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Volumn 42, Issue 4, 2012, Pages 340-348

Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma and future treatments for the poor responders

Author keywords

Advanced hepatocellular carcinoma; Branched chain amino acid; Deferoxamine; Hepatic arterial infusion chemotherapy; Iron chelator; Nutritional therapy

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; ALPHA TOCOPHEROL; CISPLATIN; DEFEROXAMINE; FLUOROURACIL; FOLINATE CALCIUM; FOLINIC ACID; PEGINTERFERON ALPHA; RETINOL; SORAFENIB;

EID: 84858840146     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2011.00938.x     Document Type: Review
Times cited : (27)

References (65)
  • 2
    • 0034856294 scopus 로고    scopus 로고
    • Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference
    • EASL Panel of Experts on HCC.
    • Bruix J, Sherman M, Llovet JM etal. EASL Panel of Experts on HCC. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. J Hepatol 2001; 35: 421-30.
    • (2001) J Hepatol , vol.35 , pp. 421-430
    • Bruix, J.1    Sherman, M.2    Llovet, J.M.3
  • 3
    • 28844480321 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology 2005; 42: 1208-36.
    • (2005) Hepatology , vol.42 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 4
    • 1842426695 scopus 로고    scopus 로고
    • Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance
    • Sangiovanni A, Del Ninno E, Fasani P etal. Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology 2004; 126: 1005-14.
    • (2004) Gastroenterology , vol.126 , pp. 1005-1014
    • Sangiovanni, A.1    Del Ninno, E.2    Fasani, P.3
  • 5
    • 43949127653 scopus 로고    scopus 로고
    • Liver cancer in Korea
    • Han KH, Kim JK. Liver cancer in Korea. Hepatol Res 2007; 37 (Suppl 2): S106-9.
    • (2007) Hepatol Res , vol.37 , Issue.2 SUPPL.
    • Han, K.H.1    Kim, J.K.2
  • 6
    • 28844435344 scopus 로고    scopus 로고
    • Treatment and outcomes of treating of hepatocellular carcinoma among Medicare recipients in the United States: a population-based study
    • El-Serag HB, Siegel AB, Davila JA etal. Treatment and outcomes of treating of hepatocellular carcinoma among Medicare recipients in the United States: a population-based study. J Hepatol 2006; 44: 458-66.
    • (2006) J Hepatol , vol.44 , pp. 458-466
    • El-Serag, H.B.1    Siegel, A.B.2    Davila, J.A.3
  • 7
    • 77958583600 scopus 로고    scopus 로고
    • th follow-up survey of primary liver cancer in Japan
    • th follow-up survey of primary liver cancer in Japan. Hepatol Res 2010; 40: 1043-59.
    • (2010) Hepatol Res , vol.40 , pp. 1043-1059
    • Ikai, I.1    Kudo, M.2    Arii, S.3
  • 8
    • 0032879468 scopus 로고    scopus 로고
    • Prognosis of hepatocellular carcinoma: the BCLC staging classification
    • Llovet JM, Brú C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 1999; 19: 329-38.
    • (1999) Semin Liver Dis , vol.19 , pp. 329-338
    • Llovet, J.M.1    Brú, C.2    Bruix, J.3
  • 9
    • 44449085884 scopus 로고    scopus 로고
    • Design and endpoints of clinical trials in hepatocellular carcinoma
    • Panel of Experts in HCC-Design Clinical Trials.
    • Llovet JM, Di Bisceglie AM, Bruix J etal. Panel of Experts in HCC-Design Clinical Trials. Design and endpoints of clinical trials in hepatocellular carcinoma. J Natl Cancer Inst 2008; 1000: 698-711.
