Connecting the lines between hypogonadism and atherosclerosis

International Journal of Endocrinology

Volumn 2012, Issue , 2012, Pages

  Fahed, Akl C ^a   Gholmieh, Joanna M ^b   Azar, Sami T ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b LEBANESE AMERICAN UNIVERSITY   (Lebanon)

^c AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

[No Author keywords available]

Indexed keywords

TESTOSTERONE; VASCULAR CELL ADHESION MOLECULE 1;

ACNE; ANDROGEN DEPRIVATION THERAPY; ARTERIAL WALL THICKNESS; ATHEROGENESIS; ATHEROSCLEROSIS; BASIC RESEARCH; CARDIOMYOPATHY; CARDIOVASCULAR INFLAMMATION; CARDIOVASCULAR PARAMETERS; CARDIOVASCULAR RISK; DISEASE ASSOCIATION; DRUG SAFETY; DYSLIPIDEMIA; ENDOTHELIAL DYSFUNCTION; ERECTILE DYSFUNCTION; EXPERIMENTAL ANIMAL; FLOW MEDIATED DILATION; HEALTH; HEART ARRHYTHMIA; HEART INFARCTION; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERTENSION; HYPOGONADISM; INSULIN RESISTANCE; LIPID STORAGE; LIVER TOXICITY; METABOLIC SYNDROME X; MORBIDITY; MORTALITY; MYOCARDIAL HEALTH; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE STRESS; POLYCYTHEMIA; PRIORITY JOURNAL; PROSTATE DISEASE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SIDE EFFECT; VASCULAR HEALTH;

EID: 84858301672     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2012/793953     Document Type: Review

References (108)

1. WHO, Global status report on noncommunicable diseases 2010. June 2011, http://www.who.int/nmh/publications/ncdreport2010/en/index.html
2. Lerner D. J., Kannel W. B., Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population American Heart Journal 1986 111 2 383 390 (Pubitemid 16107280)
3. Mercuro G., Deidda M., Piras A., Dessalvi C. C., Maffei S., Rosano G. M. C., Gender determinants of cardiovascular risk factors and diseases Journal of Cardiovascular Medicine 2010 11 3 207 220
4. Jones T. H., Saad F., The effects of testosterone on risk factors for, and the mediators of, the atherosclerotic process Atherosclerosis 2009 207 2 318 327
5. Cornoldi A., Caminiti G., Marazzi G., Vitale C., Patrizi R., Volterrani M., Miceli M., Fini M., Spera G., Rosano G., Effects of chronic testosterone administration on myocardial ischemia, lipid metabolism and insulin resistance in elderly male diabetic patients with coronary artery disease International Journal of Cardiology 2010 142 1 50 55
6. Traish A. M., Abdou R., Kypreos K. E., Androgen deficiency and atherosclerosis: the lipid link Vascular Pharmacology 2009 51 5-6 303 313
7. Muller M., van den Beld A. W., Bots M. L., Grobbee D. E., Lamberts S. W. J., van der Schouw Y. T., Endogenous Sex Hormones and Progression of Carotid Atherosclerosis in Elderly Men Circulation 2004 109 17 2074 2079 (Pubitemid 38620214)
8. Brown-Sequard C., The effects produced on man by subcutaneous injections of liquid obtained from the testicles of animals The Lancet 1889 134, article105
9. Freeman E. R., Bloom D. A., McGuire E. J., A brief history of testosterone Journal of Urology 2001 165 2 371 373 (Pubitemid 32060415)
10. Bourghardt J., Wilhelmson A. S. K., Alexanderson C., De Gendt K., Verhoeven G., Krettek A., Ohlsson C., Tivesten.., Androgen receptor-dependent and independent atheroprotection by testosterone in male mice Endocrinology 2010 151 11 5428 5437
11. Qiu Y., Yanase T., Hu H., Tanaka T., Nishi Y., Liu M., Sueishi K., Sawamura T., Nawata H., Dihydrotestosterone suppresses foam cell formation and attenuates atherosclerosis development Endocrinology 2010 151 7 3307 3316
12. Bolla M., Gonzalez D., Warde P., Dubois J. B., Mirimanoff R. O., Storme G., Bernier J., Kuten A., Sternberg C., Gil T., Collette L., Pierart M., Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin The New England Journal of Medicine 1997 337 5 295 300 (Pubitemid 27318990)
