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Volumn , Issue , 2010, Pages 244-268

Fish embryos as alternative models for drug safety evaluation

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EID: 84858614709     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511779053.015     Document Type: Chapter
Times cited : (1)

References (109)
  • 1
    • 7444222283 scopus 로고    scopus 로고
    • Accurate prediction of human drug toxicity: A major challenge in drug development
    • Li AP. Accurate prediction of human drug toxicity: A major challenge in drug development. Chem Biol Interact. 2004;150(1):3-7.
    • (2004) Chem Biol Interact , vol.150 , Issue.1 , pp. 3-7
    • Li, A.P.1
  • 2
    • 16844374093 scopus 로고    scopus 로고
    • Drug safety on trial - last years withdrawal of the anti-arthritis drug vioxx triggered a debate about how to better monitor drug safety even after approval
    • Greener M. Drug safety on trial - Last years withdrawal of the anti-arthritis drug Vioxx triggered a debate about how to better monitor drug safety even after approval. Embo Rep. 2005;6(3):202-204.
    • (2005) Embo Rep , vol.6 , Issue.3 , pp. 202-204
    • Greener, M.1
  • 3
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • DiMasi J, Hansen R, Grabowski H. The price of innovation: New estimates of drug development costs. J Health Econ. 2003;22(2).
    • (2003) J Health Econ , vol.22 , Issue.2
    • Di Masi, J.1    Hansen, R.2    Grabowski, H.3
  • 4
    • 33645675960 scopus 로고    scopus 로고
    • Estimating the cost of new drug development: Is it really $802 million?
    • Adams CP, Brantner VV. Estimating the cost of new drug development: Is it really $802 million? Health Affairs. 2006;25(2):420-428.
    • (2006) Health Affairs , vol.25 , Issue.2 , pp. 420-428
    • Adams, C.P.1    Brantner, V.V.2
  • 5
    • 84927048683 scopus 로고    scopus 로고
    • Challenge and opportunity on the critical path to new medicinal products
    • FDA. Challenge and opportunity on the critical path to new medicinal products. Retrieved from http://www.fda.gov. 2004.
    • (2004)
  • 6
    • 23944484301 scopus 로고    scopus 로고
    • Setting the record straight in the reply by dimasi, hansen and grabowski
    • Light DW, Warburton RN. Setting the record straight in the reply by DiMasi, Hansen and Grabowski. J Health Econ. 2005;24(5):1045-1048.
    • (2005) J Health Econ , vol.24 , Issue.5 , pp. 1045-1048
    • Light, D.W.1    Warburton, R.N.2
  • 7
    • 1642452747 scopus 로고    scopus 로고
    • Research and development costs for drugs
    • Riggs TL. Research and development costs for drugs. Lancet. 2004;363(9404): 184-194.
    • (2004) Lancet , vol.363 , Issue.9404 , pp. 184-194
    • Riggs, T.L.1
  • 8
    • 48049112010 scopus 로고    scopus 로고
    • Designing safe drugs: What to consider?
    • Kramer JA. Designing safe drugs: what to consider? Expert Opin Drug Discov. 2008;3(7):707-713.
    • (2008) Expert Opin Drug Discov , vol.3 , Issue.7 , pp. 707-713
    • Kramer, J.A.1
  • 9
    • 24944547571 scopus 로고    scopus 로고
    • Why drugs fail - a study on side effects in new chemical entities
    • Schuster D, Laggner C, Langer T. Why drugs fail - A study on side effects in new chemical entities. Curr Pharma Design. 2005;11(27):3545-3559.
    • (2005) Curr Pharma Design , vol.11 , Issue.27 , pp. 3545-3559
    • Schuster, D.1    Laggner, C.2    Langer, T.3
  • 10
    • 12344307477 scopus 로고    scopus 로고
    • A new system for moving drugs to market
    • Woosley RL, Rice G. A new system for moving drugs to market. Issues Sci Technol. 2005;21(2):63-68.
    • (2005) Issues Sci Technol , vol.21 , Issue.2 , pp. 63-68
    • Woosley, R.L.1    Rice, G.2
  • 11
    • 84927048682 scopus 로고    scopus 로고
    • Fifth Report on the Statistics on the Number of Animals used for Experimental and other Scientific Purposes in the Member States of the European Union{SEC(2007)1455
    • Commission of the European Communities. Fifth Report on the Statistics on the Number of Animals used for Experimental and other Scientific Purposes in the Member States of the European Union{SEC(2007)1455}. 2007.
    • (2007)
  • 12
    • 58949084341 scopus 로고    scopus 로고
    • Non-animal methodologies within biomedical research and toxicity testing
    • Knight A. Non-animal methodologies within biomedical research and toxicity testing. ALTEX Alternat Tierexp. 2008;25(3):213-231.
    • (2008) ALTEX Alternat Tierexp , vol.25 , Issue.3 , pp. 213-231
    • Knight, A.1
  • 13
    • 49449100456 scopus 로고    scopus 로고
    • Estimates for worldwide laboratory animal use in 2005
    • Taylor K, Gordon N, Langley G, et al. Estimates for worldwide laboratory animal use in 2005. Altern Lab Anim. 2008;36(3):327-342.
    • (2008) Altern Lab Anim , vol.36 , Issue.3 , pp. 327-342
    • Taylor, K.1    Gordon, N.2    Langley, G.3
  • 14
    • 41349087120 scopus 로고    scopus 로고
    • The role of early in vivo toxicity testing in drug discovery toxicology
    • Fieldent MR, Kolaja KL. The role of early in vivo toxicity testing in drug discovery toxicology. Expert Opin Drug Saf. 2008; 7(2):107-110.
