Effect of melatonin on neuroinflammation and acetylcholinesterase activity induced by LPS in rat brain

European Journal of Pharmacology

Volumn 640, Issue 1-3, 2010, Pages 206-210

  Tyagi, Ethika ^a   Agrawal, Rahul ^a   Nath, Chandishwar ^a   Shukla, Rakesh ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Acetylcholinesterase activity; Lipopolysaccharide; Melatonin; Oxidative stress; Pro inflammatory cytokine

Indexed keywords

ACETYLCHOLINESTERASE; GLUTATHIONE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MALONALDEHYDE; MELATONIN; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; BRAIN TISSUE; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE MARKER; DRUG EFFECT; DRUG EFFICACY; ENCEPHALITIS; ENZYME ACTIVITY; HIPPOCAMPUS; HYPOTHALAMUS; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYMOLOGY; INFLAMMATION; METABOLISM; SPRAGUE DAWLEY RAT;

ACETYLCHOLINESTERASE; ANIMALS; BIOLOGICAL MARKERS; BRAIN; CYTOKINES; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MELATONIN; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77953808415     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.04.041     Document Type: Article

References (40)

1. Agrawal R., Tyagi E., Shukla R., Nath C. A Study of brain insulin receptors, AChE activity and oxidative stress in rat model of i.c.v. STZ induced dementia. Neuropharmacology 2009, 56:779-787.
2. Anisman H., Zalcman S., Zacharko R.M. The impact of stressors on immune and central neurotransmitter activity bidirectional communication. Rev. Neurosci. 1993, 4:147-180.
3. Araujo D.M., Lapchak P., Collier B., Quirion R. Localization of IL-2 immunoreactivity and IL-2 receptors in the rat brain: interaction with the cholinergic system. Brain Res. 1989, 498:257-266.
4. Armour D., Paton C. Melatonin in the treatment of insomnia in children and adolescents. Psychiatric. Bull. 2004, 28:222-224.
5. Borovikova L.V., Ivanova S., Zhang M., Yang H., Botchkina G.I., Watkins L.R., Wang H., Abumrad N., Eaton J.W., Tracey K.J. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000, 405:458-462.
6. Carrillo V.A., Garcia M.S., Calvo J.R., Guerrero J.M. Melatonin counteracts the inhibitory effect of PGE2 on IL-2 production in human lymphocytes via its mt1 membrane receptor. Faseb J. 2003, 17:755-757.
7. Carrillo V.A., Guerrero J.M., Lardone P.J., Reiter R.J. A review of the multiple actions of melatonin on the immune system. Endocr. 2005, 27:189-200.
8. Carrillo V.A., Lardone P.J., Naji L., Fernández S.J.M., Martín L.I., Guerrero J.M., Calvo J.R. Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects. J. Pineal Res. 2005, 39:400-408.
9. Cheng Y., Feng Z., Zhang Q.Z., Zhang J.T. Beneficial effects of melatonin in experimental model of Alzheimer disease. Acta Pharmacol. Sin. 2006, 27:129-139.
10. Colado M.I., O'Shea E., Granados R., Misra A., Murray T.K., Green A.R. A study of the neurotoxic effect of MDMA ("ecstasy") on 5-HT neurons in the brains of mothers and neonates following administration of the drug during pregnancy. Br. J. Pharmacol. 1997, 121:827-833.
11. Cos S., Fernandez R., Guezmes A., Sánchez B.E.J. Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. Cancer Res. 1998, 58:4383-4390.
12. Das A., Dikshit M., Nath C. Profile of acetylcholinesterase in brain regions of male and female rats of adult and old age. Life Sci. 2001, 68:1545-1555.
13. Deak T., Bellamy C., D'Agostino L.G. Exposure to forced swim stress does not alter central production of IL-1. Brain Res. 2003, 972:53-63.
14. Engelhart M.J., Geerlings M.I., Ruitenberg A., Swieten J.C., Hofman A., Witteman J.C.M., Breteler M.M.B. Dietary intake of antioxidants and risk of Alzheimer disease. Jama 2002, 287:3223-3229.
15. Finocchiaro L.M.E., Nahmod V.E., Launay J.M. Melatonin biosynthesis and metabolism in peripheral blood mononuclear leucocytes. Biochem. J. 1991, 280:727-731.
16. Glowinski J., Iversen L.L. Regional studies of catecholamines in the rat brain. I. The disposition of [3H] norepinephrine, [3H] dopamine and [3H] dopa in various regions of the brain. J. Neurochem. 1966, 13:655-669.
17. Herxheimer A., Petrie K.J. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst. Rev. 2002, 2:1-17. (Review).
18. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
19. Maestroni G.J. Therapeutic potential of melatonin in immunodeficiency states, viral diseases, and cancer. Adv. Exp. Med. Biol. 1999, 467:217-226.
20. Mills E., Wu P., Seely D., Guyatt G. Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis. J. Pineal Res. 2005, 39:360-366.
21. Morrey K.M., Mclachlan J.A., Serkin C.D., Bakouche O. Activation of human monocytes by the pineal hormone melatonin. J. Immunol. 1994, 153:2671-2680.
22. Nava F., Calpai G., Facciola G., Cuzzocrea S., Giuliani G., De Sarro A., Caputi A.P. Melatonin effects on inhibition of thirst and fever induced by lipopolysaccharide in rat. Eur. J. Pharmacol. 1997, 331:267-274.
23. Nizri E., Amitay Y.H., Sicsic C., Lavon I., Brenner T. Antiinflammatory properties of cholinergic up-regulation: a new role for acetylcholinesterase inhibitors. Neuropharmacology 2006, 50:540-547.
24. Oxenkrug G., Requintina P., Bachurin S. Antioxidant and antiaging activity of N-acetylserotonin and melatonin in the in vivo models. Ann. NY Acad. Sci. 2001, 939:190-199.
25. Pappolla M.A., Chyan Y.J., Poeggeler B., Frangione B., Wilson G., Ghiso J., Reiter R.J. An assessment of the antioxidant and antiamyloidogenic properties of melatonin: implications for Alzheimer's disease. J. Neural Trans. 2000, 7:203-231.
26. Pitossi F., Delrey A., Kabiersch A., Besedovsky H. Induction of cytokine transcripts in the central nervous system and pituitary following peripheral administration of endotoxin to mice. J. Neurosci. Res. 1997, 48:287-298.
27. Pratico D., Delanty N. Oxidative injury in disease of the central nervous system. Focus on Alzheimer's disease. Am. J. Med. 2000, 109:577-585.
28. Raghavendra V., Agrewala J.N., Kulkarni S.K. Role of centrally administered melatonin and inhibitors of COX and NOS in LPS-induced hyperthermia and adepsia. Prostagland. Leuk. Essent. Fatty Acids 1999, 60:249-253.
29. Raghavendra V., Agrewala J.N., Kulkarni S.K. Melatonin reversal of lipopolysacharides-induced thermal and behavioral hyperalgesia in mice. Eur. J. Pharmacol. 2000, 395:15-21.
30. Reiter R.J., Tang L., Garcia J.J., Hoyos A.M. Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sci. 1997, 60:2255-2271.
31. Reiter R.J., Calvo J.R., Karbownik M., Qi W., Tan D.X. Melatonin and its relation to the immune system and inflammation. Ann. NY Acad. Sci. 2000, 917:376-386.
32. Sharma M., Gupta Y.K. Intracerebroventricular injection of streptozotocin in rats produces both oxidative stress in the brain and cognitive impairment. Life Sci. 2001, 68:1021-1029.
33. Shen Y.X., Xu S.Y., Wei W., Sun X.X., Yang J., Liu L.H., Dong C. Melatonin reduces memory changes and neural oxidative damage in mice treated with d-galactose. J. Pineal Res. 2002, 32:173-178.
34. Shytle R.D., Mori T., Townsend K., Vendrame M., Sun M., Zeng J., Ehrhart J., Silver A.A., Sanberg P.R., Tan J. Cholinergic modulation of microglia activation by α 7 nicotinic receptors. J. Neurochem. 2004, 89:337-343.
35. Sugino K., Dhi K., Yamada K., Kawasaki T. The role of lipid peroxidation in endotoxin-induced hepatic damage and the protective effect of antioxidants. Surgery 1987, 101:746-752.
36. Tanaka S., Ide M., Shibutani T., Ohtaki H., Numazawa S., Shioda S., Yoshida T. Lipopolysaccharide-induced microglial activation induces learning and memory deficits without neuronal cell death in rats. J. Neurosci. Res. 2006, 83:557-566.
37. Thomas J.A. Oxidative stress, oxidant defense and dietary constituents. Modern Nutrition in Health and Disease 1994, 501-512. Awaverly, Philadelphia. E. Maurice, M.E. Shils, J.A. Olson, M. Shike (Eds.).
38. Tyagi E., Agrawal R., Nath C., Shukla R. Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain. J. Neuroimmunol. 2008, 205:51-56.
39. Wang C.H., Smith R.L. Lowry determination of protein in the presence of triton X-100. Anal. Biochem. 1975, 63:414-417.
40. Zhang H., Squadrito G.L., Pryor W.A. The reaction of melatonin with peroxynitrite: formation of melatonin radical cation and absence of stable nitrated products. Biochem. Biophys. Res. Commun. 1998, 251:83-87.