13. Shahinian V. B., Kuo Y. F., Freeman J. L., Orihuela E., Goodwin J. S., Increasing use of gonadotropin-releasing hormone agonists for the treatment of localized prostate carcinoma Cancer 2005 103 8 1615 1624 (Pubitemid 40490022)
14. Basaria S., Androgen abuse in athletes: detection and consequences The Journal of Clinical Endocrinology Metabolism 2010 95 4 1533 1543
15. Choong K., Basaria S., Emerging cardiometabolic complications of androgen deprivation therapy Aging Male 2010 13 1 1 9
16. Haddad R. M., Kennedy C. C., Caples S. M., Tracz M. J., Boloa E. R., Sideras K., Uraga M. V., Erwin P. J., Montori V. M., Testosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled trials Mayo Clinic Proceedings 2007 82 1 29 39 (Pubitemid 46036319)
17. Aversa A., Bruzziches R., Francomano D., Rosano G., Isidori A. M., Lenzi A., Spera G., Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 24-month, randomized, double-blind, placebo-controlled study The Journal of Sexual Medicine 2010 7 10 3495 3503
18. Kalinchenko S. Y., Tishova Y. A., Mskhalaya G. J., Gooren L. J. G., Giltay E. J., Saad F., Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study Clinical Endocrinology 2010 73 5 602 612
19. Ding E. L., Song Y., Malik V. S., Liu S., Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis The Journal of the American Medical Association 2006 295 11 1288 1299
20. Selvin E., Feinleib M., Zhang L., Rohrmann S., Rifai N., Nelson W. G., Dobs A., Basaria S., Golden S. H., Platz E. A., Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III) Diabetes Care 2007 30 2 234 238 (Pubitemid 46198324)
21. Laaksonen D. E., Niskanen L., Punnonen K., Nyyssnen K., Tuomainen T. P., Salonen R., Rauramaa R., Salonen J. T., Sex hormones, inflammation and the metabolic syndrome: a population-based study European Journal of Endocrinology 2003 149 6 601 608 (Pubitemid 38054707)
22. Muller M., Grobbee D. E., den Tonkelaar I., Lamberts S. W. J., van der Schouw Y. T., Endogenous sex hormones and metabolic syndrome in aging men The Journal of Clinical Endocrinology Metabolism 2005 90 5 2618 2623 (Pubitemid 40686299)
23. Laaksonen D. E., Niskanen L., Punnonen K., Nyyssnen K., Tuomainen T. P., Valkonen V. P., Salonen R., Salonen J. T., Testosterone and Sex Hormone-Binding Globulin Predict the Metabolic Syndrome and Diabetes in Middle-Aged Men Diabetes Care 2004 27 5 1036 1041 (Pubitemid 38579762)
24. Rajala U. M., Keinnen-Kiukaanniemi S. M., Hirsso P. K., Jokelainen J. J., Laakso M. A., Hiltunen L. A., Ruokonen A. O., Hrknen P. K., Timonen M. J., Associations of total testosterone and sex hormone-binding globulin levels with insulin sensitivity in middle-aged Finnish men [3] Diabetes Care 2007 30 4
25. Ding E. L., Song Y., Manson J. E., Hunter D. J., Lee C. C., Rifai N., Buring J. E., Gaziano J. M., Liu S., Sex hormone-binding globulin and risk of type 2 diabetes in women and men The New England Journal of Medicine 2009 361 12 1152 1163
26. Haidar A., Yassin A., Saad F., Shabsigh R., Effects of androgen deprivation on glycaemic control and on cardiovascular biochemical risk factors in men with advanced prostate cancer with diabetes Aging Male 2007 10 4 189 196 (Pubitemid 350146723)
27. Boyanov M. A., Boneva Z., Christov V. G., Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency Aging Male 2003 6 1 1 7 (Pubitemid 36606394)
28. Kapoor D., Goodwin E., Channer K. S., Jones T. H., Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes European Journal of Endocrinology 2006 154 6 899 906 (Pubitemid 43997730)
