Regulation of macrophage function by adenosine

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 32, Issue 4, 2012, Pages 865-869

  Haskó, György ^a   Pacher, Pál ^b  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

cytokines; G proteins; immune system; immunosuppressive therapy; macrophages

Indexed keywords

ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; GAMMA INTERFERON; HEME OXYGENASE 1; INTERLEUKIN 10; INTERLEUKIN 12; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; DENDRITIC CELL; MACROPHAGE; MACROPHAGE ACTIVATION; MONOCYTE; NONHUMAN; OSTEOBLAST; PHAGOCYTE; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; UPREGULATION;

ADENOSINE; ANIMALS; CELL DIFFERENTIATION; HUMANS; INFLAMMATION; MACROPHAGE ACTIVATION; MACROPHAGES; NEOPLASMS; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOCLASTS; PHAGOCYTOSIS; RECEPTORS, PURINERGIC P1; SIGNAL TRANSDUCTION; VASCULAR DISEASES;

EID: 84858693780     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.226852     Document Type: Article

References (59)

1. Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, Ley K. Development of monocytes, macrophages, and dendritic cells. Science. 2010;327:656-661.
2. Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nature Reviews Immunology. 2011;11:723-737.
3. Hasko G, Linden J, Cronstein B, Pacher P. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov. 2008;7:759-770.
4. Ernst PB, Garrison JC, Thompson LF. Much ado about adenosine: Adenosine synthesis and function in regulatory t cell biology. J Immunol. 2010;185:1993-1998.
5. Sitkovsky MV, Lukashev D, Apasov S, Kojima H, Koshiba M, Caldwell C, Ohta A, Thiel M. Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine a2a receptors. Annu Rev Immunol. 2004;22:657-682. (Pubitemid 38680437)
6. Fredholm BB, AP IJ, Jacobson KA, Klotz KN, Linden J. International union of pharmacology: XXV. Nomenclature and classification of adenosine receptors. Pharmacological reviews. 2001;53:527-552. (Pubitemid 33136237)
7. Yegutkin GG. Nucleotide-and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade. Biochim Biophys Acta. 2008;1783:673-694.
8. Thammavongsa V, Kern JW, Missiakas DM, Schneewind O. Staphylococcus aureus synthesizes adenosine to escape host immune responses. Journal of Experimental Medicine. 2009;206:2417-2427.
9. Crane JK, Olson RA, Jones HM, Duffey ME. Release of ATP during host cell killing by enteropathogenic E. coli and its role as a secretory mediator. American journal of physiology Gastrointestinal and liver physiology. 2002;283:G74-G86. (Pubitemid 34666165)
10. Tasca T, Bonan CD, Carli GA, Battastini AM, Sarkis JJ. Characterization of an ecto-5=-nucleotidase (ec 3.1.3.5) activity in intact cells of trichomonas vaginalis. Experimental Parasitology. 2003;105:167-173. (Pubitemid 38221305)
11. Merrill JT, Shen C, Schreibman D, Coffey D, Zakharenko O, Fisher R, Lahita RG, Salmon J, Cronstein BN. Adenosine a1 receptor promotion of multinucleated giant cell formation by human monocytes: A mechanism for methotrexate-induced nodulosis in rheumatoid arthritis. Arthritis and Rheumatism. 1997;40:1308-1315. (Pubitemid 27430143)
12. Kara FM, Chitu V, Sloane J, Axelrod M, Fredholm BB, Stanley ER, Cronstein BN. Adenosine a1 receptors (a1rs) play a critical role in osteoclast formation and function. FASEB J. 2010;24:2325-2333.
