Current understanding of PTX3 protective activity on Aspergillus fumigatus infection

Medical Mycology

Volumn 50, Issue 3, 2012, Pages 225-233

  Salvatori, Giovanni ^a   Campo, Silvia ^a  

^a Sigma Tau SpA   (Italy)

Author keywords

Infection; Innate immunity; Pentraxin 3

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; CORTISONE ACETATE; FICOLIN; PATTERN RECOGNITION RECEPTOR; PENTRAXIN 3; VORICONAZOLE;

ADAPTIVE IMMUNITY; ARTICLE; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; CONIDIUM; DRUG ACTIVITY; DRUG MECHANISM; FUNGAL VIRULENCE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INNATE IMMUNITY; INVASIVE ASPERGILLOSIS; LUNG ASPERGILLOSIS; MONONUCLEAR CELL; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PROTEIN FUNCTION; PROTEIN POLYMORPHISM; UNSPECIFIED SIDE EFFECT;

ANIMALS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; C-REACTIVE PROTEIN; HUMANS; IMMUNITY, INNATE; SERUM AMYLOID P-COMPONENT;

ANIMALIA; ASPERGILLUS FUMIGATUS;

EID: 84858403609     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.3109/13693786.2011.648215     Document Type: Article

References (80)

1. Denning DW. Invasive aspergillosis. Clin Infect Dis 1998; 26: 781-803.
2. Maschmeyer G, Haas A, Cornely OA. Invasive aspergillosis: epidemiology, diagnosis and management in immunocompromised patients. Drugs 2007; 67: 1567-1601. (Pubitemid 47267298)
3. Zmeili OS, Soubani AO. Pulmonary aspergillosis: a clinical update. QJM 2007; 100: 317-334. (Pubitemid 47073808)
4. Walsh TJ, Anaissie EJ, Denning DW, et al. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis 2008; 46: 327-360. (Pubitemid 351265310)
5. Romani L. Immunity to fungal infections. Nat Rev Immunol 2004; 4: 1-23.
6. Segal BH. Aspergillosis. N Engl J Med 2009; 360: 1870-1884.
7. Crosdale DJ, Poulton K V, Ollier WE, et al. Mannose-binding lectin gene polymorphisms as a susceptibility factor for chronic necrotizing pulmonary aspergillosis. J Infect Dis 2001; 184: 653-656. (Pubitemid 32783560)
8. Thiel S, Frederiksen PD, Jensenius JC. Clinical manifestations of mannan-binding lectin deficiency. Mol Immunol 2006; 43: 86-96. (Pubitemid 41021525)
9. Valdimarsson H, Vikingsdottir T, Bang P, et al. Human plasma-derived mannose-binding lectin: a phase I safety and pharmacokinetic study. Scand J Immunol 2004; 59: 97-102. (Pubitemid 38186845)
10. Breviario F, d'Aniello EM, Golay J, et al. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. J Biol Chem 1992; 267: 22190-22197.
11. Han B, Mura M, Andrade CF, et al. TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK. J Immunol 2005; 175: 8303-8311. (Pubitemid 41798396)
12. Inforzato A, Rivieccio V, Morreale A P, et al. Structural characterization of PTX3 disulf de bond network and its multimeric status in cumulus matrix organization. J Biol Chem 2008; 283: 10147-10161.
13. Lee GW, Lee TH, Vilcek J. TSG-14, a tumor necrosis factor-and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. J Immunol 1993; 150: 1804-1812. (Pubitemid 23129656)
14. Doni A, Mantovani G, Porta C, et al. Cell-specific regulation of PTX3 by glucocorticoid hormones in hematopoietic and nonhematopoietic cells. J Biol Chem 2008; 283: 29983-29992.
15. Inforzato A, Baldock C, Jowitt TA, et al. The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2. J Biol Chem 2010; 285: 17681-17692.
16. D'Angelo C, De LA, Zelante T, et al. Exogenous pentraxin 3 restores antifungal resistance and restrains inflammation in murine chronic granulomatous disease. J Immunol 2009; 183: 4609-4618.