29. Naharci M. I., Pinar M., Bolu E., Olgun A., Effect of testosterone on insulin sensitivity in men with idiopathic hypogonadotropic hypogonadism Endocrine Practice 2007 13 6 629 635
30. Jones T. H., Arver S., Behre H. M., Buvat J., Meuleman E., Moncada I., Morales A. M., Volterrani M., Yellowlees A., Howell J. D., Channer K. S., Testosterone replacement in hypogonadal men with Type 2 diabetes and/or metabolic syndrome (the TIMES2 study) Diabetes Care 2011 34 4 828 837
31. Morimoto S., Mendoza-Rodrguez C. A., Hiriart M., Larrieta M. E., Vital P., Cerbn M. A., Protective effect of testosterone on early apoptotic damage induced by streptozotocin in rat pancreas Journal of Endocrinology 2005 187 2 217 224 (Pubitemid 41685181)
32. Smith M. R., Androgen deprivation therapy for prostate cancer: new concepts and concerns Current Opinion in Endocrinology, Diabetes and Obesity 2007 14 3 247 254 (Pubitemid 46684481)
33. Keating N. L., O'Malley A. J., Smith M. R., Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer Journal of Clinical Oncology 2006 24 27 4448 4456 (Pubitemid 46630983)
34. Isidori A. M., Giannetta E., Greco E. A., Gianfrilli D., Bonifacio V., Isidori A., Lenzi A., Fabbri A., Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis Clinical Endocrinology 2005 63 3 280 293 (Pubitemid 41233445)
35. Gustafson B., Hammarstedt A., Andersson C. X., Smith U., Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 11 2276 2283 (Pubitemid 350203940)
36. Schroeder E. T., Zheng L., Ong M. D., Martinez C., Flores C., Stewart Y., Azen C., Sattler F. R., Effects of androgen therapy on adipose tissue and metabolism in older men The Journal of Clinical Endocrinology Metabolism 2004 89 10 4863 4872 (Pubitemid 39391420)
37. Niskanen L., Laaksonen D. E., Punnonen K., Mustajoki P., Kaukua J., Rissanen A., Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome Diabetes, Obesity and Metabolism 2004 6 3 208 215 (Pubitemid 38559701)
38. Pritchard J., Després J.-P., Gagnon J., Tchernof A., Nadeau A., Tremblay A., Bouchard C., Plasma adrenal, gonadal, and conjugated steroids before and after long term overfeeding in identical twins The Journal of Clinical Endocrinology Metabolism 1998 83 9 3277 3284 (Pubitemid 28500972)
39. Laaksonen D. E., Niskanen L., Punnonen K., Nyyssnen K., Tuomainen T.-P., Valkonen V.-P., Salonen J. T., The metabolic syndrome and smoking in relation to hypogonadism in middle-aged men: a prospective cohort study The Journal of Clinical Endocrinology Metabolism 2005 90 2 712 719 (Pubitemid 40279184)
40. Traish A. M., Saad F., Guay A., The dark side of testosterone deficiency: II. type 2 diabetes and insulin resistance Journal of Andrology 2009 30 1 23 32
41. Zumoff B., Miller L. K., Strain G. W., Reversal of the hypogonadotropic hypogonadism of obese men by administration of the aromatase inhibitor testolactone Metabolism: Clinical and Experimental 2003 52 9 1126 1128 (Pubitemid 37203485)
42. Saad F., Gooren L. J., The role of testosterone in the etiology and treatment of obesity, the metabolic syndrome, and diabetes mellitus type 2 Journal of Obesity 2011 2011 10
43. Traish A. M., Feeley R. J., Guay A., Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction FEBS Journal 2009 276 20 5755 5767
44. Adiels M., Olofsson S.-O., Taskinen M.-R., Borén J., Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome Arteriosclerosis, Thrombosis, and Vascular Biology 2008 28 7 1225 1236
45. Simon D., Charles M. A., Nahoul K., Orssaud G., Kremski J., Hully V., Joubert E., Papoz L., Eschwege E., Association between plasma total testosterone and cardiovascular risk factors in healthy adult men: the telecom study The Journal of Clinical Endocrinology Metabolism 1997 82 2 682 685 (Pubitemid 27068651)
