Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 7, 2012, Pages 2282-2289

  Hundsdörfer, Claas ^a   Hemmerling, Hans Jörg ^b   Götz, Claudia ^c   Totzke, Frank ^d   Bednarski, Patrick ^e   Le Borgne, Marc ^f   Jose, Joachim ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d PROQINASE GMBH   (Germany)

^e UNIVERSITY OF GREIFSWALD   (Germany)

^f UNIVERSITÉ LYON 1   (France)

Author keywords

Cancer; CK2; Human protein kinase; Indeno 1,2 b indoles; Inhibitors

Indexed keywords

5 (3,4 DIMETHOXYPHENETHYL) 7,8 DIHYDROINDENO[1,2 B]INDOLE 9,10(5,6H) DIONE; 5 BENZYL 7 PHENYL 7,8 DIHYDROINDENO[1,2 B]INDOLE 9,10(5,6H) DIONE; 5 BENZYL 7,8 DIHYDROINDENO[1,2 B]INDOLE 9,10(5,6H) DIONE; 5 BENZYL 9 HYDROXY 7 PHENYLINDENO[1,2 B]INDOLE 10 (5H) ONE; 5 BENZYL 9 HYDROXYINDENO[1,2 B]INDOLE 10 (5H) ONE; 5 ISOPROPYL 7,8 DIHYDROINDENO[1,2 B]INDOLE 9,10(5H,6H) DIONE; 5 PHENETHYL 7,8 DIHYDROINDENO[1,2 B]INDOLE 9,10(5,6H) DIONE; 7,8 DIHYDROINDENO[1,2 B]INDOLE 9,10(5H,6H) DIONE DERIVATIVE; 9 HYDROXY 5 ISOPROPYLINDENO[1,2 B]INDOLE 10 (5H) ONE; [2 (3,4 DIMETHOXYPHENYL)ETHYL] 9 HYDROXYINDENO[1,2 B]INDOLE 10 (5H) ONE; CASEIN KINASE II; HOLOENZYME; INDENO[1,2]INDOLE DERIVATIVE; INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IC 50; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

CASEIN KINASE II; CELL MEMBRANE PERMEABILITY; HUMANS; INDOLES; KINETICS; PROTEIN KINASE INHIBITORS; STEREOISOMERISM;

ESCHERICHIA COLI;

EID: 84858283155     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.017     Document Type: Article

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