메뉴 건너뛰기




Volumn 227, Issue 7, 2012, Pages 2898-2906

A novel human hepatoma cell line, FLC-4, exhibits highly enhanced liver differentiation functions through the three-dimensional cell shape

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN E; BETA ACTIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CYTOCHROME P450 3A4; CYTOCHROME P450 3A7; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; LAMININ;

EID: 84858682540     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.23033     Document Type: Article
Times cited : (16)

References (34)
  • 1
    • 7244243931 scopus 로고    scopus 로고
    • Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1 alpha-Functional implications in hepatic cholesterol and glucose metabolism
    • Bhalla S, Ozalp C, Fang SS, Xiang LJ, Kemper K. 2004. Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1 alpha-Functional implications in hepatic cholesterol and glucose metabolism. J Biol Chem 279: 45139-45147.
    • (2004) J Biol Chem , vol.279 , pp. 45139-45147
    • Bhalla, S.1    Ozalp, C.2    Fang, S.S.3    Xiang, L.J.4    Kemper, K.5
  • 2
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 3
    • 0025058804 scopus 로고
    • Induction of albumin gene transcription in hepatocytes by extracellular matrix proteins
    • Caron JM. 1990. Induction of albumin gene transcription in hepatocytes by extracellular matrix proteins. Mol Cell Biol 10: 1239-1243.
    • (1990) Mol Cell Biol , vol.10 , pp. 1239-1243
    • Caron, J.M.1
  • 4
    • 29744467490 scopus 로고    scopus 로고
    • Which are the right cells to be used in a bioartificial liver?
    • Chamuleau RA, Deurholt T, Hoekstra R. 2005. Which are the right cells to be used in a bioartificial liver? Metab Brain Dis 20: 327-335.
    • (2005) Metab Brain Dis , vol.20 , pp. 327-335
    • Chamuleau, R.A.1    Deurholt, T.2    Hoekstra, R.3
  • 5
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 6
    • 0025813282 scopus 로고
    • The extracellular matrix coordinately modulates liver transcription factors and hepatocyte morphology
    • DiPersio CM, Jackson DA, Zaret KS. 1991. The extracellular matrix coordinately modulates liver transcription factors and hepatocyte morphology. Mol Cell Biol 11: 4405-4414.
    • (1991) Mol Cell Biol , vol.11 , pp. 4405-4414
    • DiPersio, C.M.1    Jackson, D.A.2    Zaret, K.S.3
  • 7
    • 33845459805 scopus 로고    scopus 로고
    • The formin mDia regulates GSK3beta through novel PKCs to promote microtubule stabilization but not MTOC reorientation in migrating fibroblasts
    • Eng CH, Huckaba TM, Gundersen GG. 2006. The formin mDia regulates GSK3beta through novel PKCs to promote microtubule stabilization but not MTOC reorientation in migrating fibroblasts. Mol Biol Cell 17: 5004-5016.
    • (2006) Mol Biol Cell , vol.17 , pp. 5004-5016
    • Eng, C.H.1    Huckaba, T.M.2    Gundersen, G.G.3
  • 8
    • 0030922983 scopus 로고    scopus 로고
    • Utilization of recombinant adenovirus and dominant negative mutants to characterize hepatocyte nuclear factor 4-regulated apolipoprotein AI and CIII expression
    • Fraser JD, Keller D, Martinez V, SantisoMere D, Straney R, Briggs MR. 1997. Utilization of recombinant adenovirus and dominant negative mutants to characterize hepatocyte nuclear factor 4-regulated apolipoprotein AI and CIII expression. J Biol Chem 272: 13892-13898.
    • (1997) J Biol Chem , vol.272 , pp. 13892-13898
    • Fraser, J.D.1    Keller, D.2    Martinez, V.3    SantisoMere, D.4    Straney, R.5    Briggs, M.R.6
  • 9
    • 0024725630 scopus 로고
    • CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells
    • Friedman AD, Landschulz WH, McKnight SL. 1989. CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes Dev 3: 1314-1322.
