PGE 2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth

Prostaglandins and Other Lipid Mediators

Volumn 97, Issue 3-4, 2012, Pages 109-119

  Gruzdev, Artiom ^a   Nguyen, Mytrang ^a   Kovarova, Martina ^a   Koller, Beverly H ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Conditional gene knockout; Ductus arteriosus; EP4; Prostaglandins; Remodeling; Smooth muscle

Indexed keywords

PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL TONE; CELL LINEAGE; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; DUCTUS ARTERIOSUS; ENDOTHELIUM CELL; GENE CONTROL; GENE EXPRESSION; GENETIC ASSOCIATION; MICROARRAY ANALYSIS; MOUSE; NEURAL CREST; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SMOOTH MUSCLE; SURVIVAL RATE; ANIMAL; CELL MOTION; GENETICS; GENOME; METABOLISM; MOUSE STRAIN;

ANIMALS; CELL MOVEMENT; DINOPROSTONE; DUCTUS ARTERIOSUS; GENE EXPRESSION; GENOME; MICE; MICE, INBRED STRAINS; MUSCLE, SMOOTH; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE;

EID: 84858707901     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2012.02.001     Document Type: Article

References (48)

1. De Reeder EG, Girard N, Poelmann RE, et al. Hyaluronic acid accumulation and endothelial cell detachment in intimal thickening of the vessel wall. The normal and genetically defective ductus arteriosus. Am J Pathol 1988;132:574-85.
2. Momma K, Takeuchi H. Constriction of fetal ductus arteriosus by non-steroidal anti-inflammatory drugs. Prostaglandins 1983;26:631-43. (Pubitemid 14207805)
3. Heymann MA, Rudolph AM, Silverman NH. Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis. N Engl J Med 1976;295:530-3.
4. Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A 1993;90:11693-7. (Pubitemid 24008705)
5. Smith GC. The pharmacology of the ductus arteriosus. Pharmacol Rev 1998;50:35-58.
6. Elliott RB, Starling MB, Neutze JM. Medical manipulation of the ductus arteriosus. Lancet 1975;1:140-2.
7. Coceani F, Olley PM. The response of the ductus arteriosus to prostaglandins. Can J Physiol Pharmacol 1973;51:220-5.
8. Chang HY, Locker J, Lu R, Schuster VL. Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient mice. Circulation 2010;121:529-36.
9. Coggins KG, Latour A, Nguyen MS, et al. Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus. Nat Med 2002;8:91-2. (Pubitemid 34155104)
10. Uppal S, Diggle CP, Carr IM, et al. Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. Nat Genet 2008;40:789-93. (Pubitemid 351748871)
11. Clyman RI. Ontogeny of the ductus arteriosus response to prostaglandins and inhibitors of their synthesis. Semin Perinatol 1980;4:115-24. (Pubitemid 10081290)
12. Hristovska AM, Rasmussen LE, Hansen PB, et al. Prostaglandin E2 induces vascular relaxation by E-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthase. Hypertension 2007;50:525-30. (Pubitemid 47312239)
13. Carvajal JA, Germain AM, Huidobro-Toro JP, Weiner CP. Molecular mechanism of cGMP-mediated smooth muscle relaxation. J Cell Physiol 2000;184:409-20. (Pubitemid 30625505)
14. Narumiya S, FitzGerald GA. Genetic and pharmacological analysis of prostanoid receptor function. J Clin Invest 2001;108:25-30. (Pubitemid 32634917)
15. Engelhardt JF, Yankaskas JR, Wilson JM. In vivo retroviral gene transfer into human bronchial epithelia of xenografts. J Clin Invest 1992;90:2598-607. (Pubitemid 23010083)
16. Nguyen M, Camenisch T, Snouwaert JN, et al. The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth. Nature 1997;390:78-81. (Pubitemid 27494759)
17. Tilley SL, Audoly LP, Hicks EH, et al. Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor. J Clin Invest 1999;103:1539-45.
18. Farley FW, Soriano P, Steffen LS, Dymecki SM. Widespread recombinase expression using FLPeR (flipper) mice. Genesis 2000;28:106-10.
19. Koni PA, Joshi SK, Temann UA, et al. Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J Exp Med 2001;193:741-54.
20. Holtwick R, Gotthardt M, Skryabin B, et al. Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A 2002;99:7142-7. (Pubitemid 34526269)
21. Chai Y, Jiang X, Ito Y, et al. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 2000;127:1671-9. (Pubitemid 30234924)
22. Schwenk F, Baron U, Rajewsky K. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res 1995;23:5080-1. (Pubitemid 26012492)
23. Huang J, Cheng L, Li J, et al. Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest 2008;118:515-25. (Pubitemid 351206542)