17. Garlanda C, Hirsch E, Bozza S, et al. Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature 2002; 420: 182-186. (Pubitemid 35340122)
18. Gaziano R, Bozza S, Bellocchio S, et al. Anti-Aspergillus fumigatus efficacy of pentraxin 3 alone and in combination with antifungals. Antimicrob Agents Chemother 2004; 48: 4414-4421. (Pubitemid 39434905)
19. Lo GP, Campo S, Verdoliva A, et al. Efficacy of PTX3 in a rat model of invasive aspergillosis. Antimicrob Agents Chemother 2010; 54: 4513-4515.
20. Latge JP. Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev 1999; 12: 310-350.
21. Latge JP, Mouyna I, Tekaia F, et al. Specific molecular features in the organization and biosynthesis of the cell wall of Aspergillus fumigatus. Med Mycol 2005; 43(Suppl. 1): S15-22. (Pubitemid 41038543)
22. Momany M, Lindsey R, Hill TW, et al. The Aspergillus fumigatus cell wall is organized in domains that are remodelled during polarity establishment. Microbiology 2004; 150: 3261-3268. (Pubitemid 39406197)
23. Alberti C, Bouakline A, Ribaud P, et al. Relationship between environmental fungal contamination and the incidence of invasive aspergillosis in haematology patients. J Hosp Infect 2001; 48: 198-206. (Pubitemid 32677705)
24. McCormick A, Loeffier J, Ebel F. Aspergillus fumigatus: contours of an opportunistic human pathogen. Cell Microbiol 2010; 12: 1535-1543.
25. Holt PG, Strickland DH, Wikstrom ME, Jahnsen FL. Regulation of immunological homeostasis in the respiratory tract. Nat Rev Immunol 2008; 8: 142-152. (Pubitemid 351161302)
26. Levitz SM. Innate recognition of fungal cell walls. PLoS Pathog 2010; 6: e1000758.
27. Balloy V, Chignard M. The innate immune response to Aspergillus fumigatus. Microbes Infect 2009; 11: 919-927.
28. Brakhage AA, Bruns S, Thywissen A, Zipfel PF, Behnsen J. Interaction of phagocytes with flamentous fungi. Curr Opin Microbiol 2010; 13: 409-415.
29. Greenberg S, Grinstein S. Phagocytosis and innate immunity. Curr Opin Immunol 2002; 14: 136-145. (Pubitemid 34085118)
30. Madan T, Kaur S, Saxena S, et al. Role of collectins in innate immunity against aspergillosis. Med Mycol 2005; 43(Suppl. 1): S155-163. (Pubitemid 41038564)
31. Netea MG, Van der Meer JW, Kullberg BJ. Role of the dual interaction of fungal pathogens with pattern recognition receptors in the activation and modulation of host defence. Clin Microbiol Infect 2006; 12: 404-409.
32. Aimanianda V, Bayry J, Bozza S, et al. Surface hydrophobin prevents immune recognition of airborne fungal spores. Nature 2009; 460: 1117-1121.
33. Serrano-Gomez D, Dominguez-Soto A, Ancochea J, et al. Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin mediates binding and internalization of Aspergillus fumigatus conidia by dendritic cells and macrophages. J Immunol 2004; 173: 5635-5643. (Pubitemid 39392151)
34. Steele C, Rapaka RR, Metz A, et al. The beta-glucan receptor dec-tin-1 recognizes specific morphologies of Aspergillus fumigatus. PLoS Pathog 2005; 1: e42.
35. Madan T, Reid KB, Singh M, Sarma PU, Kishore U. Susceptibility of mice genetically deficient in the surfactant protein (SP)-A or SP-D gene to pulmonary hypersensitivity induced by antigens and allergens of Aspergillus fumigatus. J Immunol 2005; 174: 6943-6954. (Pubitemid 40705659)
36. Madan T, Reid KB, Clark H, et al. Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis. Mol Immunol 2010; 47: 1923-1930.
37. Kaur S, Gupta VK, Thiel S, Sarma PU, Madan T. Protective role of mannan-binding lectin in a murine model of invasive pulmonary aspergillosis. Clin Exp Immunol 2007; 148: 382-389. (Pubitemid 46587595)