    • (1989) Genes Dev , vol.3 , pp. 1314-1322
    • Friedman, A.D.1    Landschulz, W.H.2    McKnight, S.L.3
  • 10
    • 0034803066 scopus 로고    scopus 로고
    • Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions
    • Hamilton GA, Jolley SL, Gilbert D, Coon DJ, Barros S, LeCluyse EL. 2001. Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions. Cell Tissue Res 306: 85-99.
    • (2001) Cell Tissue Res , vol.306 , pp. 85-99
    • Hamilton, G.A.1    Jolley, S.L.2    Gilbert, D.3    Coon, D.J.4    Barros, S.5    LeCluyse, E.L.6
  • 11
    • 84858670120 scopus 로고    scopus 로고
    • Two-dimensional protein analysis of functional liver cells for bioartificial liver
    • Hascilowicz T, Kosuge M, Matsuura T, Matsufuji S, Murai N. 2005. Two-dimensional protein analysis of functional liver cells for bioartificial liver. Jikeikai Med J 52: 109-114.
    • (2005) Jikeikai Med J , vol.52 , pp. 109-114
    • Hascilowicz, T.1    Kosuge, M.2    Matsuura, T.3    Matsufuji, S.4    Murai, N.5
  • 12
    • 0023977233 scopus 로고
    • [Establishment and characterization of a human hepatocellular carcinoma cell line JHH-4]
    • Hasumura S, Sujino H, Nagamori S, Kameda H. 1988. [Establishment and characterization of a human hepatocellular carcinoma cell line JHH-4]. Hum Cell 1: 98-100.
    • (1988) Hum Cell , vol.1 , pp. 98-100
    • Hasumura, S.1    Sujino, H.2    Nagamori, S.3    Kameda, H.4
  • 13
    • 0032949466 scopus 로고    scopus 로고
    • Liver enriched transcription factors and differentiation of hepatocellular carcinoma
    • Hayashi Y, Wang W, Ninomiya T, Nagano H, Ohta K, Itoh H. 1999. Liver enriched transcription factors and differentiation of hepatocellular carcinoma. Mol Pathol 52: 19-24.
    • (1999) Mol Pathol , vol.52 , pp. 19-24
    • Hayashi, Y.1    Wang, W.2    Ninomiya, T.3    Nagano, H.4    Ohta, K.5    Itoh, H.6
  • 14
    • 0025444194 scopus 로고
    • [Establishment and characterization of a human hepatocellular carcinoma cell line JHH-7 producing alpha-fetoprotein and carcinoembryonic antigen-Changes in secretion of AFP and CEA from JHH-7 cells after heat treatment]
    • Homma S, Nagamori S, Fujise K, Hasumura S, Sujino H, Matsuura T, Shimizu K, Niiya M, Kameda H. 1990. [Establishment and characterization of a human hepatocellular carcinoma cell line JHH-7 producing alpha-fetoprotein and carcinoembryonic antigen-Changes in secretion of AFP and CEA from JHH-7 cells after heat treatment]. Hum Cell 3: 152-157.
    • (1990) Hum Cell , vol.3 , pp. 152-157
    • Homma, S.1    Nagamori, S.2    Fujise, K.3    Hasumura, S.4    Sujino, H.5    Matsuura, T.6    Shimizu, K.7    Niiya, M.8    Kameda, H.9
  • 16
    • 0033580985 scopus 로고    scopus 로고
    • Initiation of mammalian liver development from endoderm by fibroblast growth factors
    • Jung JN, Zheng MH, Goldfarb M, Zaret KS. 1999. Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science 284: 1998-2003.
