Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements

American Journal of Physiology - Endocrinology and Metabolism

Volumn 290, Issue 2, 2006, Pages

  Hougaku, Hidetaka ^a,b   Fleg, Jerome L ^a   Najjar, Samer S ^a   Lakatta, Edward G ^a   Harman, S Mitchell ^c   Blackman, Marc R ^d   Metter, E Jeffrey ^a,e  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b OSAKA UNIVERSITY   (Japan)

^c Kronos Longevity Research Institute   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e HARBOR HOSPITAL   (United States)

Author keywords

Carotid ultrasonography; Coronary heart disease; Dehydroepiandrosterone; Intimal medial thickness; Testosterone

Indexed keywords

ANDROGEN; CHOLESTEROL; GLUCOSE; PRASTERONE SULFATE; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AGED; AGING; ARTERY INTIMA PROLIFERATION; ARTICLE; BODY MASS; BRACHIAL ARTERY; CARDIOVASCULAR PARAMETERS; CARDIOVASCULAR RISK; CAROTID ARTERY DISEASE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMOGRAPHY; DIASTOLIC BLOOD PRESSURE; DIET RESTRICTION; ECHOGRAPHY; FOLLOW UP; GLUCOSE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; PRIORITY JOURNAL; PULSE PRESSURE; SYSTOLIC BLOOD PRESSURE; AGE DISTRIBUTION; BLOOD; CLINICAL TRIAL; COMPUTER ASSISTED DIAGNOSIS; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY BLOOD VESSEL; ELASTICITY; LONGITUDINAL STUDY; METHODOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; PREVALENCE; PROPORTIONAL HAZARDS MODEL; RISK ASSESSMENT; RISK FACTOR; STATISTICS; UNITED STATES;

ADULT; AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; ANDROGENS; CORONARY ARTERIOSCLEROSIS; CORONARY VESSELS; ELASTICITY; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; LONGITUDINAL STUDIES; MALE; MARYLAND; MIDDLE AGED; PREVALENCE; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; RISK FACTORS; STATISTICS;

EID: 33644867881     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00059.2005     Document Type: Article

References (73)