    • (2008) J Natl Cancer Inst , vol.1000 , pp. 698-711
    • Llovet, J.M.1    Di Bisceglie, A.M.2    Bruix, J.3
  • 10
    • 77954504346 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma: report of Consensus Meeting in the 45th Annual Meeting of the Japan Society of Hepatology (2009)
    • Arii S, Sata M, Sakamoto M etal. Management of hepatocellular carcinoma: report of Consensus Meeting in the 45th Annual Meeting of the Japan Society of Hepatology (2009). Hepatol Res 2010; 40: 667-85.
    • (2010) Hepatol Res , vol.40 , pp. 667-685
    • Arii, S.1    Sata, M.2    Sakamoto, M.3
  • 11
    • 26944439521 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-alpha and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression
    • Ota H, Nagano H, Sakon M etal. Treatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-alpha and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression. Br J Cancer 2005; 93: 557-64.
    • (2005) Br J Cancer , vol.93 , pp. 557-564
    • Ota, H.1    Nagano, H.2    Sakon, M.3
  • 12
    • 33646383886 scopus 로고    scopus 로고
    • Combination therapy of intraarterial 5-fluorouracil and systemic interferon-alpha for advanced hepatocellular carcinoma with portal venous invasion
    • Obi S, Yoshida H, Toune R etal. Combination therapy of intraarterial 5-fluorouracil and systemic interferon-alpha for advanced hepatocellular carcinoma with portal venous invasion. Cancer 2006; 106: 1990-7.
    • (2006) Cancer , vol.106 , pp. 1990-1997
    • Obi, S.1    Yoshida, H.2    Toune, R.3
  • 13
    • 0030942752 scopus 로고    scopus 로고
    • A novel chemotherapy for advanced hepatocellular carcinoma with tumor thrombosis of the main trunk of the portal vein
    • Ando E, Yamashita F, Tanaka M, Tanikawa K. A novel chemotherapy for advanced hepatocellular carcinoma with tumor thrombosis of the main trunk of the portal vein. Cancer 1997; 79: 1890-6.
    • (1997) Cancer , vol.79 , pp. 1890-1896
    • Ando, E.1    Yamashita, F.2    Tanaka, M.3    Tanikawa, K.4
  • 14
    • 0036682065 scopus 로고    scopus 로고
    • Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: analysis of 48 cases
    • Ando E, Tanaka M, Yamashita F etal. Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: analysis of 48 cases. Cancer 2002; 95: 588-95.
    • (2002) Cancer , vol.95 , pp. 588-595
    • Ando, E.1    Tanaka, M.2    Yamashita, F.3
  • 15
    • 77954517851 scopus 로고    scopus 로고
    • Treatment of advanced hepatocellular carcinoma: intraarterial infusion chemotherapy combined with interferon
    • Nagano H. Treatment of advanced hepatocellular carcinoma: intraarterial infusion chemotherapy combined with interferon. Oncology 2010; 78 (Suppl 1): 142-7.
    • (2010) Oncology , vol.78 , Issue.1 SUPPL. , pp. 142-147
    • Nagano, H.1
  • 16
    • 79958061940 scopus 로고    scopus 로고
    • Long-term outcome of combined interferon-α and 5-fluorouracil treatment for advanced hepatocellular carcinoma with major portal vein thrombosis
    • Nagano H, Wada H, Kobayashi S etal. Long-term outcome of combined interferon-α and 5-fluorouracil treatment for advanced hepatocellular carcinoma with major portal vein thrombosis. Oncology 2011; 80: 63-9.
    • (2011) Oncology , vol.80 , pp. 63-69
    • Nagano, H.1    Wada, H.2    Kobayashi, S.3
  • 17
    • 20444431241 scopus 로고    scopus 로고
    • Prognostic factors in patients with advanced hepatocellular carcinoma receiving hepatic arterial infusion chemotherapy
    • Yamasaki T, Kimura T, Kurokawa F etal. Prognostic factors in patients with advanced hepatocellular carcinoma receiving hepatic arterial infusion chemotherapy. J Gastroenterol 2005; 40: 70-8.
