Process analytical technology for recombinant pandemic flu vaccines: Viral ultrastructure, aggregation, and binding

AIChE Annual Meeting, Conference Proceedings

Volumn , Issue , 2011, Pages

  Tsai, De Hao ^a   Lipin, Daniel I ^b   Guha, Suvajyoti ^a,c   Feldblyum, Jeremy I ^a,c   Cole, Kenneth D ^a   Brorson, Kurt A ^d   Zachariah, Michael R ^a,c   Tarlov, Michael J ^a   Middelberg, Anton P J ^b   Pease III, Leonard F ^a,e  

^a NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF MARYLAND   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED PROCESS CONTROL; AGGREGATION STATE; AVIAN INFLUENZA; CLINICAL TREATMENTS; DIFFERENTIAL MOBILITY ANALYSIS; ELECTROSPRAYS; PANDEMIC FLU; PROCESS ANALYTICAL TECHNOLOGY; PRODUCTION METHODS; PRODUCTION RATES; PUBLIC CONCERN; VIRUS-LIKE PARTICLES;

DRUG PRODUCTS PLANTS; INTELLIGENT CONTROL; STOICHIOMETRY; VACCINES; VIRUSES;

AGGLOMERATION;

EID: 84856754622     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (36)

1. Middelberg APJ, Rivera-Hernandez T, Wibowo N, et al. A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines. Vaccine. 2011:doi:10.1016/j.vaccine.2011.1005.1075.
2. Hanslip SJ, Zaccai NR, Middelberg AP, Falconer RJ. Intrinsic fluorescence as an analytical probe of virus-like particle assembly and maturation. Biochem Biophys Res Commun. Oct 24 2008;375(3):351-355.
3. Hanslip SJ, Zaccai NR, Middelberg AP, Falconer RJ. Assembly of human papillomavirus type-16 virus-like particles: multifactorial study of assembly and competing aggregation. Biotechnol Prog. Mar-Apr 2006;22(2):554-560.
4. Pattenden LK, Middelberg AP, Niebert M, Lipin DI. Towards the preparative and largescale precision manufacture of virus-like particles. Trends Biotechnol. Oct 2005;23(10):523-529.
5. Middelberg AP, Rivera-Hernandez T, Wibowo N, et al. A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines. Vaccine. Jun 7 2011.
6. Liew MW, Rajendran A, Middelberg AP. Microbial production of virus-like particle vaccine protein at gram-per-litre levels. J Biotechnol. Oct 15 2010;150(2):224-231.
7. Ding Y, Chuan YP, He L, Middelberg AP. Modeling the competition between aggregation and self-assembly during virus-like particle processing. Biotechnol Bioeng. Oct 15 2010;107(3):550-560.
8. Pease LF, Tsai DH, Brorson KA, Guha S, Zachariah MR, Tarlov MJ. Physical characterization of icosahedral virus ultra structure, stability, and integrity using electrospray differential mobility analysis. Anal Chem. Feb 8 2011;83:1753-1759.
9. Pease LF, Tsai DH, Zangmeister RA, Zachariah MR, Tarlov MJ. Quantifying the surface coverage of conjugate molecules on functionalized nanoparticles. J Phys Chem C. Nov 22 2007;111(46):17155-17157.
10. Bacher G, Szymanski WW, Kaufman SL, Zollner P, Blaas D, Allmaier G. Charge-reduced nano electrospray ionization combined with differential mobility analysis of peptides, proteins, glycoproteins, noncovalent protein complexes and viruses. J Mass Spectrom. Sep 2001;36(9):1038-1052.
11. Knutson EO, Whitby KT. Aerosol classification by electrical mobility: apparatus, theory, and applications. J. Aerosol. Sci. 1975;6:443-451.
12. Wiedensohler A. An approximation of the bipolar charge-distribution for particles in the sub-micron size range. J. Aerosol Sci. Jun 1988;19(3):387-389.
13. Cole KD, Pease LF, Tsai DH, et al. Particle concentration measurement of virus samples using electrospray differential mobility analysis and quantitative amino acid analysis. J Chromatogr A. Jul 24 2009;1216(30):5715-5722.
14. Pease LF, Lipin DI, Tsai DH, et al. Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopy. Biotechnol Bioeng. Feb 15 2009;102(3):845-855.
15. Lute S, Riordan W, Pease LF, et al. A consensus rating method for small virus-retentive filters. I. Method development. PDA J Pharm Sci Technol. Sep-Oct 2008;62(5):318-333.
