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Volumn 7, Issue 3, 2012, Pages

Propionyl-L-carnitine corrects metabolic and cardiovascular alterations in diet-induced obese mice and improves liver respiratory chain activity

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; FATTY ACID; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; NITRIC OXIDE; PROPIONYLCARNITINE; TRIACYLGLYCEROL; CARNITINE; DRUG DERIVATIVE;

EID: 84858760357     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034268     Document Type: Article
Times cited : (34)

References (43)
  • 1
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG, (2000) Obesity as a medical problem. Nature 404: 635-643.
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 2
    • 0034119138 scopus 로고    scopus 로고
    • The perils of portliness: causes and consequences of visceral adiposity
    • Montague CT, O'Rahilly S, (2000) The perils of portliness: causes and consequences of visceral adiposity. Diabetes 49: 883-888.
    • (2000) Diabetes , vol.49 , pp. 883-888
    • Montague, C.T.1    O'Rahilly, S.2
  • 3
    • 79952031235 scopus 로고    scopus 로고
    • Pathophysiologic mechanisms linking adipose tissue and cardiometabolic risk
    • Allende-Vigo MZ, (2010) Pathophysiologic mechanisms linking adipose tissue and cardiometabolic risk. Endocr Pract 16: 692-698.
    • (2010) Endocr Pract , vol.16 , pp. 692-698
    • Allende-Vigo, M.Z.1
  • 5
    • 0345257085 scopus 로고    scopus 로고
    • The mitochondriotropic effects of L-carnitine and its esters in the central nervous system
    • Binienda Z, Virmani A, (2003) The mitochondriotropic effects of L-carnitine and its esters in the central nervous system. Curr Med Chem 3: 275-282.
    • (2003) Curr Med Chem , vol.3 , pp. 275-282
    • Binienda, Z.1    Virmani, A.2
  • 6
    • 0025855351 scopus 로고
    • Propionyl-L-carnitine: biochemical significance and possible role in cardiac metabolism
    • Siliprandi N, Di Lisa F, Menabò R, (1991) Propionyl-L-carnitine: biochemical significance and possible role in cardiac metabolism. Cardiovasc Drugs Ther 5: 11-15.
    • (1991) Cardiovasc Drugs Ther , vol.5 , pp. 11-15
    • Siliprandi, N.1    Di Lisa, F.2    Menabò, R.3
  • 7
    • 23744493081 scopus 로고    scopus 로고
    • L-Carnitine and propionyl-L-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: different participation of NO and COX-products
    • Bueno R, Alvarez de Sotomayor M, Perez-Guerrero C, Gomez-Amores L, Vazquez CM, et al. (2005) L-Carnitine and propionyl-L-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: different participation of NO and COX-products. Life Sci 77: 2082-2097.
    • (2005) Life Sci , vol.77 , pp. 2082-2097
    • Bueno, R.1    Alvarez de Sotomayor, M.2    Perez-Guerrero, C.3    Gomez-Amores, L.4    Vazquez, C.M.5
  • 8
    • 34547494260 scopus 로고    scopus 로고
    • l-carnitine and its propionate: improvement of endothelial function in SHR through superoxide dismutase-dependent mechanisms
    • de Sotomayor MA, Mingorance C, Rodriguez-Rodriguez R, Marhuenda E, Herrera MD, (2007) l-carnitine and its propionate: improvement of endothelial function in SHR through superoxide dismutase-dependent mechanisms. Free Radic Res 4: 884-891.
    • (2007) Free Radic Res , vol.4 , pp. 884-891
    • de Sotomayor, M.A.1    Mingorance, C.2    Rodriguez-Rodriguez, R.3    Marhuenda, E.4    Herrera, M.D.5
  • 9
    • 34548185680 scopus 로고    scopus 로고
    • Effect of L-carnitine and propionyl-L-carnitine on endothelial function of small mesenteric arteries from SHR
    • Alvarez de Sotomayor M, Bueno R, Pérez-Guerrero C, Herrera MD, (2007) Effect of L-carnitine and propionyl-L-carnitine on endothelial function of small mesenteric arteries from SHR. J Vasc Res 44: 354-364.