    • (2005) J Gastroenterol , vol.40 , pp. 70-78
    • Yamasaki, T.1    Kimura, T.2    Kurokawa, F.3
  • 18
    • 69249222983 scopus 로고    scopus 로고
    • Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma: is the addition of subcutaneous interferon-alpha-2b beneficial?
    • Takaki-Hamabe S, Yamasaki T, Saeki I etal. Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma: is the addition of subcutaneous interferon-alpha-2b beneficial? Hepatol Res 2009; 39: 223-30.
    • (2009) Hepatol Res , vol.39 , pp. 223-230
    • Takaki-Hamabe, S.1    Yamasaki, T.2    Saeki, I.3
  • 19
    • 77954724878 scopus 로고    scopus 로고
    • Intra-arterial therapy with cisplatin suspension in lipiodol and 5-fluorouracila for hepatocellular carcinoma with portal vein tumor thrombosis
    • Nagamatsu H, Hiraki M, Mizukami N etal. Intra-arterial therapy with cisplatin suspension in lipiodol and 5-fluorouracila for hepatocellular carcinoma with portal vein tumor thrombosis. Aliment Pharmacol Ther 2010; 32: 543-50.
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 543-550
    • Nagamatsu, H.1    Hiraki, M.2    Mizukami, N.3
  • 20
    • 79954450480 scopus 로고    scopus 로고
    • Long-term clinical outcomes of hepatic arterial infusion chemotherapy with cisplatin with or without 5-fluorouracil in locally advanced hepatocellular carcinoma
    • Kim BK, Park JY, Choi HJ etal. Long-term clinical outcomes of hepatic arterial infusion chemotherapy with cisplatin with or without 5-fluorouracil in locally advanced hepatocellular carcinoma. J Cancer Res Clin Oncol 2011; 137: 659-67.
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 659-667
    • Kim, B.K.1    Park, J.Y.2    Choi, H.J.3
  • 21
    • 84858834188 scopus 로고    scopus 로고
    • Hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma: analysis of 114 cases
    • in Japanese).
    • Urayama N, Yamasaki T, Harima Y etal. Hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma: analysis of 114 cases. Kanzo (in Japanese) 2011; 52: 499-60.
    • (2011) Kanzo , vol.52 , pp. 499-460
    • Urayama, N.1    Yamasaki, T.2    Harima, Y.3
  • 22
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V etal. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359: 378-90.
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 23
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomized, double-blind, placebo-controlled trial
    • Cheng AL, Kang YK, Chen Z etal. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomized, double-blind, placebo-controlled trial. Lancet Oncol 2009; 10: 25-34.
    • (2009) Lancet Oncol , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3
  • 24
    • 0027941120 scopus 로고
    • Italian Multicentre Cooperative Project on Nutrition in Liver Cirrhosis. Nutritional status in cirrhosis
    • Italian Multicentre Cooperative Project on Nutrition in Liver Cirrhosis. Nutritional status in cirrhosis. J Hepatol 1994; 21: 317-25.
    • (1994) J Hepatol , vol.21 , pp. 317-325
  • 26
    • 0036194734 scopus 로고    scopus 로고
    • Prognostic value of energy metabolism in patients with viral liver cirrhosis
    • Tajika M, Kato M, Mohri H etal. Prognostic value of energy metabolism in patients with viral liver cirrhosis. Nutrition 2002; 18: 229-34.
    • (2002) Nutrition , vol.18 , pp. 229-234
    • Tajika, M.1    Kato, M.2    Mohri, H.3
  • 27
    • 0141828594 scopus 로고    scopus 로고
    • Effect of late evening snack on the blood glucose level and energy metabolism in patients with liver cirrhosis
    • Okamoto M, Sakaida I, Tsuchiya M, Suzuki C, Okita K. Effect of late evening snack on the blood glucose level and energy metabolism in patients with liver cirrhosis. Hepatol Res 2003; 27: 45-50.