16. Pease LF, Elliott JT, Tsai DH, Zachariah MR, Tarlov MJ. Determination of protein aggregation with differential mobility analysis: application to IgG antibody. Biotechnol Bioeng. Dec 15 2008;101(6):1214-1222.
17. Tsai DH, Zangmeister RA, Pease LF, Tarlov MJ, Zachariah MR. Gas-phase ion-mobility characterization of SAM-functionalized Au nanoparticles. Langmuir. Aug 19 2008;24(16):8483-8490.
18. Lute S, Aranha H, Tremblay D, et al. Characterization of coliphage PR772 and evaluation of its use for virus filter performance testing. Appl Environ Microbiol. Aug 2004;70(8):4864-4871.
19. Lute S, Bailey M, Combs J, Sukumar M, Brorson K. Phage passage after extended processing in small-virus-retentive filters. Biotechnol Appl Biochem. Jul 2007;47(Pt 3):141-151.
20. Smith JM, VanNess HS, Abbott MM. Introduction to Chemical Engineering Thermodynamics. 5th ed. New York: McGraw-Hill; 1996.
21. Kaufman SL, Skogen JW, Dorman FD, Zarrin F, Lewis KC. Macromolecule analysis based on electrophoretic mobility in air: globular proteins. Anal Chem. Jun 1 1996;68(11):1895-1904.
22. Pease LF, Tsai DH, Hertz JL, Zangmeister RA, Zachariah MR, Tarlov MJ. Packing and size determination of colloidal nanoclusters. Langmuir. Jul 6 2010;26(13):11384-11390.
23. Pease LF, Sorci M, Guha S, et al. Probing the nucleus model for oligomer formation during insulin amyloid fibrillogenesis. Biophys J. Dec 15 2010;99(12):3979-3985.
24. Pease LF, Feldblyum JI, Depaoli Lacaerda SH, et al. Structural analysis of soft multicomponent nanoparticle clusters. ACS Nano. Nov 23 2010;4(11):6982-6988.
25. Tars K, Fridborg K, Bundule M, Liljas L. The three-dimensional structure of bacteriophage PP7 from Pseudomonas aeruginosa at 3.7-A resolution. Virology. Jul 5 2000;272(2):331-337.
26. Brorson K, Krejci S, Lee K, Hamilton E, Stein K, Xu Y. Bracketed generic inactivation of rodent retroviruses by low pH treatment for monoclonal antibodies and recombinant proteins. Biotechnol Bioeng. May 5 2003;82(3):321-329.
27. Guha S, Pease LF, Brorson KA, Tarlov MJ, Zachariah MR. Evaluation of electrospray differential mobility analysis for virus particle analysis: potential applications for biomanufacturing. J. Virolog. Meth. 2011:submitted.
28. Hogan CJ, Kettleson EM, Ramaswami B, Chen DR, Biswas P. Charge reduced electrospray size spectrometry of mega- and gigadalton complexes: Whole viruses and virus fragments. Anal Chem. Feb 1 2006;78(3):844-852.
29. Laschober C, Wruss J, Blaas D, Szymanski WW, Allmaier G. Gas-phase electrophoretic molecular mobility analysis of size and stoichiometry of complexes of a common cold virus with antibody and soluble receptor molecules. Anal Chem. Mar 15 2008;80(6):2261-2264.
30. Pease LF. Optimizing the yield and selectivity of high purity nanoparticle clusters. J. Nanopart. Res. 2011;13 2157-2172.
31. Anumolu R, Gustafson JA, Magda JJ, Cappello J, Ghandehari H, Pease LF. Fabrication of highly uniform nanoparticles from recombinant silk-elastin-like protein polymers for therapeutic agent delivery. ACS Nano. Jul 5 2011;5:5374-5382.
32. Pease LF, Tsai DH, Fagan JA, et al. Length distribution of single-walled carbon nanotubes in aqueous suspension measured by electrospray differential mobility analysis. Small. Dec 2009;5(24):2894-2901.
33. Tsai DH, Pease LF, Zangmeister RA, Tarlov MJ, Zachariah MR. Aggregation kinetics of colloidal particles measured by gas-phase differential mobility analysis. Langmuir. Jan 6 2009;25(1):140-146.
34. Yim PB, Clarke ML, McKinstry M, et al. Quantitative characterization of quantum dotlabeled lambda phage for Escherichia coli detection. Biotechnol Bioeng. Dec 15 2009;104(6):1059-1067.
35. Happel J, Brenner H. Low Reynolds number hydrodynamics. The Hague: Kluwer Academic Publishers 1983.
36. Russel WB, Saville DA, Schowalter WR. Colloidal Dispersons. Cambridge, UK: Cambridge University Press; 1989.