Effect of propionyl-L-carnitine on the mechanics of right and left papillary muscles from volume-overloaded rat hearts

Journal of Cardiovascular Pharmacology

Volumn 27, Issue 1, 1996, Pages 52-57

  Micheletti, R ^a   Giacalone, G ^a   Bianchi, G ^b  

^a Prassis Sigma Tau Research Institute   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Anaplerotic activity; Aortocaval fistula; Papillary muscle; Propionyl L carnitine; Volume overload

Indexed keywords

PROPIONYLCARNITINE;

ANIMAL TISSUE; AORTOCAVAL FISTULA; ARTICLE; BIOMECHANICS; BLOOD VESSEL SHUNT; DRUG EFFECT; HEART FAILURE; HEART FUNCTION; HEART HYPERTROPHY; HEART PAPILLARY MUSCLE; HEART VENTRICLE OVERLOAD; HEART VOLUME; MUSCLE FUNCTION; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANASTOMOSIS, SURGICAL; ANIMALS; AORTA, ABDOMINAL; CARDIOMEGALY; CARDIOTONIC AGENTS; CARNITINE; MALE; PAPILLARY MUSCLES; RATS; RATS, WISTAR; VENAE CAVAE;

EID: 0030033076     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199601000-00009     Document Type: Article

References (37)

