Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization

Journal of Biological Chemistry

Volumn 283, Issue 15, 2008, Pages 10147-10161

  Inforzato, Antonio ^a,b   Rivieccio, Vincenzo ^c   Morreale, Antonio P ^a   Bastone, Antonio ^d   Salustri, Antonietta ^e   Scarchilli, Laura ^e   Verdoliva, Antonio ^c   Vincenti, Silvia ^a   Gallo, Grazia ^a   Chiapparino, Caterina ^a   Pacello, Lucrezia ^a   Nucera, Eleonora ^a   Serlupi Crescenzi, Ottaviano ^a   Day, Anthony J ^b   Bottazzi, Barbara ^f   Mantovani, Alberto ^f   De Santis, Rita ^a   Salvatori, Giovanni ^a  

^a Sigma Tau SpA   (Italy)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c Tecnogen SpA   (Italy)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^e UNIVERSITY OF ROME TOR VERGATA   (Italy)

^f HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MANAGEMENT; MASS SPECTROMETRY; OLIGOMERIZATION; OLIGOMERS; PORT TERMINALS; THREE DIMENSIONAL;

CUMULUS OOPHORUS; CYSTEINE RESIDUES; DENATURING CONDITIONS; DISULFIDE BONDS; DO-MAINS; EX-VIVO; EXTRACELLULAR MATRIXES; FEMALE FERTILITIES; FUNCTIONAL MOLECULAR UNITS; INTERCHAIN DISULFIDE BONDS; KEY COMPONENTS; MULTIMERIC; OCTAMERIC ASSEMBLIES; OCTAMERS; PAGE ANALYSIS; PROTEIN SUBUNITS; RESCUE ACTIVITIES; STRUCTURAL CHARACTERIZATIONS; STRUCTURAL CONSTRAINTS; TERMINAL DOMAINS; TETRAMERS; THREE-DIMENSIONAL MODELS; WILD TYPES;

CLOUDS;

CYSTEINE; PENTRAXIN 3; SERINE; C REACTIVE PROTEIN; DISULFIDE; NERVE PROTEIN; NEURONAL PENTRAXIN; RECOMBINANT PROTEIN; SERUM AMYLOID P;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; DENATURATION; DISULFIDE BOND; OLIGOMERIZATION; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; CHO CELL; CRICETULUS; CUMULUS CELL; EXTRACELLULAR MATRIX; FEMALE; FERTILITY; GENETICS; HAMSTER; HUMAN; METABOLISM; MOUSE; MOUSE MUTANT; OOCYTE; OVULATION; PHYSIOLOGY; PROTEIN QUATERNARY STRUCTURE;

MUS;

AMINO ACID SUBSTITUTION; ANIMALS; C-REACTIVE PROTEIN; CHO CELLS; CRICETINAE; CRICETULUS; CUMULUS CELLS; DISULFIDES; EXTRACELLULAR MATRIX; FEMALE; FERTILITY; HUMANS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; OOCYTES; OVULATION; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS; SERUM AMYLOID P-COMPONENT;

EID: 44349157685     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708535200     Document Type: Article

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