A Comparison of the Efficacy of Newly Developed Reversible Inhibitors of Acetylcholinesterase with Commonly Used Pyridostigmine as Pharmacological Pre-Treatment of Soman-Poisoned Mice

Basic and Clinical Pharmacology and Toxicology

Volumn 110, Issue 4, 2012, Pages 322-326

  Kassa, Jiri ^a   Musilek, Kamil ^a   Koomlova, Marketa ^a   Bajgar, Jiri ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ANTIDOTE; ATROPINE; CHOLINESTERASE INHIBITOR; K 298; K 344; K 474; PYRIDOSTIGMINE; SOMAN; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG INTOXICATION; DRUG SCREENING; DRUG STRUCTURE; LD 50; MALE; MOUSE; NONHUMAN; PREMEDICATION; PRIORITY JOURNAL; SOMAN POISONING; THERAPY EFFECT;

ANIMALS; ANTIDOTES; ATROPINE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; DRUG THERAPY, COMBINATION; ISOQUINOLINES; LETHAL DOSE 50; MALE; MICE; OXIMES; PYRIDINIUM COMPOUNDS; PYRIDOSTIGMINE BROMIDE; SOMAN;

MUS;

EID: 84858619874     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2011.00808.x     Document Type: Article

References (32)

1. Yanagisawa N, Morita H, Nakajima T. Sarin experience in Japan. Acute toxicity and long-term effects. J Neurol Sci 2006;249:76-85.
2. Lotti M. Organophosphorus compounds. In: Spencer PS, Schaumburg HH (eds.). Experimental and Clinical Neurotoxicology, Oxford University Press, New York, 2000; 898-925.
3. Bajgar J. Organophosphate/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis and treatment. Adv Clin Chem 2004;38:151-216.
4. Dawson RM. Review of oximes available for treatment of nerve agent poisoning. J Appl Toxicol 1994;14:317-31.
5. Kassa J. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J Toxicol Clin Toxicol 2002;40:803-16.
6. Shih TM. Comparison of several oximes on reactivation of soman-induced blood, brain and tissue cholinesterase activity in rats. Arch Toxicol 1993;67:637-46.
7. Lorke DE, Kalasz H, Petroianu GA, Tekes K. Entry of oximes into the brain: a review. Curr Med Chem 2008;15:743-53.
8. Zdarova Karasova J, Zemek F, Bajgar J, Vasatova M, Prochazka P, Novotny L et al. Partition of bispyridinium oximes (trimedoxime, K074) administered in therapeutic doses into different parts of the rat brain. J Pharm Biomed Anal 2011;54:1082-7.
9. Layish I, Krivoy A, Rotman E, Finkelstein A, Tashma Z, Yehezkelli Y. Pharmacologic prophylaxis against nerve agent poisoning. Isr Med Assoc J 2005;7:182-7.
10. Patocka J, Jun D, Bajgar J, Kuca K. Prophylaxis against nerve agent intoxication. Def Sci J 2006;56:775-84.
11. Bajgar J, Fusek J, Jun D, Kuca K, Bartosova L. Possibility of pharmacological prophylaxis against highly toxic organophosphates. Chem Listy 2007;101:81-3.
12. Wenger B, Quigley MD, Kokla MA. Seven-day pyridostigmine administration and thermoregulation during rest and exercise in dry heat. Aviat Space Environ Med 1993;64:905-11.
13. Kassa J, Vachek J. A comparison of the efficacy of pyridostigmine alone and the combination of pyridostigmine with anticholinergic drugs as pharmacological pretreatment of tabun-poisoned rats and mice. Toxicology 2002;177:179-85.
14. Marrs TC. Organophosphate poisoning. Pharmacol Therap 1993;58:51-66.
15. Musilek K, Koomlova M, Zavadova V, Holas O, Hrabinova M, Pohanka M et al. Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage - initial study for Myasthenia gravis implications. Bioorg Med Chem Lett 2010;20:1763-6.
16. Musilek K, Koomlova M, Holas O, Hrabinova M, Pohanka M, Dohnal V et al. Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage - implications for early Myasthenia gravis treatment. Eur J Med Chem 2011;46:811-8.
17. Musilek K, Roder J, Koomlova M, Holas O, Hrabinova M, Pohanka M et al. Preparation, in vitro screening and molecular modeling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors - Analogues of SAD-128. Bioorg Med Chem Lett 2011;21:150-4.
18. Tallarida R, Murray R. Manual of Pharmacological Calculation with Computer Programs. Springer-Verlag, New York, 1987.
19. Jokanovic M, Prostran M. Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds. Curr Med Chem 2009;16:2177-88.
20. Marrs TC, Rice P, Vale JA. The role of oximes in the treatment of nerve agent poisoning in civilian casualties. Toxicol Rev 2006;25:297-323.
21. Bajgar J, Fusek J, Kassa J, Kuca K, Jun D. Chemical aspects of pharmacological propylaxis against nerve agent poisoning. Curr Med Chem 2009;16:2977-86.
22. Maxwell DM, Brecht KM, Doctor BP, Wolfe AD. Comparison of antidote protection against soman by pyridostigmine, HI-6 and acetylcholinesterase. J Pharmacol Exp Therap 1993;264: 1085-9.
23. Gordon RK, Haigh JR, Garcia GE, Feaster SR, Riel MA, Lenz DE. Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex in vivo exposure to soman. Chem Biol Interact 2005;157:239-46.
24. Fusek J, Bajgar J, Merka V. Prophylaxe von Vergiftungen mit Nervenkampfstoffen (Ergebnisse einer klinischen Studie). Koord Sanitatsdienst 2006;24:48-53.
25. Abou-Donia MB, Goldstein LB, Jones KH, Abdel-Rahman AA, Damodaran TV, Dechkovskaia AM et al. Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. Toxicol Sci 2001;60:305-14.
26. Masson P, Josse O, Lockridge O, Viguie N, Taupin C, Buhler C. Enzymes hydrolyzing organophosphates as potential catalytic scavengers against organophosphate poisoning. J Physiol Paris 1998;92:357-62.
27. Masson P, Lockridge O. Butyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behavior. Arch Biochem Biophys 2010;494:107-20.
28. Rochu D, Chabriere E, Masson P. Human paraoxonase: a promising approach for pre-treatment and therapy of organophosphorus poisoning. Toxicology 2007;233:47-59.
29. Valiyaveettil M, Alamnech Y, Biggernann L, Soojhawon I, Doctor BP, Nambiar MP. Efficient hydrolysis of the chemical warfare agent tabun by recombinant and purified human and rabbit serum paraoxonase 1. Biochem Biophys Res Commun 2010;403:97-102.
30. Kovarik Z, Katalinic M, Sinko G, Binder J, Holas O, Jung YS et al. Pseudo-catalytic scavenging: searching for a suitable reactivators of phosphorylated butyrylcholinesterase. Chem Biol Interact 2010;187:167-71.
31. Jun D, Musilova L, Kink M, Loiodice M, Nachon F, Roche D et al. Preparation and characterization of methoxy polyethylene glycol-conjugated phosphotriesterase as a potential catalytic bioscavenger against organophosphate poisoning. Chem Biol Interact 2010;187:380-3.
32. Saxena A, Doctor BP, Sun W, Luo C, Bansal R, Naik RS et al. HuBChE: a bioscavanger for protection against organophosphate chemical warfare agents. U. S. Army Med Dep J 2004;7:22-9.