    • (2003) Hepatol Res , vol.27 , pp. 45-50
    • Okamoto, M.1    Sakaida, I.2    Tsuchiya, M.3    Suzuki, C.4    Okita, K.5
  • 28
    • 11144349731 scopus 로고    scopus 로고
    • Late evening snack and the change of blood glucose level in patients with liver cirrhosis
    • Sakaida I, Tsuchiya M, Okamoto M, Okita K. Late evening snack and the change of blood glucose level in patients with liver cirrhosis. Hepatol Res 2004; 30S: 67-72.
    • (2004) Hepatol Res , vol.30 S , pp. 67-72
    • Sakaida, I.1    Tsuchiya, M.2    Okamoto, M.3    Okita, K.4
  • 29
    • 15044347824 scopus 로고    scopus 로고
    • The effect of a late evening snack in patients with liver cirrhosis
    • Tsuchiya M, Sakaida I, Okamoto M, Okita K. The effect of a late evening snack in patients with liver cirrhosis. Hepatol Res 2005; 31: 95-103.
    • (2005) Hepatol Res , vol.31 , pp. 95-103
    • Tsuchiya, M.1    Sakaida, I.2    Okamoto, M.3    Okita, K.4
  • 30
    • 4344660031 scopus 로고    scopus 로고
    • Guidelines for the use of parenteral and eternal nutrition in adult and pediatric patients
    • ASPEN Board of Directors and the Clinical Guidelines Task Force.
    • ASPEN Board of Directors and the Clinical Guidelines Task Force. Guidelines for the use of parenteral and eternal nutrition in adult and pediatric patients. JPEN 2002; 26: 65SA-8SA.
    • (2002) JPEN , vol.26
  • 32
    • 33846206486 scopus 로고    scopus 로고
    • BCAA-enriched snack improves nutritional state of cirrhosis
    • Nakaya Y, Okita K, Suzuki K etal. BCAA-enriched snack improves nutritional state of cirrhosis. Nutrition 2007; 23: 113-20.
    • (2007) Nutrition , vol.23 , pp. 113-120
    • Nakaya, Y.1    Okita, K.2    Suzuki, K.3
  • 33
    • 35649026745 scopus 로고    scopus 로고
    • Restoration of innate host defense responses by oral supplementation of branched-chain amino acids in decompensated cirrhotic patients
    • Nakamura I, Ochiai K, Imai Y, Moriyasu F, Imawari M. Restoration of innate host defense responses by oral supplementation of branched-chain amino acids in decompensated cirrhotic patients. Hepatol Res 2007; 37: 1062-7.
    • (2007) Hepatol Res , vol.37 , pp. 1062-1067
    • Nakamura, I.1    Ochiai, K.2    Imai, Y.3    Moriyasu, F.4    Imawari, M.5
  • 34
    • 0031869957 scopus 로고    scopus 로고
    • Direct effect of branched-chain amino acids on the growth and metabolism of cultured human hepatocellular cells
    • Sugiyama K, Yu L, Nagasue N. Direct effect of branched-chain amino acids on the growth and metabolism of cultured human hepatocellular cells. Nutr Cancer 1998; 31: 62-8.
    • (1998) Nutr Cancer , vol.31 , pp. 62-68
    • Sugiyama, K.1    Yu, L.2    Nagasue, N.3
  • 35
    • 0034826659 scopus 로고    scopus 로고
    • Effect of the molar ratio of branched-chain to aromatic amino acids on growth and albumin mRNA expression of human liver cancer cell lines in a serum-free medium
    • Saito Y, Saito H, Nakamura M etal. Effect of the molar ratio of branched-chain to aromatic amino acids on growth and albumin mRNA expression of human liver cancer cell lines in a serum-free medium. Nutr Cancer 2001; 39: 126-31.
