Physical analysis of virus particles using electrospray differential mobility analysis

Trends in Biotechnology

Volumn 30, Issue 4, 2012, Pages 216-224

  Pease, Leonard F ^a,b,c  

^a Department of Electrical and Computer Engineering   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINS; VIRUSES;

BACTERIAL DETECTION; BIO-MANUFACTURING; ELECTROSPRAY-DIFFERENTIAL MOBILITY ANALYSIS; PHYSICAL ANALYSIS; PROCESS ANALYTICAL TECHNOLOGY; SUBNANOMETER PRECISION; VIRUS NEUTRALIZATION; VIRUS-LIKE PARTICLES;

PARTICLE SIZE ANALYSIS;

CAPSID PROTEIN; NANOCONJUGATE;

ADENOVIRUS; AMINO ACID ANALYSIS; ATOMIC FORCE MICROSCOPY; BACTERIOPHAGE; BACTERIUM DETECTION; BIOSEPARATION; BROMOVIRUS; COLIPHAGE; CORONAVIRUS; ELECTROPHORETIC MOBILITY; ELECTROSPRAY; ELECTROSPRAY DIFFERENTIAL MOBILITY ANALYSIS; FIELD FLOW FRACTIONATION; INTERMETHOD COMPARISON; ION MOBILITY SPECTROMETRY; LIGHT SCATTERING; MICROVIRIDAE; MOLECULAR WEIGHT; NONHUMAN; PARAMYXOVIRUS; PARTICLE SIZE; PARVOVIRUS; PICORNAVIRUS; PLANT VIRUS; POLYMERASE CHAIN REACTION; POLYOMA VIRUS; PRIORITY JOURNAL; PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REOVIRUS; REVIEW; SCANNING ELECTRON MICROSCOPY; TOGAVIRUS; TRANSMISSION ELECTRON MICROSCOPY; VIRAL CLEARANCE; VIRUS CELL INTERACTION; VIRUS CHARACTERIZATION; VIRUS CONCENTRATION; VIRUS IDENTIFICATION; VIRUS NEUTRALIZATION; VIRUS PARTICLE;

BACTERIA (MICROORGANISMS); MIRIDAE;

EID: 84858699364     PISSN: 01677799     EISSN: 18793096     Source Type: Journal    
DOI: 10.1016/j.tibtech.2011.11.004     Document Type: Review

References (80)

