SCOPUS 정보 검색 플랫폼

Volumn 46, Issue 2, 2011, Pages 811-818

Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage - Implications for early Myasthenia gravis treatment

(9) Musilek, Kamil a,d Komloova, Marketa b Holas, Ondrej b Hrabinova, Martina c Pohanka, Miroslav b Dohnal, Vlastimil d Nachon, Florian e Dolezal, Martin b Kuca, Kamil a,c

a UNIVERSITY OF DEFENCE (Czech Republic)

b Charles University in Prague Faculty of Pharmacy (Czech Republic)

c UNIVERSITY OF DEFENCE (Czech Republic)

d University of Jan Evangelista Purkynje (Czech Republic)

e CENTRE DE RECHERCHES (France)

Author keywords

Cholinesterase; In vitro; Inhibitor; Molecular docking; Myasthenia gravis; SAR

Indexed keywords

1,5 BIS(4 ALLYLDIMETHYLAMMONIUMPHENYL)PENTAN 3 ONE DIBROMIDE; ACETYLCHOLINESTERASE; AMBENONIUM; BIS(ISOQUINOLINIUM) 1,2 PHENYLDIMETHYLENYL DIBROMIDE; BIS(ISOQUINOLINIUM) 1,3 PHENYLDIMETHYLENYL DIBROMIDE; BIS(ISOQUINOLINIUM) 1,4 PHENYLDIMETHYLENYL DIBROMIDE; BIS(ISOQUINOLINIUM) 2 OXAPROP 1,3 DIYL DICHLORIDE; BIS(ISOQUINOLINIUM) 3 OXAPENT 1,5 DIYL DIBROMIDE; BIS(ISOQUINOLINIUM) BUT (2E) ENE 1,4 DIYL DIBROMIDE; BIS(ISOQUINOLINIUM) BUT (2Z) ENE 1,4 DIYL DICHLORIDE; BIS(ISOQUINOLINIUM) BUT 1,4 DIYL DIBROMIDE; BIS(ISOQUINOLINIUM) DEC 1,10 DIYL DIBROMIDE; BIS(ISOQUINOLINIUM) DODEC 1,12 DIYL DIBROMIDE; BIS(ISOQUINOLINIUM) ETH 1,2 DIYL DIBROMIDE; BIS(ISOQUINOLINIUM) HEPT 1,7 DIYL DIBROMIDE; BIS(ISOQUINOLINIUM) HEX 1,6 DIYL DIBROMIDE; BIS(ISOQUINOLINIUM) METH 1,1 DIYL DIBROMIDE; BIS(ISOQUINOLINIUM) NAPHTYL 3,6 DIMETHYLENYL DIBROMIDE; BIS(ISOQUINOLINIUM) NON 1,9 DIYL DIBROMIDE; BIS(ISOQUINOLINIUM) OCT 1,8 DIYL DIBROMIDE; BIS(ISOQUINOLINIUM) PENT 1,5 DIYL DIBROMIDE; BIS(ISOQUINOLINIUM) PROP 1,3 DIYL DIBROMIDE; BIS(ISOQUINOLINIUM) UNDEC 1,11 DIYL DIBROMIDE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; EDROPHONIUM CHLORIDE; ISOQUINOLINE DERIVATIVE; PROFENAMINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; EARLY INTERVENTION; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; MYASTHENIA GRAVIS;

ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; HUMANS; ISOQUINOLINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYASTHENIA GRAVIS; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79151482845 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2010.12.011 Document Type: Article

Times cited : (35)

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