    • (2008) Expert Opin Drug Saf , vol.7 , Issue.2 , pp. 107-110
    • Fieldent, M.R.1    Kolaja, K.L.2
  • 15
    • 49649113918 scopus 로고    scopus 로고
    • Toxicogenomic predictive modeling: Emerging opportunities for more efficient drug discovery and development;
    • Amir-Aslani A. Toxicogenomic predictive modeling: Emerging opportunities for more efficient drug discovery and development; Technol Forecast Social Change. 2008; 75(7):905-932.
    • (2008) Technol Forecast Social Change , vol.75 , Issue.7 , pp. 905-932
    • Amir-Aslani, A.1
  • 16
    • 48749088292 scopus 로고    scopus 로고
    • Evolutionary conservation of human drug targets in organisms used for environmental risk assessments
    • Gunnarsson L, Jauhiainen A, Kristiansson E, et al. Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environ Sci Technol. 2008;42(15):5807-5813.
    • (2008) Environ Sci Technol , vol.42 , Issue.15 , pp. 5807-5813
    • Gunnarsson, L.1    Jauhiainen, A.2    Kristiansson, E.3
  • 17
    • 65549123510 scopus 로고    scopus 로고
    • Zebrafish: A complete animal model for in vivo drug discovery and development
    • Chakraborty C, Hsu CH, Wen ZH, et al. Zebrafish: A complete animal model for in vivo drug discovery and development. Curr Drug Metab. 2009; 10(2): 116-124.
    • (2009) Curr Drug Metab , vol.10 , Issue.2 , pp. 116-124
    • Chakraborty, C.1    Hsu, C.H.2    Wen, Z.H.3
  • 18
    • 51449120635 scopus 로고    scopus 로고
    • Zebrafish assays as early safety pharmacology screens: Paradigm shift or red herring?
    • Redfern WS, Waldron G, Winter MJ, et al. Zebrafish assays as early safety pharmacology screens: Paradigm shift or red herring? J Pharmacol Toxicol Method. 2008;58(2):110-117.
    • (2008) J Pharmacol Toxicol Method , vol.58 , Issue.2 , pp. 110-117
    • Redfern, W.S.1    Waldron, G.2    Winter, M.J.3
  • 19
    • 12144273121 scopus 로고    scopus 로고
    • In vivo drug discovery in the zebrafish
    • Zon LI, Peterson RT. In vivo drug discovery in the zebrafish. Nat Rev Drug Discov. 2005;4(l):35-44.
    • (2005) Nat Rev Drug Discov , vol.4 , Issue.1 , pp. 35-44
    • Zon, L.I.1    Peterson, R.T.2
  • 20
    • 67649259218 scopus 로고    scopus 로고
    • The use of in vivo zebrafish assays in drug toxicity screening
    • Eimon PM, Rubinstein AL. The use of in vivo zebrafish assays in drug toxicity screening. Expert Opin Drug Metabol Toxicol. 2009;5(4):393-401.
    • (2009) Expert Opin Drug Metabol Toxicol , vol.5 , Issue.4 , pp. 393-401
    • Eimon, P.M.1    Rubinstein, A.L.2
  • 21
    • 0036245348 scopus 로고    scopus 로고
    • Medaka - a model organism from the far east
    • Wittbrodt J, Shima A, Schartl M. Medaka - A model organism from the far East. Nat Rev Genet. 2002;3(1):53-64.
    • (2002) Nat Rev Genet , vol.3 , Issue.1 , pp. 53-64
    • Wittbrodt, J.1    Shima, A.2    Schartl, M.3
  • 22
    • 3042655508 scopus 로고    scopus 로고
    • Medaka as a research organism: Past, present and future
    • Shima A, Mitani H. Medaka as a research organism: Past, present and future. Mech Dev. 2004;121(7-8):599-604.
    • (2004) Mech Dev , vol.121 , Issue.8 , pp. 599-604
    • Shima, A.1    Mitani, H.2
  • 25
    • 3042616999 scopus 로고    scopus 로고
    • Not just a fishing trip - environmental genomics using zebrafish
    • Coverdale LE, Lean D, Martin CC. Not just a fishing trip - Environmental genomics using zebrafish. Curr Genom. 2004;5(5):395-407.
    • (2004) Curr Genom , vol.5 , Issue.5 , pp. 395-407
    • Coverdale, L.E.1    Lean, D.2    Martin, C.C.3
  • 26
    • 26944441684 scopus 로고    scopus 로고
    • Zebrafish as a model vertebrate for investigating chemical toxicity
    • Hill AJ, Teraoka H, Heideman W, et al. Zebrafish as a model vertebrate for investigating chemical toxicity. Toxicol Sci. 2005;86(1):6-19.
    • (2005) Toxicol Sci , vol.86 , Issue.1 , pp. 6-19
    • Hill, A.J.1    Teraoka, H.2    Heideman, W.3
  • 27
    • 0000490926 scopus 로고
    • Spawning cycle and egg production of zebrafish, brachydanio rerio, in the laboratory
    • Eaton RC, Farley RD. Spawning cycle and egg production of zebrafish, Brachydanio rerio, in the laboratory. Copeia. 1974;1(1):195-209.
    • (1974) Copeia , vol.1 , Issue.1 , pp. 195-209
    • Eaton, R.C.1    Farley, R.D.2
  • 28
    • 0037015066 scopus 로고    scopus 로고
    • A duplicated copy of dmrt1 in the sexdetermining region of the y chromosome of the medaka
    • Nanda I, Kondo M, Hornung U, et al. A duplicated copy of DMRT1 in the sexdetermining region of the Y chromosome of the medaka, Oryzias latipes. Proc Natl Acad Sci USA. 2002;22(18):11778-11783.