    • (2007) J Vasc Res , vol.44 , pp. 354-364
    • Alvarez de Sotomayor, M.1    Bueno, R.2    Pérez-Guerrero, C.3    Herrera, M.D.4
  • 10
    • 73349102478 scopus 로고    scopus 로고
    • Carnitine and type 2 diabetes
    • Mynatt RL, (2009) Carnitine and type 2 diabetes. Diabetes Metab Res Rev 25 (Suppl 1): S45-S49.
    • (2009) Diabetes Metab Res Rev , vol.25 , Issue.SUPPL. 1
    • Mynatt, R.L.1
  • 11
    • 73749083758 scopus 로고    scopus 로고
    • Oral supplementation of propionyl-l-carnitine reduces body weight and hyperinsulinaemia in obese Zucker rats
    • Mingorance C, Gonzalez del Pozo M, Dolores Herrera M, Alvarez de Sotomayor M, (2009) Oral supplementation of propionyl-l-carnitine reduces body weight and hyperinsulinaemia in obese Zucker rats. Br J Nutr 102: 1145-1153.
    • (2009) Br J Nutr , vol.102 , pp. 1145-1153
    • Mingorance, C.1    Gonzalez del Pozo, M.2    Dolores Herrera, M.3    Alvarez de Sotomayor, M.4
  • 12
    • 77953868236 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance: unravelling the mechanism
    • Samuel VT, Petersen KF, Shulman GI, (2010) Lipid-induced insulin resistance: unravelling the mechanism. Lancet 375: 2267-2277.
    • (2010) Lancet , vol.375 , pp. 2267-2277
    • Samuel, V.T.1    Petersen, K.F.2    Shulman, G.I.3
  • 13
    • 77955571859 scopus 로고    scopus 로고
    • Ectopic fat and cardiovascular disease: what is the link?
    • Gastaldelli A, Basta G, (2010) Ectopic fat and cardiovascular disease: what is the link? Nutr Metab Cardiovasc Dis 20: 481-490.
    • (2010) Nutr Metab Cardiovasc Dis , vol.20 , pp. 481-490
    • Gastaldelli, A.1    Basta, G.2
  • 14
    • 0030033076 scopus 로고    scopus 로고
    • Effect of propionyl-L-carnitine on the mechanics of right and left papillary muscles from volume-overloaded rat hearts
    • Micheletti R, Giacalone G, Bianchi G, (1996) Effect of propionyl-L-carnitine on the mechanics of right and left papillary muscles from volume-overloaded rat hearts. J Cardiovasc Pharmacol 27: 52-57.
    • (1996) J Cardiovasc Pharmacol , vol.27 , pp. 52-57
    • Micheletti, R.1    Giacalone, G.2    Bianchi, G.3
  • 15
    • 0021813187 scopus 로고
    • Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5
  • 16
    • 34548474286 scopus 로고    scopus 로고
    • Sonic hedgehog carried by microparticles corrects endothelial injury through nitric oxide release
    • Agouni A, Mostefai HA, Porro C, Carusio N, Favre J, et al. (2007) Sonic hedgehog carried by microparticles corrects endothelial injury through nitric oxide release. Faseb J 21: 2735-2741.
    • (2007) Faseb J , vol.21 , pp. 2735-2741
    • Agouni, A.1    Mostefai, H.A.2    Porro, C.3    Carusio, N.4    Favre, J.5
  • 17
    • 0008321079 scopus 로고    scopus 로고
    • Enzymatic and polarographic measurements of the respiratory chain complexes
    • Patrick Lestiene (ed). Springer, Berlin
    • Malgat MLT, Durrieu G, Mazat JP, (1999) Enzymatic and polarographic measurements of the respiratory chain complexes. Mitochondrial Diseases Patrick Lestiene (ed). Springer, Berlin.