    • (1999) Science , vol.284 , pp. 1998-2003
    • Jung, J.N.1    Zheng, M.H.2    Goldfarb, M.3    Zaret, K.S.4
  • 17
    • 0345351271 scopus 로고
    • Growth factor reduced Matrigel basement membrane matrix: A matrix preparation with greatly reduced concentrations of growth factors and proteinases
    • Mannuzza J. 1994. Growth factor reduced Matrigel basement membrane matrix: A matrix preparation with greatly reduced concentrations of growth factors and proteinases. Cell Line 4: 1-6.
    • (1994) Cell Line , vol.4 , pp. 1-6
    • Mannuzza, J.1
  • 18
    • 0242500447 scopus 로고    scopus 로고
    • Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro
    • Marek CJ, Cameron GA, Elrick LJ, Hawksworth GM, Wright MC. 2003. Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro. Biochem J 370: 763-769.
    • (2003) Biochem J , vol.370 , pp. 763-769
    • Marek, C.J.1    Cameron, G.A.2    Elrick, L.J.3    Hawksworth, G.M.4    Wright, M.C.5
  • 19
    • 51349145143 scopus 로고    scopus 로고
    • Transcription factor HNF and hepatocyte differentiation
    • Nagaki M, Moriwaki H. 2008. Transcription factor HNF and hepatocyte differentiation. Hepatol Res 38: 961-969.
    • (2008) Hepatol Res , vol.38 , pp. 961-969
    • Nagaki, M.1    Moriwaki, H.2
  • 20
    • 0033924751 scopus 로고    scopus 로고
    • Developments in bioartificial liver research: Concepts, performance, and applications
    • Nagamori S, Hasumura S, Matsuura T, Aizaki H, Kawada M. 2000. Developments in bioartificial liver research: Concepts, performance, and applications. J Gastroenterol 35: 493-503.
    • (2000) J Gastroenterol , vol.35 , pp. 493-503
    • Nagamori, S.1    Hasumura, S.2    Matsuura, T.3    Aizaki, H.4    Kawada, M.5
  • 21
    • 0029165729 scopus 로고
    • Laminin-rich extracellular matrix maintains high level of hepatocyte nuclear factor 4 in rat hepatocyte culture
    • Oda H, Nozawa K, Hitomi Y, Kakinuma A. 1995. Laminin-rich extracellular matrix maintains high level of hepatocyte nuclear factor 4 in rat hepatocyte culture. Biochem Biophys Res Commun 212: 800-805.
    • (1995) Biochem Biophys Res Commun , vol.212 , pp. 800-805
    • Oda, H.1    Nozawa, K.2    Hitomi, Y.3    Kakinuma, A.4
  • 22
    • 38949218019 scopus 로고    scopus 로고
    • Cell shape, cell-cell contact, cell-extracellular matrix contact and cell polarity are all required for the maximum induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes
    • Oda H, Yoshida Y, Kawamura A, Kakinuma A. 2008. Cell shape, cell-cell contact, cell-extracellular matrix contact and cell polarity are all required for the maximum induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes. Biochem Pharmacol 75: 1209-1217.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1209-1217
    • Oda, H.1    Yoshida, Y.2    Kawamura, A.3    Kakinuma, A.4
  • 23
    • 0038745433 scopus 로고    scopus 로고
    • Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma
    • Rodriguez-Antona C, Bort R, Jover R, Tindberg N, Ingelman-Sundberg M, Gomez-Lechon MJ, Castell JV. 2003. Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. Mol Pharmacol 63: 1180-1189.
    • (2003) Mol Pharmacol , vol.63 , pp. 1180-1189
    • Rodriguez-Antona, C.1    Bort, R.2    Jover, R.3    Tindberg, N.4    Ingelman-Sundberg, M.5    Gomez-Lechon, M.J.6    Castell, J.V.7
  • 24
    • 0035851158 scopus 로고    scopus 로고
    • Novel transcriptional regulation of the human CYP3A7 gene by Sp1 and Sp3 through nuclear factor kappa B-like element
    • Saito T, Takahashi Y, Hashimoto H, Kamataki T. 2001. Novel transcriptional regulation of the human CYP3A7 gene by Sp1 and Sp3 through nuclear factor kappa B-like element. J Biol Chem 276: 38010-38022.