1. Abate N, Haffner SM, Garg A, Peshock RM, and Grundy SM. Sex steroid hormones, upper body obesity, and insulin resistance. J Clin Endocrinol Metab 87: 4522-4527, 2002.
2. Amatruda JM, Harman SM, Pourmotabbed G, and Lockwood DH. Depressed plasma testosterone and fractional binding of testosterone in obese males. J Clin Endocrinol Metab 47: 268-271, 1978.
3. Arcaro G, Laurent S, Jondeau G, Hoeks AP, and Safar ME. Stiffness of the common carotid artery in treated hypertensive patients. J Hypertens 9: 947-954, 1991.
4. Barrett-Connor E, and Goodman-Gruen D. The epidemiology of DHEAS and cardiovascular disease. Ann NY Acad Sci 774: 259-270, 1995.
5. Barrett-Connor E and Khaw KT. Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study. Circulation 78: 539-545, 1988.
6. Barrett-Connor E, Khaw KT, and Yen SS. A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease. N Engl J Med 315: 1519-1524, 1986.
7. Berr C, Lafont S, Debuire B, Dartigues JF, and Baulieu EE. Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study. Proc Natl Acad Sci USA 93: 13410-13415, 1996.
8. Birkeland KI, Hanssen KF, Torjesen PA, and Vaaler S. Level of sex hormone-binding globulin is positively correlated with insulin sensitivity in men with type 2 diabetes. J Clin Endocrinol Metab 76: 275-278, 1993.
9. Bland JM and Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1: 307-310, 1986.
10. Blankenhorn DH and Kramsch DM. Reversal of atherosis and sclerosis. The two components of atherosclerosis. Circulation 79: 1-7, 1989.
11. Brannian JD, Long P, and Kreger DO. Is the free androgen index a useful clinical marker in male patients? S D J Med 51: 449-451, 1998.
12. Cauley JA, Gutai JP, Kuller LH, and Dai WS. Usefulness of sex steroid hormone levels in predicting coronary artery disease in men. Am J Cardiol 60: 771-777, 1987.
13. Contoreggi CS, Blackman MR, Andres R, Muller DC, Lakatta EG, Fleg JL, and Harman SM. Plasma levels of estradiol, testosterone, and DHEAS do not predict risk of coronary artery disease in men. J Androl 11: 460-470, 1990.
14. Dart AM and Kingwell BA. Pulse pressure - a review of mechanisms and clinical relevance. J Am Coll Cardiol 37: 975-984, 2001.
15. De Pergola G, De Mitrio V, Sciaraffia M, Pannacciulli N, Minenna A, Giorgino F, Petronelli M, Laudadio E, and Giorginio R. Lower androgenicity is associated with higher plasma levels of prothrombotic factors irrespective of age, obesity, body fat distribution, and related metabolic parameters in men. Metabolism 46: 1287-1293, 1997.
16. Dockery F, Rajkumar C, Agarwal S, Waxman J, and Bulpitt CJ. Androgen deprivation in males is associated with decreased central arterial compliance and reduced central systolic blood pressure. J Hum Hypertens 14: 395-397, 2000.
17. Efron B and Tibshirani RJ. An Introduction to the Bootstrap. New York: Chapman & Hill, 1993, p. 239-241.
18. English KM, Mandour O, Steeds RP, Diver MJ, Jones TH, and Channer KS. Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms [see comments]. Eur Heart J 21: 890-894, 2000.
19. Fukui M, Kitagawa Y, Nakamura N, Kadono M, Mogami S, Hirata C, Ichio N, Wada K, Hasegawa G, and Yoshikawa T. Association between serum testosterone concentration and carotid atherosclerosis in men with type 2 diabetes. Diabetes Care 26: 1869-1873, 2003.
20. Giagulli VA, Kaufman JM, and Vermeulen A. Pathogenesis of the decreased androgen levels in obese men. J Clin Endocrinol Metab 79: 997-1000, 1994.
21. Glass AR, Swerdloff RS, Bray GA, Dahms WT, and Atkinson RL. Low serum testosterone and sex-hormone-binding-globulin in massively obese men. J Clin Endocrinol Metab 45: 1211-1219, 1977.
22. Glueck CJ, Glueck HI, Stroop D, Speirs J, Hamer T, and Tracy T. Endogenous testosterone, fibrinolysis, and coronary heart disease risk in hyperlipidemic men. J Lab Clin Med 122: 412-420, 1993.
23. Goodman-Gruen D and Barrett-Connor E. A prospective study of sex hormone-binding globulin and fatal cardiovascular disease in Rancho Bernardo men and women. J Clin Endocrinol Metab 81: 2999-3003, 1996.
24. Haffner SM. Sex hormones, obesity, fat distribution, type 2 diabetes and insulin resistance: epidemiological and clinical correlation. Int J Obes Relat Metab Disord 24, Suppl 2: S56-S58, 2000.
25. Haffner SM, Karhapaa P, Mykkanen L, Laakso M. Insulin resistance, body fat distribution, and sex hormones in men. Diabetes 43: 212-219, 1994.
26. Haffner SM, Laakso M, Miettinen H, Mykkanen L, Karhapaa P, and Rainwater DL. Low levels of sex hormone-binding globulin and testosterone are associated with smaller, denser low density lipoprotein in normoglycemic men. J Clin Endocrinol Metab 81: 3697-3701, 1996.
