Identification of hydrophobic interactions between proteins and lipids: Free fatty acids activate phospholipase C δ1 via allosterism

Biochemistry

Volumn 43, Issue 23, 2004, Pages 7522-7533

  Kobayashi, Minae ^a   Mutharasan, R Kannan ^a   Feng, Jianwen ^b   Roberts, Mary F ^b   Lomasney, Jon W ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b BOSTON COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CHEMICAL ACTIVATION; ENZYMES; FATTY ACIDS; HYDROPHOBICITY; PHOSPHOLIPIDS; SATURATION (MATERIALS COMPOSITION);

HYDROPHOBIC INTERACTIONS; VESICLES;

BIOCHEMISTRY;

1,2 DIBUTANOYLGLYCERO 3 PHOSPHOINOSITOL; ARACHIDONIC ACID; FATTY ACID; INOSITOL DERIVATIVE; LIGAND; LIPID; OLEIC ACID; PALMITIC ACID; PEPTIDE FRAGMENT; PHOSPHOLIPASE C; PHOSPHOLIPASE C DELTA1; PROTEIN; SATURATED FATTY ACID; STEARIC ACID; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING COMPETITION; CONCENTRATION RESPONSE; EF HAND DOMAIN; ENZYME ACTIVATION; ENZYME SUBSTRATE; HYDROPHOBICITY; KINETICS; MICELLE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; REGULATORY MECHANISM;

ALCOHOLS; ALLOSTERIC REGULATION; ALLOSTERIC SITE; EF HAND MOTIFS; ENZYME ACTIVATION; FATTY ACIDS, NONESTERIFIED; GLUCOSIDES; HYDROPHOBICITY; ISOENZYMES; LIPID METABOLISM; MUTATION; PEPTIDE FRAGMENTS; PHOSPHOLIPASE C;

EID: 2942597678     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035966c     Document Type: Article

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