The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder

Journal of Affective Disorders

Volumn 138, Issue 3, 2012, Pages 360-366

  Gałecki, Piotr ^a   Gałecka, Elzbieta ^a   Maes, Michael ^b   Chamielec, Marcelina ^a   Orzechowska, Agata ^a   Bobińska, Kinga ^a   Lewiński, Andrzej ^a,c   Szemraj, Janusz ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b Piyavate Hospital   (Thailand)

^c POLISH MOTHER S MEMORIAL HOSPITAL RESEARCH INSTITUTE   (Poland)

Author keywords

Cyclooxygenase 2; Depression; Inducible nitric oxide synthase; mRNA expression; Myeloperoxidase; Secretory phospholipase A2

Indexed keywords

CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; MYELOPEROXIDASE; SECRETORY PHOSPHOLIPASE A2;

ADULT; ARTICLE; BLOOD CELL; CONTROLLED STUDY; DEPRESSION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECURRENT DEPRESSIVE DISORDER; RECURRENT DISEASE;

ADULT; ANTIDEPRESSIVE AGENTS; CYCLOOXYGENASE 2; DEPRESSIVE DISORDER; FEMALE; GENE EXPRESSION; GROUP II PHOSPHOLIPASES A2; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE II; PEROXIDASE; RECURRENCE; RNA, MESSENGER;

EID: 84858294917     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2012.01.016     Document Type: Article

References (76)

