Recycling, degradation and sensitivity to the synergistic anion of transferrin in the receptor-independent route of iron uptake by human hepatoma (HuH-7) cells

International Journal of Biochemistry and Cell Biology

Volumn 36, Issue 2, 2004, Pages 340-352

  Ikuta, Katsuya ^a,b   Zak, Olga ^a   Aisen, Philip ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Cells; Hepatocytes; HuH 7; Iron uptake; Receptor independent route; Transferrin

Indexed keywords

ANION; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ACIDIFICATION; ARTICLE; CARCINOMA CELL; CATABOLISM; DOWN REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IRON METABOLISM; IRON TRANSPORT; LIVER CELL; LIVER CELL CARCINOMA; PROTEIN DEGRADATION;

EID: 0344845282     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(03)00258-9     Document Type: Article

References (32)

1. Aisen P., Leibman A. The role of the anion-binding site of transferrin in its interaction with the reticulocyte. Biochimica et Biophysica Acta. 304:1973;797-804.
2. Aisen, P. (1998). Transferrin, its receptor, and the uptake of iron by cells. In A. Sigel, H. Sigel, (Eds.), Metal ions in biological systems, 35, Iron transport and storage in microorganisms, plants and animals, pp. 585-631.
3. Bowman E.J., Siebers A., Altendorf K. Bafilomycins: A class of inhibitors of membrane ATPases from microorganisms animal cells and plant cells. Proceedings of the National Academy of Sciences of the United States of America. 85:1988;7972-7976.
4. Faber H.R., Baker C.J., Day C.L., Tweedie J.W., Baker E.N. Mutation of arginine 121 in lactoferrin destabilizes iron binding by disruption of anion binding: Crystal structures of R121S and R121E mutants. Biochemistry. 35:1996;14473-14479.
5. Fleming R.E., Migas M.C., Holden C.C., Waheed A., Britton R.S., Tomatsu S., Bacon B.R., Sly W.S. Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proceedings of the National Academy of Sciences of the United States of America. 97:2000;2214-2219.
6. Girelli D., Bozzini C., Roetto A., Alberti F., Daraio F., Colombari R., Olivieri O., Corrocher R., Camaschella C. Clinical and pathologic findings in hemochromatosis type 3 due to a novel mutation in transferrin receptor 2 gene. Gastroenterology. 122:2002;1295-1302.
7. Jandl J.H., Inman J.K., Simmons R.L., Allen D.W. Transfer of iron from serum iron-binding protein to human reticulocytes. Journal of Clinical Investigation. 38:1959;161-185.
8. Johnson L.S., Dunn K.W., Pytowski B., McGraw T.E. Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif. Molecular Biology of the Cell. 4:1993;1251-1266.
9. Kawabata H., Yang S., Hirama T., Vuong P.T., Kawano S., Gombart A.F., Koeffler H.P. Molecular cloning of transferrin receptor 2 - A new member of the transferrin receptor-like family. Journal of Biological Chemistry. 274:1999;20826-20832.
10. Klotz I.M., Hunston D.L. Properties of graphical representations of multiple classes of binding sites. Biochemistry. 10:1971;3065-3069.
11. Kühn L.C., McClelland A., Ruddle F.H. Gene transfer, expression and molecular cloning of the human transferrin receptor gene. Cell. 37:1984;95-103.
12. Lippincott-Schwaartz J., Yuan L., Tipper C., Amherdt M., Orci L., Klausner R.D. Brefeldin A's effect on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell. 67:1991;601-616.
13. Lombard M., Bomford A., Hynes M., Naoumov N.V., Roberts S., Crowe J., Williams R. Regulation of the hepatic transferrin receptor in hereditary hemochromatosis. Hepatology. 9:1989;1-5.
14. 131-fibrinogen. Journal of Clinical Investigation. 42:1963;346-361.
15. Misumi Y., Misumi Y., Miki K., Takatsuki A., Tamura G., Ikehara Y. Novel blockade by Brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes. Journal of Biological Chemistry. 261:1986;11398-11403.
16. 2. Biochimica Biophysica Acta. 642:1981;119-134.
17. Price E.M., Gibson J.F. A re-interpretation of bicarbonate-free ferric transferrin E.P.R. spectra. Biochemical and Biophysical Research Communication. 46:1972;646-651.
18. Sasaki K., Zak O., Aisen P. Antisense suppression of transferrin receptor gene expression in a human hepatoma cell (HuH-7) line. American Journal of Hematology. 42:1993;74-80.
19. Saurin A.J., Hamlett J., Clague M.J., Pennington S.R. Inhibition of mitogen-induced DNA synthesis by bafilomycin A1 in Swiss 3T3 fibroblasts. The Biochemical Journal. 313(Pt 1):1996;65-70.
20. Savigni D.L., Morgan E.H. Use of inhibitors of ion transport to differentiate iron transporters in erythroid cells. Biochemical Pharmacology. 52:1996;371-377.
21. Trinder D., Morgan E., Baker E. The mechanism of iron uptake by fetal rat hepatocytes in culture. Hepatology. 6:1986;852-858.
22. Trinder D., Morgan E.H., Baker E. The effects of an antibody to the rat transferrin receptor and of rat serum albumin on the uptake of diferric transferrin by rat hepatocytes. Biochimica Biophysica Acta. 943:1988;440-446.
23. Trinder D., Zak O., Aisen P. Transferrin receptor-independent uptake of diferric transferrin by human hepatoma cells with antisense inhibition of receptor expression. Hepatology. 23:1996;1512-1520.
24. +-ATPase. Journal of Biological Chemistry. 265:1990;21940-21945.
25. Van Weert A.W., Dunn K.W., Gueze H.J., Maxfield F.R., Stoorvogel W. Transport from late endosomes to lysosomes but not sorting of integral membrane proteins in endosomes depends on the vacuolar proton pump. The Journal of Cell Biology. 130:1995;821-834.
26. Vogt T.M., Blackwell A.D., Giannetti A.M., Bjorkman P.J., Enns C.A. Heterotypic interactions between transferrin receptor and transferrin receptor 2. Blood. 101:2003;2008-2014.
27. West A.P. Jr., Bennett M.J., Sellers V.M., Andrews N.C., Enns C.A., Bjorkman P.J. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. Journal of Biological Chemistry. 275:2000;38135-38138.
28. Yoshimori T., Yamamoto A., Moriyama Y., Futai M., Tashiro Y. Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. Journal of Biological Chemistry. 266:1991;17707-17712.
29. Young S.P., Aisen P. The interaction of transferrin with isolated hepatocytes. Biochimica Biophysica Acta. 633:1980;145-153.
30. Zak O., Aisen P., Crawley J.B., Joannou C.L., Patel K.J., Rafiq M., Evans R.W. Iron release from recombinant N-lobe and mutants of human transferrin. Biochemistry. 34:1995;14428-14434.
31. Zak O., Tam B., MacGillivray R.T.A., Aisen P. A kinetically active site in the C-lobe of human transferrin. Biochemistry. 36:1997;11036-11043.
32. Zak O., Trinder D., Aisen P. Primary receptor-recognition site of human transferring is in the C-terminal lobe. Journal of Biological Chemistry. 269:1994;7110-7114.