24. Tilley SL, Hartney JM, Erikson CJ, et al. Receptors and pathways mediating the effects of prostaglandin E2 on airway tone. Am J Physiol Lung Cell Mol Physiol 2003;284:L599-606. (Pubitemid 36343308)
25. Hou G, Mulholland D, Gronska MA, Bendeck MP. Type VIII collagen stimulates smooth muscle cell migration and matrix metalloproteinase synthesis after arterial injury. Am J Pathol 2000;156:467-76. (Pubitemid 30643802)
26. Koch AE, Volin MV, Woods JM, et al. Regulation of angiogenesis by the C-X-C chemokines interleukin-8 and epithelial neutrophil activating peptide 78 in the rheumatoid joint. Arthritis Rheum 2001;44:31-40. (Pubitemid 32113115)
27. Heidemann J, Ogawa H, Dwinell MB, et al. Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. J Biol Chem 2003;278:8508-15. (Pubitemid 36800603)
28. Hager HA, Bader DM. Bves: ten years after. Histol Histopathol 2009;24:777-87.
29. Wada AM, Reese DE, Bader DM. Bves: prototype of a new class of cell adhesion molecules expressed during coronary artery development. Development 2001;128:2085-93. (Pubitemid 32600469)
30. Andree B, Fleige A, Arnold HH, Brand T. Mouse Pop1 is required for muscle regeneration in adult skeletal muscle. Mol Cell Biol 2002;22:1504-12. (Pubitemid 34150786)
31. Boudreau N, Turley E, Rabinovitch M. Fibronectin, hyaluronan, and a hyaluronan binding protein contribute to increased ductus arteriosus smooth muscle cell migration. Dev Biol 1991;143:235-47. (Pubitemid 121004649)
32. Mason CA, Chang P, Fallery C, Rabinovitch M. Nitric oxide mediates LC- 3-dependent regulation of fibronectin in ductus arteriosus intimal cushion formation. FASEB J 1999;13:1423-34. (Pubitemid 29382510)
33. Fujino T, Yuhki K, Yamada T, et al. Effects of the prostanoids on the proliferation or hypertrophy of cultured murine aortic smooth muscle cells. Br J Pharmacol 2002;136:530-9. (Pubitemid 34717697)
34. Bradbury D, Clarke D, Seedhouse C, et al. Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites. J Biol Chem 2005;280:29993-30000. (Pubitemid 41216174)
35. Kochupurakkal BS, Harari D, Di-Segni A, et al. Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. J Biol Chem 2005;280:8503-12. (Pubitemid 40349755)
36. Yamanaka Y, Hayashi K, Komurasaki T, et al. EGF family ligand-dependent phenotypic modulation of smooth muscle cells through EGF receptor. Biochem Biophys Res Commun 2001;281:373-7. (Pubitemid 32928165)
37. Goessling W, North TE, Loewer S, et al. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell 2009;136:1136-47.
38. Maciel TT, Melo RS, Schor N, Campos AH. Gremlin promotes vascular smooth muscle cell proliferation and migration. J Mol Cell Cardiol 2008;44: 370-9.
39. Moser M, Binder O, Wu Y, et al. BMPER, a novel endothelial cell precursorderived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol Cell Biol 2003;23:5664-79. (Pubitemid 36951331)
40. Zhu L, Vranckx R, Khau Van Kien P, et al. Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. Nat Genet 2006;38:343-9.
41. Morano I, Chai GX, Baltas LG, et al. Smooth-muscle contraction without smoothmuscle myosin. Nat Cell Biol 2000;2:371-5.
42. Klapholz-Brown Z, Walmsley GG, Nusse YM, Nusse R, Brown PO. Transcriptional program induced by Wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments. PLoS One 2007;2:e945.
43. Tuckerman JR, Zhao Y, Hewitson KS, et al. Determination and comparison of specific activity of the HIF-prolyl hydroxylases. FEBS Lett 2004;576:145-50. (Pubitemid 39330473)
44. Tristani-Firouzi M, Reeve HL, Tolarova S, Weir EK, Archer SL. Oxygeninduced constriction of rabbit ductus arteriosus occurs via inhibition of a 4-aminopyridine-, voltage-sensitive potassium channel. J Clin Invest 1996;98:1959-65. (Pubitemid 26376282)
45. Coceani F, Kelsey L, Seidlitz E. Occurrence of endothelium-derived relaxing factor - nitric oxide in the lamb ductus arteriosus. Can J Physiol Pharmacol 1994;72:82-8. (Pubitemid 24131039)
46. Fox JJ, Ziegler JW, Ivy DD, et al. Role of nitric oxide and cGMP system in regulation of ductus arteriosus tone in ovine fetus. Am J Physiol 1996;271:H2638-45.
47. Clyman RI, Waleh N, Black SM, et al. Regulation of ductus arteriosus patency by nitric oxide in fetal lambs: the role of gestation, oxygen tension, and vasa vasorum. Pediatr Res 1998;43:633-44. (Pubitemid 28196456)
48. Fujino H, Xu W, Regan JW. Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases. J Biol Chem 2003;278:12151-6. (Pubitemid 36800194)