27. Haffner SM, Valdez RA, Mykkanen L, Stern MP, and Katz MS. Decreased testosterone and dehydroepiandrosterone sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men. Metabolism 43: 599-603, 1994.
28. Harman SM, Metter EJ, Tobin JD, Pearson J, and Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 86: 724-731, 2001.
29. Hautanen A. Synthesis and regulation of sex hormone-binding globulin in obesity. Int J Obes Relat Metab Disord 24, Suppl 2: S64-S70, 2000.
30. Heller RF, Wheeler MJ, Micallef J, Miller NE, and Lewis B. Relationship of high density lipoprotein cholesterol with total and free testosterone and sex hormone binding globulin. Acta Endocrinol (Copenh) 104: 253-256, 1983.
31. Herrington DM, Gordon GB, Achuff SC, Trejo JF, Weisman HF, Kwiterovich POJR, and Pearson TA. Plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate in patients undergoing diagnostic coronary angiography. J Am Coll Cardiol 16: 862-870, 1990.
32. Herrington DM, Nanjee N, Achuff SC, Cameron DE, Dobbs B, and Baughman KL. Dehydroepiandrosterone and cardiac allograft vasculopathy. J Heart Lung Transplant 15: 88-93, 1996.
33. Hirai T, Sasayama S, Kawasaki T, and Yagi S. Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis. Circulation 80: 78-86, 1989.
34. Hopkins KD, Lehmann ED, Jones RL, Turay RC, and Gosling RG. A family history of NIDDM is associated with decreased aortic distensibility in normal healthy young adult subjects. Diabetes Care 19: 501-503, 1996.
35. Jansson JH, Nilsson TK, and Johnson O. von Willebrand factor, tissue plasminogen activator, and dehydroepiandrosterone sulphate predict cardiovascular death in a 10 year follow up of survivors of acute myocardial infarction. Heart 80: 334-337, 1998.
36. Kabakci G, Yildirir A, Can I, Unsal I, and Erbas B. Relationship between endogenous sex hormone levels, lipoproteins and coronary atherosclerosis in men undergoing coronary angiography. Cardiology 92: 221-225, 1999.
37. Kawano H, Yasue H, Kitagawa A, Hirai N, Yoshida T, Soejima H, Miyamoto S, Nakano M, and Ogawa H. Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men. J Clin Endocrinol Metab 88: 3190-3195, 2003.
38. Kawasaki T, Sasayama S, Yagi S, Asakawa T, and Hirai T. Noninvasive assessment of the age related changes in stiffness of major branches of the human arteries. Cardiovasc Res 21: 678-687, 1987.
39. Kiechl S, Willeit J, Bonora E, Schwarz S, and Xu Q. No association between dehydroepiandrosterone sulfate and development of atherosclerosis in a prospective population study (Bruneck Study). Arterioscler Thromb Vasc Biol 20: 1094-1100, 2000.
40. King DS, Sharp RL, Vukovich MD, Brown GA, Reifenrath TA, Uhl NL, and Parsons KA. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: a randomized controlled trial [see comments]. JAMA 281: 2020-2028, 1999.
41. LaCroix AZ, Yano K, and Reed DM. Dehydroepiandrosterone sulfate, incidence of myocardial infarction, and extent of atherosclerosis in men. Circulation 86: 1529-1535, 1992.
42. Lehmann ED, Hopkins KD, Jones RL, Rudd AG, and Gosling RG. Aortic distensibility in patients with cerebrovascular disease. Clin Sci (Colch) 89: 247-253, 1995.
43. Lehmann ED, Watts GF, and Gosling RG. Aortic distensibility and hypercholesterolaemia [letter; comment]. Lancet 340: 1171-1172, 1992.
44. Marsh JD, Lehmann MH, Ritchie RH, Gwathmey JK, Green GE, and Schiebinger RJ. Androgen receptors mediate hypertrophy in cardiac myocytes. Circulation 98: 256-261, 1998.
45. Mazat L, Lafont S, Berr C, Debuire B, Tessier JF, Dartigues JF, and Baulieu EE. Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality. Proc Natl Acad Sci USA 98: 8145-8150, 2001.
46. Mitchell LE, Sprecher DL, Borecki IB, Rice T, Laskarzewski PM, and Rao DC. Evidence for an association between dehydroepiandrosterone sulfate and nonfatal, premature myocardial infarction in males. Circulation 89: 89-93, 1994.
47. Nagai Y, Earley CJ, Kemper MK, Bacal CS, and Metter EJ. Influence of age and postmenopausal estrogen replacement therapy on carotid arterial stiffness in women. Cardiovasc Res 41: 307-311, 1994.
48. Newcomer LM, Manson JE, Barbieri RL, Hennekens CH, and Stampfer MJ. Dehydroepiandrosterone sulfate and the risk of myocardial infarction in US male physicians: a prospective study. Am J Epidemiol 140: 870-875, 1994.
49. Ng MKC, Nakhla S, Baoutina A, Jessup W, Handelsman DJ, and Celermajer DS. Dehydroepiandrosterone, and adrenal androgen, increases human foam cell formation. J Am Coll Cardiol 42: 1967-1974, 2003.
50. Nichols WW, O'Rourke MF, Avolio AP, Yaginuma T, Murgo JP, Pepine CJ, and Conti CR. Effects of age on ventricular-vascular coupling. Am J Cardiol 55: 1179-1184, 1985.