38. Jensen TD, Schonheyder H, Andersen P, Stenderup A. Binding of C-reactive protein to Aspergillus fumigatus fractions. J Med Microbiol 1986; 21: 173-177. (Pubitemid 16134670)
39. Richardson MD, Shankland GS, Gray CA. Opsonizing activity of C-reactive protein in phagocytosis of Aspergillus fumigatus conidia by human neutrophils. Mycoses 1991; 34: 141-143.
40. Bellocchio S, Montagnoli C, Bozza S, et al. The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J Immunol 2004; 172: 3059-3069. (Pubitemid 38263695)
41. Bellocchio S, Moretti S, Perruccio K, et al. TLRs govern neutrophil activity in aspergillosis. J Immunol 2004; 173: 7406-7415. (Pubitemid 39628180)
42. Gersuk GM, Underhill DM, Zhu L, Marr KA. Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states. J Immunol 2006; 176: 3717-3724. (Pubitemid 43364018)
43. Luther K, Torosantucci A, Brakhage AA, Heesemann J, Ebel F. Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2. Cell Microbiol 2007; 9: 368-381. (Pubitemid 46092166)
44. Netea MG, Warris A, Van der Meer JW, et al. Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal transduction. J Infect Dis 2003; 188: 320-326. (Pubitemid 36898166)
45. Carvalho A, Pasqualotto AC, Pitzurra L, et al. Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis. J Infect Dis 2008; 197: 618-621. (Pubitemid 351321541)
46. Ben-Ami R, Lewis RE, Kontoyiannis DP. Enemy of the (immunosup-pressed) state: an update on the pathogenesis of Aspergillus fumigatus infection. Br J Haematol 2010; 150: 406-417.
47. McKenzie LJ, Pangas SA, Carson SA, et al. Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF. Hum Reprod 2004; 19: 2869-2874. (Pubitemid 40028960)
48. Salustri A, Garlanda C, Hirsch E, et al. PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization. Development 2004; 131: 1577-1586. (Pubitemid 38559284)
49. Varani S, Elvin JA, Yan C, et al. Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility. Mol Endocrinol 2002; 16: 1154-1167. (Pubitemid 34621066)
50. Mantovani A, Garlanda C, Doni A, Bottazzi B. Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3. J Clin Immunol 2008; 28: 1-13.
51. Moalli F, Doni A, Deban L, et al. Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus. Blood 2010; 116: 5170-5180.
52. Lu J, Marnell LL, Marjon KD, et al. Structural recognition and functional activation of FcgammaR by innate pentraxins. Nature 2008; 456: 989-992.
53. Diniz SN, Nomizo R, Cisalpino PS, et al. PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages. J Leukoc Biol 2004; 75: 649-656. (Pubitemid 38405656)
54. Bottazzi B, Vouret-Craviari V, Bastone A, et al. Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component. J Biol Chem 1997; 272: 32817-32823. (Pubitemid 28023616)
55. Deban L, Jarva H, Lehtinen MJ, et al. Binding of the long pentraxin PTX3 to factor H: interacting domains and function in the regulation of complement activation. J Immunol 2008; 181: 8433-8440.
56. Ma YJ, Doni A, Hummelshoj T, et al. Synergy between flcolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition. J Biol Chem 2009; 284: 28263-28275.
57. Ma YJ, Doni A, Skjoedt MO, et al. Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system. J Biol Chem 2011; 286: 3405-3417.
58. Nauta AJ, Bottazzi B, Mantovani A, et al. Biochemical and functional characterization of the interaction between pentraxin 3 and C1q. Eur J Immunol 2003; 33: 465-473. (Pubitemid 36267612)
59. Vogl G, Lesiak I, Jensen DB, et al. Immune evasion by acquisition of complement inhibitors: the mould Aspergillus binds both factor H and C4b binding protein. Mol Immunol 2008; 45: 1485-1493. (Pubitemid 350299465)