    • (2001) J Biol Chem , vol.276 , pp. 38010-38022
    • Saito, T.1    Takahashi, Y.2    Hashimoto, H.3    Kamataki, T.4
  • 25
    • 2642549921 scopus 로고    scopus 로고
    • Liver-enriched transcription factors in liver function and development. Part II: The C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation
    • Schrem H, Klempnauer J, Borlak J. 2004. Liver-enriched transcription factors in liver function and development. Part II: The C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation. Pharmacol Rev 56: 291-330.
    • (2004) Pharmacol Rev , vol.56 , pp. 291-330
    • Schrem, H.1    Klempnauer, J.2    Borlak, J.3
  • 26
    • 0347623122 scopus 로고    scopus 로고
    • Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: Requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes
    • Sidhu JS, Liu F, Omiecinski CJ. 2004. Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: Requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes. Exp Cell Res 292: 252-264.
    • (2004) Exp Cell Res , vol.292 , pp. 252-264
    • Sidhu, J.S.1    Liu, F.2    Omiecinski, C.J.3
  • 27
    • 0030695445 scopus 로고    scopus 로고
    • The maturity-onset diabetes of the young (MODY1) transcription factor HNF4 alpha regulates expression of genes required for glucose transport and metabolism
    • Stoffel M, Duncan SA. 1997. The maturity-onset diabetes of the young (MODY1) transcription factor HNF4 alpha regulates expression of genes required for glucose transport and metabolism. Proc Natl Acad Sci USA 94: 13209-13214.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13209-13214
    • Stoffel, M.1    Duncan, S.A.2
  • 29
    • 0033921664 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte
    • Sund NJ, Ang SL, Sackett SD, Shen W, Daigle N, Magnuson MA, Kaestner KH. 2000. Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol 20: 5175-5183.
    • (2000) Mol Cell Biol , vol.20 , pp. 5175-5183
    • Sund, N.J.1    Ang, S.L.2    Sackett, S.D.3    Shen, W.4    Daigle, N.5    Magnuson, M.A.6    Kaestner, K.H.7
  • 30
    • 0037672369 scopus 로고    scopus 로고
    • Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells
    • Suzuki A, Iwama A, Miyashita H, Nakauchi H, Taniguchi H. 2003. Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells. Development 130: 2513-2524.
    • (2003) Development , vol.130 , pp. 2513-2524
    • Suzuki, A.1    Iwama, A.2    Miyashita, H.3    Nakauchi, H.4    Taniguchi, H.5
  • 32
    • 0037379362 scopus 로고    scopus 로고
    • Bile salt transporters: Molecular characterization, function, and regulation
    • Trauner M, Boyer JL. 2003. Bile salt transporters: Molecular characterization, function, and regulation. Physiol Rev 83: 633-671.
    • (2003) Physiol Rev , vol.83 , pp. 633-671
    • Trauner, M.1    Boyer, J.L.2
  • 33
    • 0038241793 scopus 로고    scopus 로고
    • HNF4: A central regulator of hepatocyte differentiation and function
    • Watt AJ, Garrison WD, Duncan SA. 2003. HNF4: A central regulator of hepatocyte differentiation and function. Hepatology 37: 1249-1253.
    • (2003) Hepatology , vol.37 , pp. 1249-1253
    • Watt, A.J.1    Garrison, W.D.2    Duncan, S.A.3
  • 34
    • 44349133270 scopus 로고    scopus 로고
    • Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes
    • Zamule SM, Strom SC, Omiecinski CJ. 2008. Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes. Chem Biol Interact 173: 179-186.
    • (2008) Chem Biol Interact , vol.173 , pp. 179-186
    • Zamule, S.M.1    Strom, S.C.2    Omiecinski, C.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.