13. Kara FM, Doty SB, Boskey A, Goldring S, Zaidi M, Fredholm BB, Cronstein BN. Adenosine a(1) receptors regulate bone resorption in mice: Adenosine a(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine a(1) receptorknockout mice. Arthritis and Rheumatism. 2010;62:534-541.
14. Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM. Adenosine receptors in regulation of dendritic cell differentiation and function. Blood. 2008;112:1822-1831.
15. Ryzhov S, Novitskiy SV, Zaynagetdinov R, Goldstein AE, Carbone DP, Biaggioni I, Dikov MM, Feoktistov I. Host a(2b) adenosine receptors promote carcinoma growth. Neoplasia. 2008;10:987-995.
16. Cekic C, Sag D, Li Y, Theodorescu D, Strieter RM, Linden J. Adenosine a2b receptor blockade slows growth of bladder and breast tumors. Journal of Immunology. 2011.
17. Gordon S. Alternative activation of macrophages. Nature Reviews Immunology. 2003;3:23-35. (Pubitemid 37328697)
18. Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm. Nature Immunology. 2010; 11:889-896.
19. Hasko G, Kuhel DG, Chen JF, Schwarzschild MA, Deitch EA, Mabley JG, Marton A, Szabo C. Adenosine inhibits il-12 and tnf-[alpha] production via adenosine a2a receptor-dependent and independent mechanisms. FASEB J. 2000;14:2065-2074.
20. Szabo C, Scott GS, Virag L, Egnaczyk G, Salzman AL, Shanley TP, Hasko G. Suppression of macrophage inflammatory protein (mip)-1alpha production and collagen-induced arthritis by adenosine receptor agonists. Br J Pharmacol. 1998;125:379-387. (Pubitemid 28425204)
21. Hasko G, Szabo C, Nemeth ZH, Kvetan V, Pastores SM, Vizi ES. Adenosine receptor agonists differentially regulate il-10, TNF-alpha, and nitric oxide production in raw 264.7 macrophages and in endotoxemic mice. J Immunol. 1996;157:4634-4640. (Pubitemid 126449386)
22. Barnholt KE, Kota RS, Aung HH, Rutledge JC. Adenosine blocks ifngamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation. Journal of Immunology. 2009;183:6767-6777.
23. Hasko G, Cronstein BN. Adenosine: an endogenous regulator of innate immunity. Trends in Immunology. 2004;25:33-39. (Pubitemid 38032805)
24. Hasko G, Pacher P, Deitch EA, Vizi ES. Shaping of monocyte and macrophage function by adenosine receptors. Pharmacol Ther. 2007;113: 264-275. (Pubitemid 46149045)
25. Kreckler LM, Wan TC, Ge ZD, Auchampach JA. Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via a2a and a2b but not the a3 adenosine receptor. J Pharmacol Exp Ther. 2006;317:172-180.
26. Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Blackburn MR, Biaggioni I, Feoktistov I. Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines. J Pharmacol Exp Ther. 2008;324:694-700. (Pubitemid 351185857)
27. Scheibner KA, Boodoo S, Collins S, Black KE, Chan-Li Y, Zarek P, Powell JD, Horton MR. The adenosine A2A receptor inhibits matrixinduced inflammation in a novel fashion. Am J Respir Cell Mol Biol. 2009;40:251-259.
28. Buenestado A, Grassin Delyle S, Arnould I, Besnard F, Naline E, Blouquit-Laye S, Chapelier A, Bellamy JF, Devillier P. The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages. British Journal of Pharmacology. 2010;159:1304-1311.
29. Zhang JG, Hepburn L, Cruz G, Borman RA, Clark KL. The role of adenosine a2a and a2b receptors in the regulation of tnf-alpha production by human monocytes. Biochemical Pharmacology. 2005;69:883-889. (Pubitemid 40312706)