    • (2002) Oryzias Latipes. Proc Natl Acad Sci USA , vol.22 , Issue.18 , pp. 11778-11783
    • Nanda, I.1    Kondo, M.2    Hornung, U.3
  • 29
    • 84927099639 scopus 로고    scopus 로고
    • Zebrafish as an alternative model organism for disease modelling and drug discovery: Implications for the 3Rs. NC3Rs, Iss, National Centre for the Replacement, Refinement and Reduction of Animals in research
    • Fleming A. Zebrafish as an alternative model organism for disease modelling and drug discovery: Implications for the 3Rs. NC3Rs, Iss. 10, National Centre for the Replacement, Refinement and Reduction of Animals in research. Retrieved from www.nc3rs.org.uk. 2007:1-7.
    • (2007) , Issue.10 , pp. 1-7
    • Fleming, A.1
  • 30
    • 0036029861 scopus 로고    scopus 로고
    • Characters of larvae - what are they
    • Urho L. Characters of larvae - what are they. Folia Zool. 2002;51(3):161-186.
    • (2002) Folia Zool , vol.51 , Issue.3 , pp. 161-186
    • Urho, L.1
  • 31
    • 33749004958 scopus 로고    scopus 로고
    • Opinion on the –aspects of the biology and welfare of animals used for experimental and other scientific purposes—
    • EFSA. Opinion on the –Aspects of the biology and welfare of animals used for experimental and other scientific purposes—. EFSA J. 2005;292:1-46.
    • (2005) EFSA J , vol.292 , pp. 1-46
  • 33
    • 0036048386 scopus 로고    scopus 로고
    • Dart: The embryotest with the zebrafish danio rerio - a general model in ecotoxicology and toxicology
    • Nagel R. DarT: The embryotest with the zebrafish Danio rerio - A general model in ecotoxicology and toxicology. ALTEX Alternat Tierexp. 2002;19(1/2): 38-48.
    • (2002) ALTEX Alternat Tierexp , vol.19 , Issue.1-2 , pp. 38-48
    • Nagel, R.1
  • 34
    • 22144477546 scopus 로고    scopus 로고
    • Towards an alternative for the acute fish lc(50) test in chemical assessment: The fish embryo toxicity test goes multispecies - an update
    • Braunbeck T, Boettcher M, Hollert H, et al. Towards an alternative for the acute fish LC(50) test in chemical assessment: The fish embryo toxicity test goes multispecies - An update. ALTEX. 2005;22(2):87-102.
    • (2005) ALTEX , vol.22 , Issue.2 , pp. 87-102
    • Braunbeck, T.1    Boettcher, M.2    Hollert, H.3
  • 35
    • 63949085053 scopus 로고    scopus 로고
    • Is the fish embryo toxicity test (Fet) with the zebrafish (danio rerio) a potential alternative for the fish acute toxicity test?
    • Lammer E, Carr GJ, Wendler K, et al. Is the fish embryo toxicity test (FET) with the zebrafish (Danio rerio) a potential alternative for the fish acute toxicity test? Comp Biochem Physiol Part C: Toxicol Pharmacol. 2009;149(2):196-209.
    • (2009) Comp Biochem Physiol Part C: Toxicol Pharmacol , vol.149 , Issue.2 , pp. 196-209
    • Lammer, E.1    Carr, G.J.2    Wendler, K.3
  • 36
    • 2342475704 scopus 로고    scopus 로고
    • Zebrafish: A preclinical model for drug screening
    • Parng C, Seng WL, Semino C, et al. Zebrafish: A preclinical model for drug screening. Assay Drug Devel Technol. 2002;1(1):41-48.
    • (2002) Assay Drug Devel Technol , vol.1 , Issue.1 , pp. 41-48
    • Parng, C.1    Seng, W.L.2    Semino, C.3
  • 37
    • 54049106433 scopus 로고    scopus 로고
    • Developing a list of reference chemicals for testing alternatives to whole fish toxicity tests
    • Schirmer K, Tanneberger K, Kramer N, et al. Developing a list of reference chemicals for testing alternatives to whole fish toxicity tests. Aquat Toxicol. 2008;90(2): 128-137.
    • (2008) Aquat Toxicol , vol.90 , Issue.2 , pp. 128-137
    • Schirmer, K.1    Tanneberger, K.2    Kramer, N.3
  • 38
    • 35549008795 scopus 로고    scopus 로고
    • Developmental toxicity of low generation pamam dendrimers in zebrafish
    • Heiden TCK, Dengler E, Kao WJ, et al. Developmental toxicity of low generation PAMAM dendrimers in zebrafish. Toxicol Appl Pharmacol. 2007;225(1):70-79.
    • (2007) Toxicol Appl Pharmacol , vol.225 , Issue.1 , pp. 70-79
    • Heiden, T.1    Dengler, E.2    Kao, W.J.3
  • 39
    • 41949094635 scopus 로고    scopus 로고
    • A european pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development
    • Robinson S, Delongeas J-L, Donald E, et al. A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development. Regul Toxicol Pharmacol. 2008;50(3):345-352.
    • (2008) Regul Toxicol Pharmacol , vol.50 , Issue.3 , pp. 345-352
    • Robinson, S.1    Delongeas, J.-L.2    Donald, E.3
  • 40
    • 0033603281 scopus 로고    scopus 로고
    • International conference on harmonisation; guidance on the duration of chronic toxicity testing in animals (Rodent and nonrodent toxicity testing). Notice
    • FDA. International Conference on Harmonisation; Guidance on the Duration of Chronic Toxicity Testing in Animals (Rodent and Nonrodent Toxicity Testing). Notice. Fed Reg. 1999;64:34259-34260.
    • (1999) Fed Reg , vol.64 , pp. 34259-34260
  • 41
    • 77649188431 scopus 로고    scopus 로고
    • Gene expression analysis in zebrafish embryos: A potential approach to predict effect concentrations in the fish early life stage test
    • Weil M, Sacher F, Scholz S, et al. Gene expression analysis in zebrafish embryos: A potential approach to predict effect concentrations in the fish early life stage test. Environ Toxicol Chem. 2009;28(9):1970-1978.
