Liver regeneration in FGF-2-deficient mice: VEGF acts as potential functional substitute for FGF-2

Liver International

Volumn 24, Issue 2, 2004, Pages 161-168

  Sturm, Jörg W ^a   Keese, Michael ^a   Zhang, Honyue ^a   Bönninghoff, Roderich ^a   Magdeburg, Richard ^a   Vajkoczy, Peter ^a   Dono, Rosanna ^b   Zeller, Rolf ^b   Gretz, Norbert ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Angiogenesis; bFGF; FGF 2; FGF 2 deficient mice; HGF; Liver regeneration; VEGF

Indexed keywords

BROXURIDINE; COMPLEMENTARY DNA; FIBROBLAST GROWTH FACTOR 2; MESSENGER RNA; SEMAXANIB; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENOTYPE; HEMIHEPATECTOMY; HOMOZYGOSITY; INTERMETHOD COMPARISON; KNOCKOUT MOUSE; LIVER REGENERATION; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; PREOPERATIVE CARE; PROTEIN EXPRESSION; RNA ISOLATION;

EID: 2342627428     PISSN: 14783223     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2004.0896.x     Document Type: Article

References (41)

1. Higgins G, Anderson G. Experimental pathology of the liver Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931; 12: 186-202.
2. Lotz G, Kiss A, Novak P K, Sobel G, Schaff Z. Hepatitis viruses and hepatocarcinogenesis. J Physiol Paris 2001; 95: 417-22.
3. Streetz K L, Wustefeld T, Klein C, Manns M P, Trautwein C. Mediators of inflammation and acute phase response in the liver. Cell Mol Biol (Noisy-le-grand) 2001; 47: 661-73.
4. Michalopoulos G K, Defrances M C. Liver regeneration. Science 1997; 276: 60-6.
5. Cressman D E, Greenbaum L E, Deangilis R A, Ciliberto G, Furth E E, Poli V, et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 1996; 274: 1379-83.
6. Webber E M, Bruix J, Pierce R H, Fausto N. Tumor necrosis factor primes hepatocytes for DNA replication in the rat. Hepatology 1998; 28: 1226-34.
7. Fausto N, Laird A D, Webber E M. Liver regeneration: 2. Role of growth factors and cytokines in hepatic regeneration. Faseb J 1995; 9: 1527-36.
8. Taub R. Liver regeneration in health and disease. Clin Lab Med 1996; 16: 341-60.
9. Fausto N. Liver regeneration. J Hepatol 2000; 32(Suppl. 1): 19-31.
10. Sato T, El-Assal O N, Ono T, Yamanoi A, Dhar D K, Nagasue N. Sinusoidal endothelial cell proliferation and expression of angiopoietin/Tie family in regenerating rat liver. J Hepatol 2001; 34: 690-8.
11. Shimizu H, Miyazaki M, Wakabayashi Y, Mitsuhashi N, Kato A, Ito H, et al. Vascular endothelial growth factor secreted by replicating hepatocytes induces sinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in rats. J Hepatol 2001; 34: 683-9.
12. Jung J, Zheng M, Goldfarb M, Zaret K S. Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science 1999; 284: 1998-2003.
13. Czubayko F, Liaudet-Coopman E D, Aigner A, Tuveson A T, Berchem G J, Wellstein A. A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. Nat Med 1997; 3: 1137-40.
14. Basilico C, Moscatelli D. The FGF family of growth factors and oncogenes. Adv Cancer Res 1992; 59: 115-65.
15. Hoffmann B, Paul D. Basic fibroblast growth factor and transforming growth factor-alpha are hepatotrophic mitogens in vitro. J Cell Physiol 1990; 142: 149-54.
16. Presta M, Statuto M, Rusnati M, Dell'era P, Ragnotti G. Characterization of a Mr 25,000 basic fibroblast growth factor form in adult, regenerating, and fetal rat liver. Biochem Biophys Res Commun 1989; 164: 1182-9.
17. Baruch Y, Shoshany G, Neufeld G, Enat R. Basic fibroblast growth factor is hepatotropic for rat liver in regeneration. J Hepatol 1995; 23: 328-32.
18. Hioki O, Minemura M, Shimizu Y, Kasii Y, Nishimori H, Takahara T, et al. Expression and localization of basic fibroblast growth factor (bFGF) in the repair process of rat liver injury. J Hepatol 1996; 24: 217-24.
19. Dono R, Texido G, Dussel R, Ehmke H, Zeller R. Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice. Embo J 1998; 17: 4213-25.
20. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-9.