    • (2001) Nutr Cancer , vol.39 , pp. 126-131
    • Saito, Y.1    Saito, H.2    Nakamura, M.3
  • 36
    • 80052025887 scopus 로고    scopus 로고
    • Branched-chain amino acids as pharmacological nutrients in chronic liver disease
    • doi: 10.1002/hep.24412
    • Kawaguchi T, Izumi N, Charlton MR, Sata M. Branched-chain amino acids as pharmacological nutrients in chronic liver disease. Hepatology 2011; 54: 1063-70. doi: 10.1002/hep.24412.
    • (2011) Hepatology , vol.54 , pp. 1063-1070
    • Kawaguchi, T.1    Izumi, N.2    Charlton, M.R.3    Sata, M.4
  • 37
    • 1942534222 scopus 로고    scopus 로고
    • Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: a randomized trial
    • Poon RT, Yu W, Fan S, Wong J. Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: a randomized trial. Aliment Pharmacol Ther 2004; 19: 779-88.
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 779-788
    • Poon, R.T.1    Yu, W.2    Fan, S.3    Wong, J.4
  • 38
    • 61749097334 scopus 로고    scopus 로고
    • A snack enriched with oral branched-chain amino acids prevents a fall in albumin in patients with liver cirrhosis undergoing chemoembolization for hepatocellular carcinoma
    • Takeshita S, Ichikawa T, Nakao K etal. A snack enriched with oral branched-chain amino acids prevents a fall in albumin in patients with liver cirrhosis undergoing chemoembolization for hepatocellular carcinoma. Nutr Res 2009; 29: 89-93.
    • (2009) Nutr Res , vol.29 , pp. 89-93
    • Takeshita, S.1    Ichikawa, T.2    Nakao, K.3
  • 39
    • 77956024629 scopus 로고    scopus 로고
    • Effects of branched-chain amino acid-enriched nutrient for patients with hepatocellular carcinoma following radiofrequency ablation: a one-year prospective trial
    • Kuroda H, Ushio A, Miyamoto Y etal. Effects of branched-chain amino acid-enriched nutrient for patients with hepatocellular carcinoma following radiofrequency ablation: a one-year prospective trial. J Gastroenterol Hepatol 2010; 25: 1550-5.
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. 1550-1555
    • Kuroda, H.1    Ushio, A.2    Miyamoto, Y.3
  • 40
    • 77954369915 scopus 로고    scopus 로고
    • Effect of a late evening snack using branched-chain amino acid-enriched nutrients in patients undergoing hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma
    • Harima Y, Yamasaki T, Hamabe S etal. Effect of a late evening snack using branched-chain amino acid-enriched nutrients in patients undergoing hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma. Hepatol Res 2010; 40: 574-84.
    • (2010) Hepatol Res , vol.40 , pp. 574-584
    • Harima, Y.1    Yamasaki, T.2    Hamabe, S.3
  • 41
    • 69449101913 scopus 로고    scopus 로고
    • Influence of non-enzymatic post-translation modifications on the ability of human serum albumin to bind iron. Implications for non-transferrin-bound iron speciation
    • Silva AM, Hider RC. Influence of non-enzymatic post-translation modifications on the ability of human serum albumin to bind iron. Implications for non-transferrin-bound iron speciation. Biochim Biophys Acta 2009; 1794: 1449-58.
    • (2009) Biochim Biophys Acta , vol.1794 , pp. 1449-1458
    • Silva, A.M.1    Hider, R.C.2
  • 42
    • 4143051431 scopus 로고    scopus 로고
    • Transferrin receptor 1
    • Aisen P. Transferrin receptor 1. Int J Biochem Cell Biol 2004; 36: 2137-43.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 2137-2143
    • Aisen, P.1
  • 43
    • 0033597780 scopus 로고    scopus 로고
    • Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family
    • Kawabata H, Yang R, Hirama T etal. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem 1999; 274: 20826-32.
