Carnitine Profiles during Differentiation and Effects of Carnitine on Differentiation of 3T3-L1 Cells

Journal of Medicinal Food

Volumn 6, Issue 3, 2003, Pages 163-167

  Cha, Youn Soo ^a   Eun, Jae Soon ^b   Oh, Suk Heung ^b  

^a Chonbuk National University   (South Korea)

^b Woosuk University   (South Korea)

Author keywords

3T3 L1 cells; Carnitine; Differentiation; Total lipid; Triglyceride

Indexed keywords

3 ISOBUTYL 8 METHOXYMETHYL 1 METHYLXANTHINE; ACYLCARNITINE; BIOTIN; CARNITINE; DEXAMETHASONE; LIPID; TRIACYLGLYCEROL;

ARTICLE; CELL ACTIVATION; CELL SPECIFICITY; CELL STRAIN 3T3; COMPETITIVE INHIBITION; INTERMETHOD COMPARISON; LIPID BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0344413662     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/10966200360716562     Document Type: Article

References (29)

1. Green H, Kehinde O: Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells. Cell 1976;7:105-113.
2. Moustaid N, Sul HS: Regulation of expression of the fatty acid synthase gene in 3T3-L1 cells by differentiation and triiodothyronine. J Biol Chem 1991;266:18550-18554.
3. Weiss GH, Rosen OM, Rubin CS: Regulation of fatty acid synthetase concentration and activity during adipocyte differentiation: Studies on 3T3-L1 cells. J Biol Chem 1980;255:4751-4757.
4. Sidhu R: Two-dimensional electrophoresis analysis of proteins synthesized during differentiation of 3T3-L1 preadipocytes. J Biol Chem 1979;254:11111-11118.
5. Ono M, Aratani Y, Kitagawa I, Kitagawa Y: Ascorbic acid phosphate stimulates type IV collagen synthesis and accelerates adipose conversion of 3T3-L1 cells. Exp Cell Res 1990;187:309-314.
6. Chen JJ, London IM: Hemin enhances the differentiation of mouse 3T3 cells to adipocytes. Cell 1981;26:117-122.
7. Catalioto RM, Gaillard D, Ailhaud G, Negrel R: Terminal differentiation of mouse preadipocyte cells: the mitogenic-adipogenic role of growth hormone is mediated by the protein kinase C signalling pathway. Growth Factors 1992;6:255-264.
8. Eun JS, Yum JY, Oh SH, Kweon J, Kang, SY, Oh CH, So JN, Jeon H: Effect of glycyrrhizin on the differentiation of 3T3-L1 cells. Yakhak Hoeji 1995;39:535-540.
9. Serrero G, Khoo JC: An in vitro model to study adipose differentiation in serum free medium. Anal Biochem 1981;120:351-359.
10. Kawada T, Aoki N, Kamei Y, Maeshige K, Nishiu S, Sugimoto E: Comparative investigation of vitamins and their analogues on terminal differentiation, from preadipocytes to adipocytes to adipocytes of 3T3-L1 cells. Comp Biochem Physiol A Physiol 1990;96:323-326.
11. Shimizu Y, Shimizu N, Fujiki H, Sugimura T: Distinct inhibitory effects of dihydroteleocidin B and the phorbol ester tumor promotors on the adipocyte differentiation of 3T3-L1 cells. Cancer Res 1983;43:4974-4979.
12. Aratani Y, Sugimoto E, Kitagawa Y: Lithium ion reversibly inhibits inducer-stimulated adipose conversion of 3T3-L1 cells. FEBS Lett 1987;218:47-51.
13. Eun JS, Suh ES, So JN, Oh SH: Effect of baicalin on the differentiation of 3T3-L1 cells. Yakhak Hoeji 1994;38:238-249.
14. Fritz IB, Kaplan E, Yue KTN: Specificity of carnitine action on fatty acid oxidation by heart muscle. Am J Physiol 1962;202:117-121.
15. Maebashi M, Sato M, Kawamura N, Imamura A, Yoshinaga K: Lipid lowering effect of carnitine in patients with IV hyperlipoproteinemia. Lancet 1978;14:805-807.
16. Pola P, Savi L, Grilli M, Flore R, Serricchio M: Carnitine in the therapy of dyslipidemic patients. Curr Ther Res 1980;27:208-215.
17. Monola P, Belfiore A, Santangelo F, Santillo M: The effect of L-carnitine on the apolipoprotein pattern of rats fed a cholesterol-rich diet. Comp Biochem Physiol 1988;89:69-73.
18. Novak M, Monkus EF, Buch M, Lesmes H, Silverio J: The effect of a L-carnitine-supplemented soybean formula on plasma lipids of infants. Acta Chir Scand Suppl 1983;517:149.
19. Bieber LL: Carnitine. Annu Rev Biochem 1988;57:261-283.
20. Cederbladt G, Lindstedt S: A method for the determination of carnitine in the picomole range. Clin Chim Acta 1972;37:235-243.
21. Sachan DS, Rhew TH, Ruak RS: Ameliorating effects of carnitine and its precursors on alcohol-induced fatty liver. Am J Clin Nutr 1984;39:738-744.
22. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 1976;72:248-254.
23. Elleston RD, Caraway WT: Lipids and lipoproteins. In: Fundamentals of Clinical Chemistry (Tietz NW, ed.), 2nd ed. W.B. Saunders Co., Philadelphia, 1976, pp 492-494.
24. Sul HS, Smas CM, Moustaid N: Positive and negative regulators of adipocyte differentiation. J Nutr Biochem 1993;4:554-562.
25. Hauner H: Complete adipose differentiation of 3T3-L1 cells in a chemically defined medium: Comparison to serum-containing culture conditions. Endocrinology 1990;127:865-872.
26. Sadowski HB, Wheeler TT, Young DA: Gene expression during 3T3-L1 adipocyte differentiation: Characterization of initial responses to the inducing agents and changes during commitment to differentiation. J Biol Chem 1992;257:4722-4731.
27. Friedman S, Fraenkel GS III: Carnitine. In: The Vitamins, Vol. 5 (Sebrell WH, Harris RS, eds.). Academic Press, New York, 1972, pp 329-355.
28. Hoppel CL, Genuth S, Brass E, Fuller R, Hostetler K: Carnitine and carnitine palmitoyl transferase in metabolic studies. In: Carnitine Biosynthesis, Metabolism and Functions (Frenkel A, McGarry JD, eds.). Academic Press, New York, 1980, pp 300-301.
29. Rhew TH, Sachan DS: Dose-dependent lipotropic effect of carnitine in chronic alcoholic rats. J Nutr 1986;116:2263-2269.