Synthesis of functionalised 2-aryl-5-nitro-1H-indoles and their activity as bacterial NorA efflux pump inhibitors

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 3, 2006, Pages 857-865

  Samosorn, Siritron ^a   Bremner, John B ^a   Ball, Anthony ^b   Lewis, Kim ^b  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b NORTHEASTERN UNIVERSITY   (United States)

Author keywords

5 Nitro 2 phenyl 1H indole derivatives; Antibacterial agent potentiators; Indoles; NorA efflux pump inhibitors

Indexed keywords

2 (2 AZIDOMETHYL 5 METHOXYPHENYL) 5 NITRO 1H INDOLE; 2 (2 AZIDOMETHYLPHENYL) 5 NITRO 1H INDOLE; 2 (5 NITRO 1H INDOL 2 YL)BENZOIC ACID; 2 (5 NITRO 1H INDOL 2 YL)BENZYLAMINE; 4 METHOXY 2 (5 NITRO 1H INDOL 2 YL)BENZOIC ACID; 4 METHOXY 2 (5 NITRO 1H INDOL 2 YL)BENZYLAMINE; 5 NITRO 2 PHENYL 1H INDOLE; [2 (5 NITRO 1H INDOL 2 YL)PHENYL]METHANOL; [4 BENZYLOXY 2 (5 NITRO 1H INDOL 2 YL)PHENYL]METHANOL; [4 METHOXY 2 (5 NITRO 1H INDOL 2 YL)PHENYL]METHANOL; ACRIFLAVINE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BERBERINE; CIPROFLOXACIN; ETHIDIUM BROMIDE; INDOLE DERIVATIVE; INF 271; INF 55; MULTIDRUG RESISTANCE PROTEIN; NORFLOXACIN; PROTEIN NORA; UNCLASSIFIED DRUG; NORA PROTEIN, STAPHYLOCOCCUS;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DEBENZYLATION; DRUG POTENTIATION; DRUG SYNTHESIS; HYDROLYSIS; NONHUMAN; RING OPENING; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BERBERINE; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 28844448733     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.09.019     Document Type: Article

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