Exogenous Melatonin Enhances Cell-Mediated, but Not Humoral, Immune Function in Adult Male Deer Mice (Peromyscus maniculatus)

Journal of Biological Rhythms

Volumn 13, Issue 3, 1998, Pages 245-252

  Demas, Gregory E ^a   Nelson, Randy J ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Corticosterone; Disease; Photoperiod; Pineal; Seasonal; Testosterone

Indexed keywords

CERVIDAE; CRICETINAE; PEROMYSCUS; PEROMYSCUS MANICULATUS; RODENTIA;

IMMUNOGLOBULIN M; MELATONIN;

ANALYSIS OF VARIANCE; ANIMAL; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; BLOOD; BODY WEIGHT; CELLULAR IMMUNITY; CLIMATE; DRUG EFFECT; DRUG IMPLANT; HISTOLOGY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALE; MALE GENITAL SYSTEM; ORCHIECTOMY; ORGAN SIZE; PEROMYSCUS; PHOTOPERIODICITY; SEASON; SPLEEN; T LYMPHOCYTE;

ANALYSIS OF VARIANCE; ANIMALS; ANTIBODY FORMATION; B-LYMPHOCYTES; BODY WEIGHT; CLIMATE; DRUG IMPLANTS; GENITALIA, MALE; IMMUNITY, CELLULAR; IMMUNOGLOBULIN M; LYMPHOCYTE ACTIVATION; MALE; MELATONIN; ORCHIECTOMY; ORGAN SIZE; PEROMYSCUS; PHOTOPERIOD; SEASONS; SPLEEN; T-LYMPHOCYTES;

EID: 0032085641     PISSN: 07487304     EISSN: None     Source Type: Journal    
DOI: 10.1177/074873098129000084     Document Type: Article

References (36)

