The green tea polyphenol (-)-epigallocatechin gallate precipitates salivary proteins including alpha-amylase: Biochemical implications for oral health

European Journal of Oral Sciences

Volumn 120, Issue 2, 2012, Pages 132-139

  Hara, Kumiko ^a   Ohara, Masaru ^b   Hayashi, Ikue ^a   Hino, Takamune ^b   Nishimura, Rumi ^a   Iwasaki, Yoriko ^b   Ogawa, Tetsuji ^b   Ohyama, Yoshihiko ^c   Sugiyama, Masaru ^a   Amano, Hideaki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY HOSPITAL   (Japan)

^c YASUDA WOMEN'S UNIVERSITY   (Japan)

Author keywords

( ) epigallocatechin gallate; Alpha amylase; Salivary proteins; Tea catechin

Indexed keywords

AMYLASE; ANTIINFECTIVE AGENT; CATECHIN; CYSTATIN; DRUG DERIVATIVE; EPIGALLOCATECHIN GALLATE; PROTEOME; SALIVA PROTEIN;

ADULT; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ARTICLE; CARBOHYDRATE DIET; CHEMISTRY; DENTAL CARIES; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FEMALE; HUMAN; MALE; MASS SPECTROMETRY; METABOLISM; MIDDLE AGED; PROTEIN BINDING; SALIVA; TEA;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ADULT; ALPHA-AMYLASES; ANTI-BACTERIAL AGENTS; CATECHIN; CYSTATINS; DENTAL CARIES; DIETARY CARBOHYDRATES; FEMALE; HUMANS; MALE; MIDDLE AGED; PROTEIN BINDING; PROTEOME; SALIVA; SALIVARY PROTEINS AND PEPTIDES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TEA; YOUNG ADULT;

EID: 84858298505     PISSN: 09098836     EISSN: 16000722     Source Type: Journal    
DOI: 10.1111/j.1600-0722.2012.00947.x     Document Type: Article

References (42)