    • (2009) Environ Toxicol Chem , vol.28 , Issue.9 , pp. 1970-1978
    • Weil, M.1    Sacher, F.2    Scholz, S.3
  • 42
    • 48349111923 scopus 로고    scopus 로고
    • The zebrafish embryo model in environmental risk assessment - applications beyond acute toxicity testing
    • Scholz S, Fischer S, Gundel U, et al. The zebrafish embryo model in environmental risk assessment - Applications beyond acute toxicity testing. Environ Sci Pollut Res. 2008;15:394-404.
    • (2008) Environ Sci Pollut Res , vol.15 , pp. 394-404
    • Scholz, S.1    Fischer, S.2    Gundel, U.3
  • 43
    • 84926962167 scopus 로고    scopus 로고
    • International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use: Guidance for Industry S2B Genotoxicity: A Standard Battery for Genotoxicity Testing of Pharmaceuticals
    • ICH. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use: Guidance for Industry S2B Genotoxicity: A Standard Battery for Genotoxicity Testing of Pharmaceuticals. Retrieved from http://www.fda.gov. 1997.
    • (1997)
  • 44
    • 34447551703 scopus 로고    scopus 로고
    • Genetic toxicity assessment: Employing the best science for human safety evaluation
    • Lorge E, Gervais V, Becourt-Lhote N, et al. Genetic toxicity assessment: Employing the best science for human safety evaluation. Part IV: A strategy in genotoxicity testing in drug development: Some examples. Toxicol Sci. 2007;98(1):39-42.
    • (2007) Toxicol Sci , vol.98 , Issue.1 , pp. 39-42
    • Lorge, E.1    Gervais, V.2    Becourt-Lhote, N.3
  • 45
    • 37549032177 scopus 로고    scopus 로고
    • Differentiation between bioavailable and total hazard potential of sediment-induced dna fragmentation as measured by the comet assay with zebrafish embryos
    • Kosmehl T, Krebs F, Manz W, et al. Differentiation between bioavailable and total hazard potential of sediment-induced DNA fragmentation as measured by the comet assay with zebrafish embryos. Journal of Soils and Sediments. 2007;7(6): 377-387.
    • (2007) Journal of Soils and Sediments , vol.7 , Issue.6 , pp. 377-387
    • Kosmehl, T.1    Krebs, F.2    Manz, W.3
  • 46
    • 33751048872 scopus 로고    scopus 로고
    • A novel contact assay for testing genotoxicity of chemicals and whole sediments in zebrafish embryos
    • Kosmehl T, Hallare AV, Reifferscheid G, et al. A novel contact assay for testing genotoxicity of chemicals and whole sediments in zebrafish embryos. Environ Toxicol Chem. 2006;25(8):2097-2106.
    • (2006) Environ Toxicol Chem , vol.25 , Issue.8 , pp. 2097-2106
    • Kosmehl, T.1    Hallare, A.V.2    Reifferscheid, G.3
  • 47
    • 0033987704 scopus 로고    scopus 로고
    • Transgenic zebrafish for detecting mutations caused by compounds in aquatic environments
    • Amanuma K, Takeda H, Amanuma H, et al. Transgenic zebrafish for detecting mutations caused by compounds in aquatic environments. Nat Biotechnol. 2000; 18(1):62-65.
    • (2000) Nat Biotechnol , vol.18 , Issue.1 , pp. 62-65
    • Amanuma, K.1    Takeda, H.2    Amanuma, H.3
  • 48
    • 33744985571 scopus 로고    scopus 로고
    • Uptake, metabolism, mutant frequencies and mutational spectra in [lambda] transgenic medaka embryos exposed to benzo[[alpha]] pyrene dosed sediments
    • McElroy AE, Bogler A, Weisbaum D, et al. Uptake, metabolism, mutant frequencies and mutational spectra in [lambda] transgenic medaka embryos exposed to benzo[[alpha]] pyrene dosed sediments. Mar Environ Res. 2006;62(1):273-277.
    • (2006) Mar Environ Res , vol.62 , Issue.1 , pp. 273-277
    • Mc Elroy, A.E.1    Bogler, A.2    Weisbaum, D.3
  • 49
    • 0033730915 scopus 로고    scopus 로고
    • Detection of mutations in transgenic fish carrying a bacteriophage lambda cii transgene target
    • Winn RN, Norris MB, Brayer KJ, et al. Detection of mutations in transgenic fish carrying a bacteriophage lambda cII transgene target. Proc Natl Acad Sci USA. 2000;97(23):12655-12660.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.23 , pp. 12655-12660
    • Winn, R.N.1    Norris, M.B.2    Brayer, K.J.3
  • 50
    • 0034060666 scopus 로고    scopus 로고
    • Mechanism of action in thalidomide terato-genesis
    • Stephens TD, Bunde CJW, Fillmore BJ. Mechanism of action in thalidomide terato-genesis. Biochem Pharmacol. 2000;59(12):1489-1499.
    • (2000) Biochem Pharmacol , vol.59 , Issue.12 , pp. 1489-1499
    • Stephens, T.D.1    Bunde, C.2    Fillmore, B.J.3
  • 51
    • 84926962166 scopus 로고    scopus 로고
    • OECD guideline for testing of chemicals. Test No. 414: Prenatal Developmental Toxicity Study
    • OECD 414. OECD guideline for testing of chemicals. Test No. 414: Prenatal Developmental Toxicity Study. Available at www.oecd.org. 2000.