30. Chen H, Yang D, Carroll SH, Eltzschig HK, Ravid K. Activation of the macrophage a2b adenosine receptor regulates tumor necrosis factor-alpha levels following vascular injury. Experimental Hematology. 2009;37: 533-538.
31. Belikoff BG, Hatfield S, Georgiev P, Ohta A, Lukashev D, Buras JA, Remick DG, Sitkovsky M. A2b adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in mice. Journal of Immunology. 2011;186:2444-2453.
32. Kreckler LM, Gizewski E, Wan TC, Auchampach JA. Adenosine suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production by murine macrophages through a protein kinase a-and exchange protein activated by camp-independent signaling pathway. Journal of Pharmacology and Experimental Therapeutics. 2009;331:1051-1061.
33. Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE. Cross-regulation of carbon monoxide and the adenosine A2A receptor in macrophages. Journal of Immunology. 2007;178:5921-5929. (Pubitemid 46674389)
34. Weis N, Weigert A, von Knethen A, Brune B. Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants. Molecular Biology of the Cell. 2009;20: 1280-1288.
35. Csoka B, Nemeth ZH, Selmeczy Z, Koscso B, Pacher P, Vizi ES, Deitch EA, Hasko G. Role of a(2a) adenosine receptors in regulation of opsonized e. Coli-induced macrophage function. Purinergic Signal. 2007; 3:447-452.
36. Nemeth ZH, Lutz CS, Csoka B, Deitch EA, Leibovich SJ, Gause WC, Tone M, Pacher P, Vizi ES, Hasko G. Adenosine augments il-10 production by macrophages through an a2b receptor-mediated posttranscriptional mechanism. J Immunol. 2005;175:8260-8270. (Pubitemid 41798391)
37. Ruiz-Garcia A, Monsalve E, Novellasdemunt L, Navarro-Sabate A, Manzano A, Rivero S, Castrillo A, Casado M, Laborda J, Bartrons R, Diaz-Guerra MJ. Cooperation of adenosine with macrophage toll-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of pfkfb3 gene. Journal of Biological Chemistry. 2011;286: 19247-19258.
38. Martinez FO, Sica A, Mantovani A, Locati M. Macrophage activation and polarization. Frontiers in Bioscience: A Journal and Virtual Library. 2008;13:453-461. (Pubitemid 351599757)
39. Murray PJ, Wynn TA. Obstacles and opportunities for understanding macrophage polarization. Journal of Leukocyte Biology. 2011;89: 557-563.
40. Albina JE, Mills CD, Henry WL, Henry WL., Caldwell MD. Temporal expression of different pathways of 1-arginine metabolism in healing wounds. J Immunol. 1990;144:3877-3880. (Pubitemid 20171200)
41. Csoka B, Selmeczy Z, Koscso B, Nemeth ZH, Pacher P, Murray PJ, Kepka-Lenhart D, Morris SM, Jr., Gause WC, Leibovich SJ, Hasko G. Adenosine promotes alternative macrophage activation via a2a and a2b receptors. FASEB J. 2011; PMID: 21926236 [PubMed-as supplied by publisher].
42. Raes G, Brys L, Dahal BK, Brandt J, Grooten J, Brombacher F, Vanham G, Noel W, Bogaert P, Boonefaes T, Kindt A, Van den Bergh R, Leenen PJ, De Baetselier P, Ghassabeh GH. Macrophage galactose-type c-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation. J Leukoc Biol. 2005;77:321-327. (Pubitemid 40289561)
43. Kreider T, Anthony RM, Urban JF, Urban JF, Gause WC. Alternatively activated macrophages in helminth infections. Curr Opin Immunol. 2007; 19:448-453. (Pubitemid 47299196)
44. Koroskenyi K, Duro E, Pallai A, Sarang Z, Kloor D, Ucker DS, Beceiro S, Castrillo A, Chawla A, Ledent CA, Fesus L, Szondy Z. Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation. Journal of immunology. 2011;186:7144-7155.
