Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines

Functional and Integrative Genomics

Volumn 12, Issue 1, 2012, Pages 105-117

  Ivan, Fransiskus X ^a,b   Rajapakse, Jagath C ^a,b   Welsch, Roy E ^a,e   Rozen, Steve G ^a,d   Narasaraju, T ^c   Xiong, Gordon M ^c   Engelward, Bevin P ^e   Chow, Vincent T ^a,c  

^a SINGAPORE MIT ALLIANCE   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Cytokine chemokine dysregulation; Influenza virulence; Pulmonary transcriptomics; Severe lung damage; TREM1 signaling

Indexed keywords

CHEMOKINE; CYTOKINE; INTERFERON; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; VIRUS RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; HISTOPATHOLOGY; HOST PATHOGEN INTERACTION; IMMUNE DYSREGULATION; INFLUENZA A (H3N2); INFLUENZA VIRUS A H3N2; INTRACELLULAR SIGNALING; LETHALITY; LUNG LAVAGE; LYMPHOCYTIC INFILTRATION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTOMICS; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINES; CYTOKINES; FEMALE; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORKS; HOST-PATHOGEN INTERACTIONS; INFLUENZA A VIRUS, H3N2 SUBTYPE; LUNG; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TRANSCRIPTOME; VIRULENCE;

MURINAE; MUS; ORTHOMYXOVIRIDAE;

EID: 84858445080     PISSN: 1438793X     EISSN: 14387948     Source Type: Journal    
DOI: 10.1007/s10142-011-0247-y     Document Type: Article

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