    • (2000)
  • 52
    • 84926962165 scopus 로고    scopus 로고
    • OECD guideline for testing of chemicals. Test No. 421: Reproduction/Developmental Toxicity Screening Test
    • OECD 421. OECD guideline for testing of chemicals. Test No. 421: Reproduction/Developmental Toxicity Screening Test. Available at www.oecd.org. 2000.
    • (2000)
  • 53
    • 21344468371 scopus 로고    scopus 로고
    • The future of teratology research is in vitro
    • Bailey J, Knight A, Balcombe J. The future of teratology research is in vitro. Biogen Amines. 2005;19(2):97-146.
    • (2005) Biogen Amines , vol.19 , Issue.2 , pp. 97-146
    • Bailey, J.1    Knight, A.2    Balcombe, J.3
  • 54
    • 33751541385 scopus 로고    scopus 로고
    • The practical application of three validated in vitro embryotoxicity tests - the report and recommendations of an ecvam/zebet workshop (Ecvam workshop 57)
    • Spielmann H, Seiler A, Bremer S, et al. The practical application of three validated in vitro embryotoxicity tests - The Report and Recommendations of an ECVAM/ZEBET Workshop (ECVAM Workshop 57). ATLA. 2006;34(5):527-538.
    • (2006) ATLA , vol.34 , Issue.5 , pp. 527-538
    • Spielmann, H.1    Seiler, A.2    Bremer, S.3
  • 55
    • 57349150654 scopus 로고    scopus 로고
    • Qsar models for reproductive toxicity and endocrine disruption in regulatory use - a preliminary investigation
    • Jensen GE, Niemela JR, Wedebye EB, Nikolov NG. QSAR models for reproductive toxicity and endocrine disruption in regulatory use - a preliminary investigation. SAR and QSAR in Environmental Research. 2008;19(7):631-641.
    • (2008) SAR and QSAR in Environmental Research , vol.19 , Issue.7 , pp. 631-641
    • Jensen, G.E.1    Niemela, J.R.2    Wedebye, E.B.3    Nikolov, N.G.4
  • 56
    • 0025438001 scopus 로고
    • Computer automated structure evaluation (Case) of the teratogenicity of retinoids with the aid of a novel geometry index
    • Klopman G, Dimayuga ML. Computer Automated Structure Evaluation (CASE) of the teratogenicity of retinoids with the aid of a novel geometry index. Journal of Computer-Aided Molecular Design. 1990;4(2):117-130.
    • (1990) Journal of Computer-Aided Molecular Design , vol.4 , Issue.2 , pp. 117-130
    • Klopman, G.1    Di mayuga, M.L.2
  • 58
    • 0041817808 scopus 로고    scopus 로고
    • Zebrafish: A new model on the pharmaceutical catwalk
    • Langheinrich U. Zebrafish: A new model on the pharmaceutical catwalk. BioEssays. 2003;25(9):904-912.
    • (2003) Bioessays , vol.25 , Issue.9 , pp. 904-912
    • Langheinrich, U.1
  • 60
    • 0036048386 scopus 로고    scopus 로고
    • The embryotest with the zebrafish danio rerio - a general model in ecotoxicology and toxicology
    • Nagel R. Dar T. The embryotest with the zebrafish Danio rerio - a general model in ecotoxicology and toxicology. ALTEX Alternativen zu Tierexperimenten. 2002;19 (1/2):38-48.
    • (2002) ALTEX Alternativen Zu Tierexperimenten , vol.19 , Issue.1-2 , pp. 38-48
    • Nagel, R.1    Dar, T.2
  • 61
    • 77949350034 scopus 로고    scopus 로고
    • Identification of a primary target of thalidomide teratogenicity
    • Ito T, Ando H, Suzuki T, et al. Identification of a Primary Target of Thalidomide Teratogenicity. Science. 2010;327(5971):1345-1350.
    • (2010) Science , vol.327 , Issue.5971 , pp. 1345-1350
    • Ito, T.1    Ando, H.2    Suzuki, T.3
  • 62
    • 34547726788 scopus 로고    scopus 로고
    • Molecular targets and early response biomarkers for the prediction of developmental toxicity in vitro
    • Stigson M, Kultima K, Jergil M, et al. Molecular targets and early response biomarkers for the prediction of developmental toxicity in vitro. Altern Lab Anim. 2007;35(3):335-342.
    • (2007) Altern Lab Anim , vol.35 , Issue.3 , pp. 335-342
    • Stigson, M.1    Kultima, K.2    Jergil, M.3
  • 63
    • 45549090693 scopus 로고    scopus 로고
    • Development of a new screening assay to identify proteratogenic substances using zebrafish danio rerio embryo combined with an exogenous mammalian metabolic activation system (Mdart)
    • Busquet F, Nagel R, von Landenberg F, et al. Development of a new screening assay to identify proteratogenic substances using zebrafish Danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT). Toxicol Sci. 2008;104(1):177-188.
    • (2008) Toxicol Sci , vol.104 , Issue.1 , pp. 177-188
    • Busquet, F.1    Nagel, R.2    Von Landenberg, F.3
  • 64
    • 3042631471 scopus 로고    scopus 로고
    • Stages of normal development in the medaka oryzias latipes
    • Iwamatsu T. Stages of normal development in the medaka Oryzias latipes. Mech Devel. 2004; 121(7-8):605-618.
    • (2004) Mech Devel , vol.121 , Issue.7-8 , pp. 605-618
    • Iwamatsu, T.1
  • 65
    • 0037200078 scopus 로고    scopus 로고
    • Medulloblastoma growth inhibition by hedgehog pathway blockade
    • Berman DM, Karhadkar SS, Hallahan AR, et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science. 2002;297(5586):1559-1561.