    • (1999) Mitochondrial Diseases
    • Malgat, M.L.T.1    Durrieu, G.2    Mazat, J.P.3
  • 18
    • 0344413662 scopus 로고    scopus 로고
    • Carnitine profiles during differentiation and effects of carnitine on differentiation of 3T3-L1 cells
    • Cha YS, Eun JS, Oh SH, (2003) Carnitine profiles during differentiation and effects of carnitine on differentiation of 3T3-L1 cells. J Med Food 6: 163-167.
    • (2003) J Med Food , vol.6 , pp. 163-167
    • Cha, Y.S.1    Eun, J.S.2    Oh, S.H.3
  • 19
    • 33846203944 scopus 로고    scopus 로고
    • L-carnitine stimulates lipolysis via induction of the lipolytic gene expression and suppression of the adipogenic gene expression in 3T3-L1 adipocytes
    • Lee MS, Lee HJ, Lee HS, Kim Y, (2006) L-carnitine stimulates lipolysis via induction of the lipolytic gene expression and suppression of the adipogenic gene expression in 3T3-L1 adipocytes. J Med Food 9: 468-473.
    • (2006) J Med Food , vol.9 , pp. 468-473
    • Lee, M.S.1    Lee, H.J.2    Lee, H.S.3    Kim, Y.4
  • 20
    • 77955223112 scopus 로고    scopus 로고
    • Lotus leaf extract and L-carnitine influence different processes during the adipocyte life cycle
    • Siegner R, Heuser S, Holtzmann U, Söhle J, Schepky A, et al. (2010) Lotus leaf extract and L-carnitine influence different processes during the adipocyte life cycle. Nutr Metab (Lond) 7: 66-76.
    • (2010) Nutr Metab (Lond) , vol.7 , pp. 66-76
    • Siegner, R.1    Heuser, S.2    Holtzmann, U.3    Söhle, J.4    Schepky, A.5
  • 21
    • 33845886915 scopus 로고    scopus 로고
    • Abdominal obesity and metabolic syndrome
    • Després JP, Lemieux I, (2006) Abdominal obesity and metabolic syndrome. Nature 444: 881-887.
    • (2006) Nature , vol.444 , pp. 881-887
    • Després, J.P.1    Lemieux, I.2
  • 22
    • 77949895746 scopus 로고    scopus 로고
    • Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats
    • Amin KA, Nagy MA, (2009) Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats. Diabetol Metab Syndr 1: 17-31.
    • (2009) Diabetol Metab Syndr , vol.1 , pp. 17-31
    • Amin, K.A.1    Nagy, M.A.2
  • 23
    • 33847646640 scopus 로고    scopus 로고
    • Carnitine revisited: potential use as adjunctive treatment in diabetes
    • Power RA, Hulver MW, Zhang JY, Dubois J, Marchand RM, et al. (2007) Carnitine revisited: potential use as adjunctive treatment in diabetes. Diabetologia 50: 824-832.
    • (2007) Diabetologia , vol.50 , pp. 824-832
    • Power, R.A.1    Hulver, M.W.2    Zhang, J.Y.3    Dubois, J.4    Marchand, R.M.5
  • 24
    • 77952526597 scopus 로고    scopus 로고
    • Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance
    • Kleemann R, van Erk M, Verschuren L, van den Hoek AM, Koek M, et al. (2010) Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance. PLoS One 5: e8817.
