Synthesis, biological evaluation and 3D-QSAR of 1,3,5-trisubstituted-4,5-dihydro-(1H)-pyrazole derivates as potent and highly selective monoamine oxidase A inhibitors

Current Medicinal Chemistry

Volumn 13, Issue 12, 2006, Pages 1411-1428

  Chimenti, Franco ^a   Bolasco, Adriana ^a   Manna, Fedele ^a   Secci, Daniela ^a   Chimenti, Paola ^a   Granese, Ariana ^a   Befani, Olivia ^a   Turini, Paola ^a   Cirilli, Roberto ^b   La Torre, Francesco ^b   Alcaro, Stefano ^c   Ortuso, Francesco ^c   Langer, Thierry ^d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

(1H) pyrazole derivatives; 3D QSAR; Monoamine oxidase; Reversible monoamine oxidase A inhibitors; Selective monoamine oxidase A inhibitors

Indexed keywords

2 METHYL 5 (3,4,5 TRIMETHOXYBENZAMIDO)DECAHYDROISOQUINOLINE; AMINE OXIDASE (FLAVIN CONTAINING); AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; BEFLOXATONE; BROFAROMINE; CLORGYLINE; IPRONIAZID; ISOCARBOXAZID; ISOENZYME; LADISTOGIL; MOCLOBEMIDE; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE INHIBITOR; NIALAMIDE; PARGYLINE; PHENELZINE; PYRAZOLE DERIVATIVE; SELEGILINE; TOLOXATONE; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

CHIRALITY; CHROMATOGRAPHY; COMPARATIVE MOLECULAR FIELD ANALYSIS; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; HUMAN; IC 50; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RACEMIC MIXTURE; REVIEW;

ANIMALS; BINDING SITES; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PYRAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STEREOISOMERISM;

EID: 33646507688     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986706776872907     Document Type: Review

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