21. Marti H H, Risau W. Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors. Proc Natl Acad Sci USA 1998; 95: 15809-14.
22. Lindner G, Menrad A, Gherardi E, Merlino G, Welker P, Handjiski B, et al. Involvement of hepatocyte growth factor/scatter factor and met receptor signaling in hair follicle morphogenesis and cycling. Faseb J 2000; 14: 319-32.
23. Fong G H, Rossant J, Gertsenstein M, Breitman M L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995; 376: 60-70.
24. Roos F, Ryan A M, Chamow S M, Bennett G L, Schwall R H. Induction of liver growth in normal mice by infusion of hepatocyte growth factor/scatter factor. Am J Physiol 1995; 268: G380-6.
25. Ma T, Kikuchi M, Sarfeh I J, Shimada H, Hoa N T, Tarnawski A S. Basic fibroblast growth factor stimulates repair of wounded hepatocyte monolayer: modulatory role of protein kinase A and extracellular matrix. J Lab Clin Med 1999; 134: 363-71.
26. Cox C M, Poole T J. Angioblast differentiation is influenced by the local environment: FGF-2 induces angioblasts and patterns vessel formation in the quail embryo. Dev Dyn 2000; 218: 371-82.
27. Kubota Y, Ito K. Chemotactic migration of mesencephalic neural crest cells in the mouse. Dev Dyn 2000; 217: 170-9.
28. Davidson G, Dono R, Zeller R. FGF signalling is required for differentiation-induced cytoskeletal reorganisation and formation of actin-based processes by podocytes. J Cell Sci 2001; 114: 3359-66.
29. Sturm J W, Zhang H, Magdeburg R, Hasenberg T, Bönninghoff R, Oulmi J, Keese M, Mc Cuskey R. Altered apoptotic response and different liver structure during liver regeneration in FGF-2-deficient mice. Cell Physiol Biochem 2003, submitted.
30. Yablonka-Reuveni Z, Seger R, Rivera A J. Fibroblast growth factor promotes recruitment of skeletal muscle satellite cells in young and old rats. J Histochem Cytochem 1999; 47: 23-42.
31. Napoli J, Prentice D, Niinami C, Bishop G A, Desmond P, Mccaughan G W. Sequential increases in the intrahepatic expression of epidermal growth factor, basic fibroblast growth factor, and transforming growth factor beta in a bile duct ligated rat model of cirrhosis. Hepatology 1997; 26: 624-33.
32. Cavallaro U, Wu Z, Di Palo A, Montesano R, Pepper M S, Maier J A, et al. FGF-2 stimulates migration of Kaposi's sarcoma-like vascular cells by HGF-dependent relocalization of the urokinase receptor. Faseb J 1998; 12: 1027-34.
33. Seghezzi G, Patel S, Ren C J, Gualandris A, Pintucci G, Robbins E S, et al. Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis. J Cell Biol 1998; 141: 1659-73.
34. Guerin C, Laterra J. Regulation of angiogenesis in malignant gliomas. Exs 1997; 79: 47-64.
35. Matsumoto T, Claesson-Welsh L. VEGF receptor signal transduction. Sci STKE 2001; 2001: RE21.
36. Cavallaro U, Tenan M, Castelli V, Perilli A, Maggiano N, Van Meir E G, et al. Response of bovine endothelial cells to FGF-2 and VEGF is dependent on their site of origin: relevance to the regulation of angiogenesis. J Cell Biochem 2001; 82: 619-33.
37. Chen J H, Wang X C, Kan M, Sato J D. Effect of FGF-1 and FGF-2 on VEGF binding to human umbilical vein endothelial cells. Cell Biol Int 2001; 25: 257-60.
38. Kraizer Y, Mawasi N, Seagal J, Paizi M, Assy N, Spira G. Vascular endothelial growth factor and angiopoietin in liver regeneration. Biochem Biophys Res Commun 2001; 287: 209-15.
39. Shimizu H, Miyazaki M, Wakabayashi Y, Mitsuhashi N, Kato A, Ito H, Nakagawa K, Yoshidome H, Kataoka M, Nakajima N. Vascular endothelial growth factor secreted by replicating hepatocytes induces sinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in rats. J Hepatol 2001; 34: 683-9.
40. Ross M A, Sander C M, Kleeb T B, Watkins S C, Stolz D B. Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver. Hepatology 2001; 34: 1135-48.
41. Yamada Y, Kirillova I, Peschon J J, Fausto N. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci USA 1997; 94: 1441-6.