1. R.M. Adibhatla, and J.F. Hatcher Phospholipase A(2), reactive oxygen species, and lipid peroxidation in CNS pathologies BMB Reports 41 2008 560 567
2. F. Aktan iNOS-mediated nitric oxide production and its regulation Life Sciences 75 2004 639 653 (Pubitemid 38686696)
3. M.W. Anthonsen, D. Stengel, D. Hourton, E. Ninio, and B. Johansen Mildly oxidized LDL induces expression of group IIa secretory phospholipase A(2) in human monocyte-derived macrophages Arteriosclerosis, Thrombosis, and Vascular Biology 20 2000 1276 1282 (Pubitemid 30262928)
4. M.A. Balboa, and J. Balsinde Oxidative stress and arachidonic acid mobilization Biochimica et Biophysica Acta 1761 2006 385 391 (Pubitemid 43776462)
5. R. Belzeaux, C. Formisano-Tréziny, A. Loundou, L. Boyer, J. Gabert, J.C. Samuelian, F. Féron, J. Naudin, and E.C. Ibrahim Clinical variations modulate patterns of gene expression and define blood biomarkers in major depression Journal of Psychiatric Research 44 2010 1205 1213
6. A. Carr, and B. Frei The role of natural antioxidants in preserving the biological activity of endothelium-derived nitric oxide Free Radical Biology & Medicine 28 2000 1806 1814 (Pubitemid 30628667)
7. P. Cassano, A. Hidalgo, V. Burgos, S. Adris, and P. Argibay Hippocampal upregulation of the cyclooxygenase-2 gene following neonatal clomipramine treatment (a model of depression) The Pharmacogenomics Journal 6 2006 381 387 (Pubitemid 44811533)
8. R. Chenevard, D. Hürlimann, M. Béchir, F. Enseleit, L. Spieker, M. Hermann, W. Riesen, S. Gay, R.E. Gay, M. Neidhart, B. Michel, T.F. Lüscher, G. Noll, and F. Ruschitzka Selective COX-2 inhibition improves endothelial function in coronary artery disease Circulation 107 2003 405 409
9. L. Chwastiak, D.M. Ehde, L.E. Gibbons, M. Sullivan, J.D. Bowen, and G.H. Kraft Depressive symptoms and severity of illness in multiple sclerosis: epidemiologic study of a large community sample The American Journal of Psychiatry 159 2002 1862 1868 (Pubitemid 35283251)
10. R. Dantzer, J.C. O'Connor, G.G. Freund, R.W. Johnson, and K.W. Kelley From inflammation to sickness and depression: when the immune system subjugates the brain Nature Reviews. Neuroscience 9 2008 46 56 (Pubitemid 350295688)
11. J. de Miguel Díez, V. Hernández Barrera, L. Puente Maestu, P. Carrasco Garrido, T. Gómez García, and R. Jiménez García Psychiatric comorbidity in asthma patients. Associated factors The Journal of Asthma 48 2011 253 258
12. R.N. Dilger, and R.W. Johnson Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system Journal of Leukocyte Biology 84 2008 932 939
13. D. Divchev, and B. Schieffer The secretory phospholipase A2 group IIA: a missing link between inflammation, activated renin-angiotensin system, and atherogenesis? Vascular Health and Risk Management 4 2008 597 604 (Pubitemid 352037918)
14. R.N. Dubois, S.B. Abramson, L. Crofford, R.A. Gupta, L.S. Simon, L.B. Van De Putte, and P.E. Lipsky Cyclooxygenase in biology and disease The FASEB Journal 12 1998 1063 1073 (Pubitemid 28418937)
15. A. Dutour, V. Achard, H. Sell, N. Naour, F. Collart, B. Gaborit, A. Silaghi, J. Eckel, M.C. Alessi, C. Henegar, and K. Clément Secretory type II phospholipase A2 is produced and secreted by epicardial adipose tissue and overexpressed in patients with coronary artery disease The Journal of Clinical Endocrinology and Metabolism 95 2010 963 967
16. O.B. Ekmekci, O. Donma, E. Sardoǧan, N. Yildirim, O. Uysal, H. Demirel, and T. Demir Iron, nitric oxide, and myeloperoxidase in asthmatic patients Biochemistry 69 2004 462 467
17. M.J. Forlenza, and G.E. Miller Increased serum levels of 8-hydroxy-2′-deoxyguanosine in clinical depression Psychosomatic Medicine 68 2006 1 7 (Pubitemid 43803209)
18. P. Gałecki, J. Szemraj, M. Bieńkiewicz, A. Florkowski, and E. Gałecka Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment Pharmacological Reports 61 2009 436 447
19. P. Gałecki, A. Florkowski, M. Bieńkiewicz, and J. Szemraj Functional polymorphism of cyclooxygenase-2 gene (G-765C) in depressive patients Neuropsychobiology 62 2010 116 120
20. P. Gałecki, A. Florkowski, K. Bobińska, J. Śmigielski, M. Bieńkiewicz, and J. Szemraj Functional polymorphism of the myeloperoxidase gene (G-463A) in depressive patients Acta Neuropsychiatrica 22 2010 218 222
21. P. Gałecki, M. Maes, A. Florkowski, A. Lewiński, E. Gałecka, M. Bieńkiewicz, and J. Szemraj Association between inducible and neuronal nitric oxide synthase polymorphisms and recurrent depressive disorder Journal of Affective Disorders 129 2011 175 182
22. L.E. Goehler, M. Lyte, and R.P. Gaykema Infection-induced viscerosensory signals from the gut enhance anxiety: implications for psychoneuroimmunology Brain, Behavior, and Immunity 21 2007 721 726 (Pubitemid 47002214)
23. E. Gray, T.L. Thomas, S. Betmouni, N. Scolding, and S. Love Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis Brain Pathology 18 2008 86 95
24. P.S. Green, A.J. Mendez, J.S. Jacob, J.R. Crowley, W. Growdon, B.T. Hyman, and J.W. Heinecke Neuronal expression of myeloperoxidase is increased in Alzheimer's disease Journal of Neurochemistry 9 2004 724 733 (Pubitemid 38989404)
