Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2-NFκB pathways

Toxicology and Applied Pharmacology

Volumn 260, Issue 1, 2012, Pages 35-47

  Das, Joydeep ^a   Ghosh, Jyotirmoy ^a   Roy, Anandita ^a   Sil, Parames C ^a  

^a BOSE INSTITUTE   (India)

Author keywords

Antioxidant; Apoptosis and necrosis; Caspase 3; Cell survival; D galactosamine; Hepatic nitrosative stress; INOS; Mangiferin; NF B; Nrf2; Reactive oxygen species; TNF

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; CHOLESTEROL; GALACTOSAMINE; GAMMA INTERFERON; GLUTATHIONE; GLUTATHIONE TRANSFERASE ALPHA; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; MANGIFERIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRANSCRIPTION FACTOR NRF2; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ACUTE TOXICITY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; FLOW CYTOMETRY; IN VITRO STUDY; LIPID PEROXIDATION; LIVER CELL; LIVER HISTOLOGY; LIVER PROTECTION; LIVER TOXICITY; LIVER WEIGHT; MALE; MANGO; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; DISEASE MODELS, ANIMAL; GALACTOSAMINE; GENE EXPRESSION REGULATION; HEPATOCYTES; INFLAMMATION; LIVER DISEASES; MALE; MANGIFERA; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NITRIC OXIDE; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION; XANTHONES;

MANGIFERA INDICA; RATTUS;

EID: 84858297996     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.01.015     Document Type: Article

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