46. Barrett-Connor E., Lower endogenous androgen levels and dyslipidemia in men with non-insulin- dependent diabetes mellitus Annals of Internal Medicine 1992 117 10 807 811
47. Haffner S. M., Mykkanen L., Valdez R. A., Katz M. S., Relationship of sex hormones to lipids and lipoproteins in nondiabetic men The Journal of Clinical Endocrinology Metabolism 1993 77 6 1610 1615 (Pubitemid 24000922)
48. Uyanik B. S., Ari Z., Gms B., Yiitolu M. R., Arslan T., Beneficial effects of testosterone undecanoate on the lipoprotein profiles in healthy elderly men. A placebo controlled study Japanese Heart Journal 1997 38 1 73 82 (Pubitemid 27136226)
49. Tenover J. S., Effects of testosterone supplementation in the aging male The Journal of Clinical Endocrinology Metabolism 1992 75 4 1092 1098
50. Ly L. P., Jimenez M., Zhuang T. N., Celermajer D. S., Conway A. J., Handelsman D. J., A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency The Journal of Clinical Endocrinology Metabolism 2001 86 9 4078 4088 (Pubitemid 32848516)
51. van Pottelbergh I., Braeckman L., De Bacquer D., De Backer G., Kaufman J. M., Differential contribution of testosterone and estradiol in the determination of cholesterol and lipoprotein profile in healthy middle-aged men Atherosclerosis 2003 166 1 95 102 (Pubitemid 35449605)
52. Zgliczynski S., Ossowski M., Slowinska-Srzednicka J., Brzezinska A., Zgliczynski W., Soszynski P., Chotkowska E., Srzednicki M., Sadowski Z., Effect of testosterone replacement therapy on lipids and lipoproteins in hypogonadal and elderly men Atherosclerosis 1996 121 1 35 43
53. Zitzmann M., Nieschlag E., Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men The Journal of Clinical Endocrinology Metabolism 2007 92 10 3844 3853 (Pubitemid 47607632)
54. Thompson P. D., Cullinane E. M., Sady S. P., Chenevert C., Saritelli A. L., Sady M. A., Herbert P. N., Contrasting effects of testosterone and stanozolol on serum lipoprotein levels The Journal of the American Medical Association 1989 261 8 1165 1168 (Pubitemid 19062451)
55. Ariyo A. A., Thach C., Tracy R., Lp(a) lipoprotein, vascular disease, and mortality in the elderly The New England Journal of Medicine 2003 349 22 2108 2115 (Pubitemid 37464535)
56. Kaplan S. A., Lin J., Johnson-Levonas A. O., Shah A. K., Meehan A. G., Increased occurrence of marked elevations of lipoprotein(a) in ageing, hypercholesterolaemic men with low testosterone Aging Male 2010 13 1 40 43
57. Tomaszewski M., Charchar F. J., Maric C., Kuzniewicz R., Gola M., Grzeszczak W., Samani N. J., Zukowska-Szczechowska E., Association between lipid profile and circulating concentrations of estrogens in young men Atherosclerosis 2009 203 1 257 262
58. Johnsen S. H., Mathiesen E. B., Fosse E., Joakimsen O., Stensland-Bugge E., Njlstad I., Arnesen E., Elevated high-density lipoprotein cholesterol levels are protective against plaque progression: a follow-up study of 1952 persons with carotid atherosclerosis. The Troms Study Circulation 2005 112 4 498 504 (Pubitemid 41060789)
59. Svartberg J., von Mhlen D., Schirmer H., Barrett-Connor E., Sundfjord J., Jorde R., Association of endogenous testosterone with blood pressure and left ventricular mass in men. The Troms Study European Journal of Endocrinology 2004 150 1 65 71 (Pubitemid 38159742)
60. Maravelias C., Dona A., Stefanidou M., Spiliopoulou C., Adverse effects of anabolic steroids in athletes. A constant threat Toxicology Letters 2005 158 3 167 175 (Pubitemid 41074813)
