Synthesis and biological evaluation of 3-(substituted-benzylidene)-1,3- dihydro-indolin derivatives as human protein kinase CK2 and p60c-Src tyrosine kinase inhibitors

Biological and Pharmaceutical Bulletin

Volumn 30, Issue 4, 2007, Pages 715-718

  Ölgen, Süreyya ^a   Götz, Claudia ^b   Jose, Joachim ^c  

^a ANKARA UNIVERSITY   (Turkey)

^b SAARLAND UNIVERSITY   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Cancer; Casein kinase 2 (CK2); Human protein kinase; Neoplastic transformation; p60c Src

Indexed keywords

1 BENZYLE INDOLE 2 PIPERIDINOETHYL CARBOXYLATE; 2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 3 (3' FLUORO BENZYLIDENE) 1,3 DIHYDRO INDOLIN 2 ONE; 3 (3' FLUORO BENZYLIDENE) 1,3 DIHYDRO INDOLIN 2 THIONE; 3 (4' CHLORO BENZYLIDENE) 1,3 DIHYDRO INDOLIN 2 THIONE; 3 (4' METHOXY BENZYLIDENE) 1,3 DIHYDRO INDOLIN 2 THIONE; BENZYLIDENE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CASEIN KINASE II; INDOLE DERIVATIVE; PROTEIN KINASE P60; PROTEIN SERINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RECOMBINANT PROTEIN; SEMAXANIB; SUNITINIB; THIOKETONE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CHEMOTHERAPY; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG RESEARCH; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; PROTEIN EXPRESSION; SUBSTITUTION REACTION;

BENZYLIDENE COMPOUNDS; CASEIN KINASE II; EVALUATION STUDIES; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34147094335     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.30.715     Document Type: Article

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