Lurcher Mice Exhibit Potentiation of GABAA-Receptor-Mediated Conductance in Cerebellar Nuclei Neurons in Close Temporal Relationship to Purkinje Cell Death

Journal of Neurophysiology

Volumn 91, Issue 2, 2004, Pages 1102-1107

  Linnemann, C ^a   Sultan, F ^a   Pedroarena, C M ^a   Schwarz, C ^a   Thier, P ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CEREBELLUM NUCLEUS; CONTROLLED STUDY; GABAERGIC TRANSMISSION; INHIBITORY POSTSYNAPTIC POTENTIAL; MOUSE; MOUSE STRAIN; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEWBORN; NONHUMAN; PATCH CLAMP; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PURKINJE CELL;

EID: 0842284608     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00163.2003     Document Type: Article

References (20)

1. Aizenman CD, Manis PB, and Linden DJ. Polarity of long-term synaptic gain change is related to postsynaptic spike firing at a cerebellar inhibitory synapse. Neuron 21: 827-835, 1998.
2. Caddy KW and Biscoe TJ. Structural and quantitative studies on the normal C3H and Lurcher mutant mouse. Philos Trans R Soc Lond B 287: 167-201, 1979.
3. Caston J, Vasseur F, Stelz T, Chianale C, Delhaye-Bouchaud N, and Mariani J. Differential roles of cerebellar cortex and deep cerebellar nuclei in the leaming of the equilibrium behavior: studies in intact and cerebellectomized lurcher mutant mice. Brain Res Dev Brain Res 86: 311-316, 1995.
4. Dumesnil-Bousez N and Sotelo C. Early development of the Lurcher cerebellum: Purkinje cell alterations and impairment of synaptogenesis. J Neurocytol 21: 506-529, 1992.
5. A receptor-mediated miniature postsynaptic currents and α-subunit expression in developing cortical neurons. J Neurophysiol 82: 3286-3297, 1999.
6. Heckroth JA. Quantitative morphological analysis of the cerebellar nuclei in normal and lurcher mutant mice. I. Morphology and cell number. J Comp Neurol 343: 173-182, 1994.
7. Hollrigel GS and Soltesz I. Slow kinetics of miniature IPSCs during early postnatal development in granule cells of the dentate gyrus. J Neurosci 17: 5119-5128, 1997.
8. A receptors clustered at neocortical synapses. J Neurosci 22: 1328-1337, 2002.
9. Lalonde R, Filali M, Bensoula AN, and Lestienne F. Sensorimotor learning in three cerebellar mutant mice. Neurobiol Learn Mem 65: 113-120, 1996.
10. Mittmann T and Eysel UT. Increased synaptic plasticity in the surround of visual cortex lesions in rats. Neuroreport 12: 3341-3347, 2001.
11. A receptors underlies potentiation at hippocampal inhibitory synapses. Nature 395: 172-177, 1998.
12. Otis TS, De Koninck Y, and Mody I. Lasting potentiation of inhibition is associated with an increased number of gamma-aminobutyric acid type A receptors activated during miniature inhibitory postsynaptic currents. Proc Natl Acad Sci USA 91: 7698-7702, 1994.
13. Ouardouz M and Sastry BR. Mechanisms underlying LTP of inhibitory synaptic transmission in the deep cerebellar nuclei. J Neurophysiol 84: 1414-1421, 2000.
14. Phillips RJS. "Lurcher," new gene in the linkage group XI of the house mouse. J Genet 57: 35-42, 1960.
15. Sultan F, König T, Möck M, and Thier P. Quantitative organization of neurotransmitters in the deep cerebellar nuclei of the Lurcher mutant. J Comp Neurol 452: 311-323, 2002.
16. Traynelis SF, Silver RA, and Cull-Candy SG. Estimated conductance of glutamate receptor channels activated during EPSCs at the cerebellar mossy fiber-granule cell synapse. Neuron 11: 279-289, 1993.
17. A receptor α1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons. J Neurosci 21: 3009-3016, 2001.
18. Wetts R and Herrup K. Interaction of granule, Purkinje and inferior olivary neurons in Lurcher chimaeric mice. I. Qualitative studies. J Embryol Exp Morphol 68: 87-98, 1982.
19. Wilson RC, Levy WB, and Steward O. Functional effects of lesion-induced plasticity: long term potentiation in formal and lesion-induced temporodentate connections. Brain Res 176: 65-78, 1979.
20. Zuo J, De Jager PL, Takahashi KA, Jiang W, Linden DJ, and Heintz N. Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene. Nature 388: 769-773, 1997.