mFISH analysis of chromosomal damage in bone marrow cells collected from CBA/CaJ mice following whole body exposure to heavy ions ( 56Fe ions)

Radiation and Environmental Biophysics

Volumn 46, Issue 2, 2007, Pages 137-145

  Rithidech, K Noy ^a   Honikel, L ^a   Whorton, E B ^b  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MARROW CELLS; CHROMOSOMAL DAMAGE; RADIATION EXPOSURE; WHOLE BODY EXPOSURE;

CHROMOSOMES; DISEASES; FLUORESCENCE; HEAVY IONS; RISK ASSESSMENT; TISSUE;

RADIATION DAMAGE;

CESIUM 137; HEAVY ION; IRON;

ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL EXPERIMENT; BONE MARROW CELL; CHROMATID; CHROMOSOME; CHROMOSOME ABERRATION; CHROMOSOME DAMAGE; CONFERENCE PAPER; CONTROLLED STUDY; DICENTRIC CHROMOSOME; DOSE RESPONSE; FLUORESCENCE IN SITU HYBRIDIZATION; GAMMA RADIATION; HEALTH HAZARD; HEMATOPOIETIC CELL; IN VIVO STUDY; LEUKEMIA; MOUSE; NONHUMAN; RADIATION DOSE; RADIATION EXPOSURE; RISK ASSESSMENT; ROBERTSONIAN CHROMOSOME TRANSLOCATION;

ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CHROMOSOMES; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENVIRONMENTAL EXPOSURE; HEAVY IONS; IN SITU HYBRIDIZATION, FLUORESCENCE; IRON RADIOISOTOPES; MALE; MICE; MICE, INBRED CBA; RADIATION DOSAGE; WHOLE-BODY IRRADIATION;

MUS; ROBERTSONIA;

EID: 34248143356     PISSN: 0301634X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00411-006-0092-x     Document Type: Conference Paper

References (30)

