of Enzymatic Analysis (ed. Bergmeyer, H.U.), pp. 1831-1835. Academic Press, New York.
47. Warnick, G.R., Nguyen, T. & Albers, A.A. (1985) Comparison of improved precipitation methods for quantification of HDL cholesterol. Clinical Chemistry, 31, 217-222.
48. Whitehead, H.M., Boreham, C, Mellrath, E.M., Sheridan, B., Kennedy, L., Brew-Atkinson, A. & Hadden, D.R. (1992) GH treatment of adults with GHD: results of a 13-month placebo controlled cross-over study. Clinical Endocrinology, 36, 45-52.