C-C bond formation at C-2 of a quinoline ring: Synthesis of 2-(1H-indol-3-yl)quinoline-3-carbonitrile derivatives as a new class of PDE4 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 7, 2012, Pages 2199-2207

  Kumar, K Shiva ^a   Kiran Kumar, S ^b   Yogi Sreenivas, B ^a   Gorja, Dhilli Rao ^a   Kapavarapu, Ravikumar ^a   Rambabu, D ^a,b   Rama Krishna, G ^c   Reddy, C Malla ^c   Basaveswara Rao, M V ^d   Parsa, Kishore V L ^a   Pal, Manojit ^a  

^a INSTITUTE OF LIFE SCIENCES   (India)

^b K L UNIVERSITY   (India)

^c INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH KOLKATA   (India)

^d KRISHNA UNIVERSITY   (India)

Author keywords

AlCl 3; Indole; PDE4; Quinoline; X ray

Indexed keywords

2 (1 METHYL 1H INDOL 3 YL)QUINOLINE 3 CARBONITRILE; 2 (1H INDOL 3 YL) 6 METHYLQUINOLINE 3 CARBONITRILE; 2 (1H INDOL 3 YL)QUINOLINE 3 CARBONITRILE DERIVATIVE; 2 (5 BROMO 1H INDOL 3 YL) 6 METHYLQUINOLINE 3 CARBONITRILE; 2 (5 BROMO 1H INDOL 3 YL)QUINOLINE 3 CARBONITRILE; 2 (5 CHLORO 1H INDOL 3 YL) 6 METHYLQUINOLINE 3 CARBONITRILE; 2 (5 CHLORO 1H INDOL 3 YL)QUINOLINE 3 CARBONITRILE; 2 (5 METHOXY 1H INDOL 3 YL) 6 METHYLQUINOLINE 3 CARBONITRILE; 2 (5 METHOXY 1H INDOL 3 YL)QUINOLINE 3 CARBONITRILE; 2 (5,6 DIFLUORO 1H INDOL 3 YL)QUINOLINE 3 CARBONITRILE; 2 (6 METHOXY 1H INDOL 3 YL) 6 METHYLQUINOLINE 3 CARBONITRILE; 2 (6 METHOXY 1H INDOL 3 YL)QUINOLINE 3 CARBONITRILE; 2 [1 (PROP 2 YNYL) 1H INDOL 3 YL]QUINOLINE 3 CARBONITRILE; 2 [1 [[1 (METHYLSULFONYL) 1H INDOL 2 YL]METHYL] 1H INDOL 3 YL]QUINOLINE 3 CARBONITRILE; PHOSPHODIESTERASE IV INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CHEMICAL INTERACTION; CHEMICAL REACTION KINETICS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; SOLVENT EFFECT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUZUKI REACTION; X RAY DIFFRACTION;

ALUMINUM COMPOUNDS; BINDING SITES; CARBON; CELL PROLIFERATION; CHLORIDES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; HEK293 CELLS; HUMANS; INDOLES; MOLECULAR CONFORMATION; PHOSPHODIESTERASE 4 INHIBITORS; QUINOLINES;

EID: 84858289520     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.027     Document Type: Article

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