Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1763-1766

  Musilek, Kamil ^a,d   Komloova, Marketa ^b   Zavadova, Vlasta ^b   Holas, Ondrej ^b   Hrabinova, Martina ^c   Pohanka, Miroslav ^c   Dohnal, Vlastimil ^d   Nachon, Florian ^e   Dolezal, Martin ^b   Kuca, Kamil ^c,d   Jung, Young Sik ^f  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^c UNIVERSITY OF DEFENCE   (Czech Republic)

^d J E PURKINJE UNIVERSITY   (Czech Republic)

^e CENTRE DE RECHERCHES   (France)

^f Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Cholinesterase; Docking; In vitro; Inhibitor; Myasthenia gravis; Quaternary

Indexed keywords

ACETYLCHOLINESTERASE; AMINO ACID; ANION; CARBAMIC ACID DERIVATIVE; CARBENE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; NAPHTHALENE; NEOSTIGMINE; PYRIDINIUM DERIVATIVE; PYRIDOSTIGMINE; XYLENE;

ARTICLE; BLOOD BRAIN BARRIER; BRONCHUS SECRETION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ERYTHROCYTE; HEART ARRHYTHMIA; HUMAN; IC 50; IN VITRO STUDY; INTESTINE OBSTRUCTION; MOLECULAR INTERACTION; MYASTHENIA GRAVIS; NAUSEA; SIDE EFFECT;

ACETYLCHOLINESTERASE; BINDING SITES; BUTYRYLCHOLINESTERASE; CARBAMATES; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; COMPUTER SIMULATION; HUMANS; KINETICS; MYASTHENIA GRAVIS; PYRIDINIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 76649111038     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.034     Document Type: Article

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