    • (2010) PLoS One , vol.5
    • Kleemann, R.1    van Erk, M.2    Verschuren, L.3    van den Hoek, A.M.4    Koek, M.5
  • 26
    • 42949178968 scopus 로고    scopus 로고
    • Alterations in hepatic mitochondrial compartment in a model of obesity and insulin resistance
    • Crescenzo R, Bianco F, Falcone I, Prisco M, Liverini G, et al. (2008) Alterations in hepatic mitochondrial compartment in a model of obesity and insulin resistance. Obesity (Silver Spring) 16: 958-64.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 958-964
    • Crescenzo, R.1    Bianco, F.2    Falcone, I.3    Prisco, M.4    Liverini, G.5
  • 27
    • 78751582294 scopus 로고    scopus 로고
    • Effects of a high-fat diet on energy metabolism and ROS production in rat liver
    • Vial G, Dubouchaud H, Couturier K, Cottet-Rousselle C, Taleux N, et al. (2010) Effects of a high-fat diet on energy metabolism and ROS production in rat liver. J Hepatol 54: 348-356.
    • (2010) J Hepatol , vol.54 , pp. 348-356
    • Vial, G.1    Dubouchaud, H.2    Couturier, K.3    Cottet-Rousselle, C.4    Taleux, N.5
  • 28
    • 20444463198 scopus 로고    scopus 로고
    • Reduced insulin-mediated citrate synthase activity in cultured skeletal muscle cells from patients with type 2 diabetes: evidence for an intrinsic oxidative enzyme defect
    • Ortenblad N, Mogensen M, Petersen I, Højlund K, Levin K, et al. (2005) Reduced insulin-mediated citrate synthase activity in cultured skeletal muscle cells from patients with type 2 diabetes: evidence for an intrinsic oxidative enzyme defect. Biochim Biophys Acta 1741: 206-214.
    • (2005) Biochim Biophys Acta , vol.1741 , pp. 206-214
    • Ortenblad, N.1    Mogensen, M.2    Petersen, I.3    Højlund, K.4    Levin, K.5
  • 29
    • 20044395441 scopus 로고    scopus 로고
    • Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects
    • Kashyap SR, Roman LJ, Lamont J, Masters BS, Bajaj M, et al. (2006) Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects. J Clin Endocrinol Metab 90: 1100-5.
    • (2006) J Clin Endocrinol Metab , vol.90 , pp. 1100-1105
    • Kashyap, S.R.1    Roman, L.J.2    Lamont, J.3    Masters, B.S.4    Bajaj, M.5
  • 30
    • 78049428301 scopus 로고    scopus 로고
    • A liver-derived secretory protein, selenoprotein P, causes insulin resistance
    • Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, et al. (2010) A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Cell Metab 2: 483-495.
    • (2010) Cell Metab , vol.2 , pp. 483-495
    • Misu, H.1    Takamura, T.2    Takayama, H.3    Hayashi, H.4    Matsuzawa-Nagata, N.5
  • 31
    • 37449020075 scopus 로고    scopus 로고
    • Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
    • Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, et al. (2008) Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 7: 45-56.
    • (2008) Cell Metab , vol.7 , pp. 45-56
    • Koves, T.R.1    Ussher, J.R.2    Noland, R.C.3    Slentz, D.4    Mosedale, M.5
  • 32
    • 69249113803 scopus 로고    scopus 로고
    • Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control
    • Noland RC, Koves TR, Seiler SE, Lum H, Lust RM, et al. (2009) Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J Biol Chem 284: 22840-22852.
    • (2009) J Biol Chem , vol.284 , pp. 22840-22852
    • Noland, R.C.1    Koves, T.R.2    Seiler, S.E.3    Lum, H.4    Lust, R.M.5
  • 33
    • 66749094133 scopus 로고    scopus 로고
    • Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women
    • Adams SH, Hoppel CL, Lok KH, Zhao L, Wong SW, et al. (2009) Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women. J Nutr 139: 1073-1081.
    • (2009) J Nutr , vol.139 , pp. 1073-1081
    • Adams, S.H.1    Hoppel, C.L.2    Lok, K.H.3    Zhao, L.4    Wong, S.W.5
  • 34
    • 79551492488 scopus 로고    scopus 로고
    • Insulin says NO to cardiovascular disease
    • Yu Q, Gao F, Ma XL, (2011) Insulin says NO to cardiovascular disease. Cardiovasc Res 89: 516-524.
