8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: A potential treatment for asthma

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 12, 2002, Pages 1613-1615

  Buckley, George M ^a   Cooper, Nicola ^a   Dyke, Hazel J ^a   Galleway, Fiona P ^a   Gowers, Lewis ^a   Haughan, Alan F ^a   Kendall, Hannah J ^a   Lowe, Christopher ^a   Maxey, Robert ^a   Montana, John G ^a   Naylor, Robert ^b   Oxford, Janet ^a   Peake, Joanna C ^a   Picken, C Louise ^a   Runcie, Karen A ^a   Sabin, Verity ^a   Sharpe, Andrew ^a   Warneck, Julie B H ^a  

^a UCB PHARMA   (Belgium)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8 METHOXYQUINOLINE 4 CARBOXYLIC ACID(3,5 DICHLOROPYRIDYL 4 YL)AMIDE; AMIDE; BENZIMIDAZOLE DERIVATIVE; BENZOFURAN DERIVATIVE; PHOSPHODIESTERASE IV INHIBITOR; QUINOLINE DERIVATIVE; ROLIPRAM; UNCLASSIFIED DRUG; 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; ANTIASTHMATIC AGENT; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV;

ANIMAL EXPERIMENT; ARTICLE; ASTHMA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; GUINEA PIG; IN VITRO STUDY; IN VIVO STUDY; LOEFFLER PNEUMONIA; NONHUMAN; DRUG ANTAGONISM; HUMAN;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; AMIDES; ANTI-ASTHMATIC AGENTS; ASTHMA; HUMAN; PHOSPHODIESTERASE INHIBITORS; HUMANS;

EID: 0037124188     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00223-8     Document Type: Article

References (23)