Structural basis for calcium and phosphatidylserine regulation of phospholipase C δ1

Biochemistry

Volumn 51, Issue 11, 2012, Pages 2246-2257

  Lomasney, Jon W ^a   Cheng, Hwei Fang ^b   Kobayashi, Minae ^a,c   King, Klim ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; BASAL CONDITIONS; BINDING AFFINITIES; BINDING RESIDUES; ENZYME ACTIVATION; MUTANT ENZYMES; NATIVE ENZYMES; PHOSPHATIDYLINOSITOL 4 ,5-BISPHOSPHATE; PHOSPHATIDYLSERINE; PHOSPHOLIPASE C; REGULATION OF ENZYME ACTIVITY; SPECIFIC INTERACTION; STRUCTURAL BASIS;

AMINO ACIDS; BINDING ENERGY; ENZYMES;

CALCIUM;

ASPARTIC ACID; CALCIUM ION; GLYCINE; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLSERINE; PHOSPHOLIPASE C DELTA1;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; REGULATORY MECHANISM; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION;

ASPARTIC ACID; BINDING SITES; CALCIUM; HYDROLYSIS; KINETICS; LIGANDS; MODELS, MOLECULAR; PHOSPHATIDYLINOSITOLS; PHOSPHATIDYLSERINES; PHOSPHOLIPASE C DELTA;

EID: 84858663194     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201252f     Document Type: Article

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