    • (2011) Cardiovasc Res , vol.89 , pp. 516-524
    • Yu, Q.1    Gao, F.2    Ma, X.L.3
  • 35
    • 77954512283 scopus 로고    scopus 로고
    • Periadventitial adipose tissue promotes endothelial dysfunction via oxidative stress in diet-induced obese C57Bl/6 mice
    • Ketonen J, Shi J, Martonen E, Mervaala E, (2010) Periadventitial adipose tissue promotes endothelial dysfunction via oxidative stress in diet-induced obese C57Bl/6 mice. Circ J 74: 1479-1487.
    • (2010) Circ J , vol.74 , pp. 1479-1487
    • Ketonen, J.1    Shi, J.2    Martonen, E.3    Mervaala, E.4
  • 36
    • 20444457010 scopus 로고    scopus 로고
    • Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice
    • Molnar J, Yu S, Mzhavia N, Pau C, Chereshnev I, et al. (2005) Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice. Circ Res 96: 1178-1184.
    • (2005) Circ Res , vol.96 , pp. 1178-1184
    • Molnar, J.1    Yu, S.2    Mzhavia, N.3    Pau, C.4    Chereshnev, I.5
  • 38
    • 54049155806 scopus 로고    scopus 로고
    • Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription
    • Fang CX, Dong F, Thomas DP, Ma H, He L, et al. (2008) Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription. Am J Physiol Heart Circ Physiol 295: H1206-H1215.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Fang, C.X.1    Dong, F.2    Thomas, D.P.3    Ma, H.4    He, L.5
  • 39
    • 33745712694 scopus 로고    scopus 로고
    • Pioglitazone prevents cardiac remodeling in high-fat, high-calorie-induced Type 2 diabetes mellitus
    • Rodriguez WE, Joshua IJ, Falcone JC, Tyagi SC, (2006) Pioglitazone prevents cardiac remodeling in high-fat, high-calorie-induced Type 2 diabetes mellitus. Am J Physiol Heart Circ Physiol 291: H81-H87.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Rodriguez, W.E.1    Joshua, I.J.2    Falcone, J.C.3    Tyagi, S.C.4
  • 40
    • 68049136011 scopus 로고    scopus 로고
    • Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase
    • Ussher JR, Koves TR, Jaswal JS, Zhang L, Ilkayeva O, et al. (2009) Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase. Diabetes 58: 1766-1775.
    • (2009) Diabetes , vol.58 , pp. 1766-1775
    • Ussher, J.R.1    Koves, T.R.2    Jaswal, J.S.3    Zhang, L.4    Ilkayeva, O.5
  • 41
    • 42649127056 scopus 로고    scopus 로고
    • Cardiac output and index in obese and non-obese patients using gated single photon emission computed tomography sestamibi perfusion imaging
    • Coffey JP, Hill JC, (2005) Cardiac output and index in obese and non-obese patients using gated single photon emission computed tomography sestamibi perfusion imaging. J HK Coll Radiol 8: 226-232.
    • (2005) J HK Coll Radiol , vol.8 , pp. 226-232
    • Coffey, J.P.1    Hill, J.C.2
  • 43
    • 0034066578 scopus 로고    scopus 로고
    • Regulation by carnitine of myocardial fatty acid and carbohydrate metabolism under normal and pathological conditions
    • Calvani M, Reda E, Arrigoni-Martelli E, (2000) Regulation by carnitine of myocardial fatty acid and carbohydrate metabolism under normal and pathological conditions. Basic Res Cardiol 95: 75-83.
    • (2000) Basic Res Cardiol , vol.95 , pp. 75-83
    • Calvani, M.1    Reda, E.2    Arrigoni-Martelli, E.3


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