    • (1999) J Biol Chem , vol.274 , pp. 20826-20832
    • Kawabata, H.1    Yang, R.2    Hirama, T.3
  • 44
    • 0344845282 scopus 로고    scopus 로고
    • Recycling, degradation and sensitivity to the synergistic anion of transferrin in the receptor-independent route of iron uptake by human hepatoma (HuH-7) cells
    • Ikuta K, Zak O, Aisen P. Recycling, degradation and sensitivity to the synergistic anion of transferrin in the receptor-independent route of iron uptake by human hepatoma (HuH-7) cells. Int J Biochem Cell Biol 2004; 36: 340-52.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 340-352
    • Ikuta, K.1    Zak, O.2    Aisen, P.3
  • 45
    • 33745727879 scopus 로고    scopus 로고
    • Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF
    • Shindo M, Torimoto Y, Saito H etal. Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF. Hepatol Res 2006; 35: 152-62.
    • (2006) Hepatol Res , vol.35 , pp. 152-162
    • Shindo, M.1    Torimoto, Y.2    Saito, H.3
  • 47
    • 0141461407 scopus 로고    scopus 로고
    • L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy
    • Oudit GY, Sun H, Trivieri MG etal. L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Nat Med 2003; 9: 1187-94.
    • (2003) Nat Med , vol.9 , pp. 1187-1194
    • Oudit, G.Y.1    Sun, H.2    Trivieri, M.G.3
  • 48
    • 0036182252 scopus 로고    scopus 로고
    • Denatured H-ferritin subunit is a major constituent of haemosiderin in the liver of patients with iron overload
    • Miyazaki E, Kato J, Kobune M etal. Denatured H-ferritin subunit is a major constituent of haemosiderin in the liver of patients with iron overload. Gut 2002; 50: 413-19.
    • (2002) Gut , vol.50 , pp. 413-419
    • Miyazaki, E.1    Kato, J.2    Kobune, M.3
  • 49
    • 0029946043 scopus 로고    scopus 로고
    • Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway
    • Um HD, Orenstein JM, Wahl SM. Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway. J Immunol 1996; 156: 3469-77.
    • (1996) J Immunol , vol.156 , pp. 3469-3477
    • Um, H.D.1    Orenstein, J.M.2    Wahl, S.M.3
  • 50
    • 0025238656 scopus 로고
    • Autophagic degradation of protein generates a pool of ferric iron required for the killing of cultured hepatocytes by an oxidative stress
    • Sakaida I, Kyle ME, Farber JL. Autophagic degradation of protein generates a pool of ferric iron required for the killing of cultured hepatocytes by an oxidative stress. Mol Pharmacol 1990; 37: 435-42.
    • (1990) Mol Pharmacol , vol.37 , pp. 435-442
    • Sakaida, I.1    Kyle, M.E.2    Farber, J.L.3
  • 51
    • 0025964030 scopus 로고
    • Increases in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroperoxide
    • Sakaida I, Thomas AP, Farber JL. Increases in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroperoxide. J Biol Chem 1991; 266: 717-22.
    • (1991) J Biol Chem , vol.266 , pp. 717-722
    • Sakaida, I.1    Thomas, A.P.2    Farber, J.L.3
  • 52
    • 0033025359 scopus 로고    scopus 로고
    • Iron chelator deferoxamine reduces preneoplastic lesions in liver induced by choline-deficient L-amino acid-defined diet in rats
    • Sakaida I, Hironaka K, Uchida K, Okita K. Iron chelator deferoxamine reduces preneoplastic lesions in liver induced by choline-deficient L-amino acid-defined diet in rats. Dig Dis Sci 1999; 44: 560-9.
    • (1999) Dig Dis Sci , vol.44 , pp. 560-569
    • Sakaida, I.1    Hironaka, K.2    Uchida, K.3    Okita, K.4
  • 53
    • 33847609799 scopus 로고    scopus 로고
    • Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C
    • Fujita N, Sugimoto R, Takeo M etal. Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C. Mol Med 2007; 13: 97-104.