61. Marin P., Holmng S., Gustafsson C., Jnsson L., Kvist H., Elander A., Eldh J., Sjstrm L., Holm G., Bjrntorp P., Androgen treatment of abdominally obese men Obesity Research 1993 1 4 245 251
62. Kumanov P., Tomova A., Kirilov G., Testosterone replacement therapy in male hypogonadism is not associated with increase of endothelin-1 levels International Journal of Andrology 2007 30 1 41 47 (Pubitemid 46161039)
63. Kumanov P., Tomova A., Kirilov G., Dakovska L., Schinkov A., Increased plasma endothelin levels in patients with male hypogonadism Andrologia 2002 34 1 29 33 (Pubitemid 34175317)
64. Vignozzi L., Morelli A., Filippi S., Ambrosini S., Mancina R., Luconi M., Mungai S., Vannelli G. B., Zhang X. H., Forti G., Maggi M., Traish A., Testosterone regulates RhoA/Rho-kinase signaling in two distinct animal models of chemical diabetes The Journal of Sexual Medicine 2007 4 3 620 632 (Pubitemid 46779298)
65. Marin R., Escrig A., Abreu P., Mas M., Androgen-dependent nitric oxide release in rat penis correlates with levels of constitutive nitric oxide synthase isoenzymes Biology of Reproduction 1999 61 4 1012 1016 (Pubitemid 29455639)
66. Cakir E., Ozcan O., Yaman H., Akgul E. O., Bilgi C., Erbil M. K., Yesilova Z., Elevated plasma concentration of asymmetric dimethylarginine that is reduced by single dose testosterone administration in idiopathic hypogonadotropic hypogonadism patients The Journal of Clinical Endocrinology Metabolism 2005 90 3 1651 1654 (Pubitemid 40464033)
67. Leifke E., Kinzel M., Tsikas D., Gooren L., Frlich J. C., Brabant G., Effects of normalization of plasma testosterone levels in hypogonadal men on plasma levels and urinary excretion of asymmetric dimethylarginine (ADMA) Hormone and Metabolic Research 2008 40 1 56 59 (Pubitemid 351204826)
68. Hak A. E., Witteman J. C. M., de Jong F. H., Geerlings M. I., Hofman A., Pols H. A. P., Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam Study The Journal of Clinical Endocrinology Metabolism 2002 87 8 3632 3639 (Pubitemid 34879505)
69. McCrohon J. A., Death A. K., Nakhla S., Jessup W., Handelsman D. J., Stanley K. K., Celermajer D. S., Androgen receptor expression is greater in macrophages from male than from female donors: a sex difference with implications for atherogenesis Circulation 2000 101 3 224 226 (Pubitemid 30054145)
70. Ling S., Aozhi D., Williams M. R. I., Myles K., Dilley R. J., Komesaroff P. A., Sudhir K., Testosterone (T) enhances apoptosis-related damage in human vascular endothelial cells Endocrinology 2002 143 3 1119 1125 (Pubitemid 34164060)
71. Alexandersen P., Haarbo J., Byrjalsen I., Lawaetz H., Christiansen C., Natural androgens inhibit male atherosclerosis: a study in castrated, cholesterol-fed rabbits Circulation Research 1999 84 7 813 819 (Pubitemid 29181488)
72. Tharp D. L., Masseau I., Ivey J., Ganjam V. K., Bowles D. K., Endogenous testosterone attenuates neointima formation after moderate coronary balloon injury in male swine Cardiovascular Research 2009 82 1 152 160
73. Hanke H., Lenz C., Hess B., Spindler K. D., Weidemann W., Effect of testosterone on plaque development and androgen receptor expression in the arterial vessel wall Circulation 2001 103 10 1382 1385 (Pubitemid 32220628)
74. Nettleship J. E., Jones T. H., Channer K. S., Jones R. D., Physiological testosterone replacement therapy attenuates fatty streak formation and improves high-density lipoprotein cholesterol in the Tfm mouse: an effect that is independent of the classic androgen receptor Circulation 2007 116 21 2427 2434 (Pubitemid 350145077)
75. Heufelder A. E., Saad F., Bunck M. C., Gooren L., Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone Journal of Andrology 2009 30 6 726 733
