Aβ(1-42) assembly in the presence of scyllo-inositol derivatives: Identification of an oxime linkage as important for the development of assembly inhibitors

ACS Chemical Neuroscience

Volumn 3, Issue 3, 2012, Pages 167-177

  Shaw, J E ^a   Chio, J ^b   Dasgupta, S ^b   Lai, A Y ^a   Mo, G C H ^b   Pang, F ^a   Thomason, L A M ^a   Yang, A J ^c   Yip, C M ^b   Nitz, M ^b   McLaurin, J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Amyloid beta peptide; atomic force microscopy; fibrillogenesis; mass spectrometry; medicinal chemistry

Indexed keywords

ALDOXIME; AMIDE; AMYLOID BETA PROTEIN; CARBAMIC ACID; COLLAGEN FIBRIL; HYDROXAMIC ACID; INOSITOL DERIVATIVE; OLIGOMER;

ARTICLE; ATOMIC FORCE MICROSCOPY; BINDING AFFINITY; CONFORMATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; MASS SPECTROMETRY; MOLECULAR WEIGHT; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN SYNTHESIS INHIBITION; STEREOCHEMISTRY; TOXICITY;

AMYLOID-BETA PEPTIDE; ATOMIC FORCE MICROSCOPY; FIBRILLOGENESIS; MASS SPECTROMETRY; MEDICINAL CHEMISTRY;

AMYLOID; AMYLOID BETA-PEPTIDES; CELL LINE, TUMOR; HUMANS; INOSITOL; OXIMES; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION;

EID: 84858790492     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn2000926     Document Type: Article

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