No evidence for the in vivo induction of genomic instability by low doses of 137Cs gamma rays in bone marrow cells of BALB/cJ and C57BL/6J MICE

Dose-Response

Volumn 10, Issue 1, 2012, Pages 11-36

  Rithidech, Kanokporn Noy ^a   Udomtanakunchai, Chatchanok ^a,b   Honikel, Louise M ^a   Whorton, Elbert B ^c  

^a STONY BROOK UNIVERSITY   (United States)

^b CHIANG MAI UNIVERSITY   (Thailand)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Cytogenetics; Gamma rays; Genomic instability; Low dose; Mouse

Indexed keywords

CESIUM 137;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CHROMATID EXCHANGE; CHROMOSOME 1; CHROMOSOME 2; CHROMOSOME 3; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CONTROLLED STUDY; GAMMA RADIATION; GENOMIC INSTABILITY; IN VIVO STUDY; MALE; METAPHASE; MOUSE; NONHUMAN; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; RADIOSENSITIVITY; STRAIN DIFFERENCE;

EID: 84859056820     PISSN: None     EISSN: 15593258     Source Type: Journal    
DOI: 10.2203/dose-response.11-002.Rithidech     Document Type: Article

References (56)

1. Ban, N., Kai, M., and Kusama, T. 1997. Chromosome aberrations in bone marrow cells of C3H/He mice at an early stage after whole-body irradiation. Journal of Radiation Research 38(4): 219-231.
2. Barcellos-Hoff, M.H., Park, C., and Wright, E.G. 2005. Radiation and the microenvironment-tumorigenesis and therapy. Nat Rev Cancer 5(11): 867-875.
3. Bauer, G. 2007. Low dose radiation and intercellular induction of apoptosis: potential implications for the control of oncogenesis. Int J Radiat Biol 83(11-12): 873-888.
4. Bender, M.A., Awa, A.A., Brooks, A.L., Evans, H.J., Groer, P.G., Littlefield, L.G., Pereira, C., Preston, R.J., and Wachholz, B.W. 1988. Current status of cytogenetic procedures to detect and quantify previous exposures to radiation. Mutat Res 196(2): 103-159.
5. Bouffler, S.D., Haines, J.W., Edwards, A.A., Harrison, J.D., and Cox, R. 2001. Lack of detectable transmissible chromosomal instability after in vivo or in vitro exposure of mouse bone marrow cells to 224Ra alpha particles. Radiat Res 155(2): 345-352.
6. Bouffler, S.D., Meijne, E.I., Huiskamp, R., and Cox, R. 1996. Chromosomal abnormalities in neutroninduced acute myeloid leukemias in CBA/H mice. Radiat Res 146(3): 349-352.
7. Bouffler, S.D., Meijne, E.I., Morris, D.J., and Papworth, D. 1997. Chromosome 2 hypersensitivity and clonal development in murine radiation acute myeloid leukaemia. Int J Radiat Biol 72(2): 181-189.
8. Boulton, E., Cleary, H., Papworth, D., and Plumb, M. 2001. Susceptibility to radiation-induced leukaemia/lymphoma is genetically separable from sensitivity to radiation-induced genomic instability. Int J Radiat Biol 77(1): 21-29.
9. Brooks, A.L. 2005. Paradigm shifts in radiation biology: their impact on intervention for radiationinduced disease. Radiation Research 164(4 Pt 2): 454-461.
10. Cox, R., Breckon, G., Silver, A.R., Masson, W.K., and George, A.M. 1991. Chromosomal changes: radiation sensitive sites on chromosome 2 and their role in radiation myeloid leukaemogenesis in the mouse. Radiat Environ Biophys 30(3): 177-179.
11. Darakhshan, F., Badie, C., Moody, J., Coster, M., Finnon, R., Finnon, P., Edwards, A.A., Szluinska, M., Skidmore, C.J., Yoshida, K., Ullrich, R., Cox, R., and Bouffler, S.D. 2006. Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay. Carcinogenesis 27(2): 311-318.
12. Disteche, C.M., Carrano, A.V., Ashworth, L.K., and Latt, S.A. 1981. Flow sorting of the mouse Cattanach X chromosome, T (X; 7) 1 Ct, in an active or inactive state. Cytogenet Cell Genet 29(4): 189-197.
13. Durante, M., George, K., Wu, H., and Cucinotta, F.A. 2002. Karyotypes of human lymphocytes exposed to high-energy iron ions. Radiat Res 158(5): 581-590.
14. Feinendegen, L.E. 2005. Evidence for beneficial low level radiation effects and radiation hormesis. Br J Radiol 78(925): 3-7.
15. Giver, C.R., Moore, D.H., 2nd, and Pallavicini, M.G. 2000. Radiation-induced translocations in mice: persistence, chromosome specificity, and influence of genetic background. Radiation Research 154(3): 283-292.
16. Hagmar, L., Stromberg, U., Tinnerberg, H., and Mikoczy, Z. 2004. Epidemiological evaluation of cytogenetic biomarkers as potential surrogate end-points for cancer. IARC Scientific Publications(157): 207-215.