45. Barczyk K, Ehrchen J, Tenbrock K, Ahlmann M, Kneidl J, Viemann D, Roth J. Glucocorticoids promote survival of anti-inflammatory macrophages via stimulation of adenosine receptor A3. Blood. 2010;116: 446-455.
46. Semenza GL. Vascular responses to hypoxia and ischemia. Arterioscler Thromb Vasc Biol. 2010;30:648-652.
47. Martin P, Leibovich SJ. Inflammatory cells during wound repair: The good, the bad and the ugly. Trends in Cell Biology. 2005;15:599-607. (Pubitemid 41619424)
48. Leibovich SJ, Chen JF, Pinhal-Enfield G, Belem PC, Elson G, Rosania A, Ramanathan M, Montesinos C, Jacobson M, Schwarzschild MA, Fink JS, Cronstein B. Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin. Am J Pathol. 2002;160:2231-2244. (Pubitemid 34663413)
49. Adair TH. Growth regulation of the vascular system: An emerging role for adenosine. Am J Physiol Regul Integr Comp Physiol. 2005;289: R283-RR296.
50. Pinhal-Enfield G, Ramanathan M, Hasko G, Vogel SN, Salzman AL, Boons GJ, Leibovich SJ. An angiogenic switch in macrophages involving synergy between toll-like receptors 2, 4, 7, and 9 and adenosine a(2a) receptors. Am J Pathol. 2003;163:711-721. (Pubitemid 36909432)
51. Ramanathan M, Luo W, Csoka B, Hasko G, Lukashev D, Sitkovsky MV, Leibovich SJ. Differential regulation of hif-1alpha isoforms in murine macrophages by TLR4 and adenosine A(2A) receptor agonists. Journal of Leukocyte Biology. 2009;86:681-689.
52. De Ponti C, Carini R, Alchera E, Nitti MP, Locati M, Albano E, Cairo G, Tacchini L. Adenosine A2A receptor-mediated, normoxic induction of HIF-1 through PKC and pi-3k-dependent pathways in macrophages. Journal of Leukocyte Biology. 2007;82:392-402. (Pubitemid 47230651)
53. Ramanathan M, Pinhal-Enfield G, Hao I, Leibovich SJ. Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine a2a receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the vegf promoter. Mol Biol Cell. 2007;18:14-23. (Pubitemid 46066706)
54. Gessi S, Fogli E, Sacchetto V, Merighi S, Varani K, Preti D, Leung E, Maclennan S, Borea PA. Adenosine modulates HIF-1{alpha}, VEGF, IL-8, and foam cell formation in a human model of hypoxic foam cells. ATVB. 2010;30:90-97.
55. Ernens I, Leonard F, Vausort M, Rolland-Turner M, Devaux Y, Wagner DR. Adenosine up-regulates vascular endothelial growth factor in human macrophages. Biochemical and Biophysical Research Communications. 2010;392:351-356.
56. Leonard F, Devaux Y, Vausort M, Ernens I, Rolland-Turner M, Wagner DR. Adenosine modifies the balance between membrane and soluble forms of FLT-1. Journal of Leukocyte Biology. 2011;90:199-204.
57. McPherson JA, Barringhaus KG, Bishop GG, Sanders JM, Rieger JM, Hesselbacher SE, Gimple LW, Powers ER, Macdonald T, Sullivan G, Linden J, Sarembock IJ. Adenosine a(2a) receptor stimulation reduces inflammation and neointimal growth in a murine carotid ligation model. Arteriosclerosis, Thrombosis, and Vascular Biology. 2001;21:791-796.
58. Yang D, Koupenova M, McCrann DJ, Kopeikina KJ, Kagan HM, Schreiber BM, Ravid K. The A2B adenosine receptor protects against vascular injury. Proc Natl Acad Sci USA. 2008;105:792-796. (Pubitemid 351171787)
59. Wang H, Zhang W, Zhu C, Bucher C, Blazar BR, Zhang C, Chen JF, Linden J, Wu C, Huo Y. Inactivation of the adenosine a2a receptor protects apolipoprotein e-deficient mice from atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2009;29:1046-1052.