1. Levy D. Clinical significance of left ventricular hypertrophy: insights from the Framingham study. J Cardiovasc Pharmacol 1991;17(suppl 2):S1-6.
2. Katz AM. Cardiomyopathy of overload. A major determinant of prognosis in congestive heart failure. N Engl J Med 1990;322:100-10.
3. Anversa P, Ricci R, Olivetti G. Quantitative structural analysis of the myocardium during physiologic growth and induced cardiac hypertrophy: a review. J Am Coll Cardiol 1986;7:1140-9.
4. Kapelko VI, Veksler VI, Popvich MI, Ventura-Clapier R. Energy-linked functional alterations in experimental cardiomyopathies. Am J Physiol 1991;26(suppl):39-44.
5. Torielli L, Conti F, Cinato A, et al. Alterations in energy metabolism of hypertrophied rat cardiomyocytes: influence of propionyl-L-carnitine. J Cardiovasc Pharmacol 1995;26: 372-80.
6. Zhang J, Merkle H, Hendrich K, et al. Bioenergetic abnormalities associated with severe left ventricular hypertrophy. J Clin Invest 1993;92:993-1003.
7. Scheuer J. Metabolic factors in myocardial failure. Circulation 1993;87(suppl. VII):VII54-7.
8. Ingwall JS. Is cardiac failure a consequence of decreased energy reserve? Circulation 1993;00(suppl. VII):VII58-62.
9. Tassani V, Cattapan F, Magnanimi L, Peschechera A. Anaplerotic effect of propionyl-L-carnitine in rat heart mitochondria. Biochem Biophys Res Commun 1994;199:949-53.
10. Micheletti R, Donato di Paola E, Schiavone A, Rossi R, Bianchi G. Effect of propionyl-1-carnitine and enalapril on cardiac function of pressure-overloaded rats during increase in load. Eur J Pharmacol 1995;00:00-00.
11. Micheletti R, Giacalone G, Canepari M, Salardi S, Bianchi G, Reggiani C. Propionyl-L-carnitine prevents myocardial mechanical alterations due to pressure overload in rats. Am J Physiol 1994;266:H2190-7.
12. El Alaoui-Talibi Z, Bouhaddioni N, Moravec J. Assessment of the cardiostimulant action of propionyl-L-carnitine on chronically volume-overloaded rat hearts. Cardiovasc Drugs Ther 1993;7:357-63.
13. Liu Z, Hilbelink DR, Crockett WB, Gerdes AM. Regional changes in hemodynamics and cardiac myocyte size in rats with aortocaval fistulas. 1. Developing and established hypertrophy. Circ Res 1991;69:52-8.
14. Garcia R, Diebold S. Simple, rapid, and effective method of producing aortocaval shunts in the rat. Cardiovasc Res 990;24:430-2.
15. McGarry JD, Foster DW. Free and esterified carnitine. Radiometric method. In: Bergmeyer J, Grable M, eds. Methods of enzyme analysis, vol. 3, 3rd ed. Weinheim: Verlag Chemie GmbH, 1983:474-81.
16. Lowry OH, Rosebrough NJ, Far AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
17. Flaim SF, Minteer WJ, Nellis SH, Clark DP. Ateriovenous shunt: evaluation of a model for heart failure in rat. Am J Physiol 1979;236:H698-704.
18. Liu Z, Hilbelink DR, Gerdes AM. Regional changes in hemodynamics and cardiac myocyte size in rats with aortocaval fistulas. 2. Long-term effects. Circ Res 1991;69:59-65.
19. Mercadier J-J, Lompré A-M, Wisnewsky C, et al. Myosin isoenzymic changes in several models of rat cardiac hypertrophy. Circ Res 1981;49:525-32.
20. Gibbs CL, Wendt IR, Kotsanas G, Young IR. Mechanical, energetic, and biochemical changes in long-term volume overload of rabbit heart. Am J Physiol 1992;262:H819-27.
21. Carabello BA, Nakano K, Corin W, Biederman R, Spann JF. Left ventricular function in experimental volume overload hypertrophy. Am J Physiol 1989;256:H974-81.
22. El Alaoui-Talibi Z, Landormy S, Loireau A, Moravec J. Fatty acid oxidation and mechanical performance of volume-overloaded rat hearts. Am J Physiol 1992;262:H 1068-74.
23. Apstein CS, Lecarpentier Y, Mercadier J-J, et al. Changes in LV papillary muscle performance and myosin composition with aortic insufficiency in rats. Am J Physiol 1987;253: H1005-11.
24. Cooper G, Tomanek RJ, Ehrhardt JC, Marcus ML. Chronic progressive pressure overload of cat right ventricle. Circ Res 1981;48:488-97.
25. Capasso JM, Aronson RS, Sonnenblick EH. Reversible alterations in excitation-contraction coupling during myocardial hypertrophy in rat papillary muscle. Circ Res 1982;51: 189-95.
26. Marino TA, Kent RL, Uboh CE, Fernandez E, Thompson EW, Cooper G. Structural analysis of pressure versus volume overload hypertrophy of cat right ventricle. Am J Physiol 1985;249:H371-9.
27. Michel JB, Salzman JL, Ossondo Nlom M, Bruneval P, Barres D, Camilleri JP. Morphometric analysis of collagen network and plasma perfused capillary bed in the myocardium of rats during evolution of cardiac hypertrophy. Basic Res Cardiol 1986;81:142-54.
28. Tsutsui H, Kazuaki I, Cooper C. Cytoskeletal role in the contractile dysfunction of hypertrophied myocardium. Science 1993;260:682-7.
29. Calderone A, Takayashi N, Izzo NJ, Colucci WS. Pressure and volume overload-induced myocardial hypertrophy are associated with distinct molecular phenotypes. Circulation 1994;90:I-260.
30. Cooper G, Puga FJ, Zujko KJ, Harrison CE, Coleman HN. Normal myocardial function and energetics in volume-overload hypertrophy in the cat. Circ Res 1973;32:140-8.
31. Allard ME, Schönekess BO, Henning SL, English DR, Lopaschuk GD. Contribution of oxidative metabolism and glycolysis to ATP production in the hypertrophied heart. Am J Physiol 1994;267:H742-50.
32. El Alaoui-Talibi Z, Moravec J. Carnitine transport and exogenous palmitate oxidation in chronically volume-overloaded rat hearts. Biochem Biophys Acta 1989;1003: 109-14.
33. Motterlini R, Samaja M, Tarantola M, Micheletti R, Bianchi G. Functional and metabolic effects of propionyl-L-carnitine in the isolated perfused hypertrophied rat hearts. Mol Cell Biochem 1992;116:139-45.
34. Schönekess BO, Allard MF, Kozak RM, Barr RL, Lopaschuk GD. L-Propionylcarnitine feeding improves hypertrophied heart function. J Mol Cell Cardiol. 1994;26:CLXV.
35. Schönekess BO, Allard MF, Lopaschuk GD. Propionyl-L-carnitine improvement of hypertrophied heart function is accompanied by an increase in carbohydrate oxidation. Circ Res 1995;77:726-34.
36. Siliprandi N, Di Lisa F, Menabò R. Propionyl-L-carnitine: biochemical significance and possible role in cardiac metabolism. Cardiovasc Drugs Ther 1991;5:11-6.
37. Di Lisa F, Menabò R, Barbato R, Siliprandi N. Contrasting effects of propionate and propionyl-L-carnitine on energy-linked processes in ischemic hearts. Am J Physiol 1994;267: H455-61.