17. Hande, M.P., Boei, J.J., Granath, F., and Natarajan, A.T. 1996. Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridization. I. Dicentrics and translocations. Int J Radiat Biol 69(4): 437-446.
18. Hayata, I., Ishihara, T., Hirashima, K., Sado, T., and Yamagiwa, J. 1979. Partial deletion of chromosome No. 2 in myelocytic leukemias of irradiated C3H/He and RFM mice. J Natl Cancer Inst 63(3): 843-848.
19. Holmberg, K., Falt, S., Johansson, A., and Lambert, B. 1993. Clonal chromosome aberrations and genomic instability in X-irradiated human T-lymphocyte cultures. Mutation Research 286(2): 321-330.
20. Jagetia, G.C. 1993. Radiation-induced chromosomal aberrations in the bone marrow of mice exposed to various doses of gamma radiation. Radiation & Environmental Biophysics 32(2): 109-117.
21. Jawad, M., Cole, C., Zanker, A., Lo, P., Fitch, S., and Plumb, M. 2006. Evidence for clustered tumour suppressor gene loci on mouse chromosomes 2 and 4 in radiation-induced Acute Myeloid Leukaemia. International Journal of Radiation Biology 82(6): 383-391.
22. Kadhim, M.A., Lorimore, S.A., Hepburn, M.D., Goodhead, D.T., Buckle, V.J., and Wright, E.G. 1994. Alpha-particle-induced chromosomal instability in human bone marrow cells. Lancet 344(8928): 987-988.
23. Kadhim, M.A., Lorimore, S.A., Townsend, K.M., Goodhead, D.T., Buckle, V.J., and Wright, E.G. 1995. Radiation-induced genomic instability: delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells. International Journal of Radiation Biology 67(3): 287-293.
24. Kadhim, M.A., Macdonald, D.A., Goodhead, D.T., Lorimore, S.A., Marsden, S.J., and Wright, E.G. 1992. Transmission of chromosomal instability after plutonium alpha-particle irradiation.[see comment]. Nature 355(6362): 738-740.
25. Kanda, R., Tsuji, S., Ohmachi, Y., Ishida, Y., Ban, N., and Shimada, Y. 2008. Rapid and reliable diagnosis of murine myeloid leukemia (ML) by FISH of peripheral blood smear using probe of PU. 1, a candidate ML tumor suppressor. Molecular Cytogenetics 1(1): 22.
26. Kligerman, A.D., Halperin, E.C., Erexson, G.L., and Honore, G. 1990. The persistence of lymphocytes with dicentric chromosomes following whole-body X irradiation of mice. Radiation Research 124(1): 22-27.
27. Ko, M., Lao, X.Y., Kapadia, R., Elmore, E., and Redpath, J.L. 2006. Neoplastic transformation in vitro by low doses of ionizing radiation: Role of adaptive response and bystander effects. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 597(1-2): 11-17.
28. Little, J.B. 2003. Genomic instability and radiation. J Radiol Prot 23(2): 173-181.
29. MacDonald, D., Boulton, E., Pocock, D., Goodhead, D., Kadhim, M., and Plumb, M. 2001. Evidence of genetic instability in 3 Gy X-ray-induced mouse leukaemias and 3 Gy X-irradiated haemopoietic stem cells. International Journal of Radiation Biology 77(10): 1023-1031.
30. Marder, B.A. and Morgan, W.F. 1993. Delayed chromosomal instability induced by DNA damage. Molecular & Cellular Biology 13(11): 6667-6677.
31. Mitchel, R.E., Jackson, J.S., Morrison, D.P., and Carlisle, S.M. 2003. Low doses of radiation increase the latency of spontaneous lymphomas and spinal osteosarcomas in cancer-prone, radiation-sensitive Trp53 heterozygous mice. Radiat Res 159(3): 320-327.
32. Moorhead, P.S. and Nowell, P.C. 1964. Chromosome cytology. Methods Med Res 10(310-322).
33. Morgan, W.F. 2003. Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation? Oncogene 22(45): 7094-7099.
34. Morgan, W.F., Day, J.P., Kaplan, M.I., McGhee, E.M., and Limoli, C.L. 1996. Genomic instability induced by ionizing radiation. Radiation Research 146(3): 247-258.
35. Mothersill, C. and Seymour, C.B. 1998. Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: evidence for release during irradiation of a signal controlling survival into the medium.[see comment]. Radiation Research 149(3): 256-262.
36. Okayasu, R., Suetomi, K., Yu, Y., Silver, A., Bedford, J.S., Cox, R., and Ullrich, R.L. 2000. A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse. Cancer Research 60(16): 4342-4345.