1. Middelberg A.P.J., et al. A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines. Vaccine 2011, 29:7154-7162.
2. Pease L.F., et al. Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopy. Biotech. Bioeng. 2009, 102:845-855.
3. Yim P.B., et al. Quantitative characterization of quantum dot-labeled lambda phage for Escherichia coli detection. Biotech. Bioeng. 2009, 104:1059-1067.
4. Cole K.D., et al. Particle concentration measurement of virus samples using electrospray differential mobility analysis and quantitative amino analysis. J. Chromatogr. A 2009, 57:5715-5722.
5. Ding X., et al. Vaccine characterization using advanced technology. BioPharm. Int. 2007, 20:A16.
6. Guha S., et al. Evaluation of electrospray differential mobility analysis for virus particle analysis: potential applications for biomanufacturing. J. Virol. Methods 2011, 178:201-208.
7. Lute S., et al. Small virus retentive filter test method recommended by the PDA virus filter task force. I. Method development. PDA J. Pharm. Sci. Tech. 2008, 62:318-333.
8. Pease L.F., et al. Physical characterization of icosahedral virus ultra structure, stability and integrity. Anal. Chem. 2011, 83:1753-1759.
9. Wick C.H., et al. Detection and integration of viruses using the integrated virus detection system (IVDS) 2005, Edgewood Chemical Biological Center.
10. Bacher G., et al. Charge-reduced nano electrospray ionization combined with differential mobility analysis of peptides, proteins, glycoproteins, noncovalent protein complexes and viruses. J. Mass Spectrom. 2001, 36:1038-1052.
11. Hogan C.J., et al. Charge reduced electrospray size spectrometry of mega- and gigadalton complexes: whole viruses and virus fragments. Anal. Chem. 2006, 78:844-852.
12. Jiang J., et al. Transfer functions and penetrations of five differential mobility analyzers for sub-2nm particle classification. J. Aerosol Sci. 2011, 45:480-492.
13. Knutson E.O., Whitby K.T. Aerosol classification by electric mobility: apparatus, theory, and applications. J. Aerosol Sci. 1975, 6:443-451.
14. Pease L.F., et al. Quantifying the surface coverage of conjugate molecules on functionalized nanoparticles. J. Phys. Chem. C 2007, 111:17155-17157.
15. Stolzenburg M.R., McMurry P.H. Equations governing single and tandem DMA configurations and a new lognormal approximation to the transfer function. Aerosol Sci. Tech. 2008, 42:421-432.
16. Wiedensohler A. An approximation of the bipolar charge-distribution for particles in the sub-micron size range. J. Aerosol Sci. 1988, 19:387-389.
17. Whitehouse C.M., et al. Electrospray interface for liquid chromatographs and mass spectrometers. Anal. Chem. 1985, 57:675-679.
18. Ruotolo B.T., et al. Ion mobility-mass spectrometry analysis of large protein complexes. Nat. Protoc. 2008, 3:1139-1152.
19. Ebeling D.D., et al. Corona discharge in charge reduction electrospray mass spectrometry. Anal. Chem. 2000, 72:5158-5161.
20. Allmaier G., et al. Nano ES GEMMA and PDMA, new tools for the analysis of nanobioparticles-protein complexes, lipoparticles, and viruses. J. Am. Soc. Mass Spectrom. 2008, 19:1062-1068.
21. Hogan C.J., et al. Sampling methodologies and dosage assessment techniques for submicrometre and ultrafine virus aerosol particles. J. Appl. Microbiol. 2005, 99:1422-1434.
22. Pease L.F., et al. Packing and size determination of colloidal nanoclusters. Langmuir 2010, 26:11384-11390.
23. Tsai D.H., et al. Gas-phase ion-mobility characterization of SAM-functionalized Au nanoparticles. Langmuir 2008, 24:8483-8490.
24. Tsai D.-H., et al. Aggregation kinetics of gold nanoparticles in suspension measured by gas-phase differential mobility analysis. Langmuir 2009, 25:140-146.
25. Dixkens J., Fissan H. Development of an electrostatic precipitator for off-line particle analysis. Aerosol Sci. Tech. 1999, 30:438-453.
26. Allmaier G., et al. Parallel differential mobility analysis for electrostatic characterization and manipulation of nanoparticles and viruses. Trends Anal. Chem. 2011, 30:123-132.
27. Anumolu R., et al. Fabrication of highly uniform nanoparticles from recombinant silk-elastin polymers for gene delivery applications. ACS Nano 2011, 5:5374-5382.