1. Ader R and Cohen N (1993) Psychoneuroimmunology: Conditioning and stress. Ann Rev Psychol 44:53-85.
2. Afoke AO, Eeg-Olofsson O, Hed J, Kjellman NM, Lindblom B, and Ludvigsson J (1993) Seasonal variation and sex differences of circulating macrophages, immunoglobulins, and lymphocytes in healthy school children. Scand J Immunol 37:209-215.
3. Bartness TJ, Powers JB, Hastings MH, Bittman EL, and Goldman BD (1993) The timed infusion paradigm for melatonin delivery: What has it taught us about the melatonin signal, its reception, and the photoperiodic control of seasonal responses? J Pineal Res 15:161-190.
4. Black PH (1994) Central nervous system interactions: Psychoneuroendocrinology of stress and its immune consequences. Antimicrob Agents Chemother 38:1-6.
5. Boctor FN, Charmy RA, and Cooper EL (1989) Seasonal differences in the rhythmicity of human male and female lymphocyte blastogenic responses. Immunol Invest 18:775-784.
6. Brainard GC, Watson-Whitmyer M, Knobler RL, and Lubin FD (1988) Neuroendocrine regulation of immune parameters: Photoperiod control of the spleen in Syrian hamsters. Ann NY Acad Sci 540:704-706.
7. Calvo JR, Rafii-El-Idrissi M, Pozo D, and Guerrero JM (1995) Immunomodulatory role of melatonin: Specific binding sites in human and rodent lymphoid cells. J Pineal Res 18:119-126.
8. Caroleo, MC, Frasca, D, Nistico, G, and Doria, G (1992) Melatonin as immunomodulator in immunodeficient mice. Immunopharmacology 23: 81-89.
9. Champney TH and McMurray DN (1991) Spleen morphology and lymphoproliferative activity in short photoperiod exposed hamsters. In Role of Melatonin and Pineal Peptides in Neuroimmunomodulation, F Franschini and RJ Reiter, eds, pp 219-223, Plenum, New York.
10. Demas GE, DeVries AC, and Nelson RJ (1997) Effects of photoperiod and 2-deoxy-D-glucose-induced metabolic stress on immune function in female deer mice (Peromyscus maniculatus). Am J Physiol 272:1762-1767.
11. Demas GE, Klein SL, and Nelson RJ (1996) Reproductive and immune response to photoperiod and melatonin are linked in Peromyscus subspecies. J Comp Physiol A 179:819-825.
12. Demas GE and Nelson RJ (1996) Photoperiod and temperature interact to affect immune parameters in adult deer mice (Peromyscus maniculatus). J Biol Rhythms 11:94-102.
13. Demas GE and Nelson RJ (1998) Short-day enhancement of immune function is independent of steroid hormones in deer mice (Peromyscus maniculatus). J Comp Physiol B [in press].
14. Gaston S and Menaker M (1967) Photoperiodic control of hamster testis. Science 167:925-928.
15. Giordano M and Palmero MS (1991) Melatonin-induced enhancement of antibody-dependent cellular cytotoxicity. J Pineal Res 10:117-121.
16. Grossman CJ (1984) Regulation of the immune system by sex steroids. Endocrinol Rev 5:435-455.
17. Grossman CJ (1985) Interactions between the gonadal steroids and the immune system. Science 227:257-261.
18. Guerrero JM and Reiter RJ (1992) A brief survey of pineal gland-immune system interrelationships. Endocrinol Res 18:91-113.
19. John JL (1994) The avian spleen: A neglected organ. Q Rev Biol 69:327-351.
20. Johnston PG and Zucker I (1979) Photoperiodic influences on gonadal development and maintenance in the cotton rat, Sigmodon hispidus. Biol Reprod 21:1-8.
21. 125I]iodomelatonin binding sites in the bursa of Fabricus of birds: Binding characteristics, subcellular distribution, diurnal variations and age studies. J Endocrinol 138:51-57.
22. Lochmiller RL, Vestey MR, and McMurray ST (1994) Temporal variation in humoral and cell-mediated immune response in a Sigmodon hispidus population. Ecology 75:236-245.
23. Lopez-Gonzales MA, Calvo JR, Osuna C, and Guerrero JM (1992) Interaction of melatonin with human lymphocytes: Evidence for binding sites coupled to potentiation of cyclic AMP stimulated vasoactive intestinal peptide and activation of cyclic GMP. J Pineal Res 12:97-104.
24. Maestroni GJ (1993) The immunoendocrine role of melatonin. J Pineal Res 14:1-10.
25. Maestroni GJ, Conti A, and Pierpaoli W (1986) Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone. J Neuroimmunol 13:19-30.
26. 125I]melatonin by rat thymus membranes during postnatal development. Immunol Lett 36:59-64.
27. McCruden AB and Stimson WH (1991) Sex hormones and immune function. In Psychoneuroimmunology, R Ader and J Cohen, eds, pp 475-493, Academic Press, New York.
28. Nelson RJ and Demas GE (1996) Seasonal changes in immune function. Q Rev Biol 71:512-548.
29. Nelson RJ, Demas GE, Klein SL, and Kriegsfeld LJ (1995) The influence of season, photoperiod and pineal melatonin on immune function. J Pineal Res 9:149-165.
30. 125I]iodomelatonin by spleen membrane preparations of chicken. J Pineal Res 12:167-173.
31. Pioli C, Varleo C, Nistico G, and Doria G (1993) Melatonin increases antigen presentation and amplifies specific and non-specific signals for T-cell proliferation. Int J Immunopharmacol 15:463-468.
32. Poon AM, Liu ZM, Pang CS, and Pang SF (1994) Evidence for a direct action of melatonin on the immune system. Biol Signals 3:107-117.
33. 125I]iodomelatonin by rat splenocytes: Characterization and its role on regulation of cyclic AMP production. J Neuroimmunol 57:171-178.
34. Reber PM (1993) Prolactin and immunomodulation. Am J Med 95:637-644.
35. Vaughan MK, Hubbard GB, Champney TH, Vaughan GM, and Little JC (1987) Splenic hypertrophy and extramedullary hematopoiesis induced in male Syrian hamsters by short photoperiod or melatonin injections and reversed by melatonin pellets or pinealectomy. Am J Anat 179:131-136.
36. Zapata AG, Varas A, and Torroba M (1992) Seasonal variations in the immune system of lower vertebrates. Immunol Today 13:142-147.