37. Peng, Y., Brown, N., Finnon, R., Warner, C.L., Liu, X., Genik, P.C., Callan, M.A., Ray, F.A., Borak, T.B., Badie, C., Bouffler, S.D., Ullrich, R.L., Bedford, J.S., and Weil, M.M. 2009. Radiation Leukemogenesis in Mice: Loss of PU.1 on Chromosome 2 in CBA and C57BL/6 Mice after Irradiation with 1 GeV/nucleon 56Fe Ions, X Rays or _ Rays. Part I. Experimental Observations. Radiation Research 171(4): 474-483.
38. Portess, D.I., Bauer, G., Hill, M.A., and O'Neill, P. 2007. Low-dose irradiation of nontransformed cells stimulates the selective removal of precancerous cells via intercellular induction of apoptosis. Cancer Res 67(3): 1246-1253.
39. Rithidech, K., Bond, V.P., Cronkite, E.P., Thompson, M.H., and Bullis, J.E. 1995. Hypermutability of mouse chromosome 2 during the development of x-ray-induced murine myeloid leukemia. Proc Natl Acad Sci U S A 92(4): 1152-1156.
40. Rithidech, K., Tungjai, M., Arbab, E., and Simon, S.R. 2005. Activation of NF-kappa B in bone marrow cells of BALB/cJ mice following exposure in vivo to low doses of 137Cs gamma rays. Radiat Env Biophys 44(2): 139-143.
41. Rithidech, K.N., Bond, V.P., Cronkite, E.P., and Thompson, M.H. 1993. A specific chromosomal deletion in murine leukemic cells induced by radiation with different qualities. Exp Hematol 21(3): 427-431.
42. Rithidech, K.N., Cronkite, E.P., and Bond, V.P. 1999. Advantages of the CBA mouse in leukemogenesis research. Blood Cells Molecules and Diseases 25(1): 38-45.
43. Rithidech, K.N., Honikel, L., and Whorton, E.B. 2007. mFISH analysis of chromosomal damage in bone marrow cells collected from CBA/CaJ mice following whole body exposure to heavy ions (56Fe ions). Radiat Environ Biophys 46(2): 137-145.
44. Rithidech, K.N. and Scott, B.R. 2008. Evidence for radiation hormesis after in vitro exposure of human lymphocytes to low doses of ionizing radiation Dose-Response In Press.
45. Rithidech, K.N., Supanpaiboon, W., Honikel, L., and Whorton, E.B. 2009. Induction of genomic instability after an acute whole-body exposure of mice to 56Fe ions. Advances in Space Research 44(8): 895-906.
46. Rowley, J.D. and Potter, D. 1976. Chromosomal banding patterns in acute nonlymphocytic leukemia. Blood 47(5): 705-721.
47. Scott, B.R. and Di Palma, J. 2006. Sparsely ionizing diagnostic and natural background radiation are likely preventing cancer and other genomic-instability associated diseases. Dose Response 5: 230-255.
48. Spruill, M.D., Nelson, D.O., Ramsey, M.J., Nath, J., and Tucker, J.D. 2000. Lifetime Persistence and Clonality of Chromosome Aberrations in the Peripheral Blood of Mice Acutely Exposed to Ionizing Radiation. Radiat Res 153(1): 110-121.
49. Spruill, M.D., Ramsey, M.J., Swiger, R.R., Nath, J., and Tucker, J.D. 1996. The persistence of aberrations in mice induced by gamma radiation as measured by chromosome painting. Mutat Res 356(2): 135-145.
50. Tucker, J.D., Breneman, J.W., Briner, J.F., Eveleth, G.G., Langlois, R.G., and Moore, D.H. 1997. Persistence of radiation-induced translocations in rat peripheral blood determined by chromosome painting. Environl and Mol Mutagen 30(3): 264-272.
51. Wang, G.-J. and Cai, L. 2000. Induction of Cell-Proliferation Hormesis and Cell-Survival Adaptive Response in Mouse Hematopoietic Cells by Whole-Body Low-Dose Radiation. Toxicol Sci 53(2): 369-376.
52. Watson, G.E., Lorimore, S.A., and Wright, E.G. 1996. Long-term in vivo transmission of alpha-particle-induced chromosomal instability in murine haemopoietic cells. International Journal of Radiation Biology 69(2): 175-182.
53. Whorton, E.B., Jr. 1985. Some experimental design and analysis considerations for cytogenetics studies. Environmental Mutagenesis 7 Suppl 4: 9-15.
54. Xiao, Y., Darroudi, F., Grigorova, M., and A.T., N. 1999. Induction and persistence of chromosomal exchanges in mouse bone marrow cells following whole-body exposure to X rays. Int J Radiat Biol 75(9): 1119-1128.
55. Yu, Y., Okayasu, R., Weil, M.M., Silver, A., McCarthy, M., Zabriskie, R., Long, S., Cox, R., and Ullrich, R.L. 2001. Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) gene. Cancer Research 61(5): 1820-1824.
56. Zeng, G., Day, T.K., Hooker, A.M., Blyth, B.J., Bhat, M., Tilley, W.D., and Sykes, P.J. 2006. Non-linear chromosomal inversion response in prostate after low dose X-radiation exposure. Mutat Res 602(1-2): 65-73.