    • (2002) Science , vol.297 , Issue.5586 , pp. 1559-1561
    • Berman, D.M.1    Karhadkar, S.S.2    Hallahan, A.R.3
  • 66
    • 0037195074 scopus 로고    scopus 로고
    • Small molecule modulation of smoothened activity
    • Chen JK, Taipale J, Young KE, et al. Small molecule modulation of smoothened activity. PNAS. 2002;99(22):14071-14076.
    • (2002) PNAS , vol.99 , Issue.22 , pp. 14071-14076
    • Chen, J.K.1    Taipale, J.2    Young, K.E.3
  • 67
    • 0031723219 scopus 로고    scopus 로고
    • The teratogenic veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
    • Incardona J, Gaffield W, Kapur R, et al. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development. 1998;125(18):3553-3562.
    • (1998) Development , vol.125 , Issue.18 , pp. 3553-3562
    • Incardona, J.1    Gaffield, W.2    Kapur, R.3
  • 68
    • 84927048681 scopus 로고    scopus 로고
    • Effect of cyclopamine on medaka(Oryzias latipes) embryos. Course Experiment, Developmental Biology, Franklin & Marshall College
    • Ferrari S, Yanega R. Effect of cyclopamine on medaka (Oryzias latipes) embryos. Course Experiment, Developmental Biology, Franklin & Marshall College. Retrieved from http://www.swarthmore.edu/NatSci/sgilber1/DB_lab/Student/Medaka_cyclo.html. 2000.
    • (2000)
    • Ferrari, S.1    Yanega, R.2
  • 69
    • 67650077260 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of sant-2 and analogues as inhibitors of the hedgehog signaling pathway
    • Büttner A, Seifert K, Cottin T, et al. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem. 2009;17(14):4943-4954.
    • (2009) Bioorg Med Chem , vol.17 , Issue.14 , pp. 4943-4954
    • Büttner, A.1    Seifert, K.2    Cottin, T.3
  • 70
    • 0142209158 scopus 로고    scopus 로고
    • Drug induced qt prolongation and torsades de pointes
    • Yap YG, Camm AJ. Drug induced QT prolongation and torsades de pointes. Heart. 2003;89(11):1363-1372.
    • (2003) Heart , vol.89 , Issue.11 , pp. 1363-1372
    • Yap, Y.G.1    Camm, A.J.2
  • 71
    • 84927048680 scopus 로고    scopus 로고
    • ICH Topic S7B: The nonclinical evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals
    • EMEA. ICH Topic S7B: The nonclinical evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals. Retrieved from http://www.emea.europe.eu. 2005.
    • (2005)
  • 72
  • 73
    • 63849218381 scopus 로고    scopus 로고
    • Noninvasive technique for measurement of heartbeat regularity in zebrafish (Danio rerio) embryos
    • Chan PK, Lin CC, Cheng SH. Noninvasive technique for measurement of heartbeat regularity in zebrafish (Danio rerio) embryos. BMC Biotechnol. 2009;9:11.
    • (2009) BMC Biotechnol , vol.9 , pp. 11
    • Chan, P.K.1    Lin, C.C.2    Cheng, S.H.3
  • 74
    • 34548188788 scopus 로고    scopus 로고
    • Drug hepatotoxicity from a regulatory perspective
    • Senior JR. Drug Hepatotoxicity from a Regulatory Perspective. Clinics in Liver Disease. 2007;11(3):507-524.
    • (2007) Clinics in Liver Disease , vol.11 , Issue.3 , pp. 507-524
    • Senior, J.R.1
  • 75
    • 84926962164 scopus 로고    scopus 로고
    • Nonclinical assessment of potential hepatotoxicity in man
    • FDA. Nonclinical assessment of potential hepatotoxicity in man. Retrieved from http://www.fda.gov. 2000.
    • (2000)
  • 76
    • 43049176656 scopus 로고    scopus 로고
    • A predictive model for assessing drug-induced toxicity
    • McGrath P, Li C-Q. Zebrafish: A predictive model for assessing drug-induced toxicity. Drug Discov Today. 2008;13(9-10):394-401.
    • (2008) Drug Discov Today , vol.13 , Issue.9-10 , pp. 394-401
    • Mc Grath, P.1    Li, C.-Q.Z.2
  • 77
    • 84927005665 scopus 로고    scopus 로고
    • Larvae of the zebrafish as test organism for hepatotoxicity testing. EPAA (The European partnership for alternative approaches to animal testing) 2007 Annual Conference. Poster
    • Vanparys P, Spanhaak S, Steemans M, et al. Larvae of the zebrafish as test organism for hepatotoxicity testing. EPAA (The European partnership for alternative approaches to animal testing) 2007 Annual Conference. Poster. Retrieved from http://ec.europe.eu. 2007.
    • (2007)
    • Vanparys, P.1    Spanhaak, S.2    Steemans, M.3
  • 78
    • 34547236464 scopus 로고    scopus 로고
    • A retrospective analysis of toxicogenomics in the safety assessment of drug candidates
    • Foster WR, Chen S-J, He A, et al. A retrospective analysis of toxicogenomics in the safety assessment of drug candidates. Toxicol Pathol. 2007;35(5):621-635.
    • (2007) Toxicol Pathol , vol.35 , Issue.5 , pp. 621-635
    • Foster, W.R.1    Chen, S.-J.2    He, A.3
  • 79
    • 84927005664 scopus 로고
    • Memorandum of understanding between the United States Department of Health and Human Services, National Institutes of Health, National Institute on Aging, Laboratory of Neurosciences and the United States Department of Health and Human Services, Food and Drug Administration. MOU number: 225-94-3001
    • FDA. Memorandum of understanding between the United States Department of Health and Human Services, National Institutes of Health, National Institute on Aging, Laboratory of Neurosciences and the United States Department of Health and Human Services, Food and Drug Administration. MOU number: 225-94-3001. Retrieved from http://www.fda.gov. 1994.