28. Eichler T., et al. Improvement of the resolution of TSI's 3071 DMA via redesigned sheath air and aerosol inlets. Aerosol Sci. Tech. 1998, 29:39-49.
29. Fernandez de la Mora J. Sub-3 nm aerosol measurement with dmas and cncs. Aerosol measurement: principles, techniques and applications 2011, John Wiley & Sons. P. Kulkarni (Ed.).
30. Kaddis C.S., et al. Sizing large proteins and protein complexes by electrospray ionization mass spectrometry and ion mobility. J. Am. Soc. Mass Spectrom. 2007, 18:1206-1216.
31. Kaufman S.L., et al. Analysis of a 3.6-MDa hexagonal bilayer hemoglobin from Lumbricus terrestris using a gas-phase electrophoretic mobility molecular analyzer. Anal. Biochem. 1998, 259:195-202.
32. Kaufman S.L., et al. Macromolecule analysis based on electrophoretic mobility in air: globular proteins. Anal. Chem. 1996, 68:1895-1904.
33. Mouradian S., et al. DNA analysis using an electrospray scanning mobility particle sizer. Anal. Chem. 1997, 69:919-925.
34. Thomas J.J., et al. Electrospray ion mobility spectrometry of intact viruses. Spectrosc. Int. J. 2004, 18:31-36.
35. Fernández de la Mora J. Free-molecule mobilities of polyhedra and other convex hard-bodies. J. Aerosol Sci. 2002, 33:477-489.
36. Kapellios E.A., et al. Using nanoelectrospray ion mobility spectrometry (GEMMA) to determine the size and relative molecular mass of proteins and protein assemblies: a comparison with MALLS and QELS. Anal. Bioanal. Chem. 2011, 399:2421-2433.
37. Han L., et al. Bound anions differentially stabilize multiprotein complexes in the absence of bulk solvent. J. Am. Chem. Soc. 2011, 133:11358-11367.
38. Hogan C.J., et al. Tandem differential mobility analysis-mass spectrometry reveals partial gas-phase collapse of the GroEL complex. J. Phys. Chem. B 2011, 115:3614-3621.
39. Jung J.H., et al. Generation of nonagglomerated airborne bacteriophage particles using an electrospray technique. Anal. Chem. 2009, 81:2985-2990.
40. Hogan C.J., Biswas P. Monte Carlo simulation of macromolecular ionization by nanoelectrospray. J. Am. Soc. Mass Spectrom. 2008, 19:1098-1107.
41. Fuerstenau S.D., et al. Mass spectrometry of an intact virus. Angew. Chem. Int. Ed Engl. 2001, 40:541-544.
42. Pease L.F., et al. Structural analysis of soft multicomponent nanoparticle clusters. ACS Nano 2010, 4:6982-6988.
43. Wick C.H., McCubbin P.E. Characterization of purified MS2 bacteriophage by the physical counting methodology used in the integrated virus detection system (IVDS). Toxicol. Mech. Methods 1999, 9:245-252.
44. Pease L.F., et al. Determination of protein aggregation with differential mobility analysis: application to IgG antibody. Biotechnol. Bioeng. 2008, 101:1214-1222.
45. Li M., et al. Quantification and compensation of nonspecific analyte aggregation in electrospray sampling. Aerosol Sci. Tech. 2011, 45:849-860.
46. Lall A.A., Friedlander S.K. On-line measurement of ultrafine aggregate surface area and volume distributions by electrical mobility analysis: I. Theoretical analysis. J. Aerosol Sci. 2006, 37:260-271.
47. Tsai D.-H., et al. Process analytical technology for recombinant pandemic flu vaccines: viral ultrastructure, aggregation, and binding. Proc AIChE 2011 Annual Meeting 2011.
48. Eninger R.M., et al. Electrospray versus nebulization for aerosolization and filter testing with bacteriophage particles. Aerosol Sci. Tech. 2009, 43:298-304.
49. Pattenden L.K., et al. Towards the preparative and large-scale precision manufacture of virus-like particles. Trends Biotechnol. 2005, 23:523-529.
50. Garcea R.L., Gissmann L. Virus-like particles as vaccines and vessels for the delivery of small molecules. Curr. Opin. Biotechnol. 2004, 15:513-517.
51. Noad R., Roy P. Virus-like particles as immunogens. Trends Microbiol. 2003, 11:438-444.
52. Koutsky L.A., et al. A controlled trial of a human papillomavirus type 16 vaccine. N. Engl. J. Med. 2002, 347:1645-1651.
53. Scolnick E.M., et al. Clinical-evaluation in healthy-adults of a hepatitis-B vaccine made by recombinant DNA. JAMA 1984, 251:2812-2815.
54. Ding Y., et al. Modeling the competition between aggregation and self-assembly during virus-like particle processing. Biotechnol. Bioeng. 2010, 107:550-560.
