Effects of chronic testosterone administration on myocardial ischemia, lipid metabolism and insulin resistance in elderly male diabetic patients with coronary artery disease

International Journal of Cardiology

Volumn 142, Issue 1, 2010, Pages 50-55

  Cornoldi, Alessandra ^a   Caminiti, Giuseppe ^a   Marazzi, Giuseppe ^a   Vitale, Cristiana ^a   Patrizi, Roberto ^a   Volterrani, Maurizio ^a   Miceli, Marco ^a   Fini, Massimo ^a   Spera, Giovanni ^b   Rosano, Giuseppe ^a  

^a IRCCS SAN RAFFAELE PISANA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Coronary disease; Diabetes; Elderly male; Testosterone

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CHOLESTEROL; INSULIN; LIPID; PLACEBO; TESTOSTERONE UNDECANOATE; TRIACYLGLYCEROL;

ADULT; AGED; ANGINA PECTORIS; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ELECTROCARDIOGRAPHY MONITORING; HEART MUSCLE ISCHEMIA; HOLTER MONITORING; HUMAN; INSULIN RESISTANCE; LIPID BLOOD LEVEL; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; METABOLISM; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL;

AGED; AGED, 80 AND OVER; CHOLESTEROL; CORONARY ARTERY DISEASE; DIABETES COMPLICATIONS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FOLLOW-UP STUDIES; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; TESTOSTERONE; TRIGLYCERIDES;

EID: 77953286935     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2008.12.107     Document Type: Article

References (33)

1. Kannel W.B., Hjortland M.C., McNamara P.M., and Gordon T. Menopause and risk of cardiovascular disease: the Framingham study. Ann Intern Med 85 (1976) 447-452
2. Nasr A., and Breckwoldt M. Estrogen replacement therapy and cardiovascular protection: lipid mechanisms are the tip of an iceberg. Gynecol Endocrinol 12 (1998) 43-59
3. Sullivan M.L., Martinez C.M., Gennis P., and Gallagher E.J. The cardiac toxicity of anabolic steroids. Prog Cardiovasc Dis 41 (1998) 1-15
4. English K.M., Mandour O., Steeds R.P., Diver M.J., Jones T.H., and Channer K.S. Men with coronary artery disease have lower levels of androgens that men with normal coronary angiograms. Eur Heart J 21 (2000) 890-894
5. Phillips G.B., Pinkernell B.H., and Jing T.Y. The association of hypotestosteronemia with coronary artery disease in men. Arterioscler Thromb 14 (1994) 701-706
6. Jones D.B., Higgins B., Billet J.S., et al. The effect of testosterone replacement on plasma lipids and apolipoproteins. Eur J Clin Invest 19 (1989) 438-441
7. Uyanik B.S., Ari Z., Gumus B., Yigitoglu M.R., and Arslan T. Beneficial effects of testosterone undecanoate on the lipoproteins profiles in healthy elderly men. A placebo controlled study. Jpn Heart J 38 (1997) 73-82
8. Hanke H., Lenz C., Hess B., Spindler K.D., and Weidemann W. Effect of testosterone on plaque development and androgen receptor expression in the arterial vessel wall. Circulation 103 (2001) 1382-1385
9. Nathan L., Shi W., Dinh H., et al. Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc Natl Acad Sci USA 98 (2001) 3589-3593
10. Malkin C.J., Pugh P.J., Jones R.D., Jones T.H., and Channer K.S. Testosterone as a protective factor against atherosclerosis-immunomodulation and influence upon plaque development and stability. J Endocrinol 178 (2003) 373-380
11. Rosano G.M., Leonardo F., Pagnotta P., et al. Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation 99 (1999) 1666-1670
12. Webb C.M., Adamson D.L., De Zeigler D., and Collins P. Effect of acute testosterone on myocardial ischemia in men with coronary artery disease. Am J Cardiol 83 (1999) 437-439
13. English K.M., Steeds R.P., Hugh Jones T., Diver M.J., and Channer K.S. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina. Circulation 102 (2000) 1906-1911
14. Kiraly C.L. Androgenic-anabolic steroid effects on serum and skin surface lipids, on red cells, and on liver enzymes. Int J Sports Med 9 (1988) 249-252
15. Shephard R.J., Killinger D., and Fried T. Responses to sustained use of anabolic steroid. Br J Sports Med 11 (1977) 170-173
16. Inigo M.A., Arrimadas E., and Arroyo D. 43 cycles of anabolic steroid treatment studied in athletes: the uses and secondary effects. Rev Clin Esp 200 (2000) 133-138
17. Elbers J.M., Giltay E.J., Teerlink T., et al. Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects. Clin Endocrinol (Oxf) 58 (2003) 562-571
18. Harada N., Sasano H., Murakami H., Ohkuma T., Nagura H., and Takagi Y. Localized expression of aromatase in human vascular tissues. Circ Res 84 (1999) 1285-1291
19. Sasano H., Murakami H., Shizawa S., Satomi S., Nagura H., and Harada N. Aromatase and sex steroid receptors in human vena cava. Endocr J 46 (1999) 233-242
20. Diano S., Horvath T.L., Mor G., et al. Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects. Menopause 6 (1999) 21-28
21. Komesaroff P.A., Fullerton M., Esler M.D., Dart A., Jennings G., and Sudhir K. Low-dose estrogen supplementation improves vascular function in hypogonadal men. Hypertension 38 (2001) 1011-1016
22. Davis S.R., Bradbury J., Bell R., and Johns J.A. Acute administration of conjugated equine oestrogen does not improve exercise-induced myocardial ischaemia in men with coronary artery disease. Intern Med J 33 (2003) 221-224
23. Sih R., Morley J.E., Kaiser F.E., Perry H.M., Patrick P., and Ross C. Testosterone replacement in older hypogonadal men: a 12-months randomized controlled trial. J Clin Endocrinol Metab 82 (1997) 1661-1667
24. Holmang S., Marin P., Lindstedt G., and Hedelin H. Effects of long-term oral testosterone undecanoate treatment on prostate volume and serum prostate-specific antigen concentration in eugonadal middle aged men. Prostate 23 (1993) 99-106
25. Snyder P.J., Peachey H., Hannoush P., et al. Effects of testosterone treatment on bone mineral density in men over 65 years of age. J Clin Endocrinol Metab 84 (1999) 1966-1972
26. Nair K.S., Rizza R.A., O'Brien P., et al. DHEA in elderly women and DHEA or testosterone in elderly men. NEJM 355 (2006) 1647-1659
27. Kenny A.M., Prestwood K.M., Gruman C.A., Marcello K.M., and Raisz L.G. Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels. J Gerontol A Biol Sci Med Sci 56A (2001) M266-M272
28. Cherrier M.M., Asthana S., Plymate S., et al. Testosterone supplementation improves spatial and verbal memory in healthy older men. Neurology 57 (2001) 80-88
29. Wu F.C., and von Eckardstein A. Androgens and coronary artery disease. Endocr Rev 24 (2003) 183-1617
30. Kapoor D., Goodwin E., Channer K.S., and Jones T.H. Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. Eur J Endocrinol 154 (2006) 899-906
31. Boneva Z., and Christov V.G. Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency. Aging Male 6 (2003) 1-7
32. Katznelson L., Robinson M.W., Coyle C.L., Lee H., and Farrell C.E. Effects of modest testosterone supplementation and exercise for 12 weeks on body composition and quality of life in elderly men. Eur J Endocrinol 155 (2006) 867-875
33. Coats A.J. Ethical authorship and publishing. Int J Cardiol 131 (2009) 149-150