Synthesis, x-ray crystal structures, stabilities, and in vitro cytotoxic activities of new heteroarylacrylonitriles

Journal of Medicinal Chemistry

Volumn 47, Issue 13, 2004, Pages 3438-3449

  Sa̧czewski, Franciszek ^a   Reszka, Przemyslaw ^a,b   Gdaniec, Maria ^c   Grünert, Renate ^b   Bednarski, Patrick J ^b  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c ADAM MICKIEWICZ UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1H BENZIMIDAZOL 2 YL) 3 (5 NITROTHIOPHEN 2 YL)ACRYLONITRILE; 2 (5 BENZYL 1H 1,2,4 TRIAZOL 3 YL) 3 (5 NITROPHEN 2 YL)ACRYLONITRILE; ACRYLONITRILE; ACRYLONITRILE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; CASPASE 3; CASPASE 9; CISPLATIN; ETOPOSIDE; FURAN DERIVATIVE; HYDROGEN; NITRILE; PHENYL GROUP; THIOPHENE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CULTURE; CELL DEATH; CHEMICAL BOND; CHEMICAL REACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; KNOEVENAGEL CONDENSATION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ACRYLONITRILE; ANTINEOPLASTIC AGENTS; CELL CULTURE TECHNIQUES; CELL DEATH; CELL LINE; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG STABILITY; EPITHELIAL CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 2942580724     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0311036     Document Type: Article

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