76. Malkin C. J., Pugh P. J., Jones R. D., Kapoor D., Channer K. S., Jones T. H., The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men The Journal of Clinical Endocrinology Metabolism 2004 89 7 3313 3318 (Pubitemid 38951897)
77. Liva S. M., Voskuhl R. R., Testosterone acts directly on CD4 + T lymphocytes to increase IL-10 production Journal of Immunology 2001 167 4 2060 2067 (Pubitemid 32747513)
78. Bhatia V., Chaudhuri A., Tomar R., Dhindsa S., Ghanim H., Dandona P., Low testosterone and high C-reactive protein concentrations predict low hematocrit in type 2 diabetes Diabetes Care 2006 29 10 2289 2294 (Pubitemid 44899867)
79. Kapoor D., Clarke S., Stanworth R., Channer K. S., Jones T. H., The effect of testosterone replacement theraphy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes European Journal of Endocrinology 2007 156 5 595 602 (Pubitemid 46796527)
80. Ng M. K. C., Liu P. Y., Williams A. J., Nakhla S., Ly L. P., Handelsman D. J., Celermajer D. S., Prospective study of effect of androgens on serum inflammatory markers in men Arteriosclerosis, Thrombosis, and Vascular Biology 2002 22 7 1136 1141 (Pubitemid 34764864)
81. Fu L., Gao Q. P., Shen J. X., Relationship between testosterone and indexes indicating endothelial function in male coronary heart disease patients Asian Journal of Andrology 2008 10 2 214 218 (Pubitemid 351337982)
82. Hatakeyama H., Nishizawa M., Nakagawa A., Nakano S., Kigoshi T., Uchida K., Testosterone inhibits tumor necrosis factor- -induced vascular cell adhesion molecule-1 expression in human aortic endothelial cells FEBS Letters 2002 530 13 129 132 (Pubitemid 35248198)
83. Akishita M., Hashimoto M., Ohike Y., Ogawa S., Iijima K., Eto M., Ouchi Y., Low testosterone level is an independent determinant of endothelial dysfunction in men Hypertension Research 2007 30 11 1029 1034
84. Kang S. M., Jang Y., Kim J. Y., Chung N., Cho S. Y., Chae J. S., Lee J. H., Effect of oral administration of testosterone on brachial arterial vasoreactivity in men with coronary artery disease American Journal of Cardiology 2002 89 7 862 864 (Pubitemid 34241469)
85. Kenny A. M., Prestwood K. M., Gruman C. A., Fabregas G., Biskup B., Mansoor G., Effects of transdermal testosterone on lipids and vascular reactivity in older men with low bioavailable testosterone levels The Journals of Gerontology A 2002 57 7 M460 M465
86. Zitzmann M., Brune M., Nieschlag E., Vascular reactivity in hypogonadal men is reduced by androgen substitution The Journal of Clinical Endocrinology Metabolism 2002 87 11 5030 5037 (Pubitemid 35316342)
87. Mattace-Raso F. U. S., van der Cammen T. J. M., Hofman A., van Popele N. M., Bos M. L., Schalekamp M. A. D. H., Asmar R., Reneman R. S., Hoeks A. P. G., Breteler M. M. B., Witteman J. C. M., Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study Circulation 2006 113 5 657 663
88. Hougaku H., Fleg J. L., Najjar S. S., Lakatta E. G., Harman S. M., Blackman M. R., Metter E. J., Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements American Journal of Physiology 2006 290 2 E234 E242
89. Pearson L. J., Yandle T. G., Nicholls M. G., Evans J. J., Regulation of endothelin-1 release from human endothelial cells by sex steroids and angiotensin-II Peptides 2008 29 6 1057 1061
90. Keymel S., Kalka C., Rassaf T., Yeghiazarians Y., Kelm M., Heiss C., Impaired endothelial progenitor cell function predicts age-dependent carotid intimal thickening Basic Research in Cardiology 2008 103 6 582 586
91. Foresta C., Caretta N., Lana A., De Toni L., Biagioli A., Ferlin A., Garolla A., Reduced number of circulating endothelial progenitor cells in hypogonadal men The Journal of Clinical Endocrinology Metabolism 2006 91 11 4599 4602 (Pubitemid 44833444)