60. Chiarini M, Sabelli C, Melotti P, et al. PTX3 genetic variations affect the risk of Pseudomonas aeruginosa airway colonization in cystic flbrosis patients. Genes Immun 2010; 11: 665-670.
61. Kunert A, Losse J, Gruszin C, et al. Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tufiis a factor H and plasminogen binding protein. J Immunol 2007; 179: 2979-2988.
62. Jongstra-Bilen J, Harrison R, Grinstein S. Fcgamma-receptors induce Mac-1 (CD11b/CD18) mobilization and accumulation in the phagocytic cup for optimal phagocytosis. J Biol Chem 2003; 278: 45720-45729. (Pubitemid 37432715)
63. Bozza S, Gaziano R, Spreca A, et al. Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus. J Immunol 2002; 168: 1362-1371. (Pubitemid 34094507)
64. Wasylnka JA, Moore MM. Aspergillus fumigatus conidia survive and germinate in acidic organelles of A549 epithelial cells. J Cell Sci 2003; 116: 1579-1587. (Pubitemid 36527503)
65. Feldmesser M. Role of neutrophils in invasive aspergillosis. Infect Immun 2006; 74: 6514-6516. (Pubitemid 44913125)
66. Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science 2004; 303: 1532-1535. (Pubitemid 38314426)
67. Jaillon S, Peri G, Delneste Y, et al. The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med 2007; 204: 793-804. (Pubitemid 46631609)
68. Deban L, Russo RC, Sironi M, et al. Regulation of leukocyte recruitment by the long pentraxin PTX3. Nat Immunol 2010; 11: 328-334.
69. Mencacci A, Perruccio K, Bacci A, et al. Defective antifungal T-helper 1 (TH1) immunity in a murine model of allogeneic T-cell-depleted bone marrow transplantation and its restoration by treatment with TH2 cytokine antagonists. Blood 2001; 97: 1483-1490. (Pubitemid 32183776)
70. Gangneux JP, Camus C, Philippe B. Epidemiology of invasive aspergillosis and risk factors in non neutropaenic patients. Rev Mal Respir 2010; 27: e34-46.
71. Gavalda J, Len O, San JR, et al. Risk factors for invasive aspergillosis in solid-organ transplant recipients: a case-control study. Clin Infect Dis 2005; 41: 52-59. (Pubitemid 40863744)
72. Mikulska M, Raiola AM, Bruno B, et al. Risk factors for invasive aspergillosis and related mortality in recipients of allogeneic SCT from alternative donors: an analysis of 306 patients. Bone Marrow Transplant 2009; 44: 361-370.
73. Mamishi S, Zomorodian K, Saadat F, et al. A case of invasive asper-gillosis in CGD patient successfully treated with Amphotericin B and INF-gamma. Ann Clin Microbiol Antimicrob 2005; 4: 4.
74. Mantegazza AR, Savina A, Vermeulen M, et al. NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells. Blood 2008; 112: 4712-4722.
75. Romani L, Fallarino F, De LA, et al. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature 2008; 451: 211-215.
76. Johnson MD, MacDougall C, Ostrosky-Zeichner L, Perfect JR, Rex JH. Combination antifungal therapy. Antimicrob Agents Chemother 2004; 48: 693-715. (Pubitemid 38280314)
77. Bozza S, Bistoni F, Gaziano R, et al. Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation. Blood 2006; 108: 3387-3396.
78. Soares AC, Souza DG, Pinho V, et al. Dual function of the long pentraxin PTX3 in resistance against pulmonary infection with Klebsiella pneumoniae in transgenic mice. Microbes Infect 2006; 8: 1321-1329. (Pubitemid 43831702)
79. Okutani D, Han B, Mura M, et al. High-volume ventilation induces pentraxin 3 expression in multiple acute lung injury models in rats. Am J Physiol Lung Cell Mol Physiol 2007; 292: L144-153. (Pubitemid 46110451)
80. Mezger M, Einsele H, Loeffler J. Genetic susceptibility to infections with Aspergillus fumigatus. Crit Rev Microbiol 2010; 36: 168-177.