    • (1994)
  • 80
    • 50249148889 scopus 로고    scopus 로고
    • Validation of the use of zebrafish larvae in visual safety assessment
    • Richards FM, Alderton WK, Kimber GM, et al. Validation of the use of zebrafish larvae in visual safety assessment. J Pharmacol Toxicol Methods. 2008;58:50-58.
    • (2008) J Pharmacol Toxicol Methods , vol.58 , pp. 50-58
    • Richards, F.M.1    Alderton, W.K.2    Kimber, G.M.3
  • 81
    • 50049103885 scopus 로고    scopus 로고
    • Zebrafish based assays for the assessment of cardiac, visual and gut function - potential safety screens for early drug discovery
    • Berghmans S, Butler P, Goldsmith P, et al. Zebrafish based assays for the assessment of cardiac, visual and gut function - Potential safety screens for early drug discovery. J Pharmacol Toxicol Methods. 2008;58:59-68.
    • (2008) J Pharmacol Toxicol Methods , vol.58 , pp. 59-68
    • Berghmans, S.1    Butler, P.2    Goldsmith, P.3
  • 82
    • 26444544427 scopus 로고    scopus 로고
    • The use of zebrafish for assessing ototoxic and otoprotective agents
    • Ton C, Parng C. The use of zebrafish for assessing ototoxic and otoprotective agents. Hearing Res. 2005;208(1-2):79-88.
    • (2005) Hearing Res , vol.208 , Issue.1-2 , pp. 79-88
    • Ton, C.1    Parng, C.2
  • 83
    • 44449176477 scopus 로고    scopus 로고
    • Using the zebrafish lateral line to screen for ototoxicity
    • Chiu L, Cunningham L, Raible D, et al. Using the zebrafish lateral line to screen for ototoxicity. J Assoc Res Otolaryngol. 2008;9(2):178-190.
    • (2008) J Assoc Res Otolaryngol , vol.9 , Issue.2 , pp. 178-190
    • Chiu, L.1    Cunningham, L.2    Raible, D.3
  • 84
    • 44649084400 scopus 로고    scopus 로고
    • Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs
    • Winter MJ, Redfern WS, Hayfield AJ, et al. Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs. J Pharmacol Toxicol Methods. 2008;57(3):176-187.
    • (2008) J Pharmacol Toxicol Methods , vol.57 , Issue.3 , pp. 176-187
    • Winter, M.J.1    Redfern, W.S.2    Hayfield, A.J.3
  • 85
    • 33645450645 scopus 로고    scopus 로고
    • Antipsychotics produce locomotor impairment in larval zebrafish
    • Giacomini NJ, Rose B, Kobayashi K, et al. Antipsychotics produce locomotor impairment in larval zebrafish. Neurotoxicol Teratol. 2006;28(2):245-250.
    • (2006) Neurotoxicol Teratol , vol.28 , Issue.2 , pp. 245-250
    • Giacomini, N.J.1    Rose, B.2    Kobayashi, K.3
  • 86
    • 0037453021 scopus 로고    scopus 로고
    • Drugs that induce repolarization abnormalities cause bradycardia in zebrafish
    • Milan DJ, Peterson TA, Ruskin JN, et al. Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation. 2003; 107(10):1355-1358.
    • (2003) Circulation , vol.107 , Issue.10 , pp. 1355-1358
    • Milan, D.J.1    Peterson, T.A.2    Ruskin, J.N.3
  • 87
    • 0346848889 scopus 로고    scopus 로고
    • Zebrafish embryos express an orthologue of herg and are sensitive toward a range of qt-prolonging drugs inducing severe arrhythmia[star, open]
    • Langheinrich U, Vacun G, Wagner T. Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia[star, open]. Toxicol Appl Pharmacol. 2003;193(3):370-382.
    • (2003) Toxicol Appl Pharmacol , vol.193 , Issue.3 , pp. 370-382
    • Langheinrich, U.1    Vacun, G.2    Wagner, T.3
  • 88
    • 40649125732 scopus 로고    scopus 로고
    • Evaluation of zebrafish embryos as a model for assessing inhibition of herg
    • Mittelstadt SW, Hemenway CL, Craig MP, et al. Evaluation of zebrafish embryos as a model for assessing inhibition of hERG. J Pharmacol Toxicol Methods. 2008;57(2):100-105.
    • (2008) J Pharmacol Toxicol Methods , vol.57 , Issue.2 , pp. 100-105
    • Mittelstadt, S.W.1    Hemenway, C.L.2    Craig, M.P.3
  • 89
    • 17644368516 scopus 로고    scopus 로고
    • Acute renal failure in zebrafish: A novel system to study a complex disease
    • Hentschel DM, Park KM, Cilenti L, et al. Acute renal failure in zebrafish: A novel system to study a complex disease. Am J Physiol Renal Physiol. 2005;288(5):923-929.
    • (2005) Am J Physiol Renal Physiol , vol.288 , Issue.5 , pp. 923-929
    • Hentschel, D.M.1    Park, K.M.2    Cilenti, L.3
  • 90
    • 0032861322 scopus 로고    scopus 로고
    • Ontogeny and behaviour of early macrophages in the zebrafish embryo
    • Herbomel P, Thisse B, Thisse C. Ontogeny and behaviour of early macrophages in the zebrafish embryo. Development. 1999;126(17):3735 -3745.
    • (1999) Development , vol.126 , Issue.17
    • Herbomel, P.1    Thisse, B.2    Thisse, C.3
  • 92
    • 14744268846 scopus 로고    scopus 로고
    • Pathogenesis and inflammatory response to edwardsiella tarda infection in the zebrafish
    • Pressley ME, Phelan PE, Witten PE, et al. Pathogenesis and inflammatory response to Edwardsiella tarda infection in the zebrafish. Dev Comp Immunol. 2005;29(6):501-513.