55. Pease L.F., et al. Probing the nucleus model for oligomer formation during insulin amyloid fibrillogenesis. Biophys. J. 2010, 99:3979-3985.
56. Benesch J.L., et al. Tandem mass spectrometry reveals the quaternary organization of macromolecular assemblies. Chem. Biol. 2006, 13:597-605.
57. Knapman T.W., et al. Determining the topology of virus assembly intermediates using ion mobility spectrometry-mass spectrometry. Rapid Commun. Mass Spectrom. 2010, 24:3033-3042.
58. Ashcroft A.E. Recent developments in electrospray ionisation mass spectrometry: noncovalently bound protein complexes. Nat. Prod. Rep. 2005, 22:452-464.
59. Ruotolo B.T., et al. Evidence for macromolecular protein rings in the absence of bulk water. Science 2005, 310:1658-1661.
60. Shvartsburg A.A., et al. Optimization of algorithms for ion mobility calculations. J. Phys. Chem. A 2007, 111:2002-2010.
61. Cosma A., et al. Neutralization assay using a modified vaccinia virus Ankara vector expressing the green fluorescent protein is a high-throughput method to monitor the humoral immune response against vaccinia virus. Clin. Diagn. Lab. Immunol. 2004, 11:406-410.
62. de Graaf M., et al. An improved plaque reduction virus neutralization assay for human metapneumovirus. J. Virol. Methods 2007, 143:169-174.
63. Sprangers M.C., et al. Quantifying adenovirus-neutralizing antibodies by luciferase transgene detection: addressing preexisting immunity to vaccine and gene therapy vectors. J. Clin. Microbiol. 2003, 41:5046-5052.
64. van den Hoogen B.G., et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat. Med. 2001, 7:719-724.
65. Zielinska E., et al. Development of an improved microneutralization assay for respiratory syncytial virus by automated plaque counting using imaging analysis. Virol. J. 2005, 2:84.
66. Laschober C., et al. Gas-phase electrophoretic molecular mobility analysis of size and stoichiometry of complexes of a common cold virus with antibody and soluble receptor molecules. Anal. Chem. 2008, 80:2261-2264.
67. Dahneke B.E. Slip correction factors for nonspherical bodies-II free molecule flow. J. Aerosol Sci. 1973, 4:147-161.
68. Edgar R., et al. High-sensitivity bacterial detection using biotin-tagged phage and quantum-dot nanocomplexes. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:4841-4845.
69. Wang S.C., Flagan R.C. Scanning electrical mobility spectrometer. Aerosol Sci. Tech. 1990, 12:230-240.
70. Narayanan N., et al. A microfabricated electrical SPLITT system. Lab Chip 2006, 6:105-114.
71. Deng W.W., et al. Increase of electrospray throughput using multiplexed microfabricated sources for the scalable generation of monodisperse droplets. J. Aerosol Sci. 2006, 37:696-714.
72. Ku B.K., et al. Mass distribution measurement of water-insoluble polymers by charge-reduced electrospray mobility analysis. Anal. Chem. 2004, 76:814-822.
73. Smith D.P., et al. Deciphering drift time measurements from travelling wave ion mobility spectrometry-mass spectrometry studies. Eur. J. Mass Spectrom. (Chichester, Eng) 2009, 15:113-130.
74. Uetrecht C., et al. Stability and shape of hepatitis B virus capsids in vacuo. Angew. Chem. Int. Ed Engl. 2008, 47:6247-6251.
75. Uetrecht C., et al. High-resolution mass spectrometry of viral assemblies: molecular composition and stability of dimorphic hepatitis B virus capsids. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:9216-9220.
76. Kuzmanovic D.A., et al. A novel application of small-angle scattering techniques: Quality assurance testing of virus quantification technology. Radiat. Phys. Chem. 2008, 77:215-224.
77. Pease L.F. Optimizing the yield and selectivity of high purity nanoparticle clusters. J. Nanopart. Res. 2010, 13:2157-2172.
78. Pease L.F., et al. Length distribution of single-walled carbon nanotubes in aqueous suspension measured by electrospray differential mobility analysis. Small 2009, 5:2894-2901.
79. Song D.K., et al. Changes in the shape and mobility of colloidal gold nanorods with electrospray and differential mobility analyzer methods. Langmuir 2005, 21:10375-10382.
80. Taylor G.I. Disintegration of water drops in an electric field. Proc. R. Soc. Lond. 1964, 280:383-397.