    • (2007) Mol Med , vol.13 , pp. 97-104
    • Fujita, N.1    Sugimoto, R.2    Takeo, M.3
  • 54
    • 33750887806 scopus 로고    scopus 로고
    • Regulatory failure of serum prohepcidin levels in patients with hepatitis C
    • Nagashima M, Kudo M, Chung H etal. Regulatory failure of serum prohepcidin levels in patients with hepatitis C. Hepatol Res 2006; 36: 288-93.
    • (2006) Hepatol Res , vol.36 , pp. 288-293
    • Nagashima, M.1    Kudo, M.2    Chung, H.3
  • 55
    • 37349065804 scopus 로고    scopus 로고
    • Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription
    • Nishina S, Hino K, Korenaga M etal. Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology 2008; 134: 226-38.
    • (2008) Gastroenterology , vol.134 , pp. 226-238
    • Nishina, S.1    Hino, K.2    Korenaga, M.3
  • 56
    • 0035893552 scopus 로고    scopus 로고
    • Normalization of elevated hepatic 8-hydroxy-2'-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet
    • Kato J, Kobune M, Nakamura T etal. Normalization of elevated hepatic 8-hydroxy-2'-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet. Cancer Res 2001; 61: 8697-702.
    • (2001) Cancer Res , vol.61 , pp. 8697-8702
    • Kato, J.1    Kobune, M.2    Nakamura, T.3
  • 57
    • 35448952080 scopus 로고    scopus 로고
    • Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C
    • Kato J, Miyanishi K, Kobune M etal. Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C. J Gastroenterol 2007; 42: 830-6.
    • (2007) J Gastroenterol , vol.42 , pp. 830-836
    • Kato, J.1    Miyanishi, K.2    Kobune, M.3
  • 60
    • 34447340635 scopus 로고    scopus 로고
    • The iron chelator deferoxamine causes activated hepatic stellate cells to become quiescent and to undergo apoptosis
    • Jin H, Terai S, Sakaida I. The iron chelator deferoxamine causes activated hepatic stellate cells to become quiescent and to undergo apoptosis. J Gastroenterol 2007; 42: 475-84.
    • (2007) J Gastroenterol , vol.42 , pp. 475-484
    • Jin, H.1    Terai, S.2    Sakaida, I.3
  • 61
    • 34548286520 scopus 로고    scopus 로고
    • Tuning cell cycle regulation with an iron key
    • Yu Y, Kovacevic Z, Richardson DR. Tuning cell cycle regulation with an iron key. Cell Cycle 2007; 6: 1982-94.
    • (2007) Cell Cycle , vol.6 , pp. 1982-1994
    • Yu, Y.1    Kovacevic, Z.2    Richardson, D.R.3
  • 63
    • 80051615717 scopus 로고    scopus 로고
    • Deferoxamine for advanced hepatocellular carcinoma
    • Yamasaki T, Terai S, Sakaida I. Deferoxamine for advanced hepatocellular carcinoma. N Engl J Med 2011; 365: 576-8.
    • (2011) N Engl J Med , vol.365 , pp. 576-578
    • Yamasaki, T.1    Terai, S.2    Sakaida, I.3
  • 64
    • 78650835158 scopus 로고    scopus 로고
    • Molecular targeted therapy for advanced hepatocellular carcinoma: current status and future perspectives
    • Shen YC, Hsu C, Cheng AL. Molecular targeted therapy for advanced hepatocellular carcinoma: current status and future perspectives. J Gastroenterol 2010; 45: 794-807.
    • (2010) J Gastroenterol , vol.45 , pp. 794-807
    • Shen, Y.C.1    Hsu, C.2    Cheng, A.L.3
  • 65
    • 79955433548 scopus 로고    scopus 로고
    • Targeted therapies for hepatocellular carcinoma
    • Villanueva A, Llovet JM. Targeted therapies for hepatocellular carcinoma. Gastroenterology 2011; 140: 1410-26.
    • (2011) Gastroenterology , vol.140 , pp. 1410-1426
    • Villanueva, A.1    Llovet, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.