    • (2005) Dev Comp Immunol , vol.29 , Issue.6 , pp. 501-513
    • Pressley, M.E.1    Phelan, P.E.2    Witten, P.E.3
  • 93
    • 34547585833 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharides induce genes involved in the innate immune response in embryos of the zebrafish (Danio rerio)
    • Watzke J, Schirmer K, Scholz S. Bacterial lipopolysaccharides induce genes involved in the innate immune response in embryos of the zebrafish (Danio rerio). Fish Shellfish Immunol. 2007;23:901-905.
    • (2007) Fish Shellfish Immunol , vol.23 , pp. 901-905
    • Watzke, J.1    Schirmer, K.2    Scholz, S.3
  • 95
    • 0037052865 scopus 로고    scopus 로고
    • Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: A review of recent research data
    • Heberer T. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol Lett. 2002; 131(1-2):5-17.
    • (2002) Toxicol Lett , vol.131 , Issue.1-2 , pp. 5-17
    • Heberer, T.1
  • 97
    • 33947202134 scopus 로고    scopus 로고
    • Environmental effects of human pharmaceuticals
    • Sumpter JP. Environmental effects of human pharmaceuticals. Drug Inf J. 2007;41(2):143-147.
    • (2007) Drug Inf J , vol.41 , Issue.2 , pp. 143-147
    • Sumpter, J.P.1
  • 98
    • 0036888039 scopus 로고    scopus 로고
    • Aquatic environmental assessment of the top 25 english prescription pharmaceuticals
    • Jones OAH, Voulvoulis N, Lester JN. Aquatic environmental assessment of the top 25 English prescription pharmaceuticals. Water Res. 2002;36(20):5013-5022.
    • (2002) Water Res , vol.36 , Issue.20 , pp. 5013-5022
    • Jones, O.1    Voulvoulis, N.2    Lester, J.N.3
  • 99
    • 0033843192 scopus 로고    scopus 로고
    • Biodegradation of pharmaceutical residues investigated by spe- gc/itd-ms and on-line derivatization
    • Zwiener C, Glauner T, Frimmel FH. Biodegradation of pharmaceutical residues investigated by SPE- GC/ITD-MS and on-line derivatization. Hrc-JHigh Res Chromat. 2000;23(7-8):474-478.
    • (2000) Hrc-Jhigh Res Chromat , vol.23 , Issue.7-8 , pp. 474-478
    • Zwiener, C.1    Glauner, T.2    Frimmel, F.H.3
  • 100
    • 84927048679 scopus 로고    scopus 로고
    • Guideline on the environmental risk assessment of medicinal products for human use. EMEA/CHMP/SWP/4447/00
    • EMEA/CHMP. Guideline on the environmental risk assessment of medicinal products for human use. EMEA/CHMP/SWP/4447/00; 2006.
    • (2006)
  • 101
    • 84927092520 scopus 로고    scopus 로고
    • Guidance for industry - environmental assessment of human drug and biologics applications. US Department of Health and Human Services, Food and Drug Administration, CMC6, revision 1
    • FDA. Guidance for industry - environmental assessment of human drug and biologics applications. US Department of Health and Human Services, Food and Drug Administration, CMC6, revision 1. 1998.
    • (1998)
  • 103
    • 84927048678 scopus 로고
    • OECD guideline for testing of chemicals. Test No. 210: Fish, early life stage toxicity test
    • OECD 210. OECD guideline for testing of chemicals. Test No. 210: Fish, early life stage toxicity test. 1992.
    • (1992)
  • 104
    • 33845494471 scopus 로고    scopus 로고
    • A transgenic zebrafish model of neutrophilic inflammation
    • Renshaw SA, Loynes CA, Trushell DM, et al. A transgenic zebrafish model of neutrophilic inflammation. Blood. 2006;108(13):3976-3978.
    • (2006) Blood , vol.108 , Issue.13 , pp. 3976-3978
    • Renshaw, S.A.1    Loynes, C.A.2    Trushell, D.M.3
  • 105
    • 33644824638 scopus 로고    scopus 로고
    • High-throughput assay for small molecules that modulate zebrafish embryonic heart rate
    • Burns CG, Milan DJ, Grande EJ, et al. High-throughput assay for small molecules that modulate zebrafish embryonic heart rate. Nat Chem Biol. 2005;1(5):263-264.
    • (2005) Nat Chem Biol , vol.1 , Issue.5 , pp. 263-264
    • Burns, C.G.1    Milan, D.J.2    Grande, E.J.3
  • 106
    • 0033711164 scopus 로고    scopus 로고
    • Transgenic zebrafish as sentinels for aquatic pollution
    • Carvan MJr, Dalton TP, Stuart GW, et al. Transgenic zebrafish as sentinels for aquatic pollution. Ann N Y Acad Sci USA. 2000;919:133-147.
    • (2000) Ann N Y Acad Sci USA , vol.919 , pp. 133-147
    • Mjr, C.1    Dalton, T.P.2    Stuart, G.W.3
  • 108
    • 42949123553 scopus 로고    scopus 로고
    • Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo
    • Yang L, Kemadjou J, Zinsmeister C, et al. Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo. Genome Biol. 2007;8(10):R227.
    • (2007) Genome Biol , vol.8 , Issue.10 , pp. R227
    • Yang, L.1    Kemadjou, J.2    Zinsmeister, C.3
  • 109
    • 17044392336 scopus 로고    scopus 로고
    • Less is more: The human microdosing concept
    • Garner RC. Less is more: the human microdosing concept. Drug Discov Today. 2005;10(7):449-451.
    • (2005) Drug Discov Today , vol.10 , Issue.7 , pp. 449-451
    • Garner, R.C.1


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