1. Grove KA, Lambert JD. Laboratory, epidemiological, and human intervention studies show that tea (Camellia sinensis) may be useful in the prevention of obesity. J Nutr 2010; 140: 446-453.
2. Wang Y, Ho CT. Polyphenolic chemistry of tea and coffee: a century of progress. J Agric Food Chem 2009; 57: 8109-8114.
3. Cabrera C, Artacho R, Gimenez R. Beneficial effects on green tea - A review. J Am Coll Nutr 2006; 25: 79-99.
4. McKay DL, Blumberg JB. The role of tea in human health: an update. J Am Coll Nutr 2002; 21: 1-13.
5. Vison J, Dabbagh Y, Serry M, Jang J. Plant flavonoids, especially tea flavonoids, are powerful using an in vitro oxidation model for heart diseases. J Agric Food Chem 1995; 43: 2800-2802.
6. Yang CS, Maliakal P, Meng X. Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol 2002; 42: 25-54.
7. Leenen R, Roodenburg A, Tijburg L, Wiseman S. A single dose of tea with or without milk increases plasma antioxidant activity in humans. Eur J Clin Nutr 2000; 54: 87-92.
8. Butt MS, Sultan MT. Green tea: nature's defense against malignancies. Crit Rev Food Sci Nutr 2009; 49: 463-473.
9. Basu A, Lucas EA. Mechanisms and effects of green tea on cardiovascular health. Nutr Rev 2007; 65: 361-375.
10. Brown AL, Lane J, Coverly J, Stocks J, Jackson S, Stephen A, Bluck L, Coward A, Hendrickx H. Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. Br J Nutr 2009; 101: 886-894.
11. Nozaki A, Hori M, Kimura T, Ito H, Hatano T. Interaction of polyphenols with proteins: binding of (-)-epigallocatechin gallate to serum albumin, estimated by induced circular dichroism. Chem Pharm Bull 2009; 57: 224-228.
12. Mau M, De Almeida AM, Coelho AV, Sudekum KH. First identification of tannin-binding proteins in saliva of Papio hamadryas using MS/MS mass spectrometry. Am J Primatol 2011; 73: 896-902.
13. Balasubramanian S, Eckert RL. Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function. J Biol Chem 2004; 279: 24007-24014.
14. Kuzuhara T, Sei Y, Yamaguchi K, Suganuma M, Fujiki H. DNA and RNA as new binding targets of green tea catechins. J Biol Chem 2006; 281: 17446-17456.
15. Suganuma M, Okabe S, Sueoka E, Iida N, Komori A, Fujiki H. A new process of cancer prevention mediated through inhibition of tumor necrosis factor alpha expression. Cancer Res 1996; 56: 3711-3715.
16. Tabak LA. In defense of the oral cavity: the protective role of the salivary secretions. Pediatr Dent 2006; 28: 110-117.
17. Humphrey SP, Williamson RT. A review of saliva: normal composition, flow, and function. J Prosthet Dent 2001; 85: 162-169.
18. Dodds MW, Johnson DA, Yeh CK. Health benefits of saliva: a review. J Dent 2005; 33: 223-233.
19. Zhang J, Kashket S. Inhibition of salivary amylase by black and green teas and their effects on the intraoral hydrolysis of starch. Caries Res 1998; 32: 233-236.
20. Canon F, Ballivian R, Chirot F, Antoine R, Sarni-Manchado P, Lemoine J, Dugourd P. Folding of a salivary intrinsically disordered protein upon binding to tannins. J Am Chem Soc 2011; 133: 7847-7852.
21. Canon F, Giuliani A, Pate F, Sarni-Manchado P. Ability of a salivary intrinsically unstructured protein to bind different tannin targets revealed by mass spectrometry. Anal Bioanal Chem 2010; 398: 815-822.
22. Joiner A, Muller D, Elofssonl UM, Arnebrant T. Ellipsometry analysis of the in vitro adsorption of tea polyphenols onto salivary pellicles. Eur J Oral Sci 2004; 112: 510-515.
23. Wroblewski K, Muhandiram R, Chakrabartty A, Bennick A. The molecular interaction of human salivary histatins with polyphenolic compounds. Eur J Biochem 2001; 268: 4384-4397.
24. Yan Q, Bennick A. Identification of histatins as tannin-binding proteins in human saliva. Biochem J 1995; 311: 341-347.
25. Tadera K, Minami Y, Takamatsu K, Matsuoka T. Inhibition of alpha-glucosidase and alpha-amylase by flavonoids. J Nutr Sci Vitaminol 2006; 52: 149-153.
26. Young EG. Occurrence, classification, preparation and analysis of proteins. In: Florkin M, Stotz EH, eds. Comprehensive biochemistry. Vol. 7. Amsterdam: Elsevier Publishing Company, 1963; 1-55.
27. Hatano T, Hemingway RW. Association of (+)-catechin-(4alpha-8)-catechin with oligopeptides. Chem Commun 1996; 22: 2537-2538.
28. Kawaguchi M, Tanabe H, Nagamine K. Isolation and characterization of a novel flavonoid possessing a 4, 2''-glycosidic linkage from green mature acerola (Malpighia emarginata DC.) fruit. Biosci Biotechnol Biochem 2007; 71: 1130-1135.
29. Naurato N, Wong P, Lu Y, Wroblewski K, Bennick A. Interaction of tannin with human salivary histatins. J Argic Food Chem 1999; 47: 2229-2234.
30. Murray NJ, Williamson MP, Lilley TH, Haslam E. Study of the interaction between salivary proline-rich proteins and a polyphenol by 1H-NMR spectroscopy. Eur J Biochem 1994; 219: 923-935.
31. Baxter NJ, Lilley TH, Haslam E, Williamson MP. Multiple interactions between polyphenols and a salivary proline-rich protein repeat result in complexation and precipitation. Biochemistry 1997; 36: 5566-5577.
32. Dickinson DP. Salivary (SD-type) cystatins: over one billion years in the making - but to what purpose? Crit Rev Oral Biol Med 2002; 13: 485-508.
33. Lie MA, Loos BG, Henskens YM, Timmerman MF, Veerman EC, Van Der Velden U, Van Der Weijden GA. Salivary cystatin activity and cystatin C in natural and experimental gingivitis in smokers and non-smokers. J Clin Periodontol 2001; 28: 979-984.
34. Ramseier CA, Kinney JS, Herr AE, Braun T, Sugai JV, Shelburne CA, Rayburn LA, Tran HM, Singh AK, Giannobile WV. Identification of pathogen and host-response markers correlated with periodontal disease. J Periodontol 2009; 80: 436-446.
35. Granger DA, Kivligiian KT, El-Sheikh M, Gordis EB, Stroud LR. Salivary alpha-amylase in biobehavioral research. Recent developments and applications. Ann N Y Acad Sci 2007; 1098: 122-144.
36. Rudney JD. Saliva and dental plaque. Adv Dent Res 2000; 14: 29-39.
37. Mormann JE, Schmid R, Muhlemann HR. Effect of alpha-amylase and alpha-glucosidase inhibitors on caries incidence and plaque accumulation in rats. Caries Res 1983; 17: 353-356.
38. Fukuda I, Mukai R, Kawase M, Yoshida K, Ashida H. Interaction between the aryl hydrocarbon receptor and its antagonists, flavonoids. Biochem Biophys Res Commun 2007; 359: 822-827.
39. Siebert KJ. Effects of protein-polyphenol interactions on beverage haze, stabilization, and analysis. J Agric Food Chem 1999; 47: 353-362.
40. Piparo EL, Scheib H, Frei N, Williamson G, Grigorov M, Chou CJ. Flavonoids for controlling starch digestion: structural requirements for inhibiting human alpha-amylase. J Med Chem 2008; 52: 3555-3561.
41. Wu CD, Wei GX. Tea as a functional food for oral health. Nutrition 2002; 18: 443-444.
42. Kashket S, Zhang J, Van Houte J. Accumulation of fermentable sugars and metabolic acids in food particles that become entrapped on the dentition. J Dent Res 1996; 75: 1885-1891.