Relationship between testosterone and indexes indicating endothelial function in male coronary heart disease patients

Asian Journal of Andrology

Volumn 10, Issue 2, 2008, Pages 214-218

  Fu, Lu ^a   Gao, Qian Ping ^a   Shen, Jing Xia ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Coronary heart disease; Endothelial function; Testosterone

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TESTOSTERONE; TRIACYLGLYCEROL; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGE; AGED; ARTERY DIAMETER; ARTERY ENDOTHELIUM; ARTERY INTIMA PROLIFERATION; ARTICLE; BLOOD PRESSURE MEASUREMENT; CHOLESTEROL BLOOD LEVEL; COMMON CAROTID ARTERY; CONTROLLED STUDY; CORRELATION ANALYSIS; DATA ANALYSIS; DIASTOLIC BLOOD PRESSURE; GLUCOSE BLOOD LEVEL; HEART FUNCTION; HUMAN; ISCHEMIC HEART DISEASE; LINEAR REGRESSION ANALYSIS; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY; PROTEIN BLOOD LEVEL; SMOKING; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT;

AGED; CAROTID ARTERY, COMMON; CORONARY DISEASE; ENDOTHELIUM, VASCULAR; HUMANS; MALE; MIDDLE AGED; TESTOSTERONE; TUNICA INTIMA; TUNICA MEDIA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 40349105707     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1111/j.1745-7262.2008.00335.x     Document Type: Article

References (19)

1. English KM, Mandour O, Steeds RP, Diver MJ, Jones TH, Channer KS. Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms. Eur Heart J 2000; 21: 890-4.
2. Channer KS, Jones TH. Cardiovascular effects of testosterone: implications of the "male menopause"? Heart 2003; 89: 121-2.
3. Dobrzycki S, Serwatka W, Nadlewski S, Korecki J, Jackowski R, Paruk J, et al. An assessment of correlations between endogenous sex hormone levels and the extensiveness of coronary heart disease and the ejection fraction of the left ventricle in males. J Med Invest 2003; 50: 162-9.
4. Kajinami K, Takeda K, Takekoshi N, Matsui S, Tsugawa H, Kanemitsu S, et al. Imbalance of sex hormone levels in men with coronary artery disease. Coron Artery Dis 2004; 15: 199-203.
5. Hatakeyama H, Nishizawa M, Nakagawa A, Nakano S, Kigoshi T, Uchida K. Testosterone inhibits tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in human aortic endothelial cells. FEBS Lett 2002; 530: 129-32.
6. van den Beld AW, Bots ML, Janssen JA, Pols HA, Lamberts SW, Grobbee DE. Endogenous hormones and carotid atherosclerosis in elderly men. Am J Epidemiol 2003; 157: 25-31.
7. Fukui M, Kitagawa Y, Nakamura N, Kadono M, Mogami S, Hirata C, et al. Association between serum testosterone concentration and carotid atherosclerosis in men with type 2 diabetes. Diabetes Care 2003; 26: 1929-31.
8. De Pergola G, Pannacciulli N, Ciccone M, Tartagni M, Rizzon P, Giorgino R. Free testosterone plasma levels are negatively associated with the intima-media thickness of the common carotid artery in overweight and obese glucose-tolerant young adult men. Int J Obes Relat Metab Disord 2003; 27: 803-7.
9. Mäkinen J, Järvisalo MJ, Pöllänen P, Perheentupa A, Irjala K, Koskenvuo M, et al. Increased carotid atherosclerosisin andropausal middle-aged men. J Am Coll Cardiol 2005; 45: 1603-8.
10. Muller M, van den Beld AW, Bots ML, Grobbee DE, Lamberts SW, van der Schouw YT. Endogenous sex hormones and progression of carotid atherosclerosis in elderly men. Circulation 2004, 109: 2074-9.
11. Hak AE, Witteman JC, de Jong FH, Geerlings MI, Hofman A, Pols HA. Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: The Rotterdam study. J Clin Endocrinol Metab 2002; 87: 3632-9.
12. Malkin CJ, Pugh PJ, Jones RD, Jones TH, Channer KS. Testosterone as a protective factor against atherosclerosis-immunomodulation and influence upon plaque development and stability. J Endocrinol 2003; 178: 373-80.
13. Nathan L, Shi W, Dinh H, Mukherjee TK, Wang X, Lusis AJ, et al. Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc Natl Acad Sci U S A 2001; 98: 3589-93.
14. Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, McKinlay JB. Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab 2006; 91: 843-50.
15. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR, Baltimore Longitudinal Study of Aging Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 2001; 86: 724-31.
16. English KM, Steeds RP, Jones TH, Diver MJ, Channer KS. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: A randomized, double-blind, placebo-controlled study. Circulation 2000; 102: 1906-11.
17. Liu WJ, Xin ZC, Xin H, Yuan YM, Tian L, Guo YL. Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. Asian J Androl 2005; 7: 381-8.
18. Zhang ZB, Yang QT. The testosterone mimetic properties of icariin. Asian J Androl 2006; 8: 601-5.
19. Saad F, Kamischke A, Yassin A, Zitzmann M, Schubert M, Jochenhel F, et al. More than eight years hands-on experience with the novel long-acting parenteral testosterone undecanoate. Asian J Androl 2007; 9: 291-7.