51. O'Rourke MF and Avolio AP. Pulsatile flow and pressure in human systemic arteries. Studies in man and in a multibranched model of the human systemic arterial tree. Circ Res 46: 363-372, 1980.
52. Phillips GB, Jing TY, Resnick LM, Barbagallo M, Laragh JH, and Sealey JE. Sex hormones and hemostatic risk factors for coronary heart disease in men with hypertension. J Hypertens 11: 699-702, 1993.
53. Phillips GB, Pinkernell BH, and Jung TY. The association of hypotestosteronemia with coronary artery disease in men. Arterioscler Thromb 14: 701-706, 1994.
54. Phillips GB, Yano K, and Stemmermann GN. Serum sex hormone levels and myocardial infarction in the Honolulu Heart Program. Pitfalls in prospective studies on sex hormones. J Clin Epidemiol 41: 1151-1156, 1988.
55. Riley WA, Freedman DS, Higgs NA, Barnes RW, Zinkgraf SA, and Berenson GS. Decreased arterial elasticity associated with cardiovascular disease risk factors in the young. Bogalusa Heart Study. Arteriosclerosis 6: 378-386, 1986.
56. Rosano GM, Leonardo F, Pagnotta P, Pelliccia F, Panina G, Cerquetani E, della Monica PL, Bonfigli B, Volpe M, and Chierchia SL. Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation 99: 1666-1670, 1999.
57. Roth GS, Lane MA, Ingram DK, Mattison JA, Elahi D, Tobin JD, Muller D, and Metter EJ. Biomarkers of caloric restriction (CR) predict longevity in humans. Science 297: 811, 2002.
58. Roy TA, Blackman MR, Harman SM, Tobin JD, Schrager M, and Metter EJ. The inter-relationships of serum testosterone and free testosterone index with appendicular fat-free mass and strength in aging men. Am J Physiol Endocrinol Metab 283: E284-E294, 2002.
59. Salomaa V, Riley W, Kark JD, Nardo C, and Folsom AR. Non-insulin-dependent diabetes mellitus and fasting glucose and insulin concentrations are associated with arterial stiffness indexes. The ARIC Study Atherosclerosis Risk in Communities Study. Circulation 91: 1432-1443, 1995.
60. Scuteri A, Lakatta EG, Bos AJ, and Fleg JL. Effect of estrogen and progestin replacement on arterial stiffness indices in postmenopausal women. Aging (Milano) 13: 122-130, 2001.
61. Shapiro J, Christiana J, and Frishman WH. Testosterone and other anabolic steroids as cardiovascular drugs. Am J Ther 6: 167-174, 1999.
62. Shock NWGR, Andres RA, Arenberg D, Costa PT Jr, Lakatta EG, and Tobin JD. Design and Operation of the Baltimore Longitudinal Study of Aging. Bethesda, MD: NIH, 1984.
63. Simon D, Charles MA, Nahoul K, Orssaud G, Kremski J, Hully V, Joubert E, Papox L, and Eschwege E. Association between plasma total testosterone and cardiovascular risk factors in healthy adult men: the Telecom Study. J Clin Endocrinol Metab 82: 682-685, 1997.
64. Simoncini T, Mannella P, Fornari L, Varone G, Caruso A, and Genazzani AR. Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms. Endocrinology 144: 3449-3455, 2003.
65. Slowinska-Srzednicka J, Zgliczynski S, Soszynski P, Makowska A, Zgliczynski W, Srzednicki M, Bednarska M, Chotkowska E, Woroszylska M, and Ruzyllo W. Decreased plasma levels of dehydroepiandrosterone sulphate (DHEA-S) in normolipidaemic and hyperlipoproteinaemic young men with coronary artery disease. J Intern Med 230: 551-553, 1991.
66. Sorkin JD, Andres R, Muller DC, Baldwin HL, and Fleg JL. Cholesterol as a risk factor for coronary heart disease in elderly men. The Baltimore Longitudinal Study of Aging. Ann Epidemiol 2: 59-67, 1992.
67. Stefanadis C, Tsiamis E, Vlachopoulos C, Stratos C, Toutouzas K, Pitsavos C, Marakas S, Boudoulas H, and Toutouzas P. Unfavorable effect of smoking on the elastic properties of the human aorta. Circulation 95: 31-38, 1997.
68. Stellato RK, Feldman HA, Hamdy O, Horton ES, and McKinlay JB. Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study. Diabetes Care 23: 490-494, 2000.
69. Vermeulen A, Kaufman JM, and Giagulli VA. Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab 81: 1821-1826, 1996.
70. Vermeulen A, Verdonck L, and Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84: 3666-3672, 1999.
71. Wada T, Fujishiro K, Fukumoto T, and Yamazaki S. Relationship between ultrasound assessment of arterial wall properties and blood pressure. Angiology 48: 893-900, 1997.
72. Wu FC and von Eckardstein A. Androgens and coronary artery disease. Endocr Rev 24: 183-217, 2003.
73. Zumoff B, Strain GW, Miller LK, Rosner W, Senie R, Seres DS, and Rosenfeld RS. Plasma free and non-sex-hormone-binding-globulin-bound testosterone are decreased in obese men in proportion to their degree of obesity. J Clin Endocrinol Metab 71: 929-931, 1990.