92. Foresta C., Zuccarello D., De Toni L., Garolla A., Caretta N., Ferlin A., Androgens stimulate endothelial progenitor cells through an androgen receptor-mediated pathway Clinical Endocrinology 2008 68 2 284 289
93. Lesser M. A., The treatment of angina pectoris with testosterone propionatepreliminary report The New England Journal of Medicine 1942 226 51 54
94. Lesser M. A., Testosterone propionate therapy in one hundred cases of angina pectoris The Journal of Clinical Endocrinology Metabolism 1946 6 549 557
95. Walker T. C., Use of testosterone propionate and estrogenic substance in treatment of essential hypertension, angina pectoris and peripheral vascular disease The Journal of Clinical Endocrinology Metabolism 1942 2 9 560 568
96. Jaffe M. D., Effect of testosterone cypionate on postexercise ST segment depression British Heart Journal 1977 39 11 1217 1222 (Pubitemid 8206514)
97. Wu S., Weng X., Therapeutic effects of an androgenic preparation on myocardial ischemia and cardiac function in 62 elderly male coronary heart disease patients Chinese Medical Journal 1993 106 6 415 418 (Pubitemid 23208017)
98. Ezaki K., Nakagawa M., Taniguchi Y., Nagano Y., Teshima Y., Yufu K., Takahashi N., Nomura T., Satoh F., Mimata H., Saikawa T., Gender differences in the ST segment: effect of androgen-deprivation therapy and possible role of testosterone Circulation Journal 2010 74 11 2448 2454
99. Mathur A., Malkin C., Saeed B., Muthusamy R., Hugh Jones T., Channer K., Long-term benefits of testosterone replacement therapy on angina threshold and atheroma in men European Journal of Endocrinology 2009 161 3 443 449
100. Caminiti G., Volterrani M., Iellamo F., Marazzi G., Massaro R., Miceli M., Mammi C., Piepoli M., Fini M., Rosano G. M. C., Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study Journal of the American College of Cardiology 2009 54 10 919 927
101. Malkin C. J., Channer K. S., Jones T. H., Testosterone and heart failure Current Opinion in Endocrinology, Diabetes and Obesity 2010 17 3 262 268
102. Zitzmann M., Vorona E., Wenk M., Saad F., Nieschlag E., Testosterone administration decreases carotid artery intima media thickness as indicator of vascular damage in middle-aged overweight men Journal of Andrology 2008 54 55
103. Heitzer T., Schlinzig T., Krohn K., Meinertz T., Mnzel T., Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease Circulation 2001 104 22 2673 2678 (Pubitemid 33108132)
104. Schwartz B. G., Kloner R. A., How to save a life during a clinic visit for erectile dysfunction by modifying cardiovascular risk factors International Journal of Impotence Research 2009 21 6 327 335
105. Yeap B. B., Androgens and cardiovascular disease Current Opinion in Endocrinology, Diabetes and Obesity 2010 17 3 269 276
106. Calof O. M., Singh A. B., Lee M. L., Kenny A. M., Urban R. J., Tenover J. L., Bhasin S., Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials The Journals of Gerontology A 2005 60 11 1451 1457 (Pubitemid 41798454)
107. Fernndez-Balsells M. M., Murad M. H., Lane M., Lampropulos J. F., Albuquerque F., Mullan R. J., Agrwal N., Elamin M. B., Gallegos-Orozco J. F., Wang A. T., Erwin P. J., Bhasin S., Montori V. M., Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis The Journal of Clinical Endocrinology Metabolism 2010 95 6 2560 2575
108. Shabsigh R., Crawford E. D., Nehra A., Slawin K. M., Testosterone therapy in hypogonadal men and potential prostate cancer risk: a systematic review International Journal of Impotence Research 2009 21 1 9 23