1. Cucinotta FA, Schimmerling W, Wilson JW, Peterson LE, Badhwar GD, Saganti PB, Dicello JF (2001) Space radiation cancer risks and uncertainties for Mars missions. Radiat Res 156:682-688
2. Moore FD (1992) Radiation burdens for humans on prolonged exomagnetospheric voyages. FASEB J 6:2338-2343
3. Sutherland BM, Bennett PV, Schenk H, Sidorkina O, Laval J, Trunk J, Monteleone D, Sutherland J (2001) Clustered DNA damages induced by high and low LET radiation, including heavy ions. Phys Med 17(Suppl 1):202-204
4. Evans HH, Horng MF, Evans TE, Jordan R, Schwartz JL (2001) Genotoxic effects of high-energy iron particles in human lymphoblasts differing in radiation sensitivity. Radiat Res 156:186-194
5. Kawata T, Ito H, Motoori K, Ueda T, Shigematsu N, Furusawa Y, Durante M, George K, Wu H, Cucinotta FA (2002) Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions. J Radiat Res 43(Suppl):S169-173
6. Testard I, Ricoul M, Hoffschir F, Flury-Herard A, Dutrillaux B, Fedorenko B, Gerasimenko V, Sabatier L (1996) Radiation-induced chromosome damage in astronauts' lymphocytes. Int J Radiat Biol 70:403-411
7. Durante M, Ando K, Furusawa Y, Obe G, George K, Cucinotta FA (2004) Complex chromosomal rearrangements induced in vivo by heavy ions. Cytogenet Genome Res 104:240-244
8. George K, Durante M, Wu H, Willingham V, Badhwar G, Cucinotta FA (2001) Chromosome aberrations in the blood lymphocytes of astronauts after space flight. Radiat Res 156:731-738
9. Horstmann M, Durante M, Johannes C, Pieper R, Obe G (2005) Space radiation does not induce a significant increase of intrachromosomal exchanges in astronauts' lymphocytes. Radiat Environ Biophys 44:219-224
10. Pierce DA, Shimizu Y, Preston DL, Vaeth M, Mabuchi K (1996) Studies of the mortality of atomic bomb survivors. Report 12, Part I. Cancer 1950-1990 Radiat Res 146:1-27
11. Chang PY, Torous D, Lutze-Mann L, Winegar R (2000) Impact of p53 status on heavy-ion radiation-induced micronuclei in circulating erythrocytes. Mutat Res 466:87-96
12. 56Fe + 26 ions. Radiat Res 161:648-655
13. Brooks AL, Bao S, Rithidech K, Chrisler WB, Couch LA, Braby LA (2001) Induction and repair of HZE induced cytogenetic damage. Phys Med 17(Suppl 1):183-184
14. Wu H, Durante M, George K, Yang TC (1997) Induction of chromosome aberrations in human cells by charged particles. Radiat Res 148:S102-S107
15. Ritter S, Nasonova E, Furusawa Y, Ando K (2002) Relationship between aberration yield and mitotic delay in human lymphocytes exposed to 200 MeV/u Fe-ions or X-rays. J Radiat Res 43(Suppl):S175-S179
16. Loucas BD, Cornforth MN (2001) Complex chromosome exchanges induced by gamma rays in human lymphocytes: an mFISH study. Radiat Res 155:660-671
17. Tsoupas N, Bellavia S, Bonati R, Brown K, Chaing IH, Gardner CJ, Jao S, Marneris I, Marneris A, Phillips D, Pile P, Prigl P, Rusek A, Snydsrup L (2004) Results from the commissioning of the NSRL beam transfer line at BNL. Proceedings of EPAC: Lucerne, Switzerland
18. Rithidech KN, Tungjai M, Arbab E, Simon SR (2005) Activation of NF-κB in bone marrow cells of BALB/cJ mice following exposure in vivo to low doses of (137) Cs gamma-rays. Radiat Environ Biophys 44:139-143
19. 56Fe ions by means of mFISH and micronucleus methods. Fourth international workshop on space radiation research and 17th annual NASA space radiation health investigators' workshop
20. Rithidech K, Bond VP, Cronkite EP, Thompson MH, Bullis JE (1995) Hypermutability of mouse chromosome 2 during the development of X-ray-induced murine myeloid leukemia. Proc Natl Acad Sci USA 92:1152-1156
21. Rithidech KN, Bond VP, Cronkite EP, Thompson MH (1993) A specific chromosomal deletion in murine leukemic cells induced by radiation with different qualities. Exp Hematol 21:427-431
22. Rowley JD, Potter D (1976) Chromosomal banding patterns in acute nonlymphocytic leukemia. Blood 47:705-721
23. Durante M, George K, Wu H, Cucinotta FA (2002) Karyotypes of human lymphocytes exposed to high-energy iron ions. Radiat Res 158:581-590
24. Crocker M, Cattanach BM (1981) X-ray induction of translocations in mice carrying metacentrics (Robertsonian fusions); detection of whole arm chromosome exchanges. Mutat Res 91:353-357
25. Durante M, Gialanella G, Grossi GF, Nappo M, Pugliese M (1994) The induction of Robertsonian translocations by X-rays and mitomycin C in mouse cells. Mutat Res 323:189-196
26. Anderson RM, Marsden SJ, Wright EG, Kadhim MA, Goodhead DT, Griffin CS (2000) Complex chromosome aberrations in peripheral blood lymphocytes as a potential biomarker of exposure to high-LET alpha-particles. Int J Radiat Biol 76:31-42
27. Hande MP, Azizova TV, Burak LE, Khokhryakov VF, Geard CR, Brenner DJ (2005) Complex chromosome aberrations persist in individuals many years after occupational exposure to densely ionizing radiation: an mFISH study. Genes Chromosomes Cancer 44:1-9
28. Darroudi F, Fomina J, Meijers M, Natarajan AT (1998) Kinetics of the formation of chromosome aberrations in X-irradiated human lymphocytes, using PCC and FISH. Mutat Res 404:55-65
29. Bouffler SD, Meijne EI, Morris DJ, Papworth D (1997) Chromosome 2 hypersensitivity and clonal development in murine radiation acute myeloid leukaemia. Int J Radiat Biol 72:181-189
30. Rithidech KN, Cronkite EP, Bond VP (1999) Advantages of the CBA mouse in leukemogenesis research. Blood Cells Mol Dis 25:38-45