25. J.Y. Guo, C.Y. Li, Y.P. Ruan, M. Sun, X.L. Qi, B.S. Zhao, and F. Luo Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain European Journal of Pharmacology 612 2009 54 60
26. A. Haegens, P. Heeringa, R.J. van Suylen, C. Steele, Y. Aratani, R.J. O'Donoghue, S.E. Mutsaers, B.T. Mossman, E.F. Wouters, and J.H. Vernooy Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production Journal of Immunology 182 2009 7990 7996
27. M. Hansson, I. Olsson, and W.M. Nauseef Biosynthesis, processing, and sorting of human myeloperoxidase Archives of Biochemistry and Biophysics 445 2006 214 224 (Pubitemid 43082214)
28. J.W. Heinecke Mass spectrometric quantification of amino acid oxidation products in proteins: insights into pathways that promote LDL oxidation in the human artery wall The FASEB Journal 13 1999 1113 1120 (Pubitemid 29300358)
29. M.T. Heneka, and D.L. Feinstein Expression and function of inducible nitric oxide synthase in neurons Journal of Neuroimmunology 114 2001 8 18 (Pubitemid 32184720)
30. D.G. Hirst, and T. Robson Nitric oxide physiology and pathology Methods in Molecular Biology 704 2011 1 13
31. C. Jolivalt, B. Leininger-Muller, R. Drozdz, J.W. Naskalski, and G. Siest Apolipoprotein E is highly susceptible to oxidation by myeloperoxidase, an enzyme present in the brain Neuroscience Letters 210 1996 61 64 (Pubitemid 26176854)
32. H. Kleinert, A. Pautz, K. Linker, and P.M. Schwarz Regulation of the expression of inducible nitric oxide synthase European Journal of Pharmacology 500 2004 255 266 (Pubitemid 39304013)
33. J. Kodydková, L. Vávrová, M. Zeman, R. Jirák, J. Macásek, B. Stanková, E. Tvrzická, and A. Zák Antioxidative enzymes and increased oxidative stress in depressive women Clinical Biochemistry 42 2009 1368 1374
34. W. Koenig, C.Y. Vossen, Z. Mallat, H. Brenner, J. Benessiano, and D. Rothenbacher Association between type II secretory phospholipase A2 plasma concentrations and activity and cardiovascular events in patients with coronary heart disease European Heart Journal 30 2009 2742 2748
35. V.O. Kotan, E. Sarandol, E. Kirhan, G. Ozkaya, and S. Kirli Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: a 24-week follow-up study Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 2011 1284 1290
36. M. Kubera, E. Obuchowicz, L. Goehler, J. Brzeszcz, and M. Maes In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 2011 744 759
37. F.A. Kuehl Jr.; and R.W. Egan Prostaglandins, arachidonic acid, and inflammation Science 210 1980 978 984 (Pubitemid 11168243)
38. B.E. Leonard Inflammation, depression and dementia: are they connected? Neurochemical Research 32 2007 1749 1756 (Pubitemid 47428863)
39. P.Y. Lin, S.Y. Huang, and K.P. Su A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression Biological Psychiatry 68 2010 140 147
40. J.A. Long, M. Fogel-Petrovic, D.A. Knight, P.J. Thompson, and J.W. Upham Higher prostaglandin e2 production by dendritic cells from subjects with asthma compared with normal subjects American Journal of Respiratory and Critical Care Medicine 170 2004 485 491 (Pubitemid 39209128)
41. M. Maes Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression Progress in Neuro- Psychopharmacology & Biological Psychiatry 35 2011 664 675
42. M. Maes, I. Mihaylova, M. Kubera, M. Uytterhoeven, N. Vrydags, and E. Bosmans Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: markers that further explain the higher incidence of neurodegeneration and coronary artery disease Journal of Affective Disorders 125 2010 287 294
43. M. Maes, P. Galecki, Y.S. Chang, and M.A. Berk Review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 2011 676 692
44. M. Maes, M. Kubera, E. Obuchowiczwa, L. Goehler, and J. Brzeszcz Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative and nitrosative stress pathways Neuro Endocrinology Letters 32 2011 7 24
45. V. Magrioti, and G. Kokotos Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases Expert Opinion on Therapeutic Patents 20 2010 1 18
46. R.A. Maki, V.A. Tyurin, R.C. Lyon, R.L. Hamilton, S.T. DeKosky, V.E. Kagan, and W.F. Reynolds Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease Journal of Biological Chemistry 284 2009 3158 3169
47. J.M. McCaffery, N. Frasure-Smith, M.P. Dubé, P. Théroux, G.A. Rouleau, Q. Duan, and F. Lespérance Common genetic vulnerability to depressive symptoms and coronary artery disease: a review and development of candidate genes related to inflammation and serotonin Psychosomatic Medicine 68 2006 187 200 (Pubitemid 43740120)
48. D. Mehta, A. Menke, and E.B. Binder Gene expression studies in major depression Current Psychiatry Reports 12 2010 135 144
49. L. Minghetti Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases Journal of Neuropathology and Experimental Neurology 63 2004 901 910 (Pubitemid 39202493)
50. M. Mirjany, L. Ho, and G.M. Pasinetti Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity Journal of Pharmacology and Experimental Therapeutics 301 2002 494 500 (Pubitemid 34429959)
51. G.S. Moses, M.D. Jensen, L.F. Lue, D.G. Walker, A.Y. Sun, A. Simonyi, and G.Y. Sun Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease Journal of Neuroinflammation 7 3 2006 28
52. N. Müller, M.J. Schwarz, S. Dehning, A. Douhe, A. Cerovecki, B. Goldstein-Müller, I. Spellmann, G. Hetzel, K. Maino, N. Kleindienst, H.J. Möller, V. Arolt, and M. Riedel The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine Molecular Psychiatry 11 2006 680 684 (Pubitemid 43989814)
53. A.M. Myint, H.W. Steinbusch, L. Goeghegan, D. Luchtman, Y.K. Kim, and B.E. Leonard Effect of the COX-2 inhibitor celecoxib on behavioural and immune changes in an olfactory bulbectomised rat model of depression Neuroimmunomodulation 14 2007 65 71 (Pubitemid 47442983)
54. G.N. Pandey, Y. Dwivedi, H.S. Rizavi, X. Ren, H. Zhang, and M.N. Pavuluri Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects Progress in Neuro-Psychopharmacology & Biological Psychiatry 34 2010 645 651
55. R. Paranthaman, A.S. Greenstein, A.S. Burns, J.K. Cruickshank, A.M. Heagerty, A. Jackson, R.A. Malik, M.L. Scott, and R.C. Baldwin Vascular function in older adults with depressive disorder Biological Psychiatry 68 2010 133 139
56. G. Pasinetti, and P. Aisen Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain Neuroscience 87 1998 319 324 (Pubitemid 28370892)
57. T.N. Pham, P. Rahman, Y.M. Tobin, M.M. Khraishi, S.F. Hamilton, C. Alderdice, and V.J. Richardson Elevated serum nitric oxide levels in patients with inflammatory arthritis associated with co-expression of inducible nitric oxide synthase and protein kinase C-eta in peripheral blood monocyte-derived macrophages Journal of Rheumatology 30 2003 2529 2534 (Pubitemid 37549325)
58. E.A. Podrez, H.M. Abu-Soud, and S.L. Hazen Myeloperoxidase-generated oxidants and atherosclerosis Free Radical Biology & Medicine 28 2000 1717 1725 (Pubitemid 30628658)
59. M.B. Raeder, J. Fernø, M. Glambek, C. Stansberg, and V.M. Steen Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells Neuroscience Letters 395 2006 185 190 (Pubitemid 43213141)
60. J.S. Rao, R.N. Ertley, J.C. DeMar Jr.; S.I. Rapoport, R.P. Bazinet, and H.J. Lee Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex Molecular Psychiatry 12 2007 151 157 (Pubitemid 46160980)
61. A.E. Redington, Q.H. Meng, D.R. Springall, T.J. Evans, C. Créminon, J. Maclouf, S.T. Holgate, P.H. Howarth, and J.M. Polak Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment Thorax 56 2001 351 357 (Pubitemid 32398124)
62. E.L. Schaeffer, E.R. da Silva, A. Novaes Bde, H.D. Skaf, and W.F. Gattaz Differential roles of phospholipases A2 in neuronal death and neurogenesis: implications for Alzheimer disease Progress in Neuro-Psychopharmacology & Biological Psychiatry 34 2010 1381 1389
63. G.Y. Sun, J. Xu, M.D. Jensen, and A. Simonyi Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases Journal of Lipid Research 45 2004 205 213 (Pubitemid 38228817)
64. E. Suzuki, G. Yagi, T. Nakaki, S. Kanba, and M. Asai Elevated plasma nitrate levels in depressive states Journal of Affective Disorders 63 2001 221 224 (Pubitemid 32200517)
65. R.M. Tordera, Q. Pei, and T. Sharp Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatment Journal of Neurochemistry 94 2005 875 883 (Pubitemid 41170576)
66. M. Triggiani, F. Granata, A. Frattini, and G. Marone Activation of human inflammatory cells by secreted phospholipases A2 Biochimica et Biophysica Acta 1761 2006 1289 1300 (Pubitemid 44738703)
67. S. Usman, H.R. Chaudhary, A. Asif, and M.I. Yahya Severity and risk factors of depression in Alzheimer's disease Journal of the College of Physicians and Surgeons-Pakistan 20 2010 327 330
68. V. Vaccarino, M.L. Brennan, A.H. Miller, J.D. Bremner, J.C. Ritchie, F. Lindau, E. Veledar, S. Su, N.V. Murrah, L. Jones, F. Jawed, J. Dai, J. Goldberg, and S.L. Hazen Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study Biological Psychiatry 64 2008 476 483
69. M. Valko, D. Leibfritz, J. Moncol, M.T. Cronin, M. Mazur, and J. Telser Free radicals and antioxidants in normal physiological functions and human disease The International Journal of Biochemistry & Cell Biology 39 2007 44 84 (Pubitemid 44566469)
70. D. Wang, S.C. An, and X. Zhang Prevention of chronic stress-induced depression-like behavior by inducible nitric oxide inhibitor Neuroscience Letters 433 2008 59 64
71. G. Wegener, V. Volke, B.H. Harvey, and R. Rosenberg Local, but not systemic, administration of serotonergic antidepressants decreases hippocampal nitric oxide synthase activity Brain Research 959 2003 128 134 (Pubitemid 35435413)
72. J. Winer, C.K. Jung, I. Shackel, and P.M. Williams Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro Analytical Biochemistry 270 1999 41 49 (Pubitemid 29230718)
73. C.C. Winterbourn Biological reactivity and biomarkers of the neutrophil oxidant, hypochlorous acid Toxicology 181-182 2002 223 227 (Pubitemid 36015703)
74. World Health Organization The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Description and Diagnostic Guidelines 1992
75. K. Yasojima, C. Schwab, E.G. McGeer, and P.L. McGeer Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs Brain Research 830 1999 226 236 (Pubitemid 29297950)
76. R. Zhang, M.L. Brennan, X. Fu, R.J. Aviles, G.L. Pearce, M.S. Penn, E.J. Topol, D.L. Sprecher, and S.L. Hazen Association between myeloperoxidase levels and risk of coronary artery disease JAMA: The Journal of the American Medical